Epigenetic regulation of cell fate reprogramming in aging and disease: A predictive computational model

Lactate dehydrogenase activity drives hair follicle stem cell activation

(2017) Aimee Flores et al.   NATURE CELL BIOLOGY

Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism

(2017) John C. Schell et al.   NATURE CELL BIOLOGY

Epigenetic plasticity and the hallmarks of cancer

(2017) William A. Flavahan et al.   SCIENCE

The Fountain of Youth by Targeting Senescent Cells?

(2017) Peter L.J. de Keizer   TRENDS IN MOLECULAR MEDICINE

Metabolic Profiling of IDH Mutation and Malignant Progression in Infiltrating Glioma

(2017) Llewellyn E. Jalbert et al.   Scientific Reports

Slow Chromatin Dynamics Allow Polycomb Target Genes to Filter Fluctuations in Transcription Factor Activity

(2017) Scott Berry et al.   Cell Systems

Epigenetic Mechanisms of Longevity and Aging

(2016) Payel Sen et al.   CELL

In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming

(2016) Alejandro Ocampo et al.   CELL

α-Ketoglutarate Accelerates the Initial Differentiation of Primed Human Pluripotent Stem Cells

(2016) Tara TeSlaa et al.   Cell Metabolism

CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism

(2016) Juliana Camacho-Pereira et al.   Cell Metabolism

Metabolic control of methylation and acetylation

(2016) Xiaoyang Su et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Diverse Activities of Histone Acylations Connect Metabolism to Chromatin Function

(2016) Arnob Dutta et al.   MOLECULAR CELL

The Aging Epigenome

(2016) Lauren N. Booth et al.   MOLECULAR CELL

DNA methylation in human epigenomes depends on local topology of CpG sites

(2016) Cecilia Lövkvist et al.   NUCLEIC ACIDS RESEARCH

The physics of epigenetics

(2016) Ruggero Cortini et al.   REVIEWS OF MODERN PHYSICS

Tissue damage and senescence provide critical signals for cellular reprogramming in vivo

(2016) Lluc Mosteiro et al.   SCIENCE

Dynamics of epigenetic regulation at the single-cell level

(2016) L. Bintu et al.   SCIENCE

The Metabolic Impact on Histone Acetylation and Transcription in Ageing

(2016) Shahaf Peleg et al.   TRENDS IN BIOCHEMICAL SCIENCES

Anti-Aging Strategies Based on Cellular Reprogramming

(2016) Alejandro Ocampo et al.   TRENDS IN MOLECULAR MEDICINE

Accelerated geroncogenesis in hereditary breast-ovarian cancer syndrome

(2016) Javier A. Menendez et al.   Oncotarget

Robustness of MEK-ERK Dynamics and Origins of Cell-to-Cell Variability in MAPK Signaling

(2016) Sarah Filippi et al.   Cell Reports

Oncometabolic Nuclear Reprogramming of Cancer Stemness

(2016) Javier A. Menendez et al.   Stem Cell Reports

Epigenetics and aging

(2016) S. Pal et al.   Science Advances

Dietary and genetic effects on age-related loss of gene silencing reveal epigenetic plasticity of chromatin repression during aging

(2016) Nan Jiang et al.   Aging-US

One-carbon metabolism and epigenetics: understanding the specificity

(2015) Samantha J. Mentch et al.   Annals of the New York Academy of Sciences

Epigenetics and cancer metabolism

(2015) Christelle Johnson et al.   CANCER LETTERS

Epigenetics and Metabolism

(2015) S. T. Keating et al.   CIRCULATION RESEARCH

Oncometabolites: tailoring our genes

(2015) Stefan Nowicki et al.   FEBS Journal

New Developments in the Pathogenesis and Therapeutic Targeting of the IDH1 Mutation in Glioma

(2015) Lilia Dimitrov et al.   International Journal of Medical Sciences

The effects of intrinsic noise on the behaviour of bistable cell regulatory systems under quasi-steady state conditions

(2015) Roberto de la Cruz et al.   JOURNAL OF CHEMICAL PHYSICS

Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers

(2015) Isaac B Hilton et al.   NATURE BIOTECHNOLOGY

Epigenetic regulation of ageing: linking environmental inputs to genomic stability

(2015) Bérénice A. Benayoun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Geroncogenesis: Metabolic Changes during Aging as a Driver of Tumorigenesis

(2014) Lindsay E. Wu et al.   CANCER CELL

Geroscience: Linking Aging to Chronic Disease

(2014) Brian K. Kennedy et al.   CELL

Gerometabolites: The pseudohypoxic aging side of cancer oncometabolites

(2014) JAVIERABEL MENENDEZ MENENDEZ et al.   CELL CYCLE

Methionine Metabolism Regulates Maintenance and Differentiation of Human Pluripotent Stem Cells

(2014) Nobuaki Shiraki et al.   Cell Metabolism

Oncometabolites-driven tumorigenesis: From genetics to targeted therapy

(2014) Aurélie Morin et al.   INTERNATIONAL JOURNAL OF CANCER

Stochastic quasi-steady state approximations for asymptotic solutions of the chemical master equation

(2014) Tomás Alarcón   JOURNAL OF CHEMICAL PHYSICS

Epigenetics of Aging and Aging-related Disease

(2014) A. Brunet et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Invasion and proliferation kinetics in enhancing gliomas predict IDH1 mutation status

(2014) Anne L. Baldock et al.   NEURO-ONCOLOGY

Metabostemness: A New Cancer Hallmark

(2014) Javier A. Menendez et al.   Frontiers in Oncology

Succinate: A New Epigenetic Hacker

(2013) Ming Yang et al.   CANCER CELL

SDH Mutations Establish a Hypermethylator Phenotype in Paraganglioma

(2013) Eric Letouzé et al.   CANCER CELL

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

(2013) Ana P. Gomes et al.   CELL

IDH1 and IDH2 Mutations in Gliomas

(2013) Adam L. Cohen et al.   Current Neurology and Neuroscience Reports

Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape

(2013) P. P. Shah et al.   GENES & DEVELOPMENT

Oncometabolites: linking altered metabolism with cancer

(2013) Ming Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

IDH1-Associated Primary Glioblastoma in Young Adults Displays Differential Patterns of Tumour and Vascular Morphology

(2013) Sergey Popov et al.   PLoS One

Metabolic Regulation of Epigenetics

(2012) Chao Lu et al.   Cell Metabolism

IDH mutation impairs histone demethylation and results in a block to cell differentiation

(2012) Chao Lu et al.   NATURE

Influence of Threonine Metabolism on S-Adenosylmethionine and Histone Methylation

(2012) N. Shyh-Chang et al.   SCIENCE

A Simple Histone Code Opens Many Paths to Epigenetics

(2012) Kim Sneppen et al.   PLoS Computational Biology

Epigenetic regulation of caloric restriction in aging

(2011) Yuanyuan Li et al.   BMC Medicine

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

A Polycomb-based switch underlying quantitative epigenetic memory

(2011) Andrew Angel et al.   NATURE

Histone methylation makes its mark on longevity

(2011) Shuo Han et al.   TRENDS IN CELL BIOLOGY

The prognostic IDH1 R132 mutation is associated with reduced NADP+-dependent IDH activity in glioblastoma

(2010) Fonnet E. Bleeker et al.   ACTA NEUROPATHOLOGICA

Familial paraganglioma syndromes

(2010) R. Chetty   JOURNAL OF CLINICAL PATHOLOGY

IDH mutations in glioma and acute myeloid leukemia

(2010) Lenny Dang et al.   TRENDS IN MOLECULAR MEDICINE

Inheritance of epigenetic chromatin silencing

(2009) Diana David-Rus et al.   JOURNAL OF THEORETICAL BIOLOGY

Power-Law Distributions in Empirical Data

(2009) Aaron Clauset et al.   SIAM REVIEW

Sloppiness, robustness, and evolvability in systems biology

(2008) Bryan C Daniels et al.   CURRENT OPINION IN BIOTECHNOLOGY

Approximate Bayesian computation scheme for parameter inference and model selection in dynamical systems

(2008) T. Toni et al.   Journal of the Royal Society Interface

Ultrasensitive gene regulation by positive feedback loops in nucleosome modification

(2008) Kim Sneppen et al.   Molecular Systems Biology

Combinatorial patterns of histone acetylations and methylations in the human genome

(2008) Zhibin Wang et al.   NATURE GENETICS

Stochasticity and the Molecular Mechanisms of Induced Pluripotency

(2008) Ben D. MacArthur et al.   PLoS One