FTO contributes to hepatic metabolism regulation through regulation of leptin action and STAT3 signalling in liver

Genetic Susceptibility to Triple-Negative Breast Cancer

(2013) K. N. Stevens et al.   CANCER RESEARCH

Fat Mass and Obesity-Associated Gene Enhances Oxidative Stress and Lipogenesis in Nonalcoholic Fatty Liver Disease

(2013) Jianjin Guo et al.   DIGESTIVE DISEASES AND SCIENCES

A link between FTO, ghrelin, and impaired brain food-cue responsivity

(2013) Efthimia Karra et al.   JOURNAL OF CLINICAL INVESTIGATION

Effect of leptin treatment on mitochondrial function in obese leptin-deficient ob/ob mice

(2013) Maria H. Holmström et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The expression of FTO in human adipose tissue is influenced by fat depot, adiposity, and insulin sensitivity

(2013) Amélie Bravard et al.   Obesity

Hyperresponsivity to Low-Dose Endotoxin during Progression to Nonalcoholic Steatohepatitis Is Regulated by Leptin-Mediated Signaling

(2012) Kento Imajo et al.   Cell Metabolism

Phospho-Ser727 of STAT3 regulates STAT3 activity by enhancing dephosphorylation of phospho-Tyr705 largely through TC45

(2012) Ryohei Wakahara et al.   GENES TO CELLS

From GWAS to biology: lessons from FTO

(2011) Yi-Chun Loraine Tung et al.   Annals of the New York Academy of Sciences

Cloning and characterization of chicken fat mass and obesity associated (Fto) gene: fasting affects Fto expression

(2011) A. Tiwari et al.   DOMESTIC ANIMAL ENDOCRINOLOGY

Negative Regulation of STAT3 Protein-mediated Cellular Respiration by SIRT1 Protein

(2011) Michel Bernier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of the N-terminal domain in dimerization and nucleocytoplasmic shuttling of latent STAT3

(2011) M. Vogt et al.   JOURNAL OF CELL SCIENCE

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

Fto immunoreactivity is widespread in the rodent brain and abundant in feeding-related sites, but the number of Fto-positive cells is not affected by changes in energy balance

(2011) Pawel K. Olszewski et al.   PHYSIOLOGY & BEHAVIOR

Leptin Receptor Signaling Supports Cancer Cell Metabolism through Suppression of Mitochondrial Respiration in Vivo

(2010) Jiyoung Park et al.   AMERICAN JOURNAL OF PATHOLOGY

Relationship between blood glucose levels and hepatic Fto mRNA expression in mice

(2010) Nicole J. Poritsanos et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

STAT3 is constitutively phosphorylated on serine 727 residues, binds DNA, and activates transcription in CLL cells

(2010) I. Hazan-Halevy et al.   BLOOD

FTO Is Increased in Muscle During Type 2 Diabetes, and Its Overexpression in Myotubes Alters Insulin Signaling, Enhances Lipogenesis and ROS Production, and Induces Mitochondrial Dysfunction

(2010) A. Bravard et al.   DIABETES

The obesity-associated SNPs in intron 1 of the FTO gene affect primary transcript levels

(2010) Tea Berulava et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Protein kinase Cɛ mediates Stat3Ser727 phosphorylation, Stat3-regulated gene expression and cell invasion in various human cancer cell lines through integration with MAPK cascade (RAF-1, MEK1/2 and ERK1/2)

(2010) M H Aziz et al.   ONCOGENE

Hypothalamic-Specific Manipulation of Fto, the Ortholog of the Human Obesity Gene FTO, Affects Food Intake in Rats

(2010) Yi-Chun Loraine Tung et al.   PLoS One

The Fat Mass and Obesity Associated Gene FTO Functions in the Brain to Regulate Postnatal Growth in Mice

(2010) Xue Gao et al.   PLoS One

STAT3 Targets the Regulatory Regions of Gluconeogenic Genesin Vivo

(2009) Preeti Ramadoss et al.   MOLECULAR ENDOCRINOLOGY

Inactivation of the Fto gene protects from obesity

(2009) Julia Fischer et al.   NATURE

Leptin-mediated changes in hepatic mitochondrial metabolism, structure, and protein levels

(2009) A. Singh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Function of Mitochondrial Stat3 in Cellular Respiration

(2009) J. Wegrzyn et al.   SCIENCE

A Mouse Model for the Metabolic Effects of the Human Fat Mass and Obesity Associated FTO Gene

(2009) Chris Church et al.   PLoS Genetics

The Obesity Gene, FTO, Is of Ancient Origin, Up-Regulated during Food Deprivation and Expressed in Neurons of Feeding-Related Nuclei of the Brain

(2008) Robert Fredriksson et al.   ENDOCRINOLOGY