Insulin receptor isoforms: an integrated view focused on gestational diabetes mellitus

Identification of early transcriptome signatures in placenta exposed to insulin and obesity

(2015) Luciana Lassance et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Gestational Diabetes Mellitus Impairs Fetal Endothelial Cell Functions Through a Mechanism Involving MicroRNA-101 and Histone Methyltransferase Enhancer of Zester Homolog-2Significance

(2015) Ilaria Floris et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Management of diabetes and pregnancy – When to start and what pharmacological agent to choose?

(2015) Liran Hiersch et al.   BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY

Insulin/receptor binding: The last piece of the puzzle?

(2015) Pierre De Meyts   BIOESSAYS

Insulin therapy and fetoplacental vascular function in gestational diabetes mellitus

(2015) Luis Sobrevia et al.   EXPERIMENTAL PHYSIOLOGY

Insulin requires normal expression and signaling of insulin receptor A to reverse gestational diabetes-reduced adenosine transport in human umbilical vein endothelium

(2015) Francisco Westermeier et al.   FASEB JOURNAL

Delineation of the IGF-II C domain elements involved in binding and activation of the IR-A, IR-B and IGF-IR

(2015) S.T. Henderson et al.   GROWTH HORMONE & IGF RESEARCH

Maternal gestational diabetes is associated with genome-wide DNA methylation variation in placenta and cord blood of exposed offspring

(2015) Sarah Finer et al.   HUMAN MOLECULAR GENETICS

Placental Growth Response to Maternal Insulin in Early Pregnancy

(2015) Perrie O'Tierney-Ginn et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Adenosine signalling in diabetes mellitus—pathophysiology and therapeutic considerations

(2015) Luca Antonioli et al.   Nature Reviews Endocrinology

The placenta: a multifaceted, transient organ

(2015) G. J. Burton et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Insulin restores l-arginine transport requiring adenosine receptors activation in umbilical vein endothelium from late-onset preeclampsia

(2015) R. Salsoso et al.   PLACENTA

Increased IR-A/IR-B ratio in non-small cell lung cancers associates with lower epithelial-mesenchymal transition signature and longer survival in squamous cell lung carcinoma

(2014) Liyan Jiang et al.   BMC CANCER

Reduced Insulin-like Growth Factor I Receptor and Altered Insulin Receptor Isoform mRNAs in Normal Mucosa Predict Colorectal Adenoma Risk

(2014) M. A. Santoro et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Mild Gestational Diabetes Mellitus and Long-Term Child Health

(2014) Mark B. Landon et al.   DIABETES CARE

Transcriptome analysis of human primary endothelial cells (HUVEC) from umbilical cords of gestational diabetic mothers reveals candidate sites for an epigenetic modulation of specific gene expression

(2014) R. Ambra et al.   GENOMICS

Insulin-like Growth Factor-II (IGF-II) and IGF-II Analogs with Enhanced Insulin Receptor-a Binding Affinity Promote Neural Stem Cell Expansion

(2014) Amber N. Ziegler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Paired Basic Amino Acid-cleaving Enzyme 4 (PACE4) Is Involved in the Maturation of Insulin Receptor Isoform B

(2014) Imène Kara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decorin differentially modulates the activity of insulin receptor isoform A ligands

(2014) Alaide Morcavallo et al.   MATRIX BIOLOGY

Adiponectin Inhibits Insulin Function in Primary Trophoblasts by PPARα-Mediated Ceramide Synthesis

(2014) Irving L.M.H. Aye et al.   MOLECULAR ENDOCRINOLOGY

Mitogenic Insulin Receptor-A Is Overexpressed in Human Hepatocellular Carcinoma due to EGFR-Mediated Dysregulation of RNA Splicing Factors

(2013) Hamza Chettouh et al.   CANCER RESEARCH

Insulin Analogues in the Treatment of Gestational Diabetes Mellitus

(2013) CELESTE P. DURNWALD   CLINICAL OBSTETRICS AND GYNECOLOGY

Concentrations of Insulin Glargine and Its Metabolites During Long-Term Insulin Therapy in Type 2 Diabetic Patients and Comparison of Effects of Insulin Glargine, Its Metabolites, IGF-I, and Human Insulin on Insulin and IGF-I Receptor Signaling

(2013) A. J. Varewijck et al.   DIABETES

Diagnosis and Classification of Diabetes Mellitus

(2013)   DIABETES CARE

The use of insulin analogues in pregnancy

(2013) K. Lambert et al.   DIABETES OBESITY & METABOLISM

The elevated gene expression level of the A2Badenosine receptor is associated with hyperglycemia in women with gestational diabetes mellitus

(2013) Marzena Wojcik et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Trying to understand gestational diabetes

(2013) P. M. Catalano   DIABETIC MEDICINE

Implication of Insulin Receptor A Isoform and IRA/IGF-IR Hybrid Receptors in the Aortic Vascular Smooth Muscle Cell Proliferation: Role of TNF-α and IGF-II

(2013) Almudena Gómez-Hernández et al.   ENDOCRINOLOGY

Insulin receptor isoform switching in intestinal stem cells, progenitors, differentiated lineages and tumors: evidence that IR-B limits proliferation

(2013) Sarah F. Andres et al.   JOURNAL OF CELL SCIENCE

Hyperinsulinemia Stimulates Angiogenesis of Human Fetoplacental Endothelial Cells: A Possible Role of Insulin in Placental Hypervascularization in Diabetes Mellitus

(2013) Luciana Lassance et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Adenosine—a physiological or pathophysiological agent?

(2013) Bertil B. Fredholm   JOURNAL OF MOLECULAR MEDICINE-JMM

Role of Insulin and Adenosine in the Human Placenta Microvascular and Macrovascular Endothelial Cell Dysfunction in Gestational Diabetes Mellitus

(2013) Enrique Guzmán-Gutiérrez et al.   MICROCIRCULATION

Alternative splicing of human insulin receptor gene (INSR) in type I and type II skeletal muscle fibers of patients with myotonic dystrophy type 1 and type 2

(2013) Massimo Santoro et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Interleukin-1β inhibits insulin signaling and prevents insulin-stimulated system A amino acid transport in primary human trophoblasts

(2013) Irving L.M.H. Aye et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Epigenetics of gestational diabetes mellitus and offspring health: the time for action is in early stages of life

(2013) H. Lehnen et al.   MOLECULAR HUMAN REPRODUCTION

Muscleblind-like 1 activates insulin receptor exon 11 inclusion by enhancing U2AF65 binding and splicing of the upstream intron

(2013) Gloria V. Echeverria et al.   NUCLEIC ACIDS RESEARCH

Overexpression of the Insulin Receptor Isoform A Promotes Endometrial Carcinoma Cell Growth

(2013) Chun-Fang Wang et al.   PLoS One

Placental Adiponectin Gene DNA Methylation Levels Are Associated With Mothers’ Blood Glucose Concentration

(2012) Luigi Bouchard et al.   DIABETES

Insulin receptor isoforms are differently expressed during human osteoblastogenesis

(2012) Sofia Avnet et al.   DIFFERENTIATION

Proinsulin Binds with High Affinity the Insulin Receptor Isoform A and Predominantly Activates the Mitogenic Pathway

(2012) Roberta Malaguarnera et al.   ENDOCRINOLOGY

Insulin and Insulin-like Growth Factor II Differentially Regulate Endocytic Sorting and Stability of Insulin Receptor Isoform A

(2012) Alaide Morcavallo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fetal Insulin and IGF-II Contribute to Gestational Diabetes Mellitus (GDM)-Associated Up-Regulation of Membrane-Type Matrix Metalloproteinase 1 (MT1-MMP) in the Human Feto-Placental Endothelium

(2012) U. Hiden et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Regulation of glucose transport by insulin: traffic control of GLUT4

(2012) Dara Leto et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Insulin-Increased L-Arginine Transport Requires A2A Adenosine Receptors Activation in Human Umbilical Vein Endothelium

(2012) Enrique Guzmán-Gutiérrez et al.   PLoS One

Gestational Diabetes Reduces Adenosine Transport in Human Placental Microvascular Endothelium, an Effect Reversed by Insulin

(2012) Carlos Salomón et al.   PLoS One

Insulin Receptor Isoforms A and B as well as Insulin Receptor Substrates-1 and -2 Are Differentially Expressed in Prostate Cancer

(2012) Martin Heni et al.   PLoS One

Receptor-isoform-selective insulin analogues give tissue-preferential effects

(2011) Sara G. Vienberg et al.   BIOCHEMICAL JOURNAL

Insight into the molecular basis for the kinetic differences between the two insulin receptor isoforms

(2011) Louise Knudsen et al.   BIOCHEMICAL JOURNAL

Insulin Restores Gestational Diabetes Mellitus-Reduced Adenosine Transport Involving Differential Expression of Insulin Receptor Isoforms in Human Umbilical Vein Endothelium

(2011) F. Westermeier et al.   DIABETES

Differential expression and signaling activation of insulin receptor isoforms A and B: A link between breast cancer and diabetes

(2011) S. Kalla Singh et al.   GROWTH FACTORS

Insulin-stimulated L-arginine transport requires SLC7A1 gene expression and is associated with human umbilical vein relaxation

(2011) Marcelo González et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Chronically Increased S6K1 Is Associated with Impaired IRS1 Signaling in Skeletal Muscle of GDM Women with Impaired Glucose Tolerance Postpartum

(2011) Linda A. Barbour et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Placental Vascular Dysfunction in Diabetic Pregnancies: Intimations of Fetal Cardiovascular Disease?

(2011) LOPA LEACH   MICROCIRCULATION

Research Resource: New and Diverse Substrates for the Insulin Receptor Isoform A Revealed by Quantitative Proteomics After Stimulation With IGF-II or Insulin

(2011) Alaide Morcavallo et al.   MOLECULAR ENDOCRINOLOGY

Review: Differential placental macrovascular and microvascular endothelial dysfunction in gestational diabetes

(2011) L. Sobrevia et al.   PLACENTA

Insulin Promotes Glycogen Storage and Cell Proliferation in Primary Human Astrocytes

(2011) Martin Heni et al.   PLoS One

hnRNP A1 and hnRNP F Modulate the Alternative Splicing of Exon 11 of the Insulin Receptor Gene

(2011) Indrani Talukdar et al.   PLoS One

Altered Expression of Insulin Receptor Isoforms in Breast Cancer

(2011) Jiaqi Huang et al.   PLoS One

Full-Length Adiponectin Attenuates Insulin Signaling and Inhibits Insulin-Stimulated Amino Acid Transport in Human Primary Trophoblast Cells

(2010) H. N. Jones et al.   DIABETES

Outcomes in women with a history of gestational diabetes. Screening and prevention of type 2 diabetes. Literature review

(2010) O. Verier-Mine   DIABETES & METABOLISM

Insulin analogues differently activate insulin receptor isoforms and post-receptor signalling

(2010) L. Sciacca et al.   DIABETOLOGIA

Silencing of the Insulin Receptor Isoform A Favors Formation of Type 1 Insulin-Like Growth Factor Receptor (IGF-IR) Homodimers and Enhances Ligand-Induced IGF-IR Activation and Viability of Human Colon Carcinoma Cells

(2010) G. V. Brierley et al.   ENDOCRINOLOGY

Insulin-feedback via PI3K-C2α activated PKBα/Akt1 is required for glucose-stimulated insulin secretion

(2010) Barbara Leibiger et al.   FASEB JOURNAL

Muscleblind-like 1 (Mbnl1) Promotes Insulin Receptor Exon 11 Inclusion via Binding to a Downstream Evolutionarily Conserved Intronic Enhancer

(2010) Supriya Sen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin Receptor Isoforms and Insulin-Like Growth Factor Receptor in Human Follicular Cell Precursors from Papillary Thyroid Cancer and Normal Thyroid

(2010) Roberta Malaguarnera et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Identification of MBNL1 and MBNL3 domains required for splicing activation and repression

(2010) Ioannis Grammatikakis et al.   NUCLEIC ACIDS RESEARCH

In Vitro Metabolic and Mitogenic Signaling of Insulin Glargine and Its Metabolites

(2010) Mark R. Sommerfeld et al.   PLoS One

Regulation of amino acid transporters by glucose and growth factors in cultured primary human trophoblast cells is mediated by mTOR signaling

(2009) S. Roos et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Expression of Insulin Receptor Isoform A and Insulin-like Growth Factor-1 Receptor in Human Acute Myelogenous Leukemia: Effect of the Dual-Receptor Inhibitor BMS-536924 In vitro

(2009) A. E. Wahner Hendrickson et al.   CANCER RESEARCH

Insulin Receptor Isoform A and Insulin-like Growth Factor II as Additional Treatment Targets in Human Osteosarcoma

(2009) S. Avnet et al.   CANCER RESEARCH

Nitric oxide reduces SLC29A1 promoter activity and adenosine transport involving transcription factor complex hCHOP–C/EBPα in human umbilical vein endothelial cells from gestational diabetes

(2009) Marcelo Farías et al.   CARDIOVASCULAR RESEARCH

Synchronization in G0/G1 enhances the mitogenic response of cells overexpressing the human insulin receptor A isoform to insulin

(2009) Christine Bonnesen et al.   CELL BIOLOGY AND TOXICOLOGY

Insulin Action on the Human Placental Endothelium in Normal and Diabetic Pregnancy

(2009) Ursula Hiden et al.   Current Vascular Pharmacology

Hormonal and Metabolic Factors Associated With Variations in Insulin Sensitivity in Human Pregnancy

(2009) H. D. McIntyre et al.   DIABETES CARE

Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease

(2009) Antonino Belfiore et al.   ENDOCRINE REVIEWS

Diabetes and cancer

(2009) Paolo Vigneri et al.   ENDOCRINE-RELATED CANCER

Selective Response to InsulinVersusInsulin-Like Growth Factor-I and -II and Up-Regulation of Insulin Receptor Splice Variant B in the Differentiated Mouse Mammary Epithelium

(2009) Chiara Berlato et al.   ENDOCRINOLOGY

Differential Signaling Activation by Insulin and Insulin-Like Growth Factors I and II upon Binding to Insulin Receptor Isoform A

(2009) Antonella Sacco et al.   ENDOCRINOLOGY

Insulin-Like Growth Factor 2 and the Insulin Receptor, But Not Insulin, Regulate Fetal Hepatic Glycogen Synthesis

(2009) Li Liang et al.   ENDOCRINOLOGY

Defective insulin signaling in placenta from pregnancies complicated by gestational diabetes mellitus

(2009) Michelle Colomiere et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis

(2009) Leanne Bellamy et al.   LANCET

Comparative transcriptional and biochemical studies in muscle of myotonic dystrophies (DM1 and DM2)

(2009) Sergio Salvatori et al.   NEUROLOGICAL SCIENCES

Molecular mechanisms underlying the activation of eNOS

(2009) Ingrid Fleming   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Characterization of IRA/IRB hybrid insulin receptors using bioluminescence resonance energy transfer

(2008) Christophe Blanquart et al.   BIOCHEMICAL PHARMACOLOGY

SRp20 and CUG-BP1 Modulate Insulin Receptor Exon 11 Alternative Splicing

(2008) S. Sen et al.   MOLECULAR AND CELLULAR BIOLOGY

Role of Insulin Receptor and Balance in Insulin Receptor Isoforms A and B in Regulation of Apoptosis in Simian Virus 40-immortalized Neonatal Hepatocytes

(2008) Carmen Nevado et al.   MOLECULAR BIOLOGY OF THE CELL

The insulin receptor: a prototype for dimeric, allosteric membrane receptors?

(2008) Pierre De Meyts   TRENDS IN BIOCHEMICAL SCIENCES

The role of insulin receptors and IGF-I receptors in cancer and other diseases

(2008) Francesco Frasca et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY