14-3-3/Tau Interaction and Tau Amyloidogenesis

Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes

(2018) Sebastian A. Andrei et al.   ACS Chemical Neuroscience

Blocking the Thiol at Cysteine-322 Destabilizes Tau Protein and Prevents Its Oligomer Formation

(2018) Hui Chen et al.   ACS Chemical Neuroscience

The Binding Mode of a Tau Peptide with Tubulin

(2018) Harindranath Kadavath et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tau Proteins and Tauopathies in Alzheimer’s Disease

(2018) Fong Ping Chong et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Structure, Function, Involvement in Diseases and Targeting of 14-3-3 Proteins: An Update

(2018) Ylenia Cau et al.   CURRENT MEDICINAL CHEMISTRY

The role of heparan sulfates in protein aggregation and their potential impact on neurodegeneration

(2018) Auriane Maïza et al.   FEBS LETTERS

Association of Multiple Phosphorylated Proteins with the 14-3-3 Regulatory Hubs: Problems and Perspectives

(2018) Nikolai N. Sluchanko   JOURNAL OF MOLECULAR BIOLOGY

Near-atomic model of microtubule-tau interactions

(2018) Elizabeth H. Kellogg et al.   SCIENCE

Probable Participation of 14-3-3 in Tau Protein Oligomerization and Aggregation

(2018) Nikolai N. Sluchanko et al.   JOURNAL OF ALZHEIMERS DISEASE

Tau protein aggregation in Alzheimer's disease: An attractive target for the development of novel therapeutic agents

(2017) Marie Jouanne et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Distinct differences in prion-like seeding and aggregation between Tau protein variants provide mechanistic insights into tauopathies

(2017) Kevin H. Strang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Structure-based inhibitors of tau aggregation

(2017) P. M. Seidler et al.   Nature Chemistry

Tau-based therapies in neurodegeneration: opportunities and challenges

(2017) Chuanzhou Li et al.   NATURE REVIEWS DRUG DISCOVERY

Prediction of protein disorder based on IUPred

(2017) Zsuzsanna Dosztányi   PROTEIN SCIENCE

Amyloidogenesis of Tau protein

(2017) Bartosz Nizynski et al.   PROTEIN SCIENCE

Propagation of Tau aggregates

(2017) Michel Goedert et al.   Molecular Brain

14-3-3 Proteins in Brain Development: Neurogenesis, Neuronal Migration and Neuromorphogenesis

(2017) Brett Cornell et al.   Frontiers in Molecular Neuroscience

Remodeling of the conformational ensemble of the repeat domain of tau by an aggregation enhancer

(2016) Elias Akoury et al.   PROTEIN SCIENCE

Tau Structures

(2016) Jesus Avila et al.   Frontiers in Aging Neuroscience

14-3-3ζ Mediates Tau Aggregation in Human Neuroblastoma M17 Cells

(2016) Tong Li et al.   PLoS One

Folding of the Tau Protein on Microtubules

(2015) Harindranath Kadavath et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stabilizer-Guided Inhibition of Protein-Protein Interactions

(2015) Lech-Gustav Milroy et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau

(2015) Yuyoung Joo et al.   FASEB JOURNAL

Tau and neurodegenerative disease: the story so far

(2015) Khalid Iqbal et al.   Nature Reviews Neurology

Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer’s disease brain

(2015) Shuko Takeda et al.   Nature Communications

Hyperphosphorylation of Intrinsically Disordered Tau Protein Induces an Amyloidogenic Shift in Its Conformational Ensemble

(2015) Shaolong Zhu et al.   PLoS One

Apoptosis Signal Regulating Kinase 1 (ASK1): Potential as a Therapeutic Target for Alzheimer’s Disease

(2014) Juhyun Song et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Stages and Conformations of the Tau Repeat Domain during Aggregation and Its Effect on Neuronal Toxicity

(2014) Satish Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conformation Determines the Seeding Potencies of Native and Recombinant Tau Aggregates

(2014) Benjamin Falcon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tau-aggregation inhibitor therapy for Alzheimer's disease

(2013) Claude M. Wischik et al.   BIOCHEMICAL PHARMACOLOGY

Mechanistic Studies Unravel the Complexity Inherent in Tau Aggregation Leading to Alzheimer’s Disease and the Tauopathies

(2013) Gayathri Ramachandran et al.   BIOCHEMISTRY

Interaction of 14-3-3ζ with Microtubule-Associated Protein Tau within Alzheimer’s Disease Neurofibrillary Tangles

(2013) Hamid Y. Qureshi et al.   BIOCHEMISTRY

Human 14-3-3 Paralogs Differences Uncovered by Cross-Talk of Phosphorylation and Lysine Acetylation

(2013) Marina Uhart et al.   PLoS One

Altered Expression of 14-3-3ζ Protein in Spinal Cords of Rat Fetuses with Spina Bifida Aperta

(2013) Li-na Wu et al.   PLoS One

Overexpression of 14-3-3ζ Promotes Tau Phosphorylation at Ser262 and Accelerates Proteosomal Degradation of Synaptophysin in Rat Primary Hippocampal Neurons

(2013) Hamid Y. Qureshi et al.   PLoS One

Predictive Atomic Resolution Descriptions of Intrinsically Disordered hTau40 and α-Synuclein in Solution from NMR and Small Angle Scattering

(2013) Martin Schwalbe et al.   STRUCTURE

Neuroprotective Function of 14-3-3 Proteins in Neurodegeneration

(2013) Tadayuki Shimada et al.   Biomed Research International

Small-molecule modulators of 14-3-3 protein–protein interactions

(2012) Christian Ottmann   BIOORGANIC & MEDICINAL CHEMISTRY

14-3-3 zeta as novel molecular target for cancer therapy

(2012) Ajay Matta et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Identification of oligomers at early stages of tau aggregation in Alzheimer's disease

(2012) Cristian A. Lasagna-Reeves et al.   FASEB JOURNAL

Identification of an Aggregation-Prone Structure of Tau

(2012) Shana Elbaum-Garfinkle et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tau as a therapeutic target in neurodegenerative disease

(2012) Diana S. Himmelstein et al.   PHARMACOLOGY & THERAPEUTICS

The fuzzy coat of pathological human Tau fibrils is a two-layered polyelectrolyte brush

(2012) Susanne Wegmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical implication of 14-3-3 epsilon expression in gastric cancer

(2012) Mariana Ferreira Leal   WORLD JOURNAL OF GASTROENTEROLOGY

14-3-3 Proteins are Regulators of Autophagy

(2012) Mercedes Pozuelo-Rubio   Cells

Phosphopeptide-Dependent Labeling of 14-3-3 ζ Proteins by Fusicoccin-Based Fluorescent Probes

(2011) Michiko Takahashi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Properties of the Monomeric Form of Human 14-3-3ζ Protein and Its Interaction with Tau and HspB6

(2011) Nikolai N. Sluchanko et al.   BIOCHEMISTRY

Competing Interactions Stabilize Pro- and Anti-aggregant Conformations of Human Tau

(2011) Susanne Wegmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Understanding the Kinetic Roles of the Inducer Heparin and of Rod-like Protofibrils during Amyloid Fibril Formation by Tau Protein

(2011) Gayathri Ramachandran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphomimicking mutations of human 14-3-3ζ affect its interaction with tau protein and small heat shock protein HspB6

(2010) Nikolai N. Sluchanko et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The expression of seven 14-3-3 isoforms in human meningioma

(2010) Yang Liu et al.   BRAIN RESEARCH

14-3-3ζ as a prognostic marker and therapeutic target for cancer

(2010) Christopher L Neal et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

A New Nonpeptidic Inhibitor of 14-3-3 Induces Apoptotic Cell Death in Chronic Myeloid Leukemia Sensitive or Resistant to Imatinib

(2010) M. Mancini et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Establishment of a standard 14-3-3 protein assay of cerebrospinal fluid as a diagnostic tool for Creutzfeldt–Jakob disease

(2010) Katsuya Satoh et al.   LABORATORY INVESTIGATION

Differential interaction and aggregation of 3-repeat and 4-repeat tau isoforms with 14-3-3ζ protein

(2009) Golam Sadik et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effect of phosphorylation on interaction of human tau protein with 14-3-3ζ

(2009) Nikolai N. Sluchanko et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Phosphorylation of more than one site is required for tight interaction of human tau protein with 14-3-3ζ

(2009) Nikolai N. Sluchanko et al.   FEBS LETTERS

Quantitative Characterization of Heparin Binding to Tau Protein

(2009) Hai-Li Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Protein Clusters Predictive of Response to Chemotherapy in Breast Cancer Patients

(2009) Laura Cortesi et al.   JOURNAL OF PROTEOME RESEARCH

Structural Polymorphism of 441-Residue Tau at Single Residue Resolution

(2009) Marco D Mukrasch et al.   PLOS BIOLOGY

Domain Conformation of Tau Protein Studied by Solution Small-Angle X-ray Scattering†

(2008) Efstratios Mylonas et al.   BIOCHEMISTRY

Nucleation-dependent Tau Filament Formation

(2008) Erin E. Congdon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proline-directed Pseudo-phosphorylation at AT8 and PHF1 Epitopes Induces a Compaction of the Paperclip Folding of Tau and Generates a Pathological (MC-1) Conformation

(2008) Sadasivam Jeganathan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of tau at Ser214 mediates its interaction with 14-3-3 protein: implications for the mechanism of tau aggregation

(2008) Golam Sadik et al.   JOURNAL OF NEUROCHEMISTRY

Complementary dimerization of microtubule-associated tau protein: Implications for microtubule bundling and tau-mediated pathogenesis

(2008) K. J. Rosenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA