FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system

Export and functions of sphingosine-1-phosphate

(2009) Roger H. Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Immunosuppressive human anti-lymphocyte autoantibodies specific for the type 1 sphingosine 1-phosphate receptor

(2009) Jia-Jun Liao et al.   FASEB JOURNAL

Evaluation of the lymphocyte trafficking drug FTY720 in SHIVSF162P3-infected rhesus macaques

(2009) E. N. Kersh et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Subcellular Origin of Sphingosine 1-Phosphate Is Essential for Its Toxic Effect in Lyase-deficient Neurons

(2009) Nadine Hagen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Topical Application of Sphingosine-1-Phosphate and FTY720 Attenuate Allergic Contact Dermatitis Reaction through Inhibition of Dendritic Cell Migration

(2009) Ilka Reines et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Oral fingolimod (FTY720) in multiple sclerosis: Two-year results of a phase II extension study

(2009) P. O'Connor et al.   NEUROLOGY

FTY720 attenuates lesional interleukin-17+cell accumulation in rat experimental autoimmune neuritis

(2009) Z-Y. Zhang et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

A critical role for the sphingosine analog AAL-R in dampening the cytokine response during influenza virus infection

(2009) D. Marsolais et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Production and release of sphingosine 1-phosphate and the phosphorylated form of the immunomodulator FTY720

(2008) A KIHARA   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

FTY720 Rescue Therapy in the Dark Agouti Rat Model of Experimental Autoimmune Encephalomyelitis: Expression of Central Nervous System Genes and Reversal of Blood-Brain-Barrier Damage

(2008) Carolyn A. Foster et al.   BRAIN PATHOLOGY

Guide to Receptors and Channels (GRAC), 3rd edition

(2008) S P H Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Central nervous system effects of current and emerging multiple sclerosis-directed immuno-therapies

(2008) Jack P. Antel et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Sphingosine kinase 1/S1P receptor signaling axis controls glial proliferation in mice with Sandhoff disease

(2008) Yun-Ping Wu et al.   HUMAN MOLECULAR GENETICS

S1P1 Receptor Signaling Overrides Retention Mediated by Gαi-Coupled Receptors to Promote T Cell Egress

(2008) Trung H.M. Pham et al.   IMMUNITY

Modulation of T cell homeostasis and alloreactivity under continuous FTY720 exposure

(2008) Barbara Metzler et al.   INTERNATIONAL IMMUNOLOGY

Accumulation of Fingolimod (FTY720) in Lymphoid Tissues Contributes to Prolonged Efficacy

(2008) S.-C. Sensken et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Transient FTY720 treatment promotes immune-mediated clearance of a chronic viral infection

(2008) Mary Premenko-Lanier et al.   NATURE

Cortical sinus probing, S1P1-dependent entry and flow-based capture of egressing T cells

(2008) Irina L Grigorova et al.   NATURE IMMUNOLOGY

FTY720 therapy exerts differential effects on T cell subsets in multiple sclerosis

(2008) M. Mehling et al.   NEUROLOGY

Sphingosine 1-phosphate receptor agonism impairs skin dendritic cell migration and homing to secondary lymphoid tissue: Association with prolonged allograft survival

(2008) Yuk Yuen Lan et al.   TRANSPLANT IMMUNOLOGY

Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis

(2007) John S. Tzartos et al.   AMERICAN JOURNAL OF PATHOLOGY

FTY720 modulates human oligodendrocyte progenitor process extension and survival

(2007) Veronique E. Miron et al.   ANNALS OF NEUROLOGY

G Protein–Coupled Receptor Sorting to Endosomes and Lysosomes

(2007) Adriano Marchese et al.   Annual Review of Pharmacology and Toxicology

Requirement of secondary lymphoid tissues for the induction of primary and secondary T cell responses againstListeria monocytogenes

(2007) Mischo Kursar et al.   EUROPEAN JOURNAL OF IMMUNOLOGY