The Impact of Ghrelin in Metabolic Diseases: An Immune Perspective

Effects of Chronic Ghrelin Treatment on Hypoxia-Induced Brain Oxidative Stress and Inflammation in a Rat Normobaric Chronic Hypoxia Model

(2017) Hasan Omrani et al.   HIGH ALTITUDE MEDICINE & BIOLOGY

IL-6 Regulates M2 Polarization and Local Proliferation of Adipose Tissue Macrophages in Obesity

(2017) Julia Braune et al.   JOURNAL OF IMMUNOLOGY

Des-acyl ghrelin inhibits the capacity of macrophages to stimulate the expression of aromatase in breast adipose stromal cells

(2017) CheukMan C. Au et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

The cellular and molecular bases of leptin and ghrelin resistance in obesity

(2017) Huxing Cui et al.   Nature Reviews Endocrinology

Ghrelin receptor regulates adipose tissue inflammation in aging

(2016) Ligen Lin et al.   Aging-US

Antigen Presentation and T-Cell Activation Are Critical for RBP4-Induced Insulin Resistance

(2016) Pedro M. Moraes-Vieira et al.   DIABETES

GLUT4 Expression in Adipocytes Regulates De Novo Lipogenesis and Levels of a Novel Class of Lipids With Antidiabetic and Anti-inflammatory Effects

(2016) Pedro M. Moraes-Vieira et al.   DIABETES

Inhibiting Microglia Expansion Prevents Diet-Induced Hypothalamic and Peripheral Inflammation

(2016) Caroline André et al.   DIABETES

Effects of ghrelin on the apoptosis of human neutrophils in vitro

(2016) Bin Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Impact of Obesity and Metabolic Syndrome on Immunity

(2016) Catherine J Andersen et al.   Advances in Nutrition

Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages

(2016) Jan Van den Bossche et al.   Cell Reports

The Macrophage Switch in Obesity Development

(2016) Angela Castoldi et al.   Frontiers in Immunology

Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders

(2016) Sung Sik Choe et al.   Frontiers in Endocrinology

The Roles of Adipokines, Proinflammatory Cytokines, and Adipose Tissue Macrophages in Obesity-Associated Insulin Resistance in Modest Obesity and Early Metabolic Dysfunction

(2016) Yea Eun Kang et al.   PLoS One

Ghrelin accelerates wound healing through GHS-R1a-mediated MAPK-NF-κB/GR signaling pathways in combined radiation and burn injury in rats

(2016) Cong Liu et al.   Scientific Reports

Ghrelin’s Role in the Hypothalamic-Pituitary-Adrenal Axis Stress Response: Implications for Mood Disorders

(2015) Sarah J. Spencer et al.   BIOLOGICAL PSYCHIATRY

Ghrelin Inhibits Proinflammatory Responses and Prevents Cognitive Impairment in Septic Rats

(2015) Hua Wei et al.   CRITICAL CARE MEDICINE

Brain Innate Immunity Regulates Hypothalamic Arcuate Neuronal Activity and Feeding Behavior

(2015) Wagner L. Reis et al.   ENDOCRINOLOGY

Serum retinol binding protein 4 is associated with visceral fat in human with nonalcoholic fatty liver disease without known diabetes: a cross-sectional study

(2015) Xinxia Chang et al.   Lipids in Health and Disease

Rapid linkage of innate immunological signals to adaptive immunity by the brain-fat axis

(2015) Min Soo Kim et al.   NATURE IMMUNOLOGY

Hypothalamic innate immune reaction in obesity

(2015) Stefanie Kälin et al.   Nature Reviews Endocrinology

Effect of bariatric surgery on systemic and adipose tissue inflammation

(2015) Valerie G. Sams et al.   SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES

Adipokines as Drug Targets in Diabetes and Underlying Disturbances

(2015) Vinícius Andrade-Oliveira et al.   Journal of Diabetes Research

Metabolic Characterization of Polarized M1 and M2 Bone Marrow-derived Macrophages Using Real-time Extracellular Flux Analysis

(2015) Jan Van den Bossche et al.   Jove-Journal of Visualized Experiments

Ghrelin

(2015) T.D. Müller et al.   Molecular Metabolism

The Role of Dendritic Cells in Central Tolerance

(2015) Jaehak Oh et al.   Immune Network

Inflammatory Cytokines in General and Central Obesity and Modulating Effects of Physical Activity

(2015) Frank M. Schmidt et al.   PLoS One

The Effect of Ghrelin upon the Early Immune Response in Lean and Obese Mice during Sepsis

(2015) Daniel Siegl et al.   PLoS One

Loss of CD24 in Mice Leads to Metabolic Dysfunctions and a Reduction in White Adipocyte Tissue

(2015) Nicholas A. Fairbridge et al.   PLoS One

Xbp1s in Pomc Neurons Connects ER Stress with Energy Balance and Glucose Homeostasis

(2014) Kevin W. Williams et al.   Cell Metabolism

RBP4 Activates Antigen-Presenting Cells, Leading to Adipose Tissue Inflammation and Systemic Insulin Resistance

(2014) Pedro M. Moraes-Vieira et al.   Cell Metabolism

Macrophages, Immunity, and Metabolic Disease

(2014) Joanne C. McNelis et al.   IMMUNITY

Roux-en-Y Gastric Bypass Decreases Pro-inflammatory and Thrombotic Biomarkers in Individuals with Extreme Obesity

(2014) Bárbara Dal Molin Netto et al.   OBESITY SURGERY

From stress to inflammation and major depressive disorder: A social signal transduction theory of depression.

(2014) George M. Slavich et al.   PSYCHOLOGICAL BULLETIN

Therapeutic effect of ghrelin in experimental autoimmune encephalomyelitis by inhibiting antigen-specific Th1/Th17 responses and inducing regulatory T cells

(2013) Luciana Souza-Moreira et al.   BRAIN BEHAVIOR AND IMMUNITY

Modulation of food intake by mTOR signalling in the dorsal motor nucleus of the vagus in male rats: focus on ghrelin and nesfatin-1

(2013) Weizhen Zhang et al.   EXPERIMENTAL PHYSIOLOGY

Ghrelin-induced food intake and adiposity depend on central mTORC1/S6K1 signaling

(2013) Darko Stevanovic et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

A ghrelin–growth hormone axis drives stress-induced vulnerability to enhanced fear

(2013) R M Meyer et al.   MOLECULAR PSYCHIATRY

Physiological roles of ghrelin on obesity

(2013) Takahiro Sato et al.   Obesity Research & Clinical Practice

Dietary Oleic Acid Increases M2 Macrophages in the Mesenteric Adipose Tissue

(2013) Christina Camell et al.   PLoS One

Anti-ghrelin immunoglobulins modulate ghrelin stability and its orexigenic effect in obese mice and humans

(2013) Kuniko Takagi et al.   Nature Communications

Ghrelin receptor regulates HFCS-induced adipose inflammation and insulin resistance

(2013) X Ma et al.   Nutrition & Diabetes

The Effectiveness and Risks of Bariatric Surgery

(2013) Su-Hsin Chang et al.   JAMA Surgery

Functional Role of Adult Hippocampal Neurogenesis as a Therapeutic Strategy for Mental Disorders

(2013) Heechul Jun et al.   NEURAL PLASTICITY

Leptin Modulates Allograft Survival by Favoring a Th2 and a Regulatory Immune Profile

(2012) P. M. M. Moraes-Vieira et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Mechanisms of Inflammatory Responses in Obese Adipose Tissue

(2012) Shengyi Sun et al.   Annual Review of Nutrition

The Ghrelin Axis—Does It Have an Appetite for Cancer Progression?

(2012) Lisa K. Chopin et al.   ENDOCRINE REVIEWS

Functional implications of hypothalamic neurogenesis in the adult mammalian brain

(2012) Daniel A. Lee et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Macrophage plasticity and polarization in tissue repair and remodelling

(2012) Alberto Mantovani et al.   JOURNAL OF PATHOLOGY

Leptin as a link between the immune system and kidney-related diseases: leading actor or just a coadjuvant?

(2012) P. M. M. Moraes-Vieira et al.   Obesity Reviews

Hypothalamic mTOR Signaling Mediates the Orexigenic Action of Ghrelin

(2012) Luís Martins et al.   PLoS One

The Amygdala as a Neurobiological Target for Ghrelin in Rats: Neuroanatomical, Electrophysiological and Behavioral Evidence

(2012) Mayte Alvarez-Crespo et al.   PLoS One

Ghrelin protects spinal cord motoneurons against chronic glutamate-induced excitotoxicity via ERK1/2 and phosphatidylinositol-3-kinase/Akt/glycogen synthase kinase-3β pathways

(2011) Eunjin Lim et al.   EXPERIMENTAL NEUROLOGY

Structure, regulation and function of ghrelin

(2011) T. Sato et al.   JOURNAL OF BIOCHEMISTRY

Obesity is associated with hypothalamic injury in rodents and humans

(2011) Joshua P. Thaler et al.   JOURNAL OF CLINICAL INVESTIGATION

Aging Is Associated with an Increase in T Cells and Inflammatory Macrophages in Visceral Adipose Tissue

(2011) C. N. Lumeng et al.   JOURNAL OF IMMUNOLOGY

The effects of ghrelin on inflammation and the immune system

(2011) Dolgor Baatar et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The truncated ghrelin receptor polypeptide (GHS-R1b) is localized in the endoplasmic reticulum where it forms heterodimers with ghrelin receptors (GHS-R1a) to attenuate their cell surface expression

(2011) Kevin B.S. Chow et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Immunity as a link between obesity and insulin resistance

(2011) Nishan S. Kalupahana et al.   MOLECULAR ASPECTS OF MEDICINE

Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation

(2011) Amar Sahay et al.   NATURE

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions

(2011) Guo-li Ming et al.   NEURON

Ghrelin and glucose homeostasis

(2011) P.J.D. Delhanty et al.   PEPTIDES

Ghrelin acylation and metabolic control

(2011) O. Al Massadi et al.   PEPTIDES

Ghrelin-mediated appetite regulation in the central nervous system

(2011) Katarzyna Kirsz et al.   PEPTIDES

Central mechanisms involved in the orexigenic actions of ghrelin

(2011) Zane B. Andrews   PEPTIDES

Obesity, insulin resistance and free fatty acids

(2011) Guenther Boden   Current Opinion in Endocrinology Diabetes and Obesity

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

Unacylated Ghrelin Rescues Endothelial Progenitor Cell Function in Individuals With Type 2 Diabetes

(2010) G. Togliatto et al.   DIABETES

Ghrelin effects on neuropeptides in the rat hypothalamus depend on fatty acid metabolism actions on BSX but not on gender

(2010) Ricardo Lage et al.   FASEB JOURNAL

The Anti-Inflammatory and Neuroprotective Effects of Ghrelin in Subarachnoid Hemorrhage-Induced Oxidative Brain Damage in Rats

(2010) Mehmet Erşahin et al.   JOURNAL OF NEUROTRAUMA

Ghrelin and memory: Differential effects on acquisition and retrieval

(2010) Valeria P. Carlini et al.   PEPTIDES

Toll-like receptors: linking inflammation to metabolism

(2010) A. Christine Könner et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Metabolism and secretory function of white adipose tissue: effect of dietary fat

(2009) Cláudia M. Oller do Nascimento et al.   ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS

Weight Loss, Appetite Suppression, and Changes in Fasting and Postprandial Ghrelin and Peptide-YY Levels After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy

(2009) Stavros N. Karamanakos et al.   ANNALS OF SURGERY

Effect of Weight Loss by Diet or Gastric Bypass Surgery on Peptide YY3–36 Levels

(2009) Blanca Oliván et al.   ANNALS OF SURGERY

Ghrelin Regulates Hippocampal Neurogenesis in Adult Mice

(2009) Minho MOON et al.   ENDOCRINE JOURNAL

Complex Regulation of Mammalian Target of Rapamycin Complex 1 in the Basomedial Hypothalamus by Leptin and Nutritional Status

(2009) Eneida C. Villanueva et al.   ENDOCRINOLOGY

Ghrelin in the regulation of body weight and metabolism

(2009) T.R. Castañeda et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Rediscovering a history of nursing management: From Nightingale to the modern matron

(2009) Stuart Wildman et al.   INTERNATIONAL JOURNAL OF NURSING STUDIES

Shedding light on the intricate puzzle of ghrelin's effects on appetite regulation

(2009) Blerina Kola et al.   JOURNAL OF ENDOCRINOLOGY

Suppression of Experimental Autoimmune Encephalomyelitis by Ghrelin

(2009) M.-M. Theil et al.   JOURNAL OF IMMUNOLOGY

Monocyte Chemoattractant Protein-1 (MCP-1): An Overview

(2009) Satish L. Deshmane et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

AMPK as a mediator of hormonal signalling

(2009) Chung Thong Lim et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Ghrelin Promotes and Protects Nigrostriatal Dopamine Function via a UCP2-Dependent Mitochondrial Mechanism

(2009) Z. B. Andrews et al.   JOURNAL OF NEUROSCIENCE

Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity

(2009) M. Milanski et al.   JOURNAL OF NEUROSCIENCE

Obesity and Presenteeism: The Impact of Body Mass Index on Workplace Productivity

(2009) Donna M. Gates et al.   JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Adipose tissue as an endocrine organ

(2009) Sandra Galic et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Actions and therapeutic pathways of ghrelin for gastrointestinal disorders

(2009) Michael Camilleri et al.   Nature Reviews Gastroenterology & Hepatology

Neuroprotective Effect of Ghrelin in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson’s Disease by Blocking Microglial Activation

(2009) Minho Moon et al.   NEUROTOXICITY RESEARCH

White Adipose Tissue as Endocrine Organ and Its Role in Obesity

(2008) Maria Eugenia Frigolet Vázquez-Vela et al.   ARCHIVES OF MEDICAL RESEARCH

Identification of the Acyltransferase that Octanoylates Ghrelin, an Appetite-Stimulating Peptide Hormone

(2008) Jing Yang et al.   CELL

Hypothalamic Fatty Acid Metabolism Mediates the Orexigenic Action of Ghrelin

(2008) Miguel López et al.   Cell Metabolism

Adipokines: The missing link between insulin resistance and obesity

(2008) B. Antuna-Puente et al.   DIABETES & METABOLISM

Proliferative and Protective Effects of Growth Hormone Secretagogues on Adult Rat Hippocampal Progenitor Cells

(2008) Inger Johansson et al.   ENDOCRINOLOGY

Obesity and Free Fatty Acids

(2008) Guenther Boden   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Ghrelin antagonizes MPTP-induced neurotoxicity to the dopaminergic neurons in mouse substantia nigra

(2008) Hong Jiang et al.   EXPERIMENTAL NEUROLOGY

AMPK: a key regulator of energy balance in the single cell and the whole organism

(2008) D G Hardie   INTERNATIONAL JOURNAL OF OBESITY

Leptin reverses weight loss–induced changes in regional neural activity responses to visual food stimuli

(2008) Michael Rosenbaum et al.   JOURNAL OF CLINICAL INVESTIGATION

Obesity and Inflammation: Lessons From Bariatric Surgery

(2008) Charlene Compher et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Effect of chronic stress on gastric emptying and plasma ghrelin levels in rats

(2008) Masahiro Ochi et al.   LIFE SCIENCES

UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals

(2008) Zane B. Andrews et al.   NATURE

The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress

(2008) Michael Lutter et al.   NATURE NEUROSCIENCE

The Orexigenic Effect of Ghrelin Is Mediated through Central Activation of the Endogenous Cannabinoid System

(2008) Blerina Kola et al.   PLoS One

Ghrelin treatment suppresses neutrophil-dominant inflammation in airways of patients with chronic respiratory infection

(2008) Tsuyoshi Kodama et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Exogenous ghrelin modulates release of pro-inflammatory and anti-inflammatory cytokines in LPS-stimulated macrophages through distinct signaling pathways

(2008) Talat Waseem et al.   SURGERY

Ghrelin: A new peptide regulating growth hormone release and food intake

(2007) Carine De Vriese et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE

The discovery of ghrelin — A personal memory

(2007) Masayasu Kojima   REGULATORY PEPTIDES