Insights into Red Sea Brine Pool Specialized Metabolism Gene Clusters Encoding Potential Metabolites for Biotechnological Applications and Extremophile Survival

Antibacterial and anticancer activities of orphan biosynthetic gene clusters from Atlantis II Red Sea brine pool

(2019) Laila Ziko et al.   Microbial Cell Factories

In silico exploration of Red Sea Bacillus genomes for natural product biosynthetic gene clusters

(2018) Ghofran Othoum et al.   BMC GENOMICS

Novel soil bacteria possess diverse genes for secondary metabolite biosynthesis

(2018) Alexander Crits-Christoph et al.   NATURE

The antibiotic resistance crisis, with a focus on the United States

(2017) Evan Martens et al.   JOURNAL OF ANTIBIOTICS

The Antibiotic Resistant Target Seeker (ARTS), an exploration engine for antibiotic cluster prioritization and novel drug target discovery

(2017) Mohammad Alanjary et al.   NUCLEIC ACIDS RESEARCH

antiSMASH 4.0—improvements in chemistry prediction and gene cluster boundary identification

(2017) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

Identification of Secondary Metabolite Gene Clusters in the Pseudovibrio Genus Reveals Encouraging Biosynthetic Potential toward the Production of Novel Bioactive Compounds

(2017) Lynn M. Naughton et al.   Frontiers in Microbiology

Red Sea Atlantis II brine pool nitrilase with unique thermostability profile and heavy metal tolerance

(2016) Sarah A. Sonbol et al.   BMC BIOTECHNOLOGY

Bacterial genome engineering and synthetic biology: combating pathogens

(2016) Malathy Krishnamurthy et al.   BMC MICROBIOLOGY

Aryl Polyenes, a Highly Abundant Class of Bacterial Natural Products, Are Functionally Related to Antioxidative Carotenoids

(2016) Tim A. Schöner et al.   CHEMBIOCHEM

Insertion sequences enrichment in extreme Red sea brine pool vent

(2016) Ali H. A. Elbehery et al.   EXTREMOPHILES

Potential applications of stress solutes from extremophiles in protein folding diseases and healthcare

(2016) Carla D. Jorge et al.   EXTREMOPHILES

Gifted microbes for genome mining and natural product discovery

(2016) Richard H. Baltz   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Bioprospecting Red Sea Coastal Ecosystems for Culturable Microorganisms and Their Antimicrobial Potential

(2016) Soha Al-Amoudi et al.   Marine Drugs

Exploiting the Biosynthetic Potential of Type III Polyketide Synthases

(2016) Yan Lim et al.   MOLECULES

The evolution of genome mining in microbes – a review

(2016) Nadine Ziemert et al.   NATURAL PRODUCT REPORTS

Antibacterial drug discovery in the resistance era

(2016) Eric D. Brown et al.   NATURE

Novel thermostable antibiotic resistance enzymes from the Atlantis II Deep Red Sea brine pool

(2016) Ali H. A. Elbehery et al.   Microbial Biotechnology

Investigation of Proposed Ladderane Biosynthetic Genes from Anammox Bacteria by Heterologous Expression in E. coli

(2016) Pouya Javidpour et al.   PLoS One

Viruses-to-mobile genetic elements skew in the deep Atlantis II brine pool sediments

(2016) Mustafa Adel et al.   Scientific Reports

Functional interactions among filamentousEpsilonproteobacteriaandBacteroidetesin a deep-sea hydrothermal vent biofilm

(2015) Runar Stokke et al.   ENVIRONMENTAL MICROBIOLOGY

Computational approaches to natural product discovery

(2015) Marnix H Medema et al.   Nature Chemical Biology

antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters

(2015) Tilmann Weber et al.   NUCLEIC ACIDS RESEARCH

A RESTful API for Accessing Microbial Community Data for MG-RAST

(2015) Andreas Wilke et al.   PLoS Computational Biology

Targeted metagenomics as a tool to tap into marine natural product diversity for the discovery and production of drug candidates

(2015) Marla Trindade et al.   Frontiers in Microbiology

Bacteriocins as Potential Anticancer Agents

(2015) Sumanpreet Kaur et al.   Frontiers in Pharmacology

Insights into Secondary Metabolism from a Global Analysis of Prokaryotic Biosynthetic Gene Clusters

(2014) Peter Cimermancic et al.   CELL

A Systematic Analysis of Biosynthetic Gene Clusters in the Human Microbiome Reveals a Common Family of Antibiotics

(2014) Mohamed S. Donia et al.   CELL

Mining the Metabiome: Identifying Novel Natural Products from Microbial Communities

(2014) Aleksandr Milshteyn et al.   CHEMISTRY & BIOLOGY

Interactions between anaerobic ammonium and sulfur-oxidizing bacteria in a laboratory scale model system

(2014) Lina Russ et al.   ENVIRONMENTAL MICROBIOLOGY

Marine actinobacteria: An important source of bioactive natural products

(2014) Panchanathan Manivasagan et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Tamlana sedimentorum sp. nov., isolated from shallow sand sediments of the Sea of Japan

(2014) L. A. Romanenko et al.   INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY

Mizugakiibacter sediminis gen. nov., sp. nov., isolated from a freshwater lake

(2014) H. Kojima et al.   INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY

Core Microbial Functional Activities in Ocean Environments Revealed by Global Metagenomic Profiling Analyses

(2014) Ari J. S. Ferreira et al.   PLoS One

Aerobic methanotrophic communities at the Red Sea brine-seawater interface

(2014) Rehab Z. Abdallah et al.   Frontiers in Microbiology

Polyunsaturated fatty acid production by marine bacteria

(2013) Ahmed Abd Elrazak et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Meta-omic characterization of prokaryotic gene clusters for natural product biosynthesis

(2013) Michael M Schofield et al.   CURRENT OPINION IN BIOTECHNOLOGY

Metabolic flexibility of enigmatic SAR324 revealed through metagenomics and metatranscriptomics

(2013) Cody S. Sheik et al.   ENVIRONMENTAL MICROBIOLOGY

Bioinformatics tools for genome mining of polyketide and non-ribosomal peptides

(2013) Christopher N. Boddy   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Functional Metagenomic Investigations of Microbial Communities in a Shallow-Sea Hydrothermal System

(2013) Kai Tang et al.   PLoS One

Isolation and characterization of a heavy metal-resistant, thermophilic esterase from a Red Sea Brine Pool

(2013) Yasmine M. Mohamed et al.   Scientific Reports

Diverse antimicrobial interactions of halophilic archaea and bacteria extend over geographical distances and cross the domain barrier

(2013) Nina S. Atanasova et al.   MicrobiologyOpen

Microbial community structure across fluid gradients in the Juan de Fuca Ridge hydrothermal system

(2012) Rika E. Anderson et al.   FEMS MICROBIOLOGY ECOLOGY

The metatranscriptome of a deep-sea hydrothermal plume is dominated by water column methanotrophs and lithotrophs

(2012) Ryan A Lesniewski et al.   ISME Journal

Genome-enabled transcriptomics reveals archaeal populations that drive nitrification in a deep-sea hydrothermal plume

(2012) Brett J Baker et al.   ISME Journal

Type III polyketide synthases in natural product biosynthesis

(2012) Dayu Yu et al.   IUBMB LIFE

Anaerobic Ammonium-Oxidizing Bacteria: Unique Microorganisms with Exceptional Properties

(2012) L. van Niftrik et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Unique Prokaryotic Consortia in Geochemically Distinct Sediments from Red Sea Atlantis II and Discovery Deep Brine Pools

(2012) Rania Siam et al.   PLoS One

Quality control and preprocessing of metagenomic datasets

(2011) R. Schmieder et al.   BIOINFORMATICS

Microbiology of the Red Sea (and other) deep-sea anoxic brine lakes

(2011) André Antunes et al.   Environmental Microbiology Reports

Halophiles 2010: Life in Saline Environments

(2010) Y. Ma et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Artificial and natural duplicates in pyrosequencing reads of metagenomic data

(2010) Beifang Niu et al.   BMC BIOINFORMATICS

The Discovery of Salinosporamide K from the Marine Bacterium “Salinispora pacifica” by Genome Mining Gives Insight into Pathway Evolution

(2010) Alessandra S. Eustáquio et al.   CHEMBIOCHEM

Deep-Sea Hydrothermal Vents: Potential Hot Spots for Natural Products Discovery?⊥

(2010) Christopher C. Thornburg et al.   JOURNAL OF NATURAL PRODUCTS

Natural Products Version 2.0: Connecting Genes to Molecules

(2010) Christopher T. Walsh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Culturability and Secondary Metabolite Diversity of Extreme Microbes: Expanding Contribution of Deep Sea and Deep-Sea Vent Microbes to Natural Product Discovery

(2010) Robin K. Pettit   MARINE BIOTECHNOLOGY

Production of Metabolites as Bacterial Responses to the Marine Environment

(2010) Carla C. C. R. De Carvalho et al.   Marine Drugs

Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteria

(2010) B. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nitrosopumilus maritimus genome reveals unique mechanisms for nitrification and autotrophy in globally distributed marine crenarchaea

(2010) C. B. Walker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biosynthesis of Phosphonic and Phosphinic Acid Natural Products

(2009) William W. Metcalf et al.   Annual Review of Biochemistry

Role and Regulation of Fatty Acid Biosynthesis in the Response of Shewanella piezotolerans WP3 to Different Temperatures and Pressures

(2009) F. Wang et al.   JOURNAL OF BACTERIOLOGY

The metagenomics RAST server – a public resource for the automatic phylogenetic and functional analysis of metagenomes

(2008) F Meyer et al.   BMC BIOINFORMATICS

Nonribosomal Peptide Synthetases Involved in the Production of Medically Relevant Natural Products

(2008) Elizabeth A. Felnagle et al.   MOLECULAR PHARMACEUTICS

New alkaloids and diterpenes from a deep ocean sediment derived fungus Penicillium sp.

(2008) Lin Du et al.   TETRAHEDRON