The ethics of genome editing in non-human animals: a systematic review of reasons reported in the academic literature

Community Engagement and Field Trials of Genetically Modified Insects and Animals

(2018) Carolyn P. Neuhaus   HASTINGS CENTER REPORT

Genetically Modifying Livestock for Improved Welfare: A Path Forward

(2018) Adam Shriver et al.   JOURNAL OF AGRICULTURAL & ENVIRONMENTAL ETHICS

Wild Animal Suffering is Intractable

(2018) Nicolas Delon et al.   JOURNAL OF AGRICULTURAL & ENVIRONMENTAL ETHICS

Is CRISPR an Ethical Game Changer?

(2018) Marcus Schultz-Bergin   JOURNAL OF AGRICULTURAL & ENVIRONMENTAL ETHICS

Invited review: Breeding and ethical perspectives on genetically modified and genome edited cattle

(2018) S. Eriksson et al.   JOURNAL OF DAIRY SCIENCE

Rethink public engagement for gene editing

(2018) Simon Burall   NATURE

Xenotransplantation: back to the future?

(2018) Raphael P. H. Meier et al.   TRANSPLANT INTERNATIONAL

Recommendations for Laboratory Containment and Management of Gene Drive Systems in Arthropods

(2018) Mark Q. Benedict et al.   VECTOR-BORNE AND ZOONOTIC DISEASES

Digital Medicine: An Opportunity to Revisit the Role of Bioethicists

(2018) Karin R. Jongsma et al.   AMERICAN JOURNAL OF BIOETHICS

Exploring the potential of genome editing CRISPR-Cas9 technology

(2017) Vijai Singh et al.   GENE

The Spectacular Garden: Where Might De-extinction Lead?

(2017) Gregory E. Kaebnick   HASTINGS CENTER REPORT

Nonhuman Primates: A Vital Model for Basic and Applied Research on Female Reproduction, Prenatal Development, and Women's Health

(2017) Richard L Stouffer et al.   ILAR JOURNAL

The Pedigree Dog Breeding Debate in Ethics and Practice: Beyond Welfare Arguments

(2017) Bernice Bovenkerk et al.   JOURNAL OF AGRICULTURAL & ENVIRONMENTAL ETHICS

CRISPR Editing in Biological and Biomedical Investigation

(2017) Xing-Da Ju et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Ethical issues when modelling brain disorders innon-human primates

(2017) Carolyn P Neuhaus   JOURNAL OF MEDICAL ETHICS

Bridging the gap: large animal models in neurodegenerative research

(2017) S. L. Eaton et al.   MAMMALIAN GENOME

Editing mammalian genomes: ethical considerations

(2017) Andy Greenfield   MAMMALIAN GENOME

Principles for gene drive research

(2017) Claudia Emerson et al.   SCIENCE

Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9

(2017) Dong Niu et al.   SCIENCE

Synthetic Biology, Genome Editing, and the Risk of Bioterrorism

(2017) Marko Ahteensuu   SCIENCE AND ENGINEERING ETHICS

Genome editing: Bioethics shows the way

(2017) Carolyn P. Neuhaus et al.   PLOS BIOLOGY

Conservation demands safe gene drive

(2017) Kevin M. Esvelt et al.   PLOS BIOLOGY

How should the applications of genome editing be assessed and regulated?

(2017) Robin Fears et al.   eLife

The Hope and Hype of CRISPR-Cas9 Genome Editing

(2017) Kiran Musunuru   JAMA Cardiology

A CRISPR Path to Engineering New Genetic Mouse Models for Cardiovascular ResearchHighlights

(2016) Joseph M. Miano et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Pathways to de-extinction: how close can we get to resurrection of an extinct species?

(2016) Beth Shapiro   FUNCTIONAL ECOLOGY

Genome editing revolutionize the creation of genetically modified pigs for modeling human diseases

(2016) Jing Yao et al.   HUMAN GENETICS

Gene editing advance re-ignites debate on the merits and risks of animal to human transplantation

(2016) R. K. F. Fung et al.   INTERNAL MEDICINE JOURNAL

Promotion of alleles by genome editing in livestock breeding programmes

(2016) J.M. Hickey et al.   JOURNAL OF ANIMAL BREEDING AND GENETICS

Genome Editing in Large Animals

(2016) James West et al.   JOURNAL OF EQUINE VETERINARY SCIENCE

Genome editing in nonhuman primates: approach to generating human disease models

(2016) Y. Chen et al.   JOURNAL OF INTERNAL MEDICINE

Driven to extinction? The ethics of eradicating mosquitoes with gene-drive technologies

(2016) Jonathan Pugh   JOURNAL OF MEDICAL ETHICS

Putting the brakes on CRISPR-Cas9 gene drive systems

(2016) Dustin M. Graham   LAB ANIMAL

Turning point: Kevin Esvelt

(2016) Vijee Venkatraman   NATURE

CRISPR: gene editing is just the beginning

(2016) Heidi Ledford   NATURE

Welcome to the CRISPR zoo

(2016) Sara Reardon   NATURE

Regulate genome-edited products, not genome editing itself

(2016) Dana Carroll et al.   NATURE BIOTECHNOLOGY

Production of hornless dairy cattle from genome-edited cell lines

(2016) Daniel F Carlson et al.   NATURE BIOTECHNOLOGY

Applications of CRISPR technologies in research and beyond

(2016) Rodolphe Barrangou et al.   NATURE BIOTECHNOLOGY

New models: Gene-editing boom means changing landscape for primate work

(2016) Cassandra Willyard   NATURE MEDICINE

Opportunities and challenges in modeling human brain disorders in transgenic primates

(2016) Charles G Jennings et al.   NATURE NEUROSCIENCE

A CRISPR Way to Block PERVs — Engineering Organs for Transplantation

(2016) Daniel R. Salomon   NEW ENGLAND JOURNAL OF MEDICINE

CRISPR: express delivery to any DNA address

(2016) A Peterson   ORAL DISEASES

Emerging ethical perspectives in the clustered regularly interspaced short palindromic repeats genome-editing debate

(2016) Silvia Camporesi et al.   Personalized Medicine

Impact of mosquito gene drive on malaria elimination in a computational model with explicit spatial and temporal dynamics

(2016) Philip A. Eckhoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Silencing porcine genes significantly reduces human-anti-pig cytotoxicity profiles: an alternative to direct complement regulation

(2016) James R. Butler et al.   TRANSGENIC RESEARCH

Efficient production of biallelicGGTA1knockout pigsbycytoplasmic microinjection of CRISPR/Cas9 into zygotes

(2016) Bjoern Petersen et al.   XENOTRANSPLANTATION

Applications of genome editing in insects

(2016) William Reid et al.   Current Opinion in Insect Science

CRISPR Critters and CRISPR Cracks

(2015) R. Alta Charo et al.   AMERICAN JOURNAL OF BIOETHICS

The dawn of active genetics

(2015) Valentino M. Gantz et al.   BIOESSAYS

Targeted genome editing in primate embryos

(2015) Xiangyu Guo et al.   CELL RESEARCH

No time to waste--the ethical challenges created by CRISPR: CRISPR/Cas, being an efficient, simple, and cheap technology to edit the genome of any organism, raises many ethical and regulatory issues beyond the use to manipulate human germ line cells

(2015) A. L. Caplan et al.   EMBO REPORTS

Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9

(2015) Yongchang Chen et al.   HUMAN MOLECULAR GENETICS

Genetically modified pig models for neurodegenerative disorders

(2015) Ida E Holm et al.   JOURNAL OF PATHOLOGY

Engineering large animal models of human disease

(2015) C Bruce A Whitelaw et al.   JOURNAL OF PATHOLOGY

The role of genetically engineered pigs in xenotransplantation research

(2015) David KC Cooper et al.   JOURNAL OF PATHOLOGY

CRISPR/Cas9: a powerful genetic engineering tool for establishing large animal models of neurodegenerative diseases

(2015) Zhuchi Tu et al.   Molecular Neurodegeneration

Defensive drives

(2015)   NATURE

Regulate gene editing in wild animals

(2015) Jeantine Lunshof   NATURE

CRISPR, the disruptor

(2015) Heidi Ledford   NATURE

Gene-edited 'micropigs' to be sold as pets at Chinese institute

(2015) David Cyranoski   NATURE

New life for pig-to-human transplants

(2015) Sara Reardon   NATURE

CRISPR: Science can't solve it

(2015) Daniel Sarewitz   NATURE

Gene-edited pigs are protected from porcine reproductive and respiratory syndrome virus

(2015) Kristin M Whitworth et al.   NATURE BIOTECHNOLOGY

Opinion: Is CRISPR-based gene drive a biocontrol silver bullet or global conservation threat?: Fig. 1.

(2015) Bruce L. Webber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquitoAnopheles stephensi

(2015) Valentino M. Gantz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Safeguarding gene drive experiments in the laboratory

(2015) O. S. Akbari et al.   SCIENCE

Genome-wide inactivation of porcine endogenous retroviruses (PERVs)

(2015) L. Yang et al.   SCIENCE

Molecular scissors and their application in genetically modified farm animals

(2015) Bjoern Petersen et al.   TRANSGENIC RESEARCH

Xenotransplantation literature update, November-December 2014

(2015) Christopher Burlak   XENOTRANSPLANTATION

Targeted mutations in myostatin by zinc-finger nucleases result in double-muscled phenotype in Meishan pigs

(2015) Lili Qian et al.   Scientific Reports

Genome Editing and Its Applications in Model Organisms

(2015) Dongyuan Ma et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Genome Engineering with Targetable Nucleases

(2014) Dana Carroll   Annual Review of Biochemistry

Improving livestock for agriculture - technological progress from random transgenesis to precision genome editing heralds a new era

(2014) Götz Laible et al.   Biotechnology Journal

Development and Applications of CRISPR-Cas9 for Genome Engineering

(2014) Patrick D. Hsu et al.   CELL

Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos

(2014) Yuyu Niu et al.   CELL

TALEN-Mediated Gene Mutagenesis in Rhesus and Cynomolgus Monkeys

(2014) Hailiang Liu et al.   Cell Stem Cell

De-extinction: a novel and remarkable case of bio-objectification

(2014) Lucia Martinelli et al.   CROATIAN MEDICAL JOURNAL

The Role of Xenotransplantation in Cardiac Transplantation

(2014) Sergio De Salvatore et al.   JOURNAL OF CARDIAC SURGERY

Does CRISPR-Cas open new possibilities for patents or present a moral maze?

(2014) Philip Webber   NATURE BIOTECHNOLOGY

Regulating gene drives

(2014) K. A. Oye et al.   SCIENCE

The new frontier of genome engineering with CRISPR-Cas9

(2014) J. A. Doudna et al.   SCIENCE

The Gene Genie

(2014) Margaret Knox   SCIENTIFIC AMERICAN

Criteria for Identifying and Evaluating Candidate Sites for Open-Field Trials of Genetically Engineered Mosquitoes

(2014) David M. Brown et al.   VECTOR-BORNE AND ZOONOTIC DISEASES

Efficient bi-allelic gene knockout and site-specific knock-in mediated by TALENs in pigs

(2014) Jing Yao et al.   Scientific Reports

Concerning RNA-guided gene drives for the alteration of wild populations

(2014) Kevin M Esvelt et al.   eLife

Making Better Sense of Animal Disenhancement: A Reply to Henschke

(2014) Marcus Schultz-Bergin   NanoEthics

One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering

(2013) Haoyi Wang et al.   CELL

Gene targeting technologies in rats: Zinc finger nucleases, transcription activator-like effector nucleases, and clustered regularly interspaced short palindromic repeats

(2013) Tomoji Mashimo   DEVELOPMENT GROWTH & DIFFERENTIATION

What If Extinction Is Not Forever?

(2013) J. S. Sherkow et al.   SCIENCE

Double knockout pigs deficient in N-glycolylneuraminic acid and Galactose α-1,3-Galactose reduce the humoral barrier to xenotransplantation

(2013) Andrew J. Lutz et al.   XENOTRANSPLANTATION

Advances in targeted genome editing

(2012) Pablo Perez-Pinera et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Ethical Issues in Field Trials of Genetically Modified Disease-Resistant Mosquitoes

(2012) David B. Resnik   Developing World Bioethics

TALENs: a widely applicable technology for targeted genome editing

(2012) J. Keith Joung et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genome Engineering With Zinc-Finger Nucleases

(2011) Dana Carroll   GENETICS

Broiler Chickens and a Critique of the Epistemic Foundations of Animal Modification

(2011) Samantha Noll   JOURNAL OF AGRICULTURAL & ENVIRONMENTAL ETHICS

How to write a systematic review of reasons

(2011) Daniel Strech et al.   JOURNAL OF MEDICAL ETHICS

Scientists and public involvement: a consultation on the relation between malaria, vector control and transgenic mosquitoes

(2011) Christophe Boëte   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE

Animal Disenhancement and the Non-Identity Problem: A Response to Thompson

(2011) Clare Palmer   NanoEthics

Enhancing search efficiency by means of a search filter for finding all studies on animal experimentation in PubMed

(2010) Carlijn R Hooijmans et al.   LABORATORY ANIMALS

The Cartagena Protocol and genetically modified mosquitoes

(2010) John M Marshall   NATURE BIOTECHNOLOGY

Genome editing with engineered zinc finger nucleases

(2010) Fyodor D. Urnov et al.   NATURE REVIEWS GENETICS

RETRACING LIBERALISM AND REMAKING NATURE: DESIGNER CHILDREN, RESEARCH EMBRYOS, AND FEATHERLESS CHICKENS

(2009) DOV FOX   BIOETHICS

Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement

(2009) David Moher et al.   PLOS MEDICINE

Progress and prospects: Zinc-finger nucleases as gene therapy agents

(2008) D Carroll   GENE THERAPY