Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2

Head and Neck Cancers

(2017) David G. Pfister et al.   Journal of the National Comprehensive Cancer Network

Revisiting the sphingolipid rheostat: Evolving concepts in cancer therapy

(2015) Jason Newton et al.   EXPERIMENTAL CELL RESEARCH

The antineoplastic properties of FTY720: evidence for the repurposing of fingolimod

(2015) Sathya Narayanan Patmanathan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Gene expression profiling reveals biological pathways responsible for phenotypic heterogeneity between UK and Sri Lankan oral squamous cell carcinomas

(2015) Anas A. Saeed et al.   ORAL ONCOLOGY

Lipidomic “Deep Profiling”: An Enhanced Workflow to Reveal New Molecular Species of Signaling Lipids

(2014) Pradeep Narayanaswamy et al.   ANALYTICAL CHEMISTRY

Senescent cancer-associated fibroblasts secrete active MMP-2 that promotes keratinocyte dis-cohesion and invasion

(2014) Y Hassona et al.   BRITISH JOURNAL OF CANCER

SET-mediated NDRG1 inhibition is involved in acquisition of epithelial-to-mesenchymal transition phenotype and cisplatin resistance in human lung cancer cell

(2014) Hao Liu et al.   CELLULAR SIGNALLING

Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: The role of sphingosine 1-phosphate receptor-4

(2014) Jan Ohotski et al.   CELLULAR SIGNALLING

Sphingosine Kinase 1 and Cancer: A Systematic Review and Meta-Analysis

(2014) Yun Zhang et al.   PLoS One

Deregulation of the phosphatase, PP2A is a common event in breast cancer, predicting sensitivity to FTY720

(2014) Shawn Baldacchino et al.   EPMA Journal

FTY720 induces apoptosis of chronic myelogenous leukemia cells via dual activation of BIM and BID and overcomes various types of resistance to tyrosine kinase inhibitors

(2013) Miki Kiyota et al.   APOPTOSIS

Epidermal growth factor-induced cellular invasion requires sphingosine-1-phosphate/sphingosine-1-phosphate 2 receptor-mediated ezrin activation

(2013) K. Alexa Orr Gandy et al.   FASEB JOURNAL

Sphingosine-1-phosphate receptor 2

(2013) Mohamad Adada et al.   FEBS Journal

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1

(2012) Mark E. Schnute et al.   BIOCHEMICAL JOURNAL

Sphingosine 1-phosphate signalling in cancer

(2012) Nigel J. Pyne et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Targeting the sphingosine kinase/sphingosine 1-phosphate pathway in disease: Review of sphingosine kinase inhibitors

(2012) K. Alexa Orr Gandy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer

(2012) Jie Liang et al.   CANCER CELL

Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis

(2012) Suriyan Ponnusamy et al.   EMBO Molecular Medicine

First Evidence of Sphingosine 1-Phosphate Lyase Protein Expression and Activity Downregulation in Human Neoplasm: Implication for Resistance to Therapeutics in Prostate Cancer

(2012) L. Brizuela et al.   MOLECULAR CANCER THERAPEUTICS

TGFα shedding assay: an accurate and versatile method for detecting GPCR activation

(2012) Asuka Inoue et al.   NATURE METHODS

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Sphingolipid-based drugs selectively kill cancer cells by down-regulating nutrient transporter proteins

(2011) Kimberly Romero Rosales et al.   BIOCHEMICAL JOURNAL

A Role of Sphingosine Kinase 1 in Head and Neck Carcinogenesis

(2011) K. Shirai et al.   Cancer Prevention Research

Sphingosine Kinase-1 Enhances Resistance to Apoptosis through Activation of PI3K/Akt/NF- B Pathway in Human Non-Small Cell Lung Cancer

(2011) L. Song et al.   CLINICAL CANCER RESEARCH

Clinical immunology of the sphingosine 1-phosphate receptor modulator fingolimod (FTY720) in multiple sclerosis

(2011) M. Mehling et al.   NEUROLOGY

Sphingosine-1-phosphate signaling and its role in disease

(2011) Michael Maceyka et al.   TRENDS IN CELL BIOLOGY

The Expression of Sphingosine Kinase-1 in Head and Neck Carcinoma

(2010) María M. Facchinetti et al.   CELLS TISSUES ORGANS

FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells

(2010) Francesca Tonelli et al.   CELLULAR SIGNALLING

Increased radiation sensitivity of head and neck squamous cell carcinoma with sphingosine kinase 1 inhibition

(2010) Uttam K. Sinha et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Restoring Endocrine Response in Breast Cancer Cells by Inhibition of the Sphingosine Kinase-1 Signaling Pathway

(2009) Olga Sukocheva et al.   ENDOCRINOLOGY

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

(2009) N. C. Hait et al.   SCIENCE

Effects of Phosphorylation of Immunomodulatory Agent FTY720 (Fingolimod) on Antiproliferative Activity against Breast and Colon Cancer Cells

(2008) Yasuo Nagaoka et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Molecular profiling of LGL leukemia reveals role of sphingolipid signaling in survival of cytotoxic lymphocytes

(2008) M. V. Shah et al.   BLOOD

Filamin A Links Sphingosine Kinase 1 and Sphingosine-1-Phosphate Receptor 1 at Lamellipodia To Orchestrate Cell Migration

(2008) M. Maceyka et al.   MOLECULAR AND CELLULAR BIOLOGY

Chemosensitizing effects of sphingosine kinase-1 inhibition in prostate cancer cell and animal models

(2008) D. Pchejetski et al.   MOLECULAR CANCER THERAPEUTICS

Global epidemiology of oral and oropharyngeal cancer

(2008) Saman Warnakulasuriya   ORAL ONCOLOGY