Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1
出版年份 2019 全文链接
标题
Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1
作者
关键词
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出版物
Science Translational Medicine
Volume 11, Issue 488, Pages eaau7116
出版商
American Association for the Advancement of Science (AAAS)
发表日期
2019-04-18
DOI
10.1126/scitranslmed.aau7116
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- m6A modulates haematopoietic stem and progenitor cell specification
- (2017) Chunxia Zhang et al. NATURE
- Common and distinct regulation of human and mouse brown and beige adipose tissues: a promising therapeutic target for obesity
- (2017) Xuejiao Liu et al. Protein & Cell
- DJ-1 maintains energy and glucose homeostasis by regulating the function of brown adipose tissue
- (2017) Rong Wu et al. Cell Discovery
- Deficiency in catechol-o-methyltransferase is linked to a disruption of glucose homeostasis in mice
- (2017) Megumi Kanasaki et al. Scientific Reports
- Reversible methylation of m6Am in the 5′ cap controls mRNA stability
- (2016) Jan Mauer et al. NATURE
- An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells
- (2016) Maia Vinogradova et al. Nature Chemical Biology
- Transcriptional and epigenetic control of brown and beige adipose cell fate and function
- (2016) Takeshi Inagaki et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- N6-methyladenosine Modulates Messenger RNA Translation Efficiency
- (2015) Xiao Wang et al. CELL
- m6A RNA Methylation Is Regulated by MicroRNAs and Promotes Reprogramming to Pluripotency
- (2015) Tong Chen et al. Cell Stem Cell
- Identification of A Novel Small-Molecule Binding Site of the Fat Mass and Obesity Associated Protein (FTO)
- (2015) Wu He et al. JOURNAL OF MEDICINAL CHEMISTRY
- FTO Obesity Variant Circuitry and Adipocyte Browning in Humans
- (2015) Melina Claussnitzer et al. NEW ENGLAND JOURNAL OF MEDICINE
- A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N6-methyladenosine demethylase FTO
- (2015) Joel D. W. Toh et al. Chemical Science
- Synthesis of a FTO Inhibitor with Anticonvulsant Activity
- (2014) Guanqun Zheng et al. ACS Chemical Neuroscience
- CRISPRdirect: software for designing CRISPR/Cas guide RNA with reduced off-target sites
- (2014) Yuki Naito et al. BIOINFORMATICS
- HTSeq--a Python framework to work with high-throughput sequencing data
- (2014) S. Anders et al. BIOINFORMATICS
- Trimmomatic: a flexible trimmer for Illumina sequence data
- (2014) Anthony M. Bolger et al. BIOINFORMATICS
- FTO contributes to hepatic metabolism regulation through regulation of leptin action and STAT3 signalling in liver
- (2014) Amélie Bravard et al. Cell Communication and Signaling
- FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis
- (2014) Xu Zhao et al. CELL RESEARCH
- Obesity-associated variants within FTO form long-range functional connections with IRX3
- (2014) Scott Smemo et al. NATURE
- Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5
- (2014) Yue Huang et al. NUCLEIC ACIDS RESEARCH
- FTO Deficiency Induces UCP-1 Expression and Mitochondrial Uncoupling in Adipocytes
- (2013) D. Tews et al. ENDOCRINOLOGY
- Adaptive thermogenesis in adipocytes: Is beige the new brown?
- (2013) J. Wu et al. GENES & DEVELOPMENT
- Structural Basis for Inhibition of the Fat Mass and Obesity Associated Protein (FTO)
- (2013) WeiShen Aik et al. JOURNAL OF MEDICINAL CHEMISTRY
- N6-methyladenosine-dependent regulation of messenger RNA stability
- (2013) Xiao Wang et al. NATURE
- Brown and beige fat: development, function and therapeutic potential
- (2013) Matthew Harms et al. NATURE MEDICINE
- Adipose tissue browning and metabolic health
- (2013) Alexander Bartelt et al. Nature Reviews Endocrinology
- FOXOs: signalling integrators for homeostasis maintenance
- (2013) Astrid Eijkelenboom et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Role for the obesity-related FTO gene in the cellular sensing of amino acids
- (2013) P. Gulati et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
- (2012) Kate D. Meyer et al. CELL
- Pten Positively Regulates Brown Adipose Function, Energy Expenditure, and Longevity
- (2012) Ana Ortega-Molina et al. Cell Metabolism
- Discovery of Novel Tubulin Inhibitors via Structure-Based Hierarchical Virtual Screening
- (2012) Ran Cao et al. Journal of Chemical Information and Modeling
- ZINC: A Free Tool to Discover Chemistry for Biology
- (2012) John J. Irwin et al. Journal of Chemical Information and Modeling
- Life Beyond Kinases: Structure-Based Discovery of Sorafenib as Nanomolar Antagonist of 5-HT Receptors
- (2012) Xingyu Lin et al. JOURNAL OF MEDICINAL CHEMISTRY
- Development of Cell-Active N6-Methyladenosine RNA Demethylase FTO Inhibitor
- (2012) Baoen Chen et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- FTO genotype is associated with phenotypic variability of body mass index
- (2012) Jian Yang et al. NATURE
- Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
- (2012) Dan Dominissini et al. NATURE
- REFMAC5 for the refinement of macromolecular crystal structures
- (2011) Garib N. Murshudov et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
- (2011) Guifang Jia et al. Nature Chemical Biology
- Features and development ofCoot
- (2010) P. Emsley et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Relationship between blood glucose levels and hepatic Fto mRNA expression in mice
- (2010) Nicole J. Poritsanos et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- BEDTools: a flexible suite of utilities for comparing genomic features
- (2010) Aaron R. Quinlan et al. BIOINFORMATICS
- Rapid Context-Dependent Ligand Desolvation in Molecular Docking
- (2010) Michael M. Mysinger et al. Journal of Chemical Information and Modeling
- Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities
- (2010) Sven Heinz et al. MOLECULAR CELL
- Discovery of Novel Forkhead Box O1 Inhibitors for Treating Type 2 Diabetes: Improvement of Fasting Glycemia in Diabetic db/db Mice
- (2010) T. Nagashima et al. MOLECULAR PHARMACOLOGY
- FTO effect on energy demand versus food intake
- (2010) John R. Speakman NATURE
- Crystal structure of the FTO protein reveals basis for its substrate specificity
- (2010) Zhifu Han et al. NATURE
- Overexpression of Fto leads to increased food intake and results in obesity
- (2010) Chris Church et al. NATURE GENETICS
- Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis
- (2010) Eric E Zhang et al. NATURE MEDICINE
- DEGseq: an R package for identifying differentially expressed genes from RNA-seq data
- (2009) Likun Wang et al. BIOINFORMATICS
- TopHat: discovering splice junctions with RNA-Seq
- (2009) Cole Trapnell et al. BIOINFORMATICS
- Inactivation of the Fto gene protects from obesity
- (2009) Julia Fischer et al. NATURE
- A Mouse Model for the Metabolic Effects of the Human Fat Mass and Obesity Associated FTO Gene
- (2009) Chris Church et al. PLoS Genetics
- Catechol O-methyltransferase val158-met polymorphism is associated with abdominal obesity and blood pressure in men
- (2008) Kristina Annerbrink et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange
- (2008) Yi Liu et al. NATURE
- Phenotypic characterization of cognition and social behavior in mice with heterozygous versus homozygous deletion of catechol-O-methyltransferase
- (2008) D. Babovic et al. NEUROSCIENCE
- Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists
- (2008) Da Wei Huang et al. NUCLEIC ACIDS RESEARCH
- The role of FoxO in the regulation of metabolism
- (2008) D N Gross et al. ONCOGENE
- Model-based Analysis of ChIP-Seq (MACS)
- (2008) Yong Zhang et al. GENOME BIOLOGY
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