Top or Middle? Up or Down? Toward a Standard Lexicon for Protein Top-Down and Allied Mass Spectrometry Approaches

Top-Down Deep Sequencing of Ubiquitin Using Two-Dimensional Mass Spectrometry

(2018) Federico Floris et al.   ANALYTICAL CHEMISTRY

Collision induced unfolding of isolated proteins in the gas phase: past, present, and future

(2018) Sugyan M Dixit et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Chemical-Mediated Digestion: An Alternative Realm for Middle-down Proteomics?

(2018) Kristina Srzentić et al.   JOURNAL OF PROTEOME RESEARCH

ProForma: A Standard Proteoform Notation

(2018) Richard D. LeDuc et al.   JOURNAL OF PROTEOME RESEARCH

Detection of Amyloid Beta (Aβ) Oligomeric Composition Using Matrix-Assisted Laser Desorption Ionization Mass Spectrometry (MALDI MS)

(2018) Jasmine S.-H. Wang et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Surface Induced Dissociation Coupled with High Resolution Mass Spectrometry Unveils Heterogeneity of a 211 kDa Multicopper Oxidase Protein Complex

(2018) Mowei Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Native Top-Down Mass Spectrometry and Ion Mobility MS for Characterizing the Cobalt and Manganese Metal Binding of α-Synuclein Protein

(2018) Piriya Wongkongkathep et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Application of Tandem Two-Dimensional Mass Spectrometry for Top-Down Deep Sequencing of Calmodulin

(2018) Federico Floris et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Radical solutions: Principles and application of electron-based dissociation in mass spectrometry-based analysis of protein structure

(2018) Frederik Lermyte et al.   MASS SPECTROMETRY REVIEWS

An integrated native mass spectrometry and top-down proteomics method that connects sequence to structure and function of macromolecular complexes

(2018) Huilin Li et al.   Nature Chemistry

Multiplexed Middle-Down Mass Spectrometry Reveals Light and Heavy Chain Connectivity in a Monoclonal Antibody

(2018) Kristina Srzentic et al.   ANALYTICAL CHEMISTRY

Native Top-Down Mass Spectrometry and Ion Mobility Spectrometry of the Interaction of Tau Protein with a Molecular Tweezer Assembly Modulator

(2018) Michael Nshanian et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Liquid Native MALDI Mass Spectrometry for the Detection of Protein-Protein Complexes

(2018) Martine Beaufour et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Surface-Induced Dissociation: An Effective Method for Characterization of Protein Quaternary Structure

(2018) Alyssa Q. Stiving et al.   ANALYTICAL CHEMISTRY

Structural Analysis of Monoclonal Antibodies by Ultrahigh Resolution MALDI In-Source Decay FT-ICR Mass Spectrometry

(2018) Yuri E.M. van der Burgt et al.   ANALYTICAL CHEMISTRY

Sequencing Larger Intact Proteins (30-70 kDa) with Activated Ion Electron Transfer Dissociation

(2017) Nicholas M. Riley et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

GingisKHAN™ protease cleavage allows a high-throughput antibody to Fab conversion enabling direct functional assessment during lead identification of human monoclonal and bispecific IgG1 antibodies

(2017) Jörg Moelleken et al.   mAbs

High-fidelity mass analysis unveils heterogeneity in intact ribosomal particles

(2017) Michiel van de Waterbeemd et al.   NATURE METHODS

InSourcerer: a high-throughput method to search for unknown metabolite modifications by mass spectrometry

(2017) Aida Mrzic et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Gas-phase microsolvation of ubiquitin: investigation of crown ether complexation sites using ion mobility-mass spectrometry

(2016) Melanie Göth et al.   ANALYST

Autopiquer - a Robust and Reliable Peak Detection Algorithm for Mass Spectrometry

(2016) David P. A. Kilgour et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Native MS and ECD Characterization of a Fab–Antigen Complex May Facilitate Crystallization for X-ray Diffraction

(2016) Ying Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Salt Bridge Rearrangement (SaBRe) Explains the Dissociation Behavior of Noncovalent Complexes

(2016) Rachel R. Ogorzalek Loo et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Native Mass Spectrometry: What is in the Name?

(2016) Aneika C. Leney et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Mapping Proteoforms and Protein Complexes From King Cobra Venom Using Both Denaturing and Native Top-down Proteomics

(2016) Rafael D. Melani et al.   MOLECULAR & CELLULAR PROTEOMICS

Top-Down MALDI-In-Source Decay-FTICR Mass Spectrometry of Isotopically Resolved Proteins

(2015) Simone Nicolardi et al.   ANALYTICAL CHEMISTRY

Structural Characterization of Dihydrofolate Reductase Complexes by Top-Down Ultraviolet Photodissociation Mass Spectrometry

(2015) Michael B. Cammarata et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Extensive Charge Reduction and Dissociation of Intact Protein Complexes Following Electron Transfer on a Quadrupole-Ion Mobility-Time-of-Flight MS

(2015) Frederik Lermyte et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Electron-capture dissociation and ion mobility mass spectrometry for characterization of the hemoglobin protein assembly

(2015) Weidong Cui et al.   PROTEIN SCIENCE

Does deamidation cause protein unfolding? A top-down tandem mass spectrometry study

(2015) Andrew J. Soulby et al.   PROTEIN SCIENCE

Analyzing the higher order structure of proteins with conformer-selective ultraviolet photodissociation

(2015) Stephan Warnke et al.   PROTEOMICS

Electron transfer dissociation provides higher-order structural information of native and partially unfolded protein complexes

(2015) Frederik Lermyte et al.   PROTEOMICS

Structural characterization of holo- and apo-myoglobin in the gas phase by ultraviolet photodissociation mass spectrometry

(2015) Michael B. Cammarata et al.   Chemical Science

Refining the Structural Model of a Heterohexameric Protein Complex: Surface Induced Dissociation and Ion Mobility Provide Key Connectivity and Topology Information

(2015) Yang Song et al.   ACS Central Science

Surface Induced Dissociation: Dissecting Noncovalent Protein Complexes in the Gas phase

(2014) Mowei Zhou et al.   ACCOUNTS OF CHEMICAL RESEARCH

Middle-Down Analysis of Monoclonal Antibodies with Electron Transfer Dissociation Orbitrap Fourier Transform Mass Spectrometry

(2014) Luca Fornelli et al.   ANALYTICAL CHEMISTRY

Photodissociation mass spectrometry: new tools for characterization of biological molecules

(2014) Jennifer S. Brodbelt   CHEMICAL SOCIETY REVIEWS

Extended bottom-up proteomics with secreted aspartic protease Sap9

(2014) Ünige A. Laskay et al.   Journal of Proteomics

ETD Allows for Native Surface Mapping of a 150 kDa Noncovalent Complex on a Commercial Q-TWIMS-TOF Instrument

(2014) Frederik Lermyte et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

The first pilot project of the consortium for top-down proteomics: A status report

(2014) Xibei Dang et al.   PROTEOMICS

Native Top-Down Electrospray Ionization-Mass Spectrometry of 158 kDa Protein Complex by High-Resolution Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

(2013) Huilin Li et al.   ANALYTICAL CHEMISTRY

From Protein Complexes to Subunit Backbone Fragments: A Multi-stage Approach to Native Mass Spectrometry

(2013) Mikhail E. Belov et al.   ANALYTICAL CHEMISTRY

Proteins with Highly Similar Native Folds Can Show Vastly Dissimilar Folding Behavior When Desolvated

(2013) Moritz Schennach et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Proteome Digestion Specificity Analysis for Rational Design of Extended Bottom-up and Middle-down Proteomics Experiments

(2013) Ünige A. Laskay et al.   JOURNAL OF PROTEOME RESEARCH

Proteoform: a single term describing protein complexity

(2013) Lloyd M Smith et al.   NATURE METHODS

Native ion mobility-mass spectrometry and related methods in structural biology

(2012) A. Konijnenberg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Fragmentation methods on the balance: unambiguous top–down mass spectrometric characterization of oxaliplatin–ubiquitin binding sites

(2011) Samuel M. Meier et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Fast analysis of recombinant monoclonal antibodies using IdeS proteolytic digestion and electrospray mass spectrometry

(2011) Guillaume Chevreux et al.   ANALYTICAL BIOCHEMISTRY

Native Electrospray and Electron-Capture Dissociation FTICR Mass Spectrometry for Top-Down Studies of Protein Assemblies

(2011) Hao Zhang et al.   ANALYTICAL CHEMISTRY

Mapping a Noncovalent Protein–Peptide Interface by Top-Down FTICR Mass Spectrometry Using Electron Capture Dissociation

(2011) David J. Clarke et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Metastable Atom-Activated Dissociation Mass Spectrometry of Phosphorylated and Sulfonated Peptides in Negative Ion Mode

(2011) Shannon L. Cook et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Alternate Dissociation Pathways Identified in Charge-Reduced Protein Complex Ions

(2010) Kevin Pagel et al.   ANALYTICAL CHEMISTRY

Elucidating the Tertiary Structure of Protein Ionsin Vacuowith Site Specific Photoinitiated Radical Reactions

(2010) Tony Ly et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Native Electrospray and Electron-Capture Dissociation in FTICR Mass Spectrometry Provide Top-Down Sequencing of a Protein Component in an Intact Protein Assembly

(2010) Hao Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Infrared Photoactivation Reduces Peptide Folding and Hydrogen-Atom Migration following ETD Tandem Mass Spectrometry

(2009) Aaron R. Ledvina et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tandem Mass Spectrometry with Ultrahigh Mass Accuracy Clarifies Peptide Identification by Database Retrieval

(2008) Michael T. Boyne et al.   JOURNAL OF PROTEOME RESEARCH

The use of ECD/ETD to identify the site of electrostatic interaction in noncovalent complexes

(2008) Shelley N. Jackson et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Mass spectrometry for structural characterization of therapeutic antibodies

(2008) Zhongqi Zhang et al.   MASS SPECTROMETRY REVIEWS

Characterization of Platinum Anticancer Drug Protein-Binding Sites Using a Top-Down Mass Spectrometric Approach

(2007) Christian G. Hartinger et al.   INORGANIC CHEMISTRY

Photodissociation of non-covalent peptide-crown ether complexes

(2007) Jeffrey J. Wilson et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY