Activation of AMP-activated protein kinase by metformin protects against global cerebral ischemia in male rats: Interference of AMPK/PGC-1α pathway

Acute treatment with metformin improves cardiac function following isoproterenol induced myocardial infarction in rats

(2014) Hamid Soraya et al.   Pharmacological Reports

Revisiting the mechanisms of metformin action in the liver

(2013) Benoit Viollet et al.   ANNALES D ENDOCRINOLOGIE

Impaired mitochondrial biogenesis due to dysfunctional adiponectin-AMPK-PGC-1α signaling contributing to increased vulnerability in diabetic heart

(2013) Wenjun Yan et al.   BASIC RESEARCH IN CARDIOLOGY

Comparative analysis of the neurovascular injury and functional outcomes in experimental stroke models in diabetic Goto-Kakizaki rats

(2013) Weiguo Li et al.   BRAIN RESEARCH

Metformin Increases Mitochondrial Energy Formation in L6 Muscle Cell Cultures

(2013) Veeravenkata S. Vytla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gemfibrozil Pretreatment Resulted in a Sexually Dimorphic Outcome in the Rat Models of Global Cerebral Ischemia–Reperfusion via Modulation of Mitochondrial Pro-survival and Apoptotic Cell Death Factors as well as MAPKs

(2013) Fatemeh Mohagheghi et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Two Weeks of Metformin Treatment Enhances Mitochondrial Respiration in Skeletal Muscle of AMPK Kinase Dead but Not Wild Type Mice

(2013) Jonas M. Kristensen et al.   PLoS One

Neuroprotection with metformin and thymoquinone against ethanol-induced apoptotic neurodegeneration in prenatal rat cortical neurons

(2012) Ikram Ullah et al.   BMC NEUROSCIENCE

Assessing Post-Stroke Behavior in Mouse Models of Focal Ischemia

(2012) Mustafa Balkaya et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Effects of metformin on learning and memory behaviors and brain mitochondrial functions in high fat diet induced insulin resistant rats

(2012) Hiranya Pintana et al.   LIFE SCIENCES

Exercise induces mitochondrial biogenesis after brain ischemia in rats

(2012) Q. Zhang et al.   NEUROSCIENCE

Gemfibrozil Pretreatment Affecting Antioxidant Defense System and Inflammatory, but not Nrf-2 Signaling Pathways Resulted in Female Neuroprotection and Male Neurotoxicity in the Rat Models of Global Cerebral Ischemia–Reperfusion

(2012) Fatemeh Mohagheghi et al.   NEUROTOXICITY RESEARCH

Intracerebroventricular Injection of Metformin Induces Anorexia in Rats

(2012) Chang Koo Lee et al.   Diabetes & Metabolism Journal

Roles of Oxidative Stress, Apoptosis, PGC-1α and Mitochondrial Biogenesis in Cerebral Ischemia

(2011) Shang-Der Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Preconditioning induces sustained neuroprotection by downregulation of adenosine 5′-monophosphate-activated protein kinase

(2011) V.R. Venna et al.   NEUROSCIENCE

The importance of regulation of blood glucose levels through activation of peripheral 5′-AMP-activated protein kinase on ischemic neuronal damage

(2010) Shinichi Harada et al.   BRAIN RESEARCH

Short-term adenosine monophosphate–activated protein kinase activator 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside treatment increases the sirtuin 1 protein expression in skeletal muscle

(2010) Masataka Suwa et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Metabolic Regulation of Neuronal Plasticity by the Energy Sensor AMPK

(2010) Wyatt B. Potter et al.   PLoS One

Effects of Metformin in Experimental Stroke

(2010) Jun Li et al.   STROKE

AMP-Activated Protein Kinase (AMPK) Molecular Crossroad for Metabolic Control and Survival of Neurons

(2009) Miloš R. Spasić et al.   NEUROSCIENTIST

Activation of AMP-Activated Protein Kinase by Metformin Improves Left Ventricular Function and Survival in Heart Failure

(2008) Susheel Gundewar et al.   CIRCULATION RESEARCH

AMP-activated protein kinase mediates glucocorticoid-induced metabolic changes: a novel mechanism in Cushing’s syndrome

(2008) Mirjam Christ-Crain et al.   FASEB JOURNAL

Differential effects of energy stress on AMPK phosphorylation and apoptosis in experimental brain tumor and normal brain

(2008) Purna Mukherjee et al.   Molecular Cancer