S1PR1 as a Novel Promising Therapeutic Target in Cancer Therapy

Apolipoprotein M promotes proliferation and invasion in non-small cell lung cancers via upregulating S1PR1 and activating the ERK1/2 and PI3K/AKT signaling pathways

(2018) Yifei Zhu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sphingosine-1-phosphate promotes the proliferation and attenuates apoptosis of Endothelial progenitor cells via S1PR1/S1PR3/PI3K/Akt pathway

(2018) Hang Wang et al.   CELL BIOLOGY INTERNATIONAL

Expansion of Sphingosine Kinase and Sphingosine-1-Phosphate Receptor Function in Normal and Cancer Cells: From Membrane Restructuring to Mediation of Estrogen Signaling and Stem Cell Programming

(2018) Olga Sukocheva   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Preclinical study of the antitumor effect of sphingosine-1-phosphate receptor 1 antibody (S1PR1-antibody) against human breast cancer cells

(2018) Shujun Xiao et al.   INVESTIGATIONAL NEW DRUGS

The sphingosine 1-phosphate receptor modulator fingolimod as a therapeutic agent: Recent findings and new perspectives

(2018) Andrea Huwiler et al.   PHARMACOLOGY & THERAPEUTICS

Apolipoprotein M Protects Lipopolysaccharide-Treated Mice from Death and Organ Injury

(2018) Koichi Tsuneyama et al.   THROMBOSIS AND HAEMOSTASIS

Targeting S1PR1/STAT3 loop abrogates desmoplasia and chemosensitizes pancreatic cancer to gemcitabine

(2018) Manendra Babu Lankadasari et al.   Theranostics

Survival benefit of sphingosin-1-phosphate and receptors expressions in breast cancer patients

(2018) Fu-Ju Lei et al.   Cancer Medicine

Role of S1P/S1PR3 axis in release of CCL20 from human bronchial epithelial cells

(2018) Yoshitaka Kawa et al.   PLoS One

STAT3 expression is a prognostic marker in upper urinary tract urothelial carcinoma

(2018) Kyosuke Matsuzaki et al.   PLoS One

The significant role of interleukin-6 and its signaling pathway in the immunopathogenesis and treatment of breast cancer

(2018) Ali Masjedi et al.   BIOMEDICINE & PHARMACOTHERAPY

Smac mimetics as novel promising modulators of apoptosis in the treatment of breast cancer

(2018) Afshin Nikkhoo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Nanoparticles and targeted drug delivery in cancer therapy

(2017) Behdokht Bahrami et al.   IMMUNOLOGY LETTERS

Sphingosine 1-Phosphate (S1P) Signaling in Glioblastoma Multiforme—A Systematic Review

(2017) Shailaja Mahajan-Thakur et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CD73 specific siRNA loaded chitosan lactate nanoparticles potentiate the antitumor effect of a dendritic cell vaccine in 4T1 breast cancer bearing mice

(2017) Farhad Jadidi-Niaragh et al.   JOURNAL OF CONTROLLED RELEASE

Targeting S1P in Inflammatory Bowel Disease: New Avenues for Modulating Intestinal Leukocyte Migration

(2017) Silvio Danese et al.   Journal of Crohns & Colitis

S1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis via NLRP3/IL-1β

(2017) Benjamin Weichand et al.   JOURNAL OF EXPERIMENTAL MEDICINE

S1PR1 drives a feedforward signalling loop to regulate BATF3 and the transcriptional programme of Hodgkin lymphoma cells

(2017) K Vrzalikova et al.   LEUKEMIA

The balance between Gαi-Cdc42/Rac and Gα12/13-RhoA pathways determines endothelial barrier regulation by sphingosine-1-phosphate

(2017) Nathalie R. Reinhard et al.   MOLECULAR BIOLOGY OF THE CELL

Sphingosine-1-Phosphate Receptor-1 Promotes Environment-Mediated and Acquired Chemoresistance

(2017) Veronica Lifshitz et al.   MOLECULAR CANCER THERAPEUTICS

Sphingosine 1-Phosphate Receptor 1 Signaling in Mammalian Cells

(2017) Nigel Pyne et al.   MOLECULES

Targeting sphingosine-1-phosphate signaling for cancer therapy

(2017) Zuoquan Xie et al.   Science China-Life Sciences

Unification of de novo and acquired ibrutinib resistance in mantle cell lymphoma

(2017) Xiaohong Zhao et al.   Nature Communications

Sphingosine kinase 1/sphingosine-1-phosphate (S1P)/S1P receptor axis is involved in ovarian cancer angiogenesis

(2017) Lan Dai et al.   Oncotarget

Pathophysiological Consequences of a Break in S1P1-Dependent Homeostasis of Vascular Permeability Revealed by S1P1 Competitive Antagonism

(2017) Marc Bigaud et al.   PLoS One

Synthesis, identification, and biological activity of metabolites of two novel selective S1P1 agonists

(2016) Qiong Xiao et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Sphingosine-1-phosphate receptor 1 as a prognostic biomarker and therapeutic target for patients with primary testicular diffuse large B-cell lymphoma

(2016) Risa Koresawa et al.   BRITISH JOURNAL OF HAEMATOLOGY

Effects of HMGA2 siRNA and doxorubicin dual delivery by chitosan nanoparticles on cytotoxicity and gene expression of HT-29 colorectal cancer cell line

(2016) Homayoon Siahmansouri et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Sphingosine-1-Phosphate Signaling in Immune Cells and Inflammation: Roles and Therapeutic Potential

(2016) Masayo Aoki et al.   MEDIATORS OF INFLAMMATION

Downregulation of CD73 in 4T1 breast cancer cells through siRNA-loaded chitosan-lactate nanoparticles

(2016) Farhad Jadidi-Niaragh et al.   TUMOR BIOLOGY

The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be mined

(2016) Lei Jin et al.   World Journal of Surgical Oncology

miR-133b, a microRNA targeting S1PR1, suppresses nasopharyngeal carcinoma cell proliferation

(2016) NAN CHENG et al.   Experimental and Therapeutic Medicine

Expression of S1P metabolizing enzymes and receptors correlate with survival time and regulate cell migration in glioblastoma multiforme

(2016) Sandra Bien-Möller et al.   Oncotarget

The emerging role of FTY720 (Fingolimod) in cancer treatment

(2016) Christopher White et al.   Oncotarget

Sphingosine-1 Phosphate: A New Modulator of Immune Plasticity in the Tumor Microenvironment

(2016) Yamila I. Rodriguez et al.   Frontiers in Oncology

Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2

(2016) Sathya Narayanan Patmanathan et al.   Scientific Reports

Interference with distinct steps of sphingolipid synthesis and signaling attenuates proliferation of U87MG glioma cells

(2015) Eva Bernhart et al.   BIOCHEMICAL PHARMACOLOGY

Inhibition of breast cancer cell migration by activation of cAMP signaling

(2015) Hongli Dong et al.   BREAST CANCER RESEARCH AND TREATMENT

Enhanced Chemokine Receptor Recycling and Impaired S1P1 Expression Promote Leukemic Cell Infiltration of Lymph Nodes in Chronic Lymphocytic Leukemia

(2015) L. Patrussi et al.   CANCER RESEARCH

Sphingosine-1-phosphate receptor 1 (S1PR1) expression in non-muscle invasive urothelial carcinoma: Association with poor clinical outcome and potential therapeutic target

(2015) Heounjeong Go et al.   EUROPEAN JOURNAL OF CANCER

IL-17–Producing Vγ4+γδ T Cells Require Sphingosine 1-Phosphate Receptor 1 for Their Egress from the Lymph Nodes under Homeostatic and Inflammatory Conditions

(2015) Yasuhiro Maeda et al.   JOURNAL OF IMMUNOLOGY

The relationship between COPD and lung cancer

(2015) A.L. Durham et al.   LUNG CANCER

Filamin A Expression Negatively Regulates Sphingosine-1-Phosphate-Induced NF-κB Activation in Melanoma Cells by Inhibition of Akt Signaling

(2015) Ludmila Campos et al.   MOLECULAR AND CELLULAR BIOLOGY

FTY720 and two novel butterfly derivatives exert a general anti-inflammatory potential by reducing immune cell adhesion to endothelial cells through activation of S1P3 and phosphoinositide 3-kinase

(2015) Faik Imeri et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Sphingosine-1-phosphate receptor 1 transmits estrogens’ effects in endothelial cells

(2015) Olga Sukocheva et al.   STEROIDS

The phosphorylated prodrug FTY720 is a histone deacetylase inhibitor that reactivates ERα expression and enhances hormonal therapy for breast cancer

(2015) N C Hait et al.   Oncogenesis

Hypoxia Augments Outgrowth Endothelial Cell (OEC) Sprouting and Directed Migration in Response to Sphingosine-1-Phosphate (S1P)

(2015) Priscilla A. Williams et al.   PLoS One

Host endothelial S1PR1 regulation of vascular permeability modulates tumor growth

(2014) Gor Sarkisyan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Development of a selective S1P1 receptor agonist, Syl930, as a potential therapeutic agent for autoimmune encephalitis

(2014) Jing Jin et al.   BIOCHEMICAL PHARMACOLOGY

Overexpression of sphingosine-1-phosphate receptor 1 and phospho-signal transducer and activator of transcription 3 is associated with poor prognosis in rituximab-treated diffuse large B-cell lymphomas

(2014) Jin Ho Paik et al.   BMC CANCER

FTY720 inhibits proliferation and epithelial-mesenchymal transition in cholangiocarcinoma by inactivating STAT3 signaling

(2014) Zhaoyang Lu et al.   BMC CANCER

S1P1and VEGFR-2 Form a Signaling Complex with Extracellularly Regulated Kinase 1/2 and Protein Kinase C-α Regulating ML-1 Thyroid Carcinoma Cell Migration

(2014) Nina Bergelin et al.   ENDOCRINOLOGY

Sphingosine-1-phosphate receptors control B-cell migration through signaling components associated with primary immunodeficiencies, chronic lymphocytic leukemia, and multiple sclerosis

(2014) Heiko Sic et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Sphingosine-1-Phosphate Mediates COX-2 Expression and PGE2/IL-6 Secretion via c-Src-Dependent AP-1 Activation

(2014) Chih-Kai Hsu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Expression of Sphingosine-1 Phosphate Receptor-1 in Chronic Lymphocytic Leukemia Cells Is Impaired by Tumor Microenvironmental Signals and Enhanced by Piceatannol and R406

(2014) Mercedes Borge et al.   JOURNAL OF IMMUNOLOGY

An update on the biology of sphingosine 1-phosphate receptors

(2014) Victoria A. Blaho et al.   JOURNAL OF LIPID RESEARCH

Endothelial Differentiation Gene-1, a New Downstream Gene Is Involved in RTEF-1 Induced Angiogenesis in Endothelial Cells

(2014) Ping He et al.   PLoS One

Aberrant expression of sphingosine-1-phosphate receptor 1 correlates with metachronous liver metastasis and poor prognosis in colorectal cancer

(2014) Qi Lin et al.   TUMOR BIOLOGY

S1PR1 Is Crucial for Accumulation of Regulatory T Cells in Tumors via STAT3

(2014) Saul J. Priceman et al.   Cell Reports

Egress of CD19+CD5+ cells into peripheral blood following treatment with the Bruton tyrosine kinase inhibitor ibrutinib in mantle cell lymphoma patients

(2013) B. Y. Chang et al.   BLOOD

Sphingosine-1-phosphate receptor 1 in classical Hodgkin lymphoma: assessment of expression and role in cell migration

(2013) Michael J Kluk et al.   LABORATORY INVESTIGATION

A novel liposomal formulation of FTY720 (Fingolimod) for promising enhanced targeted delivery

(2013) Yicheng Mao et al.   Nanomedicine-Nanotechnology Biology and Medicine

Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond

(2013) Gregory T. Kunkel et al.   NATURE REVIEWS DRUG DISCOVERY

Novel Sphingosine-1-Phosphate Receptor Modulator KRP203 Combined With Locally Delivered Regulatory T Cells Induces Permanent Acceptance of Pancreatic Islet Allografts

(2013) Mithun Khattar et al.   TRANSPLANTATION

The structure and function of the S1P1 receptor

(2013) Catherine O'Sullivan et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Regulation of cell survival by sphingosine-1-phosphate receptor S1P1 via reciprocal ERK-dependent suppression of Bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1

(2013) C Rutherford et al.   Cell Death & Disease

Targeting Sphingosine-1-Phosphate Receptors in Cancer

(2012) Rebecca J. Watters et al.   Anti-Cancer Agents in Medicinal Chemistry

Fingolimod inhibits PDGF-B-induced migration of vascular smooth muscle cell by down-regulating the S1PR1/S1PR3 pathway

(2012) Yoanne Mousseau et al.   BIOCHIMIE

S1P1 expression is controlled by the pro-oxidant activity of p66Shc and is impaired in B-CLL patients with unfavorable prognosis

(2012) N. Capitani et al.   BLOOD

S1PR1 is an effective target to block STAT3 signaling in activated B cell-like diffuse large B-cell lymphoma

(2012) Y. Liu et al.   BLOOD

S1PR1-STAT3 Signaling Is Crucial for Myeloid Cell Colonization at Future Metastatic Sites

(2012) Jiehui Deng et al.   CANCER CELL

Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer

(2012) Jie Liang et al.   CANCER CELL

Sphingosine Kinase 1 Overexpression Contributes to Cetuximab Resistance in Human Colorectal Cancer Models

(2012) R. Rosa et al.   CLINICAL CANCER RESEARCH

The Sphingosine-1-Phosphate Receptor S1PR1 Restricts Sprouting Angiogenesis by Regulating the Interplay between VE-Cadherin and VEGFR2

(2012) Konstantin Gaengel et al.   DEVELOPMENTAL CELL

Flow-Regulated Endothelial S1P Receptor-1 Signaling Sustains Vascular Development

(2012) Bongnam Jung et al.   DEVELOPMENTAL CELL

Extracellular and intracellular sphingosine-1-phosphate in cancer

(2011) Jessie W. Yester et al.   CANCER AND METASTASIS REVIEWS

The sphingosine-1-phosphate receptor-1 antagonist, W146, causes early and short-lasting peripheral blood lymphopenia in mice

(2011) Gema Tarrasón et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Amelioration of Collagen-Induced Arthritis by a Novel S1P1 Antagonist with Immunomodulatory Activities

(2011) Y. Fujii et al.   JOURNAL OF IMMUNOLOGY

Sphingosine Kinase 1 Is Overexpressed and Promotes Proliferation in Human Thyroid Cancer

(2011) Hongyu Guan et al.   MOLECULAR ENDOCRINOLOGY

Therapeutic Effects of Novel Sphingosine-1-Phosphate Receptor Agonist W-061 in Murine DSS Colitis

(2011) Yasuaki Sanada et al.   PLoS One

Sphingosine-1-phosphate signaling and its role in disease

(2011) Michael Maceyka et al.   TRENDS IN CELL BIOLOGY

Discovery of CS-0777: A Potent, Selective, and Orally Active S1P1 Agonist

(2011) Takahide Nishi et al.   ACS Medicinal Chemistry Letters

High Expression of Sphingosine 1-Phosphate Receptors, S1P1 and S1P3, Sphingosine Kinase 1, and Extracellular Signal-Regulated Kinase-1/2 Is Associated with Development of Tamoxifen Resistance in Estrogen Receptor-Positive Breast Cancer Patients

(2010) Carol Watson et al.   AMERICAN JOURNAL OF PATHOLOGY

T-Lymphoblastic Lymphoma Cells Express High Levels of BCL2, S1P1, and ICAM1, Leading to a Blockade of Tumor Cell Intravasation

(2010) Hui Feng et al.   CANCER CELL

STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors

(2010) Heehyoung Lee et al.   NATURE MEDICINE

A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis

(2010) Ludwig Kappos et al.   NEW ENGLAND JOURNAL OF MEDICINE

FTY720 and SEW2871 reverse the inhibitory effect of S1P on natural killer cell mediated lysis of K562 tumor cells and dendritic cells but not on cytokine release

(2009) Johannes Rolin et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

S1P/S1P1 signaling stimulates cell migration and invasion in Wilms tumor

(2009) Mei-Hong Li et al.   CANCER LETTERS

Sphingosine-1-phosphate receptor type 1 regulates glioma cell proliferation and correlates with patient survival

(2009) Yuya Yoshida et al.   INTERNATIONAL JOURNAL OF CANCER

The expression level of sphingosine-1-phosphate receptor type 1 is related to MIB-1 labeling index and predicts survival of glioblastoma patients

(2009) Yuya Yoshida et al.   JOURNAL OF NEURO-ONCOLOGY

Sphingosine-1-Phosphate Regulates Glioblastoma Cell Invasiveness through the Urokinase Plasminogen Activator System and CCN1/Cyr61

(2009) Nicholas Young et al.   MOLECULAR CANCER RESEARCH

In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses

(2009) Marcin Kortylewski et al.   NATURE BIOTECHNOLOGY

Suppression of Hepatocellular Carcinoma Recurrence After Rat Liver Transplantation by FTY720, a Sphingosine-1-Phosphate Analog

(2009) Yuichiro Ushitora et al.   TRANSPLANTATION

New players on the center stage: Sphingosine 1-phosphate and its receptors as drug targets

(2008) Andrea Huwiler et al.   BIOCHEMICAL PHARMACOLOGY

Involvement of sphingosine-1-phosphate and S1P1 in angiogenesis: Analyses using a new S1P1 antagonist of non-sphingosine-1-phosphate analog

(2008) Kiyoaki Yonesu et al.   BIOCHEMICAL PHARMACOLOGY

Sphingosine-1-Phosphate Induces an Antiinflammatory Phenotype in Macrophages

(2008) Jeniter E. Hughes et al.   CIRCULATION RESEARCH

Common origins of lung cancer and COPD

(2008) A McGarry Houghton et al.   NATURE MEDICINE

FTY720 therapy exerts differential effects on T cell subsets in multiple sclerosis

(2008) M. Mehling et al.   NEUROLOGY

"Inside-Out" Signaling of Sphingosine-1-Phosphate: Therapeutic Targets

(2008) K. Takabe et al.   PHARMACOLOGICAL REVIEWS