Mapping Proteoforms and Protein Complexes From King Cobra Venom Using Both Denaturing and Native Top-down Proteomics

An informatic framework for decoding protein complexes by top-down mass spectrometry

(2016) Owen S Skinner et al.   NATURE METHODS

Native GELFrEE: A New Separation Technique for Biomolecular Assemblies

(2015) Owen S. Skinner et al.   ANALYTICAL CHEMISTRY

Venom Proteomics of Indonesian King Cobra, Ophiophagus hannah: Integrating Top-Down and Bottom-Up Approaches

(2015) Daniel Petras et al.   JOURNAL OF PROTEOME RESEARCH

A mass-tolerant database search identifies a large proportion of unassigned spectra in shotgun proteomics as modified peptides

(2015) Joel M Chick et al.   NATURE BIOTECHNOLOGY

Applying Label-Free Quantitation to Top Down Proteomics

(2014) Ioanna Ntai et al.   ANALYTICAL CHEMISTRY

Restriction and Recruitment—Gene Duplication and the Origin and Evolution of Snake Venom Toxins

(2014) Adam D. Hargreaves et al.   Genome Biology and Evolution

Unraveling the Processing and Activation of Snake Venom Metalloproteinases

(2014) José A. Portes-Junior et al.   JOURNAL OF PROTEOME RESEARCH

The C-Score: A Bayesian Framework to Sharply Improve Proteoform Scoring in High-Throughput Top Down Proteomics

(2014) Richard D. LeDuc et al.   JOURNAL OF PROTEOME RESEARCH

From Protein Complexes to Subunit Backbone Fragments: A Multi-stage Approach to Native Mass Spectrometry

(2013) Mikhail E. Belov et al.   ANALYTICAL CHEMISTRY

Functional proteomic approach to discover geographic variations of king cobra venoms from Southeast Asia and China

(2013) Hui-Ching Chang et al.   Journal of Proteomics

Large-scale Top-down Proteomics of the Human Proteome: Membrane Proteins, Mitochondria, and Senescence

(2013) Adam D. Catherman et al.   MOLECULAR & CELLULAR PROTEOMICS

Proteoform: a single term describing protein complexity

(2013) Lloyd M Smith et al.   NATURE METHODS

The king cobra genome reveals dynamic gene evolution and adaptation in the snake venom system

(2013) F. J. Vonk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Snake venomics: From the inventory of toxins to biology

(2013) Juan J. Calvete   TOXICON

Isolation, enzymatic characterization and antiedematogenic activity of the first reported rattlesnake hyaluronidase from Crotalus durissus terrificus venom

(2012) Karla C.F. Bordon et al.   BIOCHIMIE

Peptidomics of Three Bothrops Snake Venoms: Insights Into the Molecular Diversification of Proteomes and Peptidomes

(2012) Alexandre K. Tashima et al.   MOLECULAR & CELLULAR PROTEOMICS

Spinning up mass spectrometry for whole protein complexes

(2012) Philip D Compton et al.   NATURE METHODS

High-sensitivity Orbitrap mass analysis of intact macromolecular assemblies

(2012) Rebecca J Rose et al.   NATURE METHODS

Search engine processor: Filtering and organizing peptide spectrum matches

(2012) Paulo C. Carvalho et al.   PROTEOMICS

Molecular cloning and characterization of a complement-depleting factor from king cobra, Ophiophagus hannah

(2012) Lin Zeng et al.   TOXICON

Non-enzymatic proteins from snake venoms: A gold mine of pharmacological tools and drug leads

(2012) Ryan J.R. McCleary et al.   TOXICON

On the Scalability and Requirements of Whole Protein Mass Spectrometry

(2011) Philip D. Compton et al.   ANALYTICAL CHEMISTRY

Crystal Structure of Crotoxin Reveals Key Residues Involved in the Stability and Toxicity of This Potent Heterodimeric β-Neurotoxin

(2011) Grazyna Faure et al.   JOURNAL OF MOLECULAR BIOLOGY

Mapping intact protein isoforms in discovery mode using top-down proteomics

(2011) John C. Tran et al.   NATURE

Cloning and sequence analysis of an Ophiophagus hannah cDNA encoding a precursor of two natriuretic pepide domains

(2011) Weiwei Lei et al.   TOXICON

Venomics: a new paradigm for natural products-based drug discovery

(2010) Irina Vetter et al.   AMINO ACIDS

mMass3: A Cross-Platform Software Environment for Precise Analysis of Mass Spectrometric Data

(2010) Martin Strohalm et al.   ANALYTICAL CHEMISTRY

Structural and Functional Characterization of a Novel Homodimeric Three-finger Neurotoxin from the Venom ofOphiophagus hannah(King Cobra)

(2010) Amrita Roy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Simplified capillary electrophoresis nanospray sheath-flow interface for high efficiency and sensitive peptide analysis

(2010) Roza Wojcik et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

ESIprot: a universal tool for charge state determination and molecular weight calculation of proteins from electrospray ionization mass spectrometry data

(2010) Robert Winkler   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Protein complexes in snake venom

(2009) R. Doley et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Venomics as a drug discovery platform

(2009) Pierre Escoubas et al.   Expert Review of Proteomics

Structures of two elapid snake venom metalloproteases with distinct activities highlight the disulfide patterns in the D domain of ADAMalysin family proteins

(2009) Hong-Hsiang Guan et al.   JOURNAL OF STRUCTURAL BIOLOGY

Gel-Eluted Liquid Fraction Entrapment Electrophoresis:  An Electrophoretic Method for Broad Molecular Weight Range Proteome Separation

(2008) John C. Tran et al.   ANALYTICAL CHEMISTRY

Proteome analysis of snake venom toxins: pharmacological insights

(2008) Dessislava Georgieva et al.   Expert Review of Proteomics

Rapid and Effective Focusing in a Carrier Ampholyte Solution Isoelectric Focusing System: A Proteome Prefractionation Tool

(2008) John C. Tran et al.   JOURNAL OF PROTEOME RESEARCH

Caititu: A tool to graphically represent peptide sequence coverage and domain distribution

(2008) Paulo C. Carvalho et al.   Journal of Proteomics

Orbitrap mass spectrometry: Instrumentation, ion motion and applications

(2008) Richard H. Perry et al.   MASS SPECTROMETRY REVIEWS

Exploring snake venom proteomes: multifaceted analyses for complex toxin mixtures

(2008) Jay W. Fox et al.   PROTEOMICS