Plasmodium falciparum SERA5 plays a non-enzymatic role in the malarial asexual blood-stage lifecycle

Synthetic peptides derived from the C-terminal 6kDa region of Plasmodium falciparum SERA5 inhibit the enzyme activity and malaria parasite development

(2014) Shivani Kanodia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Spread of Artemisinin Resistance in Plasmodium falciparum Malaria

(2014) Elizabeth A. Ashley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Emerging role of rhomboid family proteins in mammalian biology and disease

(2013) Nina Bergbold et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation

(2013) Yonka Christova et al.   EMBO REPORTS

Efficient expression and purification of recombinant human μ-calpain using anEscherichia coliexpression system

(2013) Shoji Hata et al.   GENES TO CELLS

Malaria

(2013) Nicholas J White et al.   LANCET

Designing the next generation of medicines for malaria control and eradication

(2013) Jeremy N Burrows et al.   MALARIA JOURNAL

Robust inducible Cre recombinase activity in the human malaria parasitePlasmodium falciparumenables efficient gene deletion within a single asexual erythrocytic growth cycle

(2013) Christine R. Collins et al.   MOLECULAR MICROBIOLOGY

Malaria Parasite cGMP-dependent Protein Kinase Regulates Blood Stage Merozoite Secretory Organelle Discharge and Egress

(2013) Christine R. Collins et al.   PLoS Pathogens

Plasmodium subtilisin-like protease 1 (SUB1): Insights into the active-site structure, specificity and function of a pan-malaria drug target

(2012) Chrislaine Withers-Martinez et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Proteolytic Activation of the Essential Parasitophorous Vacuole Cysteine Protease SERA6 Accompanies Malaria Parasite Egress from Its Host Erythrocyte

(2012) Andrea Ruecker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New lives for old: evolution of pseudoenzyme function illustrated by iRhoms

(2012) Colin Adrain et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inhibitory Potential of Prodomain of Plasmodium falciparum Protease Serine Repeat Antigen 5 for Asexual Blood Stages of Parasite

(2012) Asrar Alam et al.   PLoS One

Time-Lapse Imaging of Red Blood Cell Invasion by the Rodent Malaria Parasite Plasmodium yoelii

(2012) Kazuhide Yahata et al.   PLoS One

Tumor Necrosis Factor Signaling Requires iRhom2 to Promote Trafficking and Activation of TACE

(2012) C. Adrain et al.   SCIENCE

Virulence without catalysis: how can a pseudokinase affect host cell signaling?

(2012) Michael L. Reese et al.   TRENDS IN PARASITOLOGY

Rhomboid Family Pseudoproteases Use the ER Quality Control Machinery to Regulate Intercellular Signaling

(2011) Markus Zettl et al.   CELL

Plasmodium falciparum 19-Kilodalton Merozoite Surface Protein 1 (MSP1)-Specific Antibodies That Interfere with Parasite GrowthIn VitroCan Inhibit MSP1 Processing, Merozoite Invasion, and Intracellular Parasite Development

(2011) David K. Moss et al.   INFECTION AND IMMUNITY

Trypanosoma bruceiMetacaspase 4 Is a Pseudopeptidase and a Virulence Factor

(2011) William R. Proto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clues to Evolution of the SERA Multigene Family in 18 Plasmodium Species

(2011) Nobuko Arisue et al.   PLoS One

Evidences of protection against blood-stage infection of Plasmodium falciparum by the novel protein vaccine SE36

(2010) Toshihiro Horii et al.   PARASITOLOGY INTERNATIONAL

The Plasmodium serine-type SERA proteases display distinct expression patterns and non-essential in vivo roles during life cycle progression of the malaria parasite

(2009) Elyzana D. Putrianti et al.   CELLULAR MICROBIOLOGY

Structural Insights into the Protease-like Antigen Plasmodium falciparum SERA5 and Its Noncanonical Active-Site Serine

(2009) Anthony N. Hodder et al.   JOURNAL OF MOLECULAR BIOLOGY

An Inhibitory Antibody Blocks Interactions between Components of the Malarial Invasion Machinery

(2009) Christine R. Collins et al.   PLoS Pathogens

Neurobin/TMPRSS11c, a novel type II transmembrane serine protease that cleaves fibroblast growth factor-2in vitro

(2008) Robert Stallmach et al.   BIOCHEMICAL JOURNAL

Malarial proteases and host cell egress: an ‘emerging’ cascade

(2008) Michael J. Blackman   CELLULAR MICROBIOLOGY

Inhibition of Malaria Parasite Development by a Cyclic Peptide That Targets the Vital Parasite Protein SERA5

(2008) W. D. Fairlie et al.   INFECTION AND IMMUNITY

Identification of proteases that regulate erythrocyte rupture by the malaria parasite Plasmodium falciparum

(2008) Shirin Arastu-Kapur et al.   Nature Chemical Biology