Sestrin2, as a negative feedback regulator of mTOR, provides neuroprotection by activation AMPK phosphorylation in neonatal hypoxic-ischemic encephalopathy in rat pups

Sestrin2–AMPK activation protects mitochondrial function against glucose deprivation-induced cytotoxicity

(2015) Kyuhwa Seo et al.   CELLULAR SIGNALLING

Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart

(2015) Alex Morrison et al.   FASEB JOURNAL

Roles of Sestrin2 and Ribosomal Protein S6 in Transient Global Ischemia-Induced Hippocampal Neuronal Injury

(2015) Yao-Chung Chuang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Reduced Cortical Activity Impairs Development and Plasticity after Neonatal Hypoxia Ischemia

(2015) S. Ranasinghe et al.   JOURNAL OF NEUROSCIENCE

AMPK binds to Sestrins and mediates the effect of exercise to increase insulin-sensitivity through autophagy

(2015) Xiaolei Liu et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Protease-Activated Receptor 1 and 4 Signal Inhibition Reduces Preterm Neonatal Hemorrhagic Brain Injury

(2015) Tim Lekic et al.   STROKE

Cutting through the Complexities of mTOR for the Treatment of Stroke

(2014) Kenneth Maiese   CURRENT NEUROVASCULAR RESEARCH

Sestrin 3 Protein Enhances Hepatic Insulin Sensitivity by Direct Activation of the mTORC2-Akt Signaling

(2014) Rongya Tao et al.   DIABETES

Adamts1 Mediates Ethanol-Induced Alterations in Collagen and Elastin via a FoxO1-Sestrin3-AMPK Signaling Cascade in Myocytes

(2014) Ly Q Hong-Brown et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

mTOR Signaling Inhibition Modulates Macrophage/Microglia-Mediated Neuroinflammation and Secondary Injury via Regulatory T Cells after Focal Ischemia

(2014) L. Xie et al.   JOURNAL OF IMMUNOLOGY

PRAS40 plays a pivotal role in protecting against stroke by linking the Akt and mTOR pathways

(2014) Xiaoxing Xiong et al.   NEUROBIOLOGY OF DISEASE

Sestrins Inhibit mTORC1 Kinase Activation through the GATOR Complex

(2014) Anita Parmigiani et al.   Cell Reports

Chronic Hydrocephalus and Perihematomal Tissue Injury Developed in a Rat Model of Intracerebral Hemorrhage with Ventricular Extension

(2014) Qianwei Chen et al.   Translational Stroke Research

Sestrins Orchestrate Cellular Metabolism to Attenuate Aging

(2013) Jun Hee Lee et al.   Cell Metabolism

The rationale of targeting mammalian target of rapamycin for ischemic stroke

(2013) Zhao Zhong Chong et al.   CELLULAR SIGNALLING

Stem cells for brain repair in neonatal hypoxia–ischemia

(2013) L. Chicha et al.   CHILDS NERVOUS SYSTEM

SESN-1 is a positive regulator of lifespan in Caenorhabditis elegans

(2013) Ya-Luen Yang et al.   EXPERIMENTAL GERONTOLOGY

Induction of sestrin2 as an endogenous protective mechanism against amyloid beta-peptide neurotoxicity in primary cortical culture

(2013) Yueh-Sheng Chen et al.   EXPERIMENTAL NEUROLOGY

Upregulation of Sestrin-2 Expression via P53 Protects Against 1-Methyl-4-Phenylpyridinium (MPP+) Neurotoxicity

(2013) Zhou Daixing et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Sestrin 2 and AMPK Connect Hyperglycemia to Nox4-Dependent Endothelial Nitric Oxide Synthase Uncoupling and Matrix Protein Expression

(2013) Assaad A. Eid et al.   MOLECULAR AND CELLULAR BIOLOGY

Rapamycin Treatment Improves Neuron Viability in an In Vitro Model of Stroke

(2013) Lauren Fletcher et al.   PLoS One

Nasal Administration of Recombinant Osteopontin Attenuates Early Brain Injury After Subarachnoid Hemorrhage

(2013) Basak Caner Topkoru et al.   STROKE

Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death

(2012) I Ben-Sahra et al.   CELL DEATH AND DIFFERENTIATION

Maintenance of Metabolic Homeostasis by Sestrin2 and Sestrin3

(2012) Jun Hee Lee et al.   Cell Metabolism

Vascular Endothelial Growth Factors A and C are Induced in the SVZ Following Neonatal Hypoxia–Ischemia and Exert Different Effects on Neonatal Glial Progenitors

(2012) Jennifer M. Bain et al.   Translational Stroke Research

Osteopontin Reduced Hypoxia–Ischemia Neonatal Brain Injury by Suppression of Apoptosis in a Rat Pup Model

(2011) Wanqiu Chen et al.   STROKE

Prolonged Exposure to Isoflurane Ameliorates Infarction Severity in the Rat Pup Model of Neonatal Hypoxia-Ischemia

(2011) Hank Chen et al.   Translational Stroke Research

Stressin' Sestrins take an aging fight

(2010) Andrei V. Budanov et al.   EMBO Molecular Medicine

Sestrin as a Feedback Inhibitor of TOR That Prevents Age-Related Pathologies

(2010) J. H. Lee et al.   SCIENCE

Omega-3 Polyunsaturated Fatty Acid Supplementation Confers Long-Term Neuroprotection Against Neonatal Hypoxic–Ischemic Brain Injury Through Anti-Inflammatory Actions

(2010) Wenting Zhang et al.   STROKE