DNA Nanotechnology as an Emerging Tool to Study Mechanotransduction in Living Systems

Modular Design of Programmable Mechanofluorescent DNA Hydrogels

(2019) Remi Merindol et al.   Nature Communications

Heterogeneous and rate-dependent streptavidin–biotin unbinding revealed by high-speed force spectroscopy and atomistic simulations

(2019) Felix Rico et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Folding/unfolding kinetics of G-quadruplexes upstream of the P1 promoter of the human BCL-2 oncogene

(2019) Yuanlei Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantifying Molecular Forces with Serially Connected Force Sensors

(2019) Yousif Murad et al.   BIOPHYSICAL JOURNAL

Force-activatable biosensor enables single platelet force mapping directly by fluorescence imaging

(2018) Yongliang Wang et al.   BIOSENSORS & BIOELECTRONICS

Programmable Multivalent DNA-Origami Tension Probes for Reporting Cellular Traction Forces

(2018) Palash K. Dutta et al.   NANO LETTERS

Dynamics of force generation by spreading platelets

(2018) Jana Hanke et al.   Soft Matter

Structural–elastic determination of the force-dependent transition rate of biomolecules

(2018) Shiwen Guo et al.   Chemical Science

Molecular Tension Probes to Investigate the Mechanopharmacology of Single Cells: A Step toward Personalized Mechanomedicine

(2018) Kornelia Galior et al.   Advanced Healthcare Materials

Tunable molecular tension sensors reveal extension-based control of vinculin loading

(2018) Andrew S LaCroix et al.   eLife

Scaling up molecular pattern recognition with DNA-based winner-take-all neural networks

(2018) Kevin M. Cherry et al.   NATURE

A TCR mechanotransduction signaling loop induces negative selection in the thymus

(2018) Jinsung Hong et al.   NATURE IMMUNOLOGY

Functional and Sustainable 3D Human Neural Network Models from Pluripotent Stem Cells

(2018) William L. Cantley et al.   ACS Biomaterials-Science & Engineering

Visualizing Intercellular Tensile Forces by DNA-Based Membrane Molecular Probes

(2017) Bin Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mapping the 3D orientation of piconewton integrin traction forces

(2017) Joshua M Brockman et al.   NATURE METHODS

Platelet integrins exhibit anisotropic mechanosensing and harness piconewton forces to mediate platelet aggregation

(2017) Yun Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hidden dynamics in the unfolding of individual bacteriorhodopsin proteins

(2017) Hao Yu et al.   SCIENCE

Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity

(2017) Vincent C. Luca et al.   SCIENCE

Recent advances in DNAzyme-based gene silencing

(2017) Huanhuan Fan et al.   Science China-Chemistry

Mapping cell surface adhesion by rotation tracking and adhesion footprinting

(2017) Isaac T. S. Li et al.   Scientific Reports

The Beauty and Utility of DNA Origami

(2017) Pengfei Wang et al.   Chem

Single Molecule Force Measurements in Living Cells Reveal a Minimally Tensioned Integrin State

(2016) Alice C. Chang et al.   ACS Nano

Mechanically Induced Catalytic Amplification Reaction for Readout of Receptor-Mediated Cellular Forces

(2016) Victor Pui-Yan Ma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Probing of miniPEGγ-PNA–DNA Hybrid Duplex Stability with AFM Force Spectroscopy

(2016) Samrat Dutta et al.   BIOCHEMISTRY

Knockdown of TNF-α by DNAzyme gold nanoparticles as an anti-inflammatory therapy for myocardial infarction

(2016) Inthirai Somasuntharam et al.   BIOMATERIALS

Dynamic Melting Properties of Photoswitch-Modified DNA: Shearing versus Unzipping

(2016) Jie Zhang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

A General Approach for Generating Fluorescent Probes to Visualize Piconewton Forces at the Cell Surface

(2016) Yuan Chang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A beginner's guide to atomic force microscopy probing for cell mechanics

(2016) Núria Gavara   MICROSCOPY RESEARCH AND TECHNIQUE

Ratiometric Tension Probes for Mapping Receptor Forces and Clustering at Intermembrane Junctions

(2016) Victor Pui-Yan Ma et al.   NANO LETTERS

Defining Single Molecular Forces Required for Notch Activation Using Nano Yoyo

(2016) Farhan Chowdhury et al.   NANO LETTERS

Germinal center B cells recognize antigen through a specialized immune synapse architecture

(2016) Carla R Nowosad et al.   NATURE IMMUNOLOGY

Transcription upregulation via force-induced direct stretching of chromatin

(2016) Arash Tajik et al.   NATURE MATERIALS

Mechanical properties of DNA origami nanoassemblies are determined by Holliday junction mechanophores

(2016) Prakash Shrestha et al.   NUCLEIC ACIDS RESEARCH

DNA-based nanoparticle tension sensors reveal that T-cell receptors transmit defined pN forces to their antigens for enhanced fidelity

(2016) Yang Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct observation of transition paths during the folding of proteins and nucleic acids

(2016) K. Neupane et al.   SCIENCE

Catalytic DNA: Scope, Applications, and Biochemistry of Deoxyribozymes

(2016) Scott K. Silverman   TRENDS IN BIOCHEMICAL SCIENCES

Constructing modular and universal single molecule tension sensor using protein G to study mechano-sensitive receptors

(2016) Xuefeng Wang et al.   Scientific Reports

Integrins outside focal adhesions transmit tensions during stable cell adhesion

(2016) Yongliang Wang et al.   Scientific Reports

Force-Induced Rupture of a DNA Duplex: From Fundamentals to Force Sensors

(2015) Majid Mosayebi et al.   ACS Nano

Investigating cell mechanics with atomic force microscopy

(2015) K. Haase et al.   Journal of the Royal Society Interface

Lighting Up the Force: Investigating Mechanisms of Mechanotransduction Using Fluorescent Tension Probes

(2015) Carol Jurchenko et al.   MOLECULAR AND CELLULAR BIOLOGY

Titin-Based Nanoparticle Tension Sensors Map High-Magnitude Integrin Forces within Focal Adhesions

(2015) Kornelia Galior et al.   NANO LETTERS

Visualizing the Interior Architecture of Focal Adhesions with High-Resolution Traction Maps

(2015) Masatoshi Morimatsu et al.   NANO LETTERS

Supported lipid bilayers as dynamic platforms for tethered particles

(2015) Kevin L. Hartman et al.   Nanoscale

High-speed DNA-based rolling motors powered by RNase H

(2015) Kevin Yehl et al.   Nature Nanotechnology

Programmable materials and the nature of the DNA bond

(2015) M. R. Jones et al.   SCIENCE

Mechanochemical regulations of RPA's binding to ssDNA

(2015) Jin Chen et al.   Scientific Reports

Functional DNA nanomaterials for sensing and imaging in living cells

(2014) Seyed-Fakhreddin Torabi et al.   CURRENT OPINION IN BIOTECHNOLOGY

Nanoparticle Tension Probes Patterned at the Nanoscale: Impact of Integrin Clustering on Force Transmission

(2014) Yang Liu et al.   NANO LETTERS

Spatial control of membrane receptor function using ligand nanocalipers

(2014) Alan Shaw et al.   NATURE METHODS

A DNA-based molecular probe for optically reporting cellular traction forces

(2014) Brandon L Blakely et al.   NATURE METHODS

A Force-Based, Parallel Assay for the Quantification of Protein-DNA Interactions

(2014) Katja Limmer et al.   PLoS One

Traction force microscopy in physics and biology

(2014) Robert W. Style et al.   Soft Matter

DNA-based digital tension probes reveal integrin forces during early cell adhesion

(2014) Yun Zhang et al.   Nature Communications

Tension Sensing Nanoparticles for Mechano-Imaging at the Living/Nonliving Interface

(2013) Yang Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In retrospect: On Growth and Form

(2013) Philip Ball   NATURE

A synthetic DNA motor that transports nanoparticles along carbon nanotubes

(2013) Tae-Gon Cha et al.   Nature Nanotechnology

B Cells Use Mechanical Energy to Discriminate Antigen Affinities

(2013) E. Natkanski et al.   SCIENCE

Defining Single Molecular Forces Required to Activate Integrin and Notch Signaling

(2013) X. Wang et al.   SCIENCE

Catalytic Deoxyribozyme-Modified Nanoparticles for RNAi-Independent Gene Regulation

(2012) Kevin Yehl et al.   ACS Nano

Recent advances in luminescent heavy metal complexes for sensing

(2012) Dik-Lung Ma et al.   COORDINATION CHEMISTRY REVIEWS

Force field evolution during human blood platelet activation

(2012) S. Schwarz Henriques et al.   JOURNAL OF CELL SCIENCE

Fluorescence lifetime imaging - techniques and applications

(2012) W. BECKER   JOURNAL OF MICROSCOPY

Cells test substrate rigidity by local contractions on submicrometer pillars

(2012) S. Ghassemi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Visualizing mechanical tension across membrane receptors with a fluorescent sensor

(2011) Daniel R Stabley et al.   NATURE METHODS

Nanoparticle Superlattice Engineering with DNA

(2011) R. J. Macfarlane et al.   SCIENCE

Applications of Aptamers as Sensors

(2010) Eun Jeong Cho et al.   Annual Review of Analytical Chemistry

Force induced melting of the constrained DNA

(2010) Amit Raj Singh et al.   JOURNAL OF CHEMICAL PHYSICS

Coexistence of an ILPR i-Motif and a Partially Folded Structure with Comparable Mechanical Stability Revealed at the Single-Molecule Level

(2010) Soma Dhakal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Peptide Nucleic Acids as Tools for Single-Molecule Sequence Detection and Manipulation

(2010) Hagar Zohar et al.   NANO LETTERS

Single-molecule force spectroscopy: a method for quantitative analysis of ligand–receptor interactions

(2010) Alexander Fuhrmann et al.   Nanomedicine

Mechanical regulation of cell function with geometrically modulated elastomeric substrates

(2010) Jianping Fu et al.   NATURE METHODS

Spatial organization and signal transduction at intercellular junctions

(2010) Boryana N. Manz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA as a Force Sensor in an Aptamer-Based Biochip for Adenosine

(2009) Dominik Ho et al.   ANALYTICAL CHEMISTRY

ILPR G-Quadruplexes Formed in Seconds Demonstrate High Mechanical Stabilities

(2009) Zhongbo Yu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quantifying cellular traction forces in three dimensions

(2009) Stacey A. Maskarinec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative Fluorescence Microscopy Using Supported Lipid Bilayer Standards

(2008) William J. Galush et al.   BIOPHYSICAL JOURNAL

DNAzyme technology and cancer therapy: cleave and let die

(2008) C. R. Dass et al.   MOLECULAR CANCER THERAPEUTICS

DNA-programmable nanoparticle crystallization

(2008) Sung Yong Park et al.   NATURE

DNA-guided crystallization of colloidal nanoparticles

(2008) Dmytro Nykypanchuk et al.   NATURE

Single-molecule force spectroscopy: optical tweezers, magnetic tweezers and atomic force microscopy

(2008) Keir C Neuman et al.   NATURE METHODS

Demonstration that the shear force required to separate short double-stranded DNA does not increase significantly with sequence length for sequences longer than 25 base pairs

(2008) K. Hatch et al.   PHYSICAL REVIEW E