Paeoniflorin attenuates impairment of spatial learning and hippocampal long-term potentiation in mice subjected to chronic unpredictable mild stress

Paeoniflorin exerts neuroprotective effects by modulating the M1/M2 subset polarization of microglia/macrophages in the hippocampal CA1 region of vascular dementia rats via cannabinoid receptor 2

(2018) Xian-Qin Luo et al.   Chinese Medicine

Inhibition of Phosphodiesterase 4 by FCPR03 Alleviates Chronic Unpredictable Mild Stress-Induced Depressive-Like Behaviors and Prevents Dendritic Spine Loss in Mice Hippocampi

(2018) Hui Yu et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Paeoniflorin exerts neuroprotective effects against glutamate-induced PC12 cellular cytotoxicity by inhibiting apoptosis

(2017) Ahong Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Gene deficiency and pharmacological inhibition of caspase-1 confers resilience to chronic social defeat stress via regulating the stability of surface AMPARs

(2017) M-X Li et al.   MOLECULAR PSYCHIATRY

Paeoniflorin Attenuates Cerebral Ischemia-Induced Injury by Regulating Ca2+/CaMKII/CREB Signaling Pathway

(2017) Yuqin Zhang et al.   MOLECULES

Effect of agomelatine on memory deficits and hippocampal gene expression induced by chronic social defeat stress in mice

(2017) Vincent Martin et al.   Scientific Reports

Mouse strain differences in SSRI sensitivity correlate with serotonin transporter binding and function

(2017) Zeng-liang Jin et al.   Scientific Reports

Blood oxygen level-dependent signals via fMRI in the mood-regulating circuit using two animal models of depression are reversed by chronic escitalopram treatment

(2016) Jiao-jie Hui et al.   BEHAVIOURAL BRAIN RESEARCH

Neuroprotective effect of a novel Chinese herbal decoction on cultured neurons and cerebral ischemic rats

(2016) Fanny Chui-Fun Ip et al.   BMC Complementary and Alternative Medicine

Antidepressant-like effects of acupuncture involved the ERK signaling pathway in rats

(2016) Xuhui Zhang et al.   BMC Complementary and Alternative Medicine

Antidepressant-like effects of albiflorin extracted from Radix paeoniae Alba

(2016) Yu-Lu Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Hippocampal MicroRNA-124 Enhances Chronic Stress Resilience in Mice

(2016) F. Higuchi et al.   JOURNAL OF NEUROSCIENCE

Protective effect of paeoniflorin on inflammation and apoptosis in the cerebral cortex of a transgenic mouse model of Alzheimer's disease

(2016) XINYI GU et al.   Molecular Medicine Reports

Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants

(2016) Ronald S Duman et al.   NATURE MEDICINE

Protective Effects of Paeoniflorin Against MPP+-induced Neurotoxicity in PC12 Cells

(2016) Meizhu Zheng et al.   NEUROCHEMICAL RESEARCH

BDNF – a key transducer of antidepressant effects

(2016) Carl Björkholm et al.   NEUROPHARMACOLOGY

Paeonol attenuates lipopolysaccharide-induced depressive-like behavior in mice

(2016) Weiwei Tao et al.   PSYCHIATRY RESEARCH

Paeoniflorin attenuates hippocampal damage in a rat model of vascular dementia

(2016) Ying Zhang et al.   Experimental and Therapeutic Medicine

Wip1 phosphatase modulates both long-term potentiation and long-term depression through the dephosphorylation of CaMKII

(2016) Zhi-Yong He et al.   Cell Adhesion & Migration

The skin-depigmenting potential of Paeonia lactiflora root extract and paeoniflorin:in vitroevaluation using reconstructed pigmented human epidermis

(2016) J. Qiu et al.   INTERNATIONAL JOURNAL OF COSMETIC SCIENCE

Gamma-H2AX upregulation caused by Wip1 deficiency increases depression-related cellular senescence in hippocampus

(2016) Zhi-Yong He et al.   Scientific Reports

Herbal Medicine for Anxiety, Depression and Insomnia

(2015) Lei Liu et al.   Current Neuropharmacology

Triple reuptake inhibitors as potential next-generation antidepressants: a new hope?

(2015) Horrick Sharma et al.   Future Medicinal Chemistry

Progressive alterations of hippocampal CA3-CA1 synapses in an animal model of depression

(2014) Hui Qiao et al.   BEHAVIOURAL BRAIN RESEARCH

Vortioxetine restores reversal learning impaired by 5-HT depletion or chronic intermittent cold stress in rats

(2014) Ashley Wallace et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Antidepressant drug development: Focus on triple monoamine reuptake inhibition

(2014) Roger M Lane   JOURNAL OF PSYCHOPHARMACOLOGY

Comparative studies of paeoniflorin and albiflorin fromPaeonia lactifloraon anti-inflammatory activities

(2014) Qiang-Song Wang et al.   PHARMACEUTICAL BIOLOGY

Antidepressant-like effects of paeoniflorin on the behavioural, biochemical, and neurochemical patterns of rats exposed to chronic unpredictable stress

(2013) Feng-Mei Qiu et al.   NEUROSCIENCE LETTERS

The antidepressant-like effects of paeoniflorin in mouse models

(2013) FENGMEI QIU et al.   Experimental and Therapeutic Medicine

Selective Serotonin Reuptake Inhibitors (SSRIs): Therapeutic Drug Monitoring and Pharmacological Interactions

(2012) R. Mandrioli et al.   CURRENT MEDICINAL CHEMISTRY

Application of quantitative 1H-NMR method to determination of paeoniflorin in Paeoniae radix

(2012) Rie Tanaka et al.   Journal of Natural Medicines

Sertraline behavioral response associates closer and dose-dependently with cortical rather than hippocampal serotonergic activity in the rat forced swim stress

(2012) Hudu G. Mikail et al.   PHYSIOLOGY & BEHAVIOR

Anti-depressant-like effect of peony: a mini-review

(2011) Qing-Qiu Mao et al.   PHARMACEUTICAL BIOLOGY

Learning and Memory Alterations Are Associated with Hippocampal N-acetylaspartate in a Rat Model of Depression as Measured by 1H-MRS

(2011) Guangjun Xi et al.   PLoS One

The Roles of BDNF in the Pathophysiology of Major Depression and in Antidepressant Treatment

(2011) Bun-Hee Lee et al.   Psychiatry Investigation

Anti-Inflammatory and Immunomodulatory Effects of Paeonia Lactiflora Pall., a Traditional Chinese Herbal Medicine

(2011) Dong-Yi He et al.   Frontiers in Pharmacology

The role of BDNF in depression on the basis of its location in the neural circuitry

(2010) Hui Yu et al.   ACTA PHARMACOLOGICA SINICA

Protective Effects of Paeoniflorin Against Glutamate-Induced Neurotoxicity in PC12 Cells via Antioxidant Mechanisms and Ca2+ Antagonism

(2010) Qing-Qiu Mao et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The role of BDNF and its receptors in depression and antidepressant drug action: Reactivation of developmental plasticity

(2010) Eero Castrén et al.   Developmental Neurobiology

A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression

(2008) André Russowsky Brunoni et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Antidepressant-like effect of peony glycosides in mice

(2008) Qing-Qiu Mao et al.   JOURNAL OF ETHNOPHARMACOLOGY

The molecular neurobiology of depression

(2008) Vaishnav Krishnan et al.   NATURE

Decreased postnatal neurogenesis in the hippocampus combined with stress experience during adolescence is accompanied by an enhanced incidence of behavioral pathologies in adult mice

(2008) Fumihiko Hayashi et al.   Molecular Brain