Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains

Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart

(2015) Alex Morrison et al.   FASEB JOURNAL

The antioxidant function of sestrins is mediated by promotion of autophagic degradation of Keap1 and Nrf2 activation and by inhibition of mTORC1

(2015) Sue Goo Rhee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sestrin2 Protects Dopaminergic Cells against Rotenone Toxicity through AMPK-Dependent Autophagy Activation

(2015) Yi-Sheng Hou et al.   MOLECULAR AND CELLULAR BIOLOGY

Skp2-Mediated RagA Ubiquitination Elicits a Negative Feedback to Prevent Amino-Acid-Dependent mTORC1 Hyperactivation by Recruiting GATOR1

(2015) Guoxiang Jin et al.   MOLECULAR CELL

The Ubiquitination of RagA GTPase by RNF152 Negatively Regulates mTORC1 Activation

(2015) Lu Deng et al.   MOLECULAR CELL

Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus

(2015) Michael R. Johnson et al.   Nature Communications

Sestrin2 inhibits mTORC1 through modulation of GATOR complexes

(2015) Jeong Sig Kim et al.   Scientific Reports

The inhibitory effect of ethanol on Sestrin3 in the pathogenesis of ethanol-induced liver injury

(2014) Xinqin Kang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Sestrins Function as Guanine Nucleotide Dissociation Inhibitors for Rag GTPases to Control mTORC1 Signaling

(2014) Min Peng et al.   CELL

The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism

(2014) Chen-Song Zhang et al.   Cell Metabolism

Sestrin 3 Protein Enhances Hepatic Insulin Sensitivity by Direct Activation of the mTORC2-Akt Signaling

(2014) Rongya Tao et al.   DIABETES

Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1

(2014) Seung-Hyun Ro et al.   FEBS Journal

Sestrin2 inhibits uncoupling protein 1 expression through suppressing reactive oxygen species

(2014) S.-H. Ro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological correction of obesity-induced autophagy arrest using calcium channel blockers

(2014) Hwan-Woo Park et al.   Nature Communications

The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1

(2014) Lynne Chantranupong et al.   Cell Reports

Sestrins Inhibit mTORC1 Kinase Activation through the GATOR Complex

(2014) Anita Parmigiani et al.   Cell Reports

Decision making inxia2

(2013) Graeme Winter et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Antioxidant Activity of Sestrin 2 Controls Neuropathic Pain After Peripheral Nerve Injury

(2013) Wiebke Kallenborn-Gerhardt et al.   ANTIOXIDANTS & REDOX SIGNALING

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Sestrins Orchestrate Cellular Metabolism to Attenuate Aging

(2013) Jun Hee Lee et al.   Cell Metabolism

Sestrin-2, a repressor of PDGFR  signalling, promotes cigarette-smoke-induced pulmonary emphysema in mice and is upregulated in individuals with COPD

(2013) J. Heidler et al.   Disease Models & Mechanisms

SESN-1 is a positive regulator of lifespan in Caenorhabditis elegans

(2013) Ya-Luen Yang et al.   EXPERIMENTAL GERONTOLOGY

NemR Is a Bleach-sensing Transcription Factor

(2013) Michael J. Gray et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sestrin 2 and AMPK Connect Hyperglycemia to Nox4-Dependent Endothelial Nitric Oxide Synthase Uncoupling and Matrix Protein Expression

(2013) Assaad A. Eid et al.   MOLECULAR AND CELLULAR BIOLOGY

A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

(2013) L. Bar-Peled et al.   SCIENCE

Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death

(2012) I Ben-Sahra et al.   CELL DEATH AND DIFFERENTIATION

Maintenance of Metabolic Homeostasis by Sestrin2 and Sestrin3

(2012) Jun Hee Lee et al.   Cell Metabolism

Sestrins Activate Nrf2 by Promoting p62-Dependent Autophagic Degradation of Keap1 and Prevent Oxidative Liver Damage

(2012) Soo Han Bae et al.   Cell Metabolism

Sestrin2 Modulates AMPK Subunit Expression and Its Response to Ionizing Radiation in Breast Cancer Cells

(2012) Toran Sanli et al.   PLoS One

Lipid peroxidation and neurodegenerative disease

(2011) Tanea T. Reed   FREE RADICAL BIOLOGY AND MEDICINE

Crystal structure of alkyl hydroperoxidase D like protein PA0269 from Pseudomonas aeruginosa: Homology of the AhpD-like structural family

(2011) Teresa E Clarke et al.   BMC STRUCTURAL BIOLOGY

Experimental phasing withSHELXC/D/E: combining chain tracing with density modification

(2010) George M. Sheldrick   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Glyceraldehyde 3-Phosphate Dehydrogenase is Unlikely to Mediate Hydrogen Peroxide Signaling: Studies with a Novel Anti-Dimedone Sulfenic Acid Antibody

(2010) Claire Maller et al.   ANTIOXIDANTS & REDOX SIGNALING

Is Overoxidation of Peroxiredoxin Physiologically Significant?

(2010) Maike Thamsen et al.   ANTIOXIDANTS & REDOX SIGNALING

Inactivation of sestrin 2 induces TGF-  signaling and partially rescues pulmonary emphysema in a mouse model of COPD

(2010) F. Wempe et al.   Disease Models & Mechanisms

Stressin' Sestrins take an aging fight

(2010) Andrei V. Budanov et al.   EMBO Molecular Medicine

Sestrin as a Feedback Inhibitor of TOR That Prevents Age-Related Pathologies

(2010) J. H. Lee et al.   SCIENCE

Decision-making in structure solution using Bayesian estimates of map quality: thePHENIX AutoSolwizard

(2009) Thomas C. Terwilliger et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Role of sestrin2 in peroxide signaling in macrophages

(2009) Silke Essler et al.   FEBS LETTERS

Sestrin 2 Is Not a Reductase for Cysteine Sulfinic Acid of Peroxiredoxins

(2008) Hyun Ae Woo et al.   ANTIOXIDANTS & REDOX SIGNALING

Akt Determines Replicative Senescence and Oxidative or Oncogenic Premature Senescence and Sensitizes Cells to Oxidative Apoptosis

(2008) Veronique Nogueira et al.   CANCER CELL

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

(2008) Andrei V. Budanov et al.   CELL

Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

(2008) Sofia Papadia et al.   NATURE NEUROSCIENCE