The Ras/MAPK pathway and hepatocarcinoma: pathogenesis and therapeutic implications
Published 2015 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The Ras/MAPK pathway and hepatocarcinoma: pathogenesis and therapeutic implications
Authors
Keywords
-
Journal
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
Volume 45, Issue 6, Pages 609-623
Publisher
Wiley
Online
2015-04-02
DOI
10.1111/eci.12441
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Dysregulated serum response factor triggers formation of hepatocellular carcinoma
- (2015) Stefan Ohrnberger et al. HEPATOLOGY
- EASL–EORTC Clinical Practice Guidelines: Management of hepatocellular carcinoma
- (2015) et al. JOURNAL OF HEPATOLOGY
- Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health
- (2015) William H. Chappell et al. Oncotarget
- Targeted therapy for hepatocellular carcinoma: novel agents on the horizon
- (2015) Melchiorre Cervello et al. Oncotarget
- Allosteric MEK1/2 Inhibitor Refametinib (BAY 86-9766) in Combination with Sorafenib Exhibits Antitumor Activity in Preclinical Murine and Rat Models of Hepatocellular Carcinoma
- (2015) Roberta Schmieder et al. NEOPLASIA
- The developing story of Sprouty and cancer
- (2014) Samar Masoumi-Moghaddam et al. CANCER AND METASTASIS REVIEWS
- Ras in digestive oncology
- (2014) Nicolas Charette et al. CURRENT OPINION IN ONCOLOGY
- Molecular Therapies in Hepatocellular Carcinoma: What Can We Target?
- (2014) Roberto Galuppo et al. DIGESTIVE DISEASES AND SCIENCES
- RASSF tumor suppressor gene family: Biological functions and regulation
- (2014) Natalia Volodko et al. FEBS LETTERS
- Cell Cycle Restriction Is More Important Than Apoptosis Induction for RASSF1A Protein Tumor Suppression
- (2014) Howard Donninger et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Growth factor transduction pathways: paradigm of anti-neoplastic targeted therapy
- (2014) Francesca Carlomagno et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- RalA signaling pathway as a therapeutic target in hepatocellular carcinoma (HCC)
- (2014) Mohamad Ezzeldin et al. Molecular Oncology
- NORE1A sensitises cancer cells to sorafenib-induced apoptosis and indicates hepatocellular carcinoma prognosis
- (2014) Li-Li Liu et al. TUMOR BIOLOGY
- Molecular targeted therapy for hepatocellular carcinoma: Current and future
- (2014) Jung Woo Shin WORLD JOURNAL OF GASTROENTEROLOGY
- Reversibility of regorafenib effects in hepatocellular carcinoma cells
- (2013) Rosalba D’Alessandro et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Functional crosstalk between AKT/mTOR and Ras/MAPK pathways in hepatocarcinogenesis: Implications for the treatment of human liver cancer
- (2013) Chunmei Wang et al. CELL CYCLE
- Recent progress in the identification of BRAF inhibitors as anti-cancer agents
- (2013) Hala Bakr El-Nassan EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Crosstalk between Beta-Catenin and Snail in the Induction of Epithelial to Mesenchymal Transition in Hepatocarcinoma: Role of the ERK1/2 Pathway
- (2013) Nathalie Zucchini-Pascal et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- MAPKs and Signal Transduction in the Control of Gastrointestinal Epithelial Cell Proliferation and Differentiation
- (2013) Luciana Osaki et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- RASSF1A-Mediated Regulation of AREG via the Hippo Pathway in Hepatocellular Carcinoma
- (2013) Ei Yong Ahn et al. MOLECULAR CANCER RESEARCH
- MEK in cancer and cancer therapy
- (2013) Cindy Neuzillet et al. PHARMACOLOGY & THERAPEUTICS
- Salirasib sensitizes hepatocarcinoma cells to TRAIL-induced apoptosis through DR5 and survivin-dependent mechanisms
- (2013) N Charette et al. Cell Death & Disease
- Clinical Trials in Hepatocellular Carcinoma: An Update
- (2013) Ying-Chun Shen et al. Liver Cancer
- Cellular and molecular mechanisms of hepatocellular carcinoma: an update
- (2012) Rajagopal N. Aravalli et al. ARCHIVES OF TOXICOLOGY
- Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance
- (2012) Edita Aksamitiene et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Tiam1 is associated with hepatocellular carcinoma metastasis
- (2012) Jing Huang et al. INTERNATIONAL JOURNAL OF CANCER
- Fluoro-Sorafenib (Regorafenib) effects on hepatoma cells: Growth inhibition, quiescence, and recovery
- (2012) Brian I. Carr et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Targeted therapy of hepatocellular carcinoma: Present and future
- (2012) Stephen L Chan et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- Inactivation of Spry2 accelerates AKT-driven hepatocarcinogenesis via activation of MAPK and PKM2 pathways
- (2012) Chunmei Wang et al. JOURNAL OF HEPATOLOGY
- A rare point mutation in the Ras oncogene in hepatocellular carcinoma
- (2012) Akinobu Taketomi et al. SURGERY TODAY
- BRAF and PIK3CA genes are somatically mutated in hepatocellular carcinoma among patients from South Italy
- (2012) M Colombino et al. Cell Death & Disease
- Regulation of human hepatocellular carcinoma cells by Spred2 and correlative studies on its mechanism
- (2011) Xiao-Ni Ma et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Sprouty keeps bowel kinases regular in colon cancer, while miR-21 targets Sprouty
- (2011) Mark R. Frey et al. CANCER BIOLOGY & THERAPY
- Expression and prognostic role of pan-Ras, Raf-1, pMEK1 and pERK1/2 in patients with hepatocellular carcinoma
- (2011) L. Chen et al. EJSO
- HCV core protein promotes heparin binding EGF-like growth factor expression and activates Akt
- (2011) Hitomi Nakamura et al. HEPATOLOGY RESEARCH
- Phase II Study of the Mitogen-Activated Protein Kinase 1/2 Inhibitor Selumetinib in Patients With Advanced Hepatocellular Carcinoma
- (2011) Bert H. O'Neil et al. JOURNAL OF CLINICAL ONCOLOGY
- Low expression of DAB2IP contributes to malignant development and poor prognosis in hepatocellular carcinoma
- (2011) Xiaojing Zhang et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- Differential expression of sprouty genes in hepatocellular carcinoma
- (2011) Yongyut Sirivatanauksorn et al. JOURNAL OF SURGICAL ONCOLOGY
- Ras inhibition in hepatocarcinoma by S-trans-trans-farnesylthiosalicyclic acid: Association of its tumor preventive effect with cell proliferation, cell cycle events, and angiogenesis
- (2011) Peter Stärkel et al. MOLECULAR CARCINOGENESIS
- IQGAP1 and IQGAP2 are Reciprocally Altered in Hepatocellular Carcinoma
- (2010) Colin D White et al. BMC GASTROENTEROLOGY
- AZD6244 (ARRY-142886) enhances the antitumor activity of rapamycin in mouse models of human hepatocellular carcinoma
- (2010) Hung Huynh CANCER
- Molecular approaches to treatment of hepatocellular carcinoma
- (2010) Anja Lachenmayer et al. DIGESTIVE AND LIVER DISEASE
- The changing pattern of epidemiology in hepatocellular carcinoma
- (2010) Helena Nordenstedt et al. DIGESTIVE AND LIVER DISEASE
- Synergistic role of sprouty2 inactivation and c-Met up-regulation in mouse and human hepatocarcinogenesis
- (2010) Susie A. Lee et al. HEPATOLOGY
- Clinicopathological significance of RASSF1A reduced expression and hypermethylation in hepatocellular carcinoma
- (2010) Lang Hu et al. Hepatology International
- Regorafenib (BAY 73-4506): A new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity
- (2010) Scott M. Wilhelm et al. INTERNATIONAL JOURNAL OF CANCER
- From basic research to clinical development of MEK1/2 inhibitors for cancer therapy
- (2010) Christophe Frémin et al. Journal of Hematology & Oncology
- Cancer gene discovery in hepatocellular carcinoma
- (2010) Lars Zender et al. JOURNAL OF HEPATOLOGY
- Inactivation of Ras GTPase-activating proteins promotes unrestrained activity of wild-type Ras in human liver cancer
- (2010) Diego F. Calvisi et al. JOURNAL OF HEPATOLOGY
- RASSF2A promoter methylation in hepatitis B virus-related hepatocellular carcinogenesis and its correlation with elevated serum α-fetoprotein level
- (2010) Jinghua Ren et al. Journal of Huazhong University of Science and Technology-Medical Sciences
- Salirasib inhibits the growth of hepatocarcinoma cell lines in vitro and tumor growth in vivo through ras and mTOR inhibition
- (2010) Nicolas Charette et al. Molecular Cancer
- Mitogen-activated protein kinases in hepatocellular carcinoma development
- (2010) Lihua Min et al. SEMINARS IN CANCER BIOLOGY
- Overactivation of the MEK/ERK Pathway in Liver Tumor Cells Confers Resistance to TGF- -Induced Cell Death through Impairing Up-regulation of the NADPH Oxidase NOX4
- (2009) L. Caja et al. CANCER RESEARCH
- The Ras inhibitor farnesylthiosalicyclic acid (FTS) prevents nodule formation and development of preneoplastic foci of altered hepatocytes in rats
- (2009) T. Schneider-Merck et al. EUROPEAN JOURNAL OF CANCER
- Genetic and Epigenetic Control of Molecular Alterations in Hepatocellular Carcinoma
- (2009) Francesco Feo et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- AZD6244 enhances the anti-tumor activity of sorafenib in ectopic and orthotopic models of human hepatocellular carcinoma (HCC)
- (2009) Hung Huynh et al. JOURNAL OF HEPATOLOGY
- Dual-Specificity Phosphatase 1 Ubiquitination in Extracellular Signal-Regulated Kinase-Mediated Control of Growth in Human Hepatocellular Carcinoma
- (2008) D. F. Calvisi et al. CANCER RESEARCH
- Variable DNA methylation patterns associated with progression of disease in hepatocellular carcinomas
- (2008) Wentao Gao et al. CARCINOGENESIS
- Molecular targeted therapies in hepatocellular carcinoma
- (2008) Josep M. Llovet et al. HEPATOLOGY
- Ras-driven proliferation and apoptosis signaling during rat liver carcinogenesis is under genetic control
- (2008) Diego F. Calvisi et al. INTERNATIONAL JOURNAL OF CANCER
- Overexpression of Tiam1 in hepatocellular carcinomas predicts poor prognosis of HCC patients
- (2008) Yi Ding et al. INTERNATIONAL JOURNAL OF CANCER
- Development of Hepatocellular Carcinoma in Iqgap2-Deficient Mice Is IQGAP1 Dependent
- (2008) V. A. Schmidt et al. MOLECULAR AND CELLULAR BIOLOGY
- Sorafenib in Advanced Hepatocellular Carcinoma
- (2008) Josep M. Llovet et al. NEW ENGLAND JOURNAL OF MEDICINE
- RNAi-mediated ERK2 knockdown inhibits growth of tumor cells in vitro and in vivo
- (2008) A Bessard et al. ONCOGENE
- Differential selection for B-raf and Ha-ras mutated liver tumors in mice with high and low susceptibility to hepatocarcinogenesis
- (2007) Albrecht Buchmann et al. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started