- Home
- Publications
- Publication Search
- Publication Details
Title
Humanising the mouse genome piece by piece
Authors
Keywords
-
Journal
Nature Communications
Volume 10, Issue 1, Pages -
Publisher
Springer Nature
Online
2019-04-23
DOI
10.1038/s41467-019-09716-7
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Application of long single-stranded DNA donors in genome editing: generation and validation of mouse mutants
- (2018) Gemma F. Codner et al. BMC BIOLOGY
- A Huntingtin Knockin Pig Model Recapitulates Features of Selective Neurodegeneration in Huntington’s Disease
- (2018) Sen Yan et al. CELL
- Mice with endogenous TDP‐43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis
- (2018) Pietro Fratta et al. EMBO JOURNAL
- CRISPR off-target analysis in genetically engineered rats and mice
- (2018) Keith R. Anderson et al. NATURE METHODS
- TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD
- (2018) Matthew A. White et al. NATURE NEUROSCIENCE
- Alternative 3′ UTRs Modify the Localization, Regulatory Potential, Stability, and Plasticity of mRNAs in Neuronal Compartments
- (2018) Georgi Tushev et al. NEURON
- CUG initiation and frameshifting enable production of dipeptide repeat proteins from ALS/FTD C9ORF72 transcripts
- (2018) Ricardos Tabet et al. Nature Communications
- Universal Alternative Splicing of Noncoding Exons
- (2018) Ira W. Deveson et al. Cell Systems
- Classification of Transcription Boundary-Associated RNAs (TBARs) in Animals and Plants
- (2018) Dongliang Yu et al. Frontiers in Genetics
- The heterozygous R155C VCP mutation: Toxic in humans! Harmless in mice?
- (2018) Christoph S. Clemen et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- One‐step CRISPR/Cas9 method for the rapid generation of human antibody heavy chain knock‐in mice
- (2018) Ying‐Cing Lin et al. EMBO JOURNAL
- Evolved Cas9 variants with broad PAM compatibility and high DNA specificity
- (2018) Johnny H. Hu et al. NATURE
- Transmission of amyloid-β protein pathology from cadaveric pituitary growth hormone
- (2018) Silvia A. Purro et al. NATURE
- In vivo modeling of human neuron dynamics and Down syndrome
- (2018) Raquel Real et al. SCIENCE
- CRISPR/Cas9-mediated gene editing ameliorates neurotoxicity in mouse model of Huntington’s disease
- (2017) Su Yang et al. JOURNAL OF CLINICAL INVESTIGATION
- Combinations of chromosome transfer and genome editing for the development of cell/animal models of human disease and humanized animal models
- (2017) Narumi Uno et al. JOURNAL OF HUMAN GENETICS
- Apolipoprotein E and Alzheimer’s disease: the influence of apolipoprotein E on amyloid-β and other amyloidogenic proteins
- (2017) Tien-Phat V. Huynh et al. JOURNAL OF LIPID RESEARCH
- ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy
- (2017) Yang Shi et al. NATURE
- Codon optimality, bias and usage in translation and mRNA decay
- (2017) Gavin Hanson et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Antisense Oligonucleotides: Translation from Mouse Models to Human Neurodegenerative Diseases
- (2017) Kathleen M. Schoch et al. NEURON
- Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis
- (2017) Tien-Phat V. Huynh et al. NEURON
- Hallmarks of Alzheimer’s Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain
- (2017) Ira Espuny-Camacho et al. NEURON
- The contribution of homology arms to nuclease-assisted genome engineering
- (2017) Oliver Baker et al. NUCLEIC ACIDS RESEARCH
- Prevalence, incidence and carrier frequency of 5q–linked spinal muscular atrophy – a literature review
- (2017) Ingrid E. C. Verhaart et al. Orphanet Journal of Rare Diseases
- Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation
- (2017) Cristina Cariulo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Humanized mouse model supports development, function, and tissue residency of human natural killer cells
- (2017) Dietmar Herndler-Brandstetter et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mouse Models of C9orf72 Hexanucleotide Repeat Expansion in Amyotrophic Lateral Sclerosis/ Frontotemporal Dementia
- (2017) Ranjan Batra et al. Frontiers in Cellular Neuroscience
- Mouse Models of Human GWAS Hits for Obesity and Diabetes in the Post Genomic Era: Time for Reevaluation
- (2017) Samantha Laber et al. Frontiers in Endocrinology
- Efficient and rapid generation of large genomic variants in rats and mice using CRISMERE
- (2017) Marie-Christine Birling et al. Scientific Reports
- Beta-agonist stimulation ameliorates the phenotype of spinal and bulbar muscular atrophy mice and patient-derived myotubes
- (2017) Carmelo Milioto et al. Scientific Reports
- Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss
- (2016) Jelena Scekic‐Zahirovic et al. EMBO JOURNAL
- An African-specific polymorphism in theTP53gene impairs p53 tumor suppressor function in a mouse model
- (2016) Matthew Jennis et al. GENES & DEVELOPMENT
- Neuromuscular junctions are pathological but not denervated in two mouse models of spinal bulbar muscular atrophy
- (2016) Jessica E. Poort et al. HUMAN MOLECULAR GENETICS
- Apolipoprotein E: from cardiovascular disease to neurodegenerative disorders
- (2016) Robert W. Mahley JOURNAL OF MOLECULAR MEDICINE-JMM
- Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
- (2016) Alexis C. Komor et al. NATURE
- Integrated genomics and proteomics define huntingtin CAG length–dependent networks in mice
- (2016) Peter Langfelder et al. NATURE NEUROSCIENCE
- Foxp2 controls synaptic wiring of corticostriatal circuits and vocal communication by opposing Mef2c
- (2016) Yi-Chuan Chen et al. NATURE NEUROSCIENCE
- Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice
- (2016) D. Sok et al. SCIENCE
- Transcription Termination: Variations on Common Themes
- (2016) Odil Porrua et al. TRENDS IN GENETICS
- ssODN-mediated knock-in with CRISPR-Cas for large genomic regions in zygotes
- (2016) Kazuto Yoshimi et al. Nature Communications
- In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery
- (2016) Raman Bahal et al. Nature Communications
- Rescue of Metabolic Alterations in AR113Q Skeletal Muscle by Peripheral Androgen Receptor Gene Silencing
- (2016) Elisa Giorgetti et al. Cell Reports
- Mechanisms and Regulation of Alternative Pre-mRNA Splicing
- (2015) Yeon Lee et al. Annual Review of Biochemistry
- A Pharmacogenetic Determinant of Mu-Opioid Receptor Antagonist Effects on Alcohol Reward and Consumption: Evidence from Humanized Mice
- (2015) Ainhoa Bilbao et al. BIOLOGICAL PSYCHIATRY
- Glucagon Receptor Blockade With a Human Antibody Normalizes Blood Glucose in Diabetic Mice and Monkeys
- (2015) Haruka Okamoto et al. ENDOCRINOLOGY
- Disrupting SUMOylation enhances transcriptional function and ameliorates polyglutamine androgen receptor–mediated disease
- (2015) Jason P. Chua et al. JOURNAL OF CLINICAL INVESTIGATION
- Identification of cis-suppression of human disease mutations by comparative genomics
- (2015) Daniel M. Jordan et al. NATURE
- A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome
- (2015) Frances K. Wiseman et al. NATURE REVIEWS NEUROSCIENCE
- Dissecting Alzheimer disease in Down syndrome using mouse models
- (2015) Xun Yu Choong et al. Frontiers in Behavioral Neuroscience
- Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits
- (2015) Guilian Xu et al. Acta Neuropathologica Communications
- Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease
- (2014) G. A. Smith et al. HUMAN MOLECULAR GENETICS
- Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: interplay with cerebral blood flow
- (2014) Hongmei Li et al. Molecular Neurodegeneration
- Development and function of human innate immune cells in a humanized mouse model
- (2014) Anthony Rongvaux et al. NATURE BIOTECHNOLOGY
- Complete humanization of the mouse immunoglobulin loci enables efficient therapeutic antibody discovery
- (2014) E-Chiang Lee et al. NATURE BIOTECHNOLOGY
- Single App knock-in mouse models of Alzheimer's disease
- (2014) Takashi Saito et al. NATURE NEUROSCIENCE
- Humanized Foxp2 accelerates learning by enhancing transitions from declarative to procedural performance
- (2014) Christiane Schreiweis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes
- (2014) L. E. Macdonald et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice
- (2014) A. J. Murphy et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Generation and utility of genetically humanized mouse models
- (2013) Nico Scheer et al. DRUG DISCOVERY TODAY
- Phosphatidylserine increases IKBKAP levels in a humanized knock-in IKBKAP mouse model
- (2013) Ron Bochner et al. HUMAN MOLECULAR GENETICS
- Transcriptional activation of TFEB/ZKSCAN3 target genes underlies enhanced autophagy in spinobulbar muscular atrophy
- (2013) J. P. Chua et al. HUMAN MOLECULAR GENETICS
- Cognitive Deficits and Disruption of Neurogenesis in a Mouse Model of Apolipoprotein E4 Domain Interaction
- (2013) Samuel O. Adeosun et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Overexpression of human wild-type FUS causes progressive motor neuron degeneration in an age- and dose-dependent fashion
- (2012) Jacqueline C. Mitchell et al. ACTA NEUROPATHOLOGICA
- Apolipoprotein E4 Domain Interaction Accelerates Diet-Induced Atherosclerosis in Hypomorphic Arg-61 Apoe Mice
- (2012) Delphine Eberlé et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Mouse models of SMA: tools for disease characterization and therapeutic development
- (2012) Thomas W. Bebee et al. HUMAN GENETICS
- Latent Regulatory Potential of Human-Specific Repetitive Elements
- (2012) Michelle C. Ward et al. MOLECULAR CELL
- The long-range interaction landscape of gene promoters
- (2012) Amartya Sanyal et al. NATURE
- Comprehensive Behavioral and Molecular Characterization of a New Knock-In Mouse Model of Huntington’s Disease: zQ175
- (2012) Liliana B. Menalled et al. PLoS One
- A BACwards glance at neurodegeneration: molecular insights into disease fromLRRK2,SNCAandMAPTBAC-transgenic mice
- (2011) Sara J. Johnson et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Efficient differentiation and function of human macrophages in humanized CSF-1 mice
- (2011) C. Rathinam et al. BLOOD
- Quantitative Prediction of Human Pregnane X Receptor and Cytochrome P450 3A4 Mediated Drug-Drug Interaction in a Novel Multiple Humanized Mouse Line
- (2011) M. Hasegawa et al. MOLECULAR PHARMACOLOGY
- Pathogenic exon-trapping by SVA retrotransposon and rescue in Fukuyama muscular dystrophy
- (2011) Mariko Taniguchi-Ikeda et al. NATURE
- Genomically humanized mice: technologies and promises
- (2011) Anny Devoy et al. NATURE REVIEWS GENETICS
- Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo
- (2011) A. Rongvaux et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung
- (2011) T. Willinger et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Humanized mouse models of Cooley's anemia: correct fetal-to-adult hemoglobin switching, disease onset, and disease pathology
- (2010) Yongliang Huo et al. Annals of the New York Academy of Sciences
- In Vivo Responses of the Human and Murine Pregnane X Receptor to Dexamethasone in Mice
- (2010) N. Scheer et al. DRUG METABOLISM AND DISPOSITION
- A genetic determinant of the striatal dopamine response to alcohol in men
- (2010) V A Ramchandani et al. MOLECULAR PSYCHIATRY
- Chromosome looping at the human -globin locus is mediated via the major upstream regulatory element (HS -40)
- (2009) D. Vernimmen et al. BLOOD
- Preclinical transfusion-dependent humanized mouse model of β thalassemia major
- (2009) Yongliang Huo et al. BLOOD
- A Humanized Version of Foxp2 Affects Cortico-Basal Ganglia Circuits in Mice
- (2009) Wolfgang Enard et al. CELL
- RNA repair restores hemoglobin expression in IVS2-654 thalassemic mice
- (2009) S. Svasti et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Humanized Mouse Model of Cooley's Anemia
- (2008) Yongliang Huo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Denosumab, a Fully Human Monoclonal Antibody to RANKL, Inhibits Bone Resorption and Increases BMD in Knock-In Mice That Express Chimeric (Murine/Human) RANKL*
- (2008) Paul J Kostenuik et al. JOURNAL OF BONE AND MINERAL RESEARCH
- A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response
- (2008) Nico Scheer et al. JOURNAL OF CLINICAL INVESTIGATION
- Species-Specific Transcription in Mice Carrying Human Chromosome 21
- (2008) M. D. Wilson et al. SCIENCE
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started