Sphingosine 1-Phosphate Receptor 1 Signaling in Mammalian Cells

Genome-wide in vivo screen identifies novel host regulators of metastatic colonization

(2017) Louise van der Weyden et al.   NATURE

Sphingosine 1-phosphate signaling contributes to cardiac inflammation, dysfunction, and remodeling following myocardial infarction

(2016) Fuyang Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Ozanimod (RPC1063) is a potent sphingosine-1-phosphate receptor-1 (S1P1) and receptor-5 (S1P5) agonist with autoimmune disease-modifying activity

(2016) F L Scott et al.   BRITISH JOURNAL OF PHARMACOLOGY

GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling

(2016) Alex R.B. Thomsen et al.   CELL

Sphingosine 1-phosphate receptor-1 in cardiomyocytes is required for normal cardiac development

(2016) Hilary Clay et al.   DEVELOPMENTAL BIOLOGY

Safety and efficacy of amiselimod in relapsing multiple sclerosis (MOMENTUM): a randomised, double-blind, placebo-controlled phase 2 trial

(2016) Ludwig Kappos et al.   LANCET NEUROLOGY

Ozanimod Induction and Maintenance Treatment for Ulcerative Colitis

(2016) William J. Sandborn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sphingosine-1-phosphate induced epithelial-mesenchymal transition of hepatocellular carcinoma via an MMP-7/ syndecan-1/TGF-β autocrine loop

(2016) Ye Zeng et al.   Oncotarget

Essential role for SphK1/S1P signaling to regulate hypoxia-inducible factor 2α expression and activity in cancer

(2016) P Bouquerel et al.   Oncogenesis

Enhanced Chemokine Receptor Recycling and Impaired S1P1 Expression Promote Leukemic Cell Infiltration of Lymph Nodes in Chronic Lymphocytic Leukemia

(2015) L. Patrussi et al.   CANCER RESEARCH

Spinster 2, a sphingosine-1-phosphate transporter, plays a critical role in inflammatory and autoimmune diseases

(2015) Michael S. Donoviel et al.   FASEB JOURNAL

Intracellular sphingosine kinase 2–derived sphingosine-1-phosphate mediates epidermal growth factor–induced ezrin-radixin-moesin phosphorylation and cancer cell invasion

(2015) Mohamad M. Adada et al.   FASEB JOURNAL

S1P1deletion in oligodendroglial lineage cells: Effect on differentiation and myelination

(2015) Danuta E. Dukala et al.   GLIA

S1PR1 Tyr143 phosphorylation downregulates endothelial cell surface S1PR1 expression and responsiveness

(2015) A. Chavez et al.   JOURNAL OF CELL SCIENCE

IL-17–Producing Vγ4+γδ T Cells Require Sphingosine 1-Phosphate Receptor 1 for Their Egress from the Lymph Nodes under Homeostatic and Inflammatory Conditions

(2015) Yasuhiro Maeda et al.   JOURNAL OF IMMUNOLOGY

HDL-bound sphingosine-1-phosphate restrains lymphopoiesis and neuroinflammation

(2015) Victoria A. Blaho et al.   NATURE

A map of the distribution of sphingosine 1-phosphate in the spleen

(2015) Willy D Ramos-Perez et al.   NATURE IMMUNOLOGY

HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1to limit vascular inflammation

(2015) Sylvain Galvani et al.   Science Signaling

Sphingosine-1-phosphate receptor 1 transmits estrogens’ effects in endothelial cells

(2015) Olga Sukocheva et al.   STEROIDS

Endocytosis of Ligand-Activated Sphingosine 1-Phosphate Receptor 1 Mediated by the Clathrin-Pathway

(2015) Patrick M. Reeves et al.   TRAFFIC

HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1to limit vascular inflammation

(2015) Sylvain Galvani et al.   Science Signaling

Lysophospholipid receptor nomenclature review: IUPHAR Review 8

(2014) Yasuyuki Kihara et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sphingosine kinase 1 mediates head & neck squamous cell carcinoma invasion through sphingosine 1-phosphate receptor 1

(2014) Paulette M Tamashiro et al.   Cancer Cell International

Angiogenesis and Cardiac Hypertrophy

(2014) Toru Oka et al.   CIRCULATION RESEARCH

Sphingosine-1-phosphate receptor 1 reporter mice reveal receptor activation sites in vivo

(2014) Mari Kono et al.   JOURNAL OF CLINICAL INVESTIGATION

Dynamin 2–dependent endocytosis is required for sustained S1PR1 signaling

(2014) Tim Willinger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Individual variation of human S1P1coding sequence leads to heterogeneity in receptor function and drug interactions

(2014) Hideru Obinata et al.   JOURNAL OF LIPID RESEARCH

Oral ponesimod in relapsing-remitting multiple sclerosis: a randomised phase II trial

(2014) T. Olsson et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Oral ponesimod in patients with chronic plaque psoriasis: a randomised, double-blind, placebo-controlled phase 2 trial

(2014) Andrea Vaclavkova et al.   LANCET

Visualization of arrestin recruitment by a G-protein-coupled receptor

(2014) Arun K. Shukla et al.   NATURE

Molecular and physiological functions of sphingosine 1-phosphate transporters

(2013) Tsuyoshi Nishi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Second generation S1P pathway modulators: Research strategies and clinical developments

(2013) Marc Bigaud et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Sphingosine 1-Phosphate Is a Missing Link between Chronic Inflammation and Colon Cancer

(2013) Nigel J. Pyne et al.   CANCER CELL

Noncanonical Control of Vasopressin Receptor Type 2 Signaling by Retromer and Arrestin

(2013) Timothy N. Feinstein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fingolimod phosphate promotes the neuroprotective effects of microglia

(2013) Hiromi Noda et al.   JOURNAL OF NEUROIMMUNOLOGY

Conformational biosensors reveal GPCR signalling from endosomes

(2013) Roshanak Irannejad et al.   NATURE

Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation

(2013) Christopher S Garris et al.   NATURE IMMUNOLOGY

Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond

(2013) Gregory T. Kunkel et al.   NATURE REVIEWS DRUG DISCOVERY

Sphingosine-1-phosphate-induced Flk-1 transactivation stimulates mouse embryonic stem cell proliferation through S1P1/S1P3-dependent β-arrestin/c-Src pathways

(2013) Jung Min Ryu et al.   Stem Cell Research

Regulation of cell survival by sphingosine-1-phosphate receptor S1P1 via reciprocal ERK-dependent suppression of Bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1

(2013) C Rutherford et al.   Cell Death & Disease

Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer

(2012) Jie Liang et al.   CANCER CELL

S1P1 inhibits sprouting angiogenesis during vascular development

(2012) A. B. Shoham et al.   DEVELOPMENT

The Sphingosine-1-Phosphate Receptor S1PR1 Restricts Sprouting Angiogenesis by Regulating the Interplay between VE-Cadherin and VEGFR2

(2012) Konstantin Gaengel et al.   DEVELOPMENTAL CELL

Sphingosine 1-Phosphate (S1P) Carrier-dependent Regulation of Endothelial Barrier

(2012) Brent A. Wilkerson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Sphingosine-1-Phosphate Receptor 1-Directed Agonist Reduces Central Nervous System Inflammation in a Plasmacytoid Dendritic Cell-Dependent Manner

(2012) G. Galicia-Rosas et al.   JOURNAL OF IMMUNOLOGY

Mouse SPNS2 Functions as a Sphingosine-1-Phosphate Transporter in Vascular Endothelial Cells

(2012) Yu Hisano et al.   PLoS One

Crystal Structure of a Lipid G Protein-Coupled Receptor

(2012) M. A. Hanson et al.   SCIENCE

Photolysis of caged sphingosine-1-phosphate induces barrier enhancement and intracellular activation of lung endothelial cell signaling pathways

(2011) Peter V. Usatyuk et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Therapeutic Effects of Novel Sphingosine-1-Phosphate Receptor Agonist W-061 in Murine DSS Colitis

(2011) Yasuaki Sanada et al.   PLoS One

Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M

(2011) C. Christoffersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translational aspects of sphingosine 1-phosphate biology

(2011) Susan Pyne et al.   TRENDS IN MOLECULAR MEDICINE

β-arrestin-mediated receptor trafficking and signal transduction

(2011) Sudha K. Shenoy et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Receptor tyrosine kinase–G-protein-coupled receptor signalling platforms: out of the shadow?

(2011) Nigel J. Pyne et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

High Expression of Sphingosine 1-Phosphate Receptors, S1P1 and S1P3, Sphingosine Kinase 1, and Extracellular Signal-Regulated Kinase-1/2 Is Associated with Development of Tamoxifen Resistance in Estrogen Receptor-Positive Breast Cancer Patients

(2010) Carol Watson et al.   AMERICAN JOURNAL OF PATHOLOGY

Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration

(2010) Roger A. Sabbadini   BRITISH JOURNAL OF PHARMACOLOGY

S1P1 receptor directs the release of immature B cells from bone marrow into blood

(2010) Maria L. Allende et al.   JOURNAL OF EXPERIMENTAL MEDICINE

STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors

(2010) Heehyoung Lee et al.   NATURE MEDICINE

Th17 central memory T cells are reduced by FTY720 in patients with multiple sclerosis

(2010) M. Mehling et al.   NEUROLOGY

HDL and sphingosine-1-phosphate activate stat3 in prostate cancer DU145 cells via ERK1/2 and S1P receptors, and promote cell migration and invasion

(2010) Yoshitaka Sekine et al.   PROSTATE

Characterization of the ATP-dependent Sphingosine 1-Phosphate Transporter in Rat Erythrocytes

(2009) Naoki Kobayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sustained cyclic AMP production by parathyroid hormone receptor endocytosis

(2009) Sébastien Ferrandon et al.   Nature Chemical Biology

Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors

(2009) Florian Mullershausen et al.   Nature Chemical Biology

The receptor S1P1 overrides regulatory T cell–mediated immune suppression through Akt-mTOR

(2009) Guangwei Liu et al.   NATURE IMMUNOLOGY

Persistent cAMP-Signals Triggered by Internalized G-Protein–Coupled Receptors

(2009) Davide Calebiro et al.   PLOS BIOLOGY

Anti-sphingosine-1-phosphate monoclonal antibodies inhibit angiogenesis and sub-retinal fibrosis in a murine model of laser-induced choroidal neovascularization

(2008) Sergio Caballero et al.   EXPERIMENTAL EYE RESEARCH

Protein Kinase C-ϵ Regulates Sphingosine 1-Phosphate-mediated Migration of Human Lung Endothelial Cells through Activation of Phospholipase D2, Protein Kinase C-ζ, and Rac1

(2008) Irina Gorshkova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Filamin A Links Sphingosine Kinase 1 and Sphingosine-1-Phosphate Receptor 1 at Lamellipodia To Orchestrate Cell Migration

(2008) M. Maceyka et al.   MOLECULAR AND CELLULAR BIOLOGY