Leptin in the regulation of the immunometabolism of adipose tissue‐macrophages

Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis

(2018) Ajit S. Divakaruni et al.   Cell Metabolism

Macrophage polarization and meta-inflammation

(2018) Chuan Li et al.   Translational Research

Metabolic Modulation in Macrophage Effector Function

(2018) Ciana Diskin et al.   Frontiers in Immunology

Leptin Mediates In Vivo Neutrophil Migration: Involvement of Tumor Necrosis Factor-Alpha and CXCL1

(2018) Glaucia Souza-Almeida et al.   Frontiers in Immunology

Leptin Stimulates Cellular Glycolysis Through a STAT3 Dependent Mechanism in Tilapia

(2018) Jonathan D. Douros et al.   Frontiers in Endocrinology

Subcutaneous Adipose Tissue Accumulation Protects Systemic Glucose Tolerance and Muscle Metabolism

(2018) A.D. Booth et al.   Adipocyte

Fatty Acid Oxidation in Macrophages and T Cells: Time for Reassessment?

(2018) Jan Van den Bossche et al.   Cell Metabolism

T Cells in Adipose Tissue: Critical Players in Immunometabolism

(2018) Qun Wang et al.   Frontiers in Immunology

A Single-Cell Sequencing Guide for Immunologists

(2018) Peter See et al.   Frontiers in Immunology

Crosstalk between Mitochondrial Fission and Oxidative Stress in Paraquat-Induced Apoptosis in Mouse Alveolar Type II Cells

(2017) Guangju Zhao et al.   International Journal of Biological Sciences

Higher phagocytic activity of thioglycollate-elicited peritoneal macrophages is related to metabolic status of the cells

(2017) Sofia Pavlou et al.   Journal of Inflammation-London

Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

(2017) W. K. Eddie Ip et al.   SCIENCE

Macrophage Immunometabolism: Where Are We (Going)?

(2017) Jan Van den Bossche et al.   TRENDS IN IMMUNOLOGY

Metabolically Activated Adipose Tissue Macrophages Perform Detrimental and Beneficial Functions during Diet-Induced Obesity

(2017) Brittney R. Coats et al.   Cell Reports

The Impact of Ghrelin in Metabolic Diseases: An Immune Perspective

(2017) Jéssica Aparecida da Silva Pereira et al.   Journal of Diabetes Research

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

(2016) Michael D. Buck et al.   CELL

The Adipose Tissue Microenvironment Regulates Depot-Specific Adipogenesis in Obesity

(2016) Elise Jeffery et al.   Cell Metabolism

Leptin Receptor Promotes Adipogenesis and Reduces Osteogenesis by Regulating Mesenchymal Stromal Cells in Adult Bone Marrow

(2016) Rui Yue et al.   Cell Stem Cell

HIF-1α in Myeloid Cells Promotes Adipose Tissue Remodeling Toward Insulin Resistance

(2016) Akiko Takikawa et al.   DIABETES

Interleukin-6 induces impairment in human subcutaneous adipogenesis in obesity-associated insulin resistance

(2016) Shamma Almuraikhy et al.   DIABETOLOGIA

Adipose tissue macrophages: going off track during obesity

(2016) Lily Boutens et al.   DIABETOLOGIA

Leptin directly promotes T-cell glycolytic metabolism to drive effector T-cell differentiation in a mouse model of autoimmunity

(2016) Valerie A. Gerriets et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tissue-Resident Macrophage Ontogeny and Homeostasis

(2016) Florent Ginhoux et al.   IMMUNITY

Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation

(2016) Stanley Ching-Cheng Huang et al.   IMMUNITY

Adipose tissue in control of metabolism

(2016) Liping Luo et al.   JOURNAL OF ENDOCRINOLOGY

Minireview: CNS Mechanisms of Leptin Action

(2016) Jonathan N. Flak et al.   MOLECULAR ENDOCRINOLOGY

Specification of tissue-resident macrophages during organogenesis

(2016) E. Mass et al.   SCIENCE

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

Leptin Regulation of Immune Responses

(2016) Caitlin Naylor et al.   TRENDS IN MOLECULAR MEDICINE

Physiological role for leptin in the control of thermal conductance

(2016) Karl J. Kaiyala et al.   Molecular Metabolism

Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma

(2016) Hweixian Leong Penny et al.   OncoImmunology

Possible Integrative Actions of Leptin and Insulin Signaling in the Hypothalamus Targeting Energy Homeostasis

(2016) Mina Thon et al.   Frontiers in Endocrinology

The soluble leptin receptor

(2015) Michael Schaab et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Sympathetic Neuro-adipose Connections Mediate Leptin-Driven Lipolysis

(2015) Wenwen Zeng et al.   CELL

Population of Monocyte-Derived Macrophages

(2015) Naomi McGovern et al.   IMMUNITY

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

Leptin Receptor Signaling in T Cells Is Required for Th17 Differentiation

(2015) Bernardo S. Reis et al.   JOURNAL OF IMMUNOLOGY

CD11c-Expressing B Cells Are Located at the T Cell/B Cell Border in Spleen and Are Potent APCs

(2015) Anatoly V. Rubtsov et al.   JOURNAL OF IMMUNOLOGY

The role of leptin in the sporadic form of Alzheimer's disease. Interactions with the adipokines amylin, ghrelin and the pituitary hormone prolactin

(2015) Jaume Folch et al.   LIFE SCIENCES

Leptin in osteoarthritis: Focus on articular cartilage and chondrocytes

(2015) Morena Scotece et al.   LIFE SCIENCES

Leptin resistance in obesity: An epigenetic landscape

(2015) Ana B. Crujeiras et al.   LIFE SCIENCES

Leptin in autoimmune diseases

(2015) Claudio Procaccini et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Adipose tissue as an immunological organ

(2015) Ryan W. Grant et al.   Obesity

Macrophage recruitment in obese adipose tissue

(2015) Y. Bai et al.   Obesity Reviews

Adipokines as Drug Targets in Diabetes and Underlying Disturbances

(2015) Vinícius Andrade-Oliveira et al.   Journal of Diabetes Research

Loss of CD24 in Mice Leads to Metabolic Dysfunctions and a Reduction in White Adipocyte Tissue

(2015) Nicholas A. Fairbridge et al.   PLoS One

Effects of leptin on macrophages in vivo

(2014) A. Hoffmann et al.   ATHEROSCLEROSIS

Attenuated adipose tissue and skeletal muscle inflammation in obese mice with combined CD4+ and CD8+ T cell deficiency

(2014) Ilvira M. Khan et al.   ATHEROSCLEROSIS

Metabolic Dysfunction Drives a Mechanistically Distinct Proinflammatory Phenotype in Adipose Tissue Macrophages

(2014) Mario Kratz et al.   Cell Metabolism

RBP4 Activates Antigen-Presenting Cells, Leading to Adipose Tissue Inflammation and Systemic Insulin Resistance

(2014) Pedro M. Moraes-Vieira et al.   Cell Metabolism

Local Proliferation of Macrophages Contributes to Obesity-Associated Adipose Tissue Inflammation

(2014) Shinya U. Amano et al.   Cell Metabolism

TNF-α reduces g0s2 expression and stimulates lipolysis through PPAR-γ inhibition in 3T3-L1 adipocytes

(2014) Dan Jin et al.   CYTOKINE

Macrophages, Immunity, and Metabolic Disease

(2014) Joanne C. McNelis et al.   IMMUNITY

Origin and Functions of Tissue Macrophages

(2014) Slava Epelman et al.   IMMUNITY

Metabolic Reprogramming of Macrophages

(2014) Alex J. Freemerman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

20 YEARS OF LEPTIN: Insights into signaling assemblies of the leptin receptor

(2014) Frank Peelman et al.   JOURNAL OF ENDOCRINOLOGY

Leptin Increases TNF-α Expression and Production through Phospholipase D1 in Raw 264.7 Cells

(2014) Se-Min Lee et al.   PLoS One

Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step

(2014) Alexander A Shestov et al.   eLife

Leptin: molecular mechanisms, systemic pro-inflammatory effects, and clinical implications

(2013) Gilberto Paz-Filho et al.   Arquivos Brasileiros de Endocrinologia e Metabologia

Direct and indirect effects of leptin on adipocyte metabolism

(2013) Ruth B.S. Harris   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Adipose tissue hypoxia induces inflammatory M1 polarity of macrophages in an HIF-1α-dependent and HIF-1α-independent manner in obese mice

(2013) S. Fujisaka et al.   DIABETOLOGIA

Leptin deficiency impairs maturation of dendritic cells and enhances induction of regulatory T and Th17 cells

(2013) Pedro M.M. Moraes-Vieira et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Metabolic Pathways in Immune Cell Activation and Quiescence

(2013) Erika L. Pearce et al.   IMMUNITY

Participation of leptin in the determination of the macrophage phenotype: an additional role in adipocyte and macrophage crosstalk

(2013) Simone Coghetto Acedo et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages

(2013) Ari B. Molofsky et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Tissue-resident macrophages

(2013) Luke C Davies et al.   NATURE IMMUNOLOGY

The role of leptin in the control of insulin-glucose axis

(2013) Marie Amitani et al.   Frontiers in Neuroscience

Phenotypic effects of an induced mutation of the ObRa isoform of the leptin receptor

(2013) Zhiying Li et al.   Molecular Metabolism

Hunting for the functions of short leptin receptor isoforms

(2013) Julie Dam et al.   Molecular Metabolism

Leptin Modulates Allograft Survival by Favoring a Th2 and a Regulatory Immune Profile

(2012) P. M. M. Moraes-Vieira et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Regulation of Immune Responses by mTOR

(2012) Jonathan D. Powell et al.   Annual Review of Immunology

PI3K/Akt contributes to increased expression of Toll-like receptor 4 in macrophages exposed to hypoxic stress

(2012) So Young Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis

(2012) Luis Varela et al.   EMBO REPORTS

Adipose tissue: friend or foe?

(2012) Mohamed Hassan et al.   Nature Reviews Cardiology

Leptin as a link between the immune system and kidney-related diseases: leading actor or just a coadjuvant?

(2012) P. M. M. Moraes-Vieira et al.   Obesity Reviews

Rapid Nitration of Adipocyte Phosphoenolpyruvate Carboxykinase by Leptin Reduces Glyceroneogenesis and Induces Fatty Acid Release

(2012) Anne-Marie Jaubert et al.   PLoS One

Adipose tissue-resident immune cells: key players in immunometabolism

(2012) Henk S. Schipper et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Regulation of HIF-1α activity in adipose tissue by obesity-associated factors: adipogenesis, insulin, and hypoxia

(2011) Qing He et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Alternative Macrophage Activation and Metabolism

(2011) Justin I. Odegaard et al.   Annual Review of Pathology-Mechanisms of Disease

Estimates of obesity trends in Brazil, 2006–2009

(2011) Erly Catarina Moura et al.   International Journal of Public Health

Obesity and Type 2 Diabetes: What Can Be Unified and What Needs to Be Individualized?

(2011) Robert H. Eckel et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Leptin Action in the Dorsomedial Hypothalamus Increases Sympathetic Tone to Brown Adipose Tissue in Spite of Systemic Leptin Resistance

(2011) P. J. Enriori et al.   JOURNAL OF NEUROSCIENCE

Immunity as a link between obesity and insulin resistance

(2011) Nishan S. Kalupahana et al.   MOLECULAR ASPECTS OF MEDICINE

Leptin as an immunomodulator

(2011) Claudio Procaccini et al.   MOLECULAR ASPECTS OF MEDICINE

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Intracellular Leptin-Signaling Pathways in Hypothalamic Neurons: The Emerging Role of Phosphatidylinositol-3 Kinase-Phosphodiesterase-3B-cAMP Pathway

(2011) Abhiram Sahu   NEUROENDOCRINOLOGY

The adipocyte as an endocrine organ in the regulation of metabolic homeostasis

(2011) H. James Harwood   NEUROPHARMACOLOGY

Leptin and the Central Nervous System Control of Glucose Metabolism

(2011) Gregory J. Morton et al.   PHYSIOLOGICAL REVIEWS

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

(2010) C. M. Krawczyk et al.   BLOOD

Leptin and mTOR: Partners in metabolism and inflammation

(2010) Clarissa Maya-Monteiro et al.   CELL CYCLE

Pro-Inflammatory CD11c+CD206+ Adipose Tissue Macrophages Are Associated With Insulin Resistance in Human Obesity

(2010) J. M. Wentworth et al.   DIABETES

JNK1 and IKKβ: molecular links between obesity and metabolic dysfunction

(2010) Giovanni Solinas et al.   FASEB JOURNAL

Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation

(2010) J.-C. Rodriguez-Prados et al.   JOURNAL OF IMMUNOLOGY

Role of Leptin in the Activation of Immune Cells

(2010) Patricia Fernández-Riejos et al.   MEDIATORS OF INFLAMMATION

A historical perspective on leptin

(2010) Douglas L Coleman   NATURE MEDICINE

Leptin as a metabolic link to multiple sclerosis

(2010) Giuseppe Matarese et al.   Nature Reviews Neurology

Leptin, Leptin Receptors, and the Control of Body Weight

(2010) Jeffrey M. Friedman   NUTRITION REVIEWS

Adaptive immunity and adipose tissue biology

(2010) Denise A. Kaminski et al.   TRENDS IN IMMUNOLOGY

Leptin modulates ACAT1 expression and cholesterol efflux from human macrophages

(2009) Shigeki Hongo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Metabolism and secretory function of white adipose tissue: effect of dietary fat

(2009) Cláudia M. Oller do Nascimento et al.   ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS

Leptin enhances CC-chemokine ligand expression in cultured murine macrophage

(2009) Norikazu Kiguchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Loss of AMPK exacerbates experimental autoimmune encephalomyelitis disease severity

(2009) Narender Nath et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Leptin modulates cell morphology and cytokine release in microglia

(2009) Véronique Lafrance et al.   BRAIN BEHAVIOR AND IMMUNITY

Hypoxic stress up-regulates the expression of Toll-like receptor 4 in macrophages via hypoxia-inducible factor

(2009) So Young Kim et al.   IMMUNOLOGY

Adipose tissue as an endocrine organ

(2009) Sandra Galic et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome

(2009) E. Maury et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

Up-regulation of adipogenesis in adipocytes expressing stably cyclooxygenase-2 in the antisense direction

(2009) Xiaoqing Chu et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

White Adipose Tissue as Endocrine Organ and Its Role in Obesity

(2008) Maria Eugenia Frigolet Vázquez-Vela et al.   ARCHIVES OF MEDICAL RESEARCH

Hypoxia in adipose tissue: a basis for the dysregulation of tissue function in obesity?

(2008) Paul Trayhurn et al.   BRITISH JOURNAL OF NUTRITION

Adipokines: The missing link between insulin resistance and obesity

(2008) B. Antuna-Puente et al.   DIABETES & METABOLISM