Review
Biochemistry & Molecular Biology
Carlos M. Gonzalez-Casimiro, Beatriz Merino, Elena Casanueva-Alvarez, Tamara Postigo-Casado, Patricia Camara-Torres, Cristina M. Fernandez-Diaz, Malcolm A. Leissring, Irene Cozar-Castellano, German Perdomo
Summary: IDE is not only involved in insulin clearance, but also plays important roles in insulin secretion and sensitivity.
Article
Food Science & Technology
Qian Su, Juan Huang, Xi Chen, Yijie Wang, Muqing Shao, Hongjia Yan, Caiyu Chen, Hongmei Ren, Fuwei Zhang, Yinxing Ni, Pedro A. Jose, Jian Zhong, Jian Yang
Summary: Long-term high-fat diet causes insulin resistance and impairs insulin clearance, with a decrease in renal IDE expression. The PPAR gamma pathway is involved in the inhibition of IDE expression by palmitic acid. Rosiglitazone improves insulin clearance and insulin resistance and increases renal IDE expression in HFD fed-mice.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Review
Endocrinology & Metabolism
Marta Pablos, Elena Casanueva-Alvarez, Carlos M. Gonzalez-Casimiro, Beatriz Merino, German Perdomo, Irene Cozar-Castellano
Summary: The primary cilium is a cell organelle located at the cell surface, which plays a role in sensing external stimuli and mediating cell-to-cell communication. Recent studies have uncovered the emerging roles of primary cilium and cilia-mediated signaling pathways in the regulation of pancreatic beta- and alpha-cell functions and glucose homeostasis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, Research & Experimental
Elif Sahin, Neslihan Saglam, Seniz Erdem, Elif Alvuroglu, Ismail Abidin, Esin Yulug, Ahmet Alver
Summary: This study investigated the effect of 7,8-Dihydroxyflavone (7,8-DHF) on Endoplasmic Reticulum Stress (ERS) in liver and pancreas tissues. The findings showed that 7,8-DHF significantly reduced metabolic abnormalities and suppressed ERS-induced metabolic disorders in both liver and pancreas.
Article
Medicine, Research & Experimental
Dina E. Al-Wakeel, Dalia H. El-Kashef, Manar A. Nader
Summary: This study found that empagliflozin (EMPA) has a protective effect against insulin resistance (IR) induced by junk food. EMPA can improve IR through various mechanisms, including reducing obesity, improving glucose metabolism, alleviating liver and kidney damage, and reducing inflammation. Additionally, the combination of EMPA and metformin (MET) has a synergistic effect in improving dyslipidemia, oxidative stress, and kidney function.
Review
Biochemistry & Molecular Biology
Malcolm A. Leissring, Carlos M. Gonzalez-Casimiro, Beatriz Merino, Caitlin N. Suire, German Perdomo
Summary: Hepatic insulin clearance and the activity of insulin-degrading enzyme might be involved in the pathogenesis of type 2 diabetes mellitus, and the development of IDE inhibitors as therapeutics for diabetic patients has garnered attention.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Malcolm A. Leissring
Summary: There are still many important unresolved questions in the field of IDE, such as how IDE interacts with extracellular substrates, its localization and functional roles within the cell, and how it avoids getting clogged and losing activity. The author provides personal insights and experimental strategies to address these challenges, aiming to advance the research on the physiology and pathophysiology of IDE with the development of new technologies and specific reagents.
Article
Chemistry, Medicinal
Nicolas Kraupner, Chau Phi Dinh, Xiaoan Wen, Valerie Landry, Adrien Herledan, Florence Leroux, Damien Bosc, Julie Charton, Clara Maillard, Sandrine Warenghem, Isabelle Duplan, Catherine Piveteau, Nathalie Hennuyer, Bart Staels, Benoit Deprez, Rebecca Deprez-Poulain
Summary: Insulin degrading enzyme (IDE) is linked to the risk of type-2 diabetes (T2D) or Alzheimer's disease (AD). Activating IDE could be a potential therapeutic strategy for AD and also beneficial in diabetes.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Cell Biology
Laetitia Lesire, Florence Leroux, Rebecca Deprez-Poulain, Benoit Deprez
Summary: Insulin-degrading enzyme (IDE) is a multifunctional protease that has been implicated in metabolic and neuronal diseases. Recent studies have also shown IDE's overexpression in different cancers, suggesting its potential as a target in cancer therapeutics. Further research is needed to fully understand IDE's role in cancer development, but pharmacological modulation of IDE has shown promising results in cancer models.
Review
Biochemistry & Molecular Biology
Grazia Raffaella Tundo, Giuseppe Grasso, Marco Persico, Oleh Tkachuk, Francesco Bellia, Alessio Bocedi, Stefano Marini, Mariacristina Parravano, Grazia Graziani, Caterina Fattorusso, Diego Sbardella
Summary: Insulin-degrading enzyme (IDE) is a key enzyme involved in the degradation of insulin and other amyloidogenic peptides. Its role in curing diabetes and Alzheimer's disease has long been anticipated, but its exact role in degrading amyloidogenic proteins is not yet clearly defined. Recently, novel non-proteolytic functions of IDE have been proposed. A better understanding of the structure-function relationship of IDE may help solve existing paradoxes and lead to new therapeutic approaches.
Article
Nutrition & Dietetics
Carme Grau-Bove, Iris Gines, Raul Beltran-Debon, Ximena Terra, M. Teresa Blay, Montserrat Pinent, Anna Ardevol
Summary: The endocrine pancreas is influenced by GSPE treatment, with continued effects on glucagon and increased GLP-1 response and receptor expression in the pancreas. When GSPE treatment is given every two weeks, the behavior of the endocrine pancreas changes, with glucagon being a more sensitive parameter to GSPE treatments, dependent on GLP-1 functionality.
Article
Cell Biology
Bingyuan Wang, Jiankang Guo, Mingrui Zhang, Zhiguo Liu, Rong Zhou, Fei Guo, Kui Li, Yulian Mu
Summary: The study revealed that IDE regulates the proliferation and apoptosis of PSMSCs via the MSTN/MYOD pathway, playing a crucial role in porcine skeletal muscle development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qiuchen Zheng, Micheal T. Kebede, Bethany Lee, Claire A. Krasinski, Saadman Islam, Liliana A. Wurfl, Merc M. Kemeh, Valerie A. Ivancic, Charles E. Jakobsche, Donald E. Spratt, Noel D. Lazo
Summary: The study found that resveratrol enhances IDE's activity toward A beta 42, while EGCG inhibits IDE's activity. These findings suggest a potential path for developing therapeutic strategies that can selectively target IDE substrate specificity.
Article
Biochemistry & Molecular Biology
Dorota Waclawczyk, Jerzy Silberring, Giuseppe Grasso
Summary: The study found that IDE can cleave NPFF and NPAF to generate specific cryptic peptides, and NPs may have a mutual influence on insulin degradation, hinting at IDE as the possible link between insulin and NPs metabolism.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Diego O. Borges, Rita S. Patarrao, Rogerio T. Ribeiro, Rita Machado de Oliveira, Nadia Duarte, Getachew Debas Belew, Madalena Martins, Rita Andrade, Joao Costa, Isabel Correia, Jose Manuel Boavida, Rui Duarte, Luis Gardete-Correia, Jose Luis Medina, Joao F. Raposo, John G. Jones, Carlos Penha-Goncalves, M. Paula Macedo
Summary: The study suggests that IDE plays a crucial role in regulating postprandial insulin clearance and liver metabolic resilience. Dysfunctional IDE regulation directly impairs postprandial hepatic glucose disposal and increases susceptibility to dysmetabolic conditions.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Review
Biochemistry & Molecular Biology
Carme Grau-Bove, Xavier Grau-Bove, Ximena Terra, Santi Garcia-Vallve, Esther Rodriguez-Gallego, Raul Beltran-Debon, M. Teresa Blay, Anna Ardevol, Montserrat Pinent
Summary: Bitter taste receptor hTAS2R5 has a unique functional specificity in humans and its closest functional homolog in mouse is mTas2r144, which is phylogenetically distant from hTAS2R5. There is no consensus about the role of hTAS2R5. Comparison with other species' bitter taste receptors reveals that hTAS2R5 has no ortholog in pig, mouse, or rat genomes.
Article
Neurosciences
Oriol Busquets, Marina Carrasco, Triana Espinosa-Jimenez, Miren Ettcheto, Ester Verdaguer, Carme Auladell, Monica Bullo, Antoni Camins, Montserrat Pinent, Esther Rodriguez-Gallego, Jaume Folch
Summary: The study aimed to evaluate the protective effects of short-term GSPE pre-treatment in the hippocampus of rats against prolonged feeding with cafeteria diet. Results showed that GSPE was able to protect against cellular damage through AKT activation and promote mitochondrial function maintenance. Additionally, GSPE decreased inflammatory activation and reduced reactivity of astrocytes.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Engineering, Chemical
Teresa Auguet, Miguel Lopez-Dupla, Jessica Ramos, Laia Bertran, David Riesco, Carmen Aguilar, Anna Ardevol, Montserrat Pinent, Fatima Sabench, Daniel Del Castillo, Cristobal Richart
Summary: This study aimed to determine whether adipocytokines and microbiota-derived metabolites can be used as predictive biomarkers for metabolic improvement post-surgery in women with clinically severe obesity. The results showed that levels of certain cytokines and microbiota-derived metabolites changed after surgery, correlating with improvements in glucose, insulin, and lipid levels.
Article
Biochemistry & Molecular Biology
Carme Grau-Bove, Carlos Gonzalez-Quilen, Giulia Cantini, Patrizia Nardini, Beatriz Espina, Daniele Bani, Ximena Terra, MTeresa Blay, Esther Rodriguez-Gallego, Michaela Luconi, Anna Ardevol, Montserrat Pinent
Summary: This study investigated the secretion mechanisms of GLP1 and PYY in the human colon and discovered a potential direct paracrine function of GLP1 through the expression of its receptors in the colon epithelium.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Alba Miguens-Gomez, Marta Sierra-Cruz, Esther Rodriguez-Gallego, Raul Beltran-Debon, M. Teresa Blay, Ximena Terra, Montserrat Pinent, Anna Ardevol
Summary: This study compared the effects of insect and almond preloads on appetite and food intake. The results showed that the insect preload increased protein intake without increasing total energy intake, and had a lower impact on sleepiness and tiredness compared to the almond preload. Insect-derived protein could be a suitable and safe ingredient for snacks intended for elderly or infirm patients.
Review
Endocrinology & Metabolism
Florijan Jalsevac, Ximena Terra, Esther Rodriguez-Gallego, Raul Beltran-Debon, Maria Teresa Blay, Montserrat Pinent, Anna Ardevol
Summary: Over thousands of years of evolution, animals have developed various ways to protect themselves. The bitter taste receptor 39 (TAS2R39) is present not only in the oral cavity but also in the gastrointestinal tract, respiratory system, nervous system, and reproductive system. It plays a role in sensing the bitter components of food and protecting the organism from harmful compounds. Further research is needed to determine its precise role in these and other tissues.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Helena Segu, Florijan Jalsevac, Montserrat Pinent, Anna Ardevol, Ximena Terra, Maria Teresa Blay
Summary: This study examined the effects of a Cafeteria diet on the intestines of rats and found that it caused adaptive morphologic and functional changes. Additionally, it was discovered that supplementation with grape seed proanthocyanidin extract (GSPE) partially reversed the intestinal morphological changes induced by the high fat/sucrose diet.
Article
Agriculture, Multidisciplinary
Alba Miguens-Gomez, Marta Sierra-Cruz, Helena Segu, Raul Beltran-Debon, Esther Rodriguez-Gallego, Ximena Terra, Maria Teresa Blay, Anna Maria Perez-Vendrell, Montserrat Pinent, Anna Ardevol
Summary: This study found that acutely ingesting insect Alphitobius diaperinus protein increases food intake in rats and modifies the ex vivo enterohormone secretory profile differently than beef or almond proteins. However, these effects cannot be maintained for a longer period. The results suggest that consuming insect protein increases food intake by reducing ghrelin secretion in the small intestine.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Cell Biology
Teresa Villanueva-Carmona, Lidia Cedo, Ana Madeira, Victoria Ceperuelo-Mallafre, M. -Mar Rodriguez-Pena, Catalina Nunez-Roa, Elsa Maymo-Masip, Maria Repolles-de-Dalmau, Joan Badia, Noelia Keiran, Mercedes Mirasierra, Carolina Pimenta-Lopes, Joan Sabadell-Basallote, Ramon Bosch, Laura Caubet, Joan Carles Escola-Gil, Jose-Manuel Fernandez-Real, Nuria Vilarrasa, Francesc Ventura, Mario Vallejo, Joan Vendrell, Sonia Fernandez-Veledo
Summary: Adipose tissue secretes leptin to modulate energy homeostasis, and this process is regulated by succinate through its receptor SUCNR1. Deletion of Sucnr1 in adipocytes affects metabolic health based on nutritional status. Activation of SUCNR1 controls leptin expression via the circadian clock in an AMPK/JNK-C/EBPa-dependent manner. Succinate/SUCNR1 axis serves as a metabolite-sensing pathway mediating nutrient-related leptin dynamics to maintain whole-body homeostasis.
Article
Biochemistry & Molecular Biology
Alba Miguens-Gomez, Marta Sierra-Cruz, M. Teresa Blay, Esther Rodriguez-Gallego, Raul Beltran-Debon, Ximena Terra, Montserrat Pinent, Anna Ardevol
Summary: The impact of healthy aging on society has generated interest in studying aging mechanisms, yet the effects of this process on the gastrointestinal tract are not fully understood. Controversial results have been found regarding changes in the enteroendocrine system along the gastrointestinal tract. Grape seed proanthocyanidin extracts (GSPE) have been shown to protect against aging-related pathologies. In this study, researchers hypothesized that GSPE pre-treatment could prevent aging processes affecting the enteroendocrine system. By treating aged rats with GSPE, they found that the expression of enterohormones in the colon was preserved, suggesting that GSPE may be effective in preventing decreased enterohormone expression induced by aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Marta Sierra-Cruz, Alba Miguens-Gomez, Esther Rodriguez-Gallego, Claudio D'Addario, Martina Di Bartolomeo, M. Teresa Blay, Montserrat Pinent, Raill Beltran-Debon, Ximena Terra
Summary: Diet-induced changes in the intestinal barrier and gut microbiota lead to the translocation of lipopolysaccharide (LPS) from the lumen to the lamina propria through different mechanisms, resulting in metabolic endotoxemia. The study evaluated the role of grape seed proanthocyanidin extract (GSPE) in modulating LPS translocation and the underlying mechanisms using in vitro and in vivo experiments. GSPE was found to regulate intestinal permeability by modulating receptor-mediated endocytosis and the interaction between gut microbiota and the endocannabinoid system through epigenetic mechanisms. These findings suggest that GSPE can improve intestinal dysfunction and metabolic endotoxemia caused by a high-fat diet.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Food Science & Technology
Anna Valentina Luparelli, Alba Miguens-Gomez, Anna Ardevol, Stefano Sforza, Augusta Caligiani, Montserrat Pinent
Summary: In this study, we investigated the effects of gastrointestinal digested black soldier fly (BSF) prepupae on GLP-1 and DPP-IV. The results showed that these digested proteins have a high ability to stimulate GLP-1 secretion and inhibit DPP-IV enzyme activity in human cells. Furthermore, optimizing diets or fermentation processes did not improve the efficacy of the answer. The bioactivity of BSF on glycaemic control systems after simulated digestion makes it even more promising as a suitable edible insect for human consumption.
Article
Biochemistry & Molecular Biology
Alba Miguens-Gomez, Marta Sierra-Cruz, Anna Maria Perez-Vendrell, Esther Rodriguez-Gallego, Raul Beltran-Debon, Ximena Terra, Anna Ardevol, Montserrat Pinent
Summary: This study found that grape seed derived procyanidins (GSPE) have different effects on enterohormone secretion and intestinal sizes in aged rats, compared to young rats. The cafeteria diet affects the duodenum and colon differently in aged rats, while procyanidins have a larger effect on the ileum.
