Preclinical study of the antitumor effect of sphingosine-1-phosphate receptor 1 antibody (S1PR1-antibody) against human breast cancer cells

Stimulation of S1PR5 with A-971432, a selective agonist, preserves blood–brain barrier integrity and exerts therapeutic effect in an animal model of Huntington’s disease

(2018) Alba Di Pardo et al.   HUMAN MOLECULAR GENETICS

Targeting sphingosine-1-phosphate lyase as an anabolic therapy for bone loss

(2018) Sarah Weske et al.   NATURE MEDICINE

Sphingosine 1-Phosphate Receptor 1 Is Required for MMP-2 Function in Bone Marrow Mesenchymal Stromal Cells: Implications for Cytoskeleton Assembly and Proliferation

(2018) Chiara Sassoli et al.   Stem Cells International

Doxorubicin effect is enhanced by sphingosine-1-phosphate signaling antagonist in breast cancer

(2017) Eriko Katsuta et al.   JOURNAL OF SURGICAL RESEARCH

Beyond Immune Cell Migration: The Emerging Role of the Sphingosine-1-phosphate Receptor S1PR4 as a Modulator of Innate Immune Cell Activation

(2017) Catherine Olesch et al.   MEDIATORS OF INFLAMMATION

Overexpression of sphingosine kinase 1 is predictive of poor prognosis in human breast cancer

(2017) Ya-Jing Zhu et al.   Oncology Letters

S1PR1 mediates anti-apoptotic/pro-proliferative processes in human acute myeloid leukemia cells

(2016) Xiao-Qian Xu et al.   Molecular Medicine Reports

miR-133b, a microRNA targeting S1PR1, suppresses nasopharyngeal carcinoma cell proliferation

(2016) NAN CHENG et al.   Experimental and Therapeutic Medicine

Sphingosine-1-phosphate receptor 1 (S1PR1) expression in non-muscle invasive urothelial carcinoma: Association with poor clinical outcome and potential therapeutic target

(2015) Heounjeong Go et al.   EUROPEAN JOURNAL OF CANCER

Sphingosine kinase 1 as an anticancer therapeutic target

(2015) Ying Gao et al.   Drug Design Development and Therapy

Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: The role of sphingosine 1-phosphate receptor-4

(2014) Jan Ohotski et al.   CELLULAR SIGNALLING

Sphingolipid metabolites in inflammatory disease

(2014) Michael Maceyka et al.   NATURE

Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation

(2014) Naoya Hirata et al.   Nature Communications

Synergistic Effect between Sphingosine-1-Phosphate and Chemotherapy Drugs against Human Brain-metastasized Breast Cancer MDA-MB-361 cells

(2013) Ahlam Sultan et al.   Journal of Cancer

Blocking S1P interaction with S1P1 receptor by a novel competitive S1P1-selective antagonist inhibits angiogenesis

(2012) Yasuyuki Fujii et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Derivation and characterization of matched cell lines from primary and recurrent serous ovarian cancer

(2012) Isabelle J Létourneau et al.   BMC CANCER

Targeting sphingosine kinase-1 to inhibit melanoma

(2012) SubbaRao V. Madhunapantula et al.   Pigment Cell & Melanoma Research

Sphingosine kinase 1 overexpression is regulated by signaling through PI3K, AKT2, and mTOR in imatinib-resistant chronic myeloid leukemia cells

(2011) Gabriella Marfe et al.   EXPERIMENTAL HEMATOLOGY

Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

(2011) Brian D. Lehmann et al.   JOURNAL OF CLINICAL INVESTIGATION

Platinum resistance in breast and ovarian cancer cell lines

(2011) Niels Eckstein   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Sphingosine Kinase 1 Induces Tolerance to Human Epidermal Growth Factor Receptor 2 and Prevents Formation of a Migratory Phenotype in Response to Sphingosine 1-Phosphate in Estrogen Receptor-Positive Breast Cancer Cells

(2010) J. S. Long et al.   MOLECULAR AND CELLULAR BIOLOGY

Sphingosine Kinase 1 Is Associated with Gastric Cancer Progression and Poor Survival of Patients

(2009) W. Li et al.   CLINICAL CANCER RESEARCH

Sphingosine-1-phosphate: a potential therapeutic agent against human breast cancer

(2009) Binbing Ling et al.   INVESTIGATIONAL NEW DRUGS

"Inside-Out" Signaling of Sphingosine-1-Phosphate: Therapeutic Targets

(2008) K. Takabe et al.   PHARMACOLOGICAL REVIEWS