Hepatic Insulin Clearance: Mechanism and Physiology

Variability of Directly Measured First-Pass Hepatic Insulin Extraction and Its Association With Insulin Sensitivity and Plasma Insulin

(2018) Isaac Asare-Bediako et al.   DIABETES

Role of fatty liver in the association between obesity and reduced hepatic insulin clearance

(2018) Y. Matsubayashi et al.   DIABETES & METABOLISM

Interferon regulatory factor 1 and a variant of heterogeneous nuclear ribonucleoprotein L coordinately silence the gene for adhesion protein CEACAM1

(2018) Kenneth J. Dery et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The cell biology of systemic insulin function

(2018) Victoria L. Tokarz et al.   JOURNAL OF CELL BIOLOGY

Liver-specific rescuing of CEACAM1 reverses endothelial and cardiovascular abnormalities in male mice with null deletion of Ceacam1 gene

(2018) Lucia Russo et al.   Molecular Metabolism

Liver-specific ablation of insulin-degrading enzyme causes hepatic insulin resistance and glucose intolerance, without affecting insulin clearance in mice

(2018) Pablo Villa-Pérez et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Hepatic Insulin Clearance in Regulation of Systemic Insulin Concentrations—Role of Carbohydrate and Energy Availability

(2018) Kirstine N. Bojsen-Møller et al.   DIABETES

CEACAM1 in Liver Injury, Metabolic and Immune Regulation

(2018) Andrea Horst et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Biochemical and cellular properties of insulin receptor signalling

(2017) Rebecca A. Haeusler et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inositol phosphates and phosphoinositides activate insulin-degrading enzyme, while phosphoinositides also mediate binding to endosomes

(2017) Eun Suk Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Insulin Receptor Isoforms in Diabetes and Its Metabolic and Vascular Complications

(2017) O. Escribano et al.   Journal of Diabetes Research

Loss of Hepatic CEACAM1: A Unifying Mechanism Linking Insulin Resistance to Obesity and Non-Alcoholic Fatty Liver Disease

(2017) Garrett Heinrich et al.   Frontiers in Endocrinology

Reduced Hepatic Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 Level in Obesity

(2017) Garrett Heinrich et al.   Frontiers in Endocrinology

Insulin-Degrading Enzyme Sorting in Exosomes: A Secretory Pathway for a Key Brain Amyloid-β Degrading Protease

(2017) Ayelén Bulloj et al.   JOURNAL OF ALZHEIMERS DISEASE

Correlates of insulin clearance in apparently healthy non-obese Japanese men

(2017) Hideyoshi Kaga et al.   Scientific Reports

Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance

(2016) Mashani Mohamad et al.   AGING CELL

Long-Term Pioglitazone Treatment for Patients With Nonalcoholic Steatohepatitis and Prediabetes or Type 2 Diabetes Mellitus

(2016) Kenneth Cusi et al.   ANNALS OF INTERNAL MEDICINE

Insulin-degrading enzyme: new therapeutic target for diabetes and Alzheimer’s disease?

(2016) Olga Pivovarova et al.   ANNALS OF MEDICINE

Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production

(2016) Paul M. Titchenell et al.   Cell Metabolism

Complexcis-regulatory landscape of the insulin receptor gene underlies the broad expression of a central signaling regulator

(2016) Yiliang Wei et al.   DEVELOPMENT

Hepatic and Extrahepatic Insulin Clearance Are Differentially Regulated: Results From a Novel Model-Based Analysis of Intravenous Glucose Tolerance Data

(2016) David C. Polidori et al.   DIABETES

PPARα (Peroxisome Proliferator-activated Receptor α) Activation Reduces Hepatic CEACAM1 Protein Expression to Regulate Fatty Acid Oxidation during Fasting-refeeding Transition

(2016) Sadeesh K. Ramakrishnan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fenofibrate Decreases Insulin Clearance and Insulin Secretion to Maintain Insulin Sensitivity

(2016) Sadeesh K. Ramakrishnan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chronic hyperinsulinemia reduces insulin sensitivity and metabolic functions of brown adipocyte

(2016) Sujith Rajan et al.   JOURNAL OF ENDOCRINOLOGY

Role for hepatic CEACAM1 in regulating fatty acid metabolism along the adipocyte-hepatocyte axis

(2016) Lucia Russo et al.   JOURNAL OF LIPID RESEARCH

Dissecting the relationship between obesity and hyperinsulinemia: Role of insulin secretion and insulin clearance

(2016) Mee Kyoung Kim et al.   Obesity

Endothelial Transcytosis of Insulin: Does It Contribute to Insulin Resistance?

(2016) Warren L. Lee et al.   PHYSIOLOGY

Insulin-degrading enzyme is activated by the C-terminus of α-synuclein

(2015) Sandeep K. Sharma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A neglected modulator of insulin-degrading enzyme activity and conformation: The pH

(2015) Giuseppe Grasso et al.   BIOPHYSICAL CHEMISTRY

Modulation of insulin degrading enzyme activity and liver cell proliferation

(2015) Olga Pivovarova et al.   CELL CYCLE

Forced Hepatic Overexpression of CEACAM1 Curtails Diet-Induced Insulin Resistance

(2015) Qusai Y. Al-Share et al.   DIABETES

Insulin receptor isoforms: an integrated view focused on gestational diabetes mellitus

(2015) F. Westermeier et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Suppression of hyperinsulinaemia in growing female mice provides long-term protection against obesity

(2015) Nicole M. Templeman et al.   DIABETOLOGIA

Sorting Nexin 5 and Dopamine D1Receptor Regulate the Expression of the Insulin Receptor in Human Renal Proximal Tubule Cells

(2015) Fengmin Li et al.   ENDOCRINOLOGY

Pathogenesis of Selective Insulin Resistance in Isolated Hepatocytes

(2015) Joshua R. Cook et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures of Human CCL18, CCL3, and CCL4 Reveal Molecular Determinants for Quaternary Structures and Sensitivity to Insulin-Degrading Enzyme

(2015) Wenguang G. Liang et al.   JOURNAL OF MOLECULAR BIOLOGY

Pulsatile insulin secretion, impaired glucose tolerance and type 2 diabetes

(2015) Leslie S. Satin et al.   MOLECULAR ASPECTS OF MEDICINE

Hyperinsulinemia in individuals with obesity: Role of insulin clearance

(2015) Mee Kyoung Kim et al.   Obesity

Insulin-degrading enzyme prevents α-synuclein fibril formation in a nonproteolytical manner

(2015) Sandeep K. Sharma et al.   Scientific Reports

Hepatic CEACAM1 Over-Expression Protects Against Diet-Induced Fibrosis and Inflammation in White Adipose Tissue

(2015) Sumona G. Lester et al.   Frontiers in Endocrinology

FFA-induced hepatic insulin resistance in vivo is mediated by PKCδ, NADPH oxidase, and oxidative stress

(2014) Sandra Pereira et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones

(2014) Juan Pablo Maianti et al.   NATURE

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

(2014) Rachel J. Perry et al.   NATURE

Regulation of Insulin Degrading Enzyme Activity by Obesity-Associated Factors and Pioglitazone in Liver of Diet-Induced Obese Mice

(2014) Xiuqing Wei et al.   PLoS One

Differences in insulin clearance between metabolically healthy and unhealthy obese subjects

(2013) Maria A. Marini et al.   ACTA DIABETOLOGICA

Ceacam1 deletion causes vascular alterations in large vessels

(2013) Sonia M. Najjar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis

(2013) Nicole Beauchemin et al.   CANCER AND METASTASIS REVIEWS

Insulin-degrading enzyme deficiency in bone marrow cells increases atherosclerosis in LDL receptor-deficient mice

(2013) Justin W. Caravaggio et al.   CARDIOVASCULAR PATHOLOGY

The Type 2 Diabetes-Associated Gene Ide Is Required for Insulin Secretion and Suppression of  -Synuclein Levels in  -Cells

(2013) P. Steneberg et al.   DIABETES

Hepatic Insulin Clearance Is Closely Related to Metabolic Syndrome Components

(2013) O. Pivovarova et al.   DIABETES CARE

Insulin signalling mechanisms for triacylglycerol storage

(2013) M. P. Czech et al.   DIABETOLOGIA

Relationship between disease severity, hyperinsulinemia, and impaired insulin clearance in patients with nonalcoholic steatohepatitis

(2013) Fernando Bril et al.   HEPATOLOGY

Targeted Deletion of Murine CEACAM 1 Activates PI3K-Akt Signaling and Contributes to the Expression of (Pro)Renin Receptor via CREB Family and NF-κB Transcription Factors

(2013) Jiqian Huang et al.   HYPERTENSION

Cafeteria diet inhibits insulin clearance by reduced insulin-degrading enzyme expression and mRNA splicing

(2013) P Brandimarti et al.   JOURNAL OF ENDOCRINOLOGY

CEACAM1 loss links inflammation to insulin resistance in obesity and non-alcoholic steatohepatitis (NASH)

(2013) Sonia M. Najjar et al.   Seminars in Immunopathology

Hyperinsulinemia Drives Diet-Induced Obesity Independently of Brain Insulin Production

(2012) Arya E. Mehran et al.   Cell Metabolism

Pulsatile Portal Vein Insulin Delivery Enhances Hepatic Insulin Action and Signaling

(2012) A. V. Matveyenko et al.   DIABETES

Relationship of Insulin Sensitivity, Insulin Secretion, and Adiposity With Insulin Clearance in a Multiethnic Population: The Insulin Resistance Atherosclerosis Study

(2012) C. Lorenzo et al.   DIABETES CARE

Insulin Clearance and the Incidence of Type 2 Diabetes in Hispanics and African Americans: The IRAS Family Study

(2012) C. C. Lee et al.   DIABETES CARE

Diabetes: Have We Got It All Wrong?: Hyperinsulinism as the culprit: surgery provides the evidence

(2012) W. J. Pories et al.   DIABETES CARE

Modulation of β-cell function: a translational journey from the bench to the bedside

(2012) A. B. Goldfine et al.   DIABETES OBESITY & METABOLISM

The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association

(2012) Naga Chalasani et al.   HEPATOLOGY

The Barrier Within: Endothelial Transport of Hormones

(2012) Cathryn M. Kolka et al.   PHYSIOLOGY

Fasting insulin reflects heterogeneous physiological processes: role of insulin clearance

(2011) Mark O. Goodarzi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The effects of a cafeteria diet on insulin production and clearance in rats

(2011) Anna Castell-Auví et al.   BRITISH JOURNAL OF NUTRITION

Microautophagy of Cytosolic Proteins by Late Endosomes

(2011) Ranjit Sahu et al.   DEVELOPMENTAL CELL

Banting Lecture 2011: Hyperinsulinemia: Cause or Consequence?

(2011) B. E. Corkey   DIABETES

The CEACAM1 expression is decreased in the liver of severely obese patients with or without diabetes

(2011) Wonae Lee   Diagnostic Pathology

Deletion of Insulin-Degrading Enzyme Elicits Antipodal, Age-Dependent Effects on Glucose and Insulin Tolerance

(2011) Samer O. Abdul-Hay et al.   PLoS One

Insulin metabolism in human adipocytes from subcutaneous and visceral depots

(2010) Janet Fawcett et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Stunned β Cell: A Brief History

(2010) Ele Ferrannini   Cell Metabolism

Caloric Restriction Reverses Hepatic Insulin Resistance and Steatosis in Rats with Low Aerobic Capacity

(2010) Thomas A. Bowman et al.   ENDOCRINOLOGY

A Role of DNA-PK for the Metabolic Gene Regulation in Response to Insulin

(2009) Roger H.F. Wong et al.   CELL

Insulin-Degrading Enzyme: Structure-Function Relationship and its Possible Roles in Health and Disease

(2009) A. Fernandez-Gamba et al.   CURRENT PHARMACEUTICAL DESIGN

The vascular actions of insulin control its delivery to muscle and regulate the rate-limiting step in skeletal muscle insulin action

(2009) E. J. Barrett et al.   DIABETOLOGIA

Targeted Disruption of Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 Promotes Diet-Induced Hepatic Steatosis and Insulin Resistance

(2009) Elaine Xu et al.   ENDOCRINOLOGY

Rats selectively bred for low aerobic capacity have reduced hepatic mitochondrial oxidative capacity and susceptibility to hepatic steatosis and injury

(2009) John P. Thyfault et al.   JOURNAL OF PHYSIOLOGY-LONDON

Development of hyperinsulinemia and insulin resistance during the early stage of weight gain

(2008) Johannes Erdmann et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Aerobic interval training vs. continuous moderate exercise in the metabolic syndrome of rats artificially selected for low aerobic capacity

(2008) P. M. Haram et al.   CARDIOVASCULAR RESEARCH

Selective versus Total Insulin Resistance: A Pathogenic Paradox

(2008) Michael S. Brown et al.   Cell Metabolism

Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1: A Link Between Insulin and Lipid Metabolism

(2008) A. M. DeAngelis et al.   DIABETES

Insulin Resistance and Hyperinsulinemia: Is hyperinsulinemia the cart or the horse?

(2008) M. H. Shanik et al.   DIABETES CARE

Increased Liver Fat, Impaired Insulin Clearance, and Hepatic and Adipose Tissue Insulin Resistance in Type 2 Diabetes

(2008) Anna Kotronen et al.   GASTROENTEROLOGY

Weight-dependent differential contribution of insulin secretion and clearance to hyperinsulinemia of obesity

(2008) Johannes Erdmann et al.   REGULATORY PEPTIDES