Assessing Activity and Inhibition of Middle East Respiratory Syndrome Coronavirus Papain-Like and 3C-Like Proteases Using Luciferase-Based Biosensors

Middle East Respiratory Syndrome Coronavirus (MERS-CoV): Announcement of the Coronavirus Study Group

(2013) R. J. de Groot et al.   JOURNAL OF VIROLOGY

Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus: a report of nosocomial transmission

(2013) Benoit Guery et al.   LANCET

Hospital Outbreak of Middle East Respiratory Syndrome Coronavirus

(2013) Abdullah Assiri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Family Cluster of Middle East Respiratory Syndrome Coronavirus Infections

(2013) Ziad A. Memish et al.   NEW ENGLAND JOURNAL OF MEDICINE

Imaging Proteolytic Activity in Live Cells and Animal Models

(2013) Stefanie Galbán et al.   PLoS One

Two cases of novel coronavirus are confirmed in France

(2013) A. Gulland   BMJ-British Medical Journal

The newly emerged SARS-Like coronavirus HCoV-EMC also has an “Achilles’ heel”: current effective inhibitor targeting a 3C-like protease

(2013) Zhilin Ren et al.   Protein & Cell

Recent development of 3C and 3CL protease inhibitors for anti-coronavirus and anti-picornavirus drug discovery

(2012) R. Ramajayam et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Discovery, Synthesis, And Structure-Based Optimization of a Series of N-(tert-Butyl)-2-(N-arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease

(2012) Jon Jacobs et al.   JOURNAL OF MEDICINAL CHEMISTRY

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

(2012) Ali M. Zaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genomic Characterization of a Newly Discovered Coronavirus Associated with Acute Respiratory Distress Syndrome in Humans

(2012) S. van Boheemen et al.   mBio

A Luminescent Biosensor with Increased Dynamic Range for Intracellular cAMP

(2011) Brock F. Binkowski et al.   ACS Chemical Biology

Bioluminescence technologies to detect calicivirus protease activity in cell-free system and in infected cells

(2011) Tomoichiro Oka et al.   ANTIVIRAL RESEARCH

Recent developments in anti-severe acute respiratory syndrome coronavirus chemotherapy

(2011) Dale L Barnard et al.   Future Virology

Profiling of Substrate Specificities of 3C-Like Proteases from Group 1, 2a, 2b, and 3 Coronaviruses

(2011) Chi-Pang Chuck et al.   PLoS One

Severe Acute Respiratory Syndrome Coronavirus Papain-like Novel Protease Inhibitors: Design, Synthesis, Protein−Ligand X-ray Structure and Biological Evaluation

(2010) Arun K. Ghosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Engineered luciferases for molecular sensing in living cells

(2009) Brock Binkowski et al.   CURRENT OPINION IN BIOTECHNOLOGY

Severe Acute Respiratory Syndrome Coronavirus Papain-Like Protease Ubiquitin-Like Domain and Catalytic Domain Regulate Antagonism of IRF3 and NF- B Signaling

(2009) M. Frieman et al.   JOURNAL OF VIROLOGY

Coronaviruses post-SARS: update on replication and pathogenesis

(2009) Stanley Perlman et al.   NATURE REVIEWS MICROBIOLOGY

Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors

(2008) Arun K. Ghosh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Structural View of the Inactivation of the SARS Coronavirus Main Proteinase by Benzotriazole Esters

(2008) Koen H.G. Verschueren et al.   CHEMISTRY & BIOLOGY

A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication

(2008) K. Ratia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA