Role for hepatic CEACAM1 in regulating fatty acid metabolism along the adipocyte-hepatocyte axis

Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production

(2016) Paul M. Titchenell et al.   Cell Metabolism

PPARα (Peroxisome Proliferator-activated Receptor α) Activation Reduces Hepatic CEACAM1 Protein Expression to Regulate Fatty Acid Oxidation during Fasting-refeeding Transition

(2016) Sadeesh K. Ramakrishnan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fenofibrate Decreases Insulin Clearance and Insulin Secretion to Maintain Insulin Sensitivity

(2016) Sadeesh K. Ramakrishnan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-fat diet decreases energy expenditure and expression of genes controlling lipid metabolism, mitochondrial function and skeletal system development in the adipose tissue, along with increased expression of extracellular matrix remodelling- and inflammation-related genes

(2015) Myung-Sook Choi et al.   BRITISH JOURNAL OF NUTRITION

Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes

(2015) Rachel J. Perry et al.   CELL

Forced Hepatic Overexpression of CEACAM1 Curtails Diet-Induced Insulin Resistance

(2015) Qusai Y. Al-Share et al.   DIABETES

Pathogenesis of Selective Insulin Resistance in Isolated Hepatocytes

(2015) Joshua R. Cook et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FFA-induced hepatic insulin resistance in vivo is mediated by PKCδ, NADPH oxidase, and oxidative stress

(2014) Sandra Pereira et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

FGF21 Acts Centrally to Induce Sympathetic Nerve Activity, Energy Expenditure, and Weight Loss

(2014) Bryn M. Owen et al.   Cell Metabolism

Interplay between FGF21 and insulin action in the liver regulates metabolism

(2014) Brice Emanuelli et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21

(2014) M. Cornu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endotrophin triggers adipose tissue fibrosis and metabolic dysfunction

(2014) Kai Sun et al.   Nature Communications

A 5-Day High-Fat, High-Calorie Diet Impairs Insulin Sensitivity in Healthy, Young South Asian Men but Not in Caucasian Men

(2013) L. E. H. Bakker et al.   DIABETES

Hepatic Insulin Clearance Is Closely Related to Metabolic Syndrome Components

(2013) O. Pivovarova et al.   DIABETES CARE

Hepatic insulin clearance is the primary determinant of insulin sensitivity in the normal dog

(2013) Marilyn Ader et al.   Obesity

Niacin Increases Adiponectin and Decreases Adipose Tissue Inflammation in High Fat Diet-Fed Mice

(2013) Desiree Wanders et al.   PLoS One

CEACAM1 loss links inflammation to insulin resistance in obesity and non-alcoholic steatohepatitis (NASH)

(2013) Sonia M. Najjar et al.   Seminars in Immunopathology

Partial Inhibition of Adipose Tissue Lipolysis Improves Glucose Metabolism and Insulin Sensitivity Without Alteration of Fat Mass

(2013) Amandine Girousse et al.   PLOS BIOLOGY

Insulin Clearance and the Incidence of Type 2 Diabetes in Hispanics and African Americans: The IRAS Family Study

(2012) C. C. Lee et al.   DIABETES CARE

Diabetes: Have We Got It All Wrong?: Hyperinsulinism as the culprit: surgery provides the evidence

(2012) W. J. Pories et al.   DIABETES CARE

Short Term Voluntary Overfeeding Disrupts Brain Insulin Control of Adipose Tissue Lipolysis

(2012) Thomas Scherer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

USP2a Protein Deubiquitinates and Stabilizes the Circadian Protein CRY1 in Response to Inflammatory Signals

(2012) Xin Tong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protection from Obesity and Diabetes by Blockade of TGF-β/Smad3 Signaling

(2011) Hariom Yadav et al.   Cell Metabolism

Inflammation Is Necessary for Long-Term but Not Short-Term High-Fat Diet-Induced Insulin Resistance

(2011) Y. S. Lee et al.   DIABETES

Banting Lecture 2011: Hyperinsulinemia: Cause or Consequence?

(2011) B. E. Corkey   DIABETES

The CEACAM1 expression is decreased in the liver of severely obese patients with or without diabetes

(2011) Wonae Lee   Diagnostic Pathology

Hyperinsulinemia leads to uncoupled insulin regulation of the GLUT4 glucose transporter and the FoxO1 transcription factor

(2011) E. Gonzalez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fibrosis in Human Adipose Tissue: Composition, Distribution, and Link With Lipid Metabolism and Fat Mass Loss

(2010) A. Divoux et al.   DIABETES

Carcinoembryonic Antigen-Related Cell Adhesion Molecule 2 Controls Energy Balance and Peripheral Insulin Action in Mice

(2010) Garrett Heinrich et al.   GASTROENTEROLOGY

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

(2010) Matthew D. Hirschey et al.   NATURE

Basal-State Hyperinsulinemia in Healthy Normoglycemic Adults Is Predictive of Type 2 Diabetes Over a 24-Year Follow-Up: A preliminary report

(2009) R. Dankner et al.   DIABETES CARE

Targeted Disruption of Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 Promotes Diet-Induced Hepatic Steatosis and Insulin Resistance

(2009) Elaine Xu et al.   ENDOCRINOLOGY

Cytokines in the Pathogenesis of Fatty Liver and Disease Progression to Steatohepatitis: Implications for Treatment

(2008) Christine Carter-Kent et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1: A Link Between Insulin and Lipid Metabolism

(2008) A. M. DeAngelis et al.   DIABETES

Insulin Resistance and Hyperinsulinemia: Is hyperinsulinemia the cart or the horse?

(2008) M. H. Shanik et al.   DIABETES CARE

Development of Nonalcoholic Steatohepatitis in Insulin-Resistant Liver-Specific S503A Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 Mutant Mice

(2008) Sang Jun Lee et al.   GASTROENTEROLOGY