Broadening the functionality of a J-protein/Hsp70 molecular chaperone system

How Do J-Proteins Get Hsp70 to Do So Many Different Things?

(2017) Elizabeth A. Craig et al.   TRENDS IN BIOCHEMICAL SCIENCES

Evolution of an intricate J-protein network driving protein disaggregation in eukaryotes

(2017) Nadinath B Nillegoda et al.   eLife

Monitoring conformational heterogeneity of the lid of DnaK substrate-binding domain during its chaperone cycle

(2016) Rupa Banerjee et al.   FEBS Journal

Rqc1 and Ltn1 Prevent C-terminal Alanine-Threonine Tail (CAT-tail)-induced Protein Aggregation by Efficient Recruitment of Cdc48 on Stalled 60S Subunits

(2016) Quentin Defenouillère et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The AUDANA algorithm for automated protein 3D structure determination from NMR NOE data

(2016) Woonghee Lee et al.   JOURNAL OF BIOMOLECULAR NMR

Integrative NMR for biomolecular research

(2016) Woonghee Lee et al.   JOURNAL OF BIOMOLECULAR NMR

Alternative modes of client binding enable functional plasticity of Hsp70

(2016) Alireza Mashaghi et al.   NATURE

In vivo aspects of protein folding and quality control

(2016) D. Balchin et al.   SCIENCE

The Rqc2/Tae2 subunit of the ribosome-associated quality control (RQC) complex marks ribosome-stalled nascent polypeptide chains for aggregation

(2016) Ryo Yonashiro et al.   eLife

Specific Binding of Tetratricopeptide Repeat Proteins to Heat Shock Protein 70 (Hsp70) and Heat Shock Protein 90 (Hsp90) Is Regulated by Affinity and Phosphorylation

(2015) Victoria A. Assimon et al.   BIOCHEMISTRY

Roles of Intramolecular and Intermolecular Interactions in Functional Regulation of the Hsp70 J-protein Co-Chaperone Sis1

(2015) Hyun Young Yu et al.   JOURNAL OF MOLECULAR BIOLOGY

How Hsp70 Molecular Machines Interact with Their Substrates to Mediate Diverse Physiological Functions

(2015) Eugenia M. Clerico et al.   JOURNAL OF MOLECULAR BIOLOGY

Close and Allosteric Opening of the Polypeptide-Binding Site in a Human Hsp70 Chaperone BiP

(2015) Jiao Yang et al.   STRUCTURE

NMRFAM-SPARKY: enhanced software for biomolecular NMR spectroscopy

(2014) Woonghee Lee et al.   BIOINFORMATICS

The Assembly and Intermolecular Properties of the Hsp70-Tomm34-Hsp90 Molecular Chaperone Complex

(2014) Filip Trcka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PONDEROSA-C/S: client–server based software package for automated protein 3D structure determination

(2014) Woonghee Lee et al.   JOURNAL OF BIOMOLECULAR NMR

SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information

(2014) Marco Biasini et al.   NUCLEIC ACIDS RESEARCH

Functional Diversification of Hsp40: Distinct J-Protein Functional Requirements for Two Prions Allow for Chaperone-Dependent Prion Selection

(2014) Julia M. Harris et al.   PLoS Genetics

Hsp40s Specify Functions of Hsp104 and Hsp90 Protein Chaperone Machines

(2014) Michael Reidy et al.   PLoS Genetics

The Cotranslational Function of Ribosome-Associated Hsp70 in Eukaryotic Protein Homeostasis

(2013) Felix Willmund et al.   CELL

PolyQ Proteins Interfere with Nuclear Degradation of Cytosolic Proteins by Sequestering the Sis1p Chaperone

(2013) Sae-Hun Park et al.   CELL

Protein backbone and sidechain torsion angles predicted from NMR chemical shifts using artificial neural networks

(2013) Yang Shen et al.   JOURNAL OF BIOMOLECULAR NMR

Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP

(2013) Ruifeng Qi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Hsp70 chaperone dynamics and molecular mechanism

(2013) Matthias P. Mayer   TRENDS IN BIOCHEMICAL SCIENCES

An Interdomain Energetic Tug-of-War Creates the Allosterically Active State in Hsp70 Molecular Chaperones

(2012) Anastasia Zhuravleva et al.   CELL

ADP ribosylation adapts an ER chaperone response to short-term fluctuations in unfolded protein load

(2012) Joseph E. Chambers et al.   JOURNAL OF CELL BIOLOGY

Molecular chaperones and stress-inducible protein-sorting factors coordinate the spatiotemporal distribution of protein aggregates

(2012) Liliana Malinovska et al.   MOLECULAR BIOLOGY OF THE CELL

Structure and Dynamics of the ATP-Bound Open Conformation of Hsp70 Chaperones

(2012) Roman Kityk et al.   MOLECULAR CELL

Objective identification of residue ranges for the superposition of protein structures

(2011) Donata K Kirchner et al.   BMC BIOINFORMATICS

Functions of Yeast Hsp40 Chaperone Sis1p Dispensable for Prion Propagation but Important for Prion Curing and Protection From Prion Toxicity

(2011) P. Aaron Kirkland et al.   GENETICS

Substrate discrimination of the chaperone BiP by autonomous and cochaperone-regulated conformational transitions

(2011) Moritz Marcinowski et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanics of Hsp70 chaperones enables differential interaction with client proteins

(2011) Rainer Schlecht et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Analysis of the [RNQ+] Prion Reveals Stability of Amyloid Fibers as the Key Determinant of Yeast Prion Variant Propagation

(2010) Tejas Kalastavadi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of DnaJ G/F-rich Domain in Conformational Recognition and Binding of Protein Substrates

(2010) Judit Perales-Calvo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A dual function for chaperones SSB–RAC and the NAC nascent polypeptide–associated complex on ribosomes

(2010) Ansgar Koplin et al.   JOURNAL OF CELL BIOLOGY

The Conformational Dynamics of the Mitochondrial Hsp70 Chaperone

(2010) Koyeli Mapa et al.   MOLECULAR CELL

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

(2010) Harm H. Kampinga et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The influence of C-terminal extension on the structure of the “J-domain” in E. coli DnaJ

(2010) Kai Huang et al.   PROTEIN SCIENCE

PINE-SPARKY: graphical interface for evaluating automated probabilistic peak assignments in protein NMR spectroscopy

(2009) W. Lee et al.   BIOINFORMATICS

Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate

(2009) E. B. Bertelsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Probabilistic Interaction Network of Evidence Algorithm and its Application to Complete Labeling of Peak Lists from Protein NMR Spectroscopy

(2009) Arash Bahrami et al.   PLoS Computational Biology

Guidelines for the nomenclature of the human heat shock proteins

(2008) Harm H. Kampinga et al.   CELL STRESS & CHAPERONES

Structural proteomics by NMR spectroscopy

(2008) Joon Shin et al.   Expert Review of Proteomics

In Vivo Monitoring of the Prion Replication Cycle Reveals a Critical Role for Sis1 in Delivering Substrates to Hsp104

(2008) Kimberly A. Tipton et al.   MOLECULAR CELL

Specificity of the J-protein Sis1 in the propagation of 3 yeast prions

(2008) T. Higurashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA