Non‐viral nucleic acid delivery to the central nervous system and brain tumors

In vitro efficacy of a gene-activated nerve guidance conduit incorporating non-viral PEI-pDNA nanoparticles carrying genes encoding for NGF, GDNF and c-Jun

(2018) William A. Lackington et al.   Acta Biomaterialia

Micro RNA as a potential blood-based epigenetic biomarker for Alzheimer's disease

(2018) Peter D. Fransquet et al.   CLINICAL BIOCHEMISTRY

Non-viral gene therapy using multifunctional nanoparticles: Status, challenges, and opportunities

(2018) Guimiao Lin et al.   COORDINATION CHEMISTRY REVIEWS

A Dual Targeting Drug Delivery System for Penetrating Blood-Brain Barrier and Selectively Delivering siRNA to Neurons for Alzheimer’s Disease Treatment

(2018) Chi Zhang et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

miRNA-124-3p/neuropilin-1(NRP-1) axis plays an important role in mediating glioblastoma growth and angiogenesis

(2018) Guilong Zhang et al.   INTERNATIONAL JOURNAL OF CANCER

A ternary-complex of a suicide gene, a RAGE-binding peptide, and polyethylenimine as a gene delivery system with anti-tumor and anti-angiogenic dual effects in glioblastoma

(2018) Eunji Choi et al.   JOURNAL OF CONTROLLED RELEASE

Systemic delivery of BACE1 siRNA through neuron-targeted nanocomplexes for treatment of Alzheimer's disease

(2018) Pengzhen Wang et al.   JOURNAL OF CONTROLLED RELEASE

Recent progress and considerations for AAV gene therapies targeting the central nervous system

(2018) Erik Allen Lykken et al.   Journal of Neurodevelopmental Disorders

Intranasal Delivery of pGDNF DNA Nanoparticles Provides Neuroprotection in the Rat 6-Hydroxydopamine Model of Parkinson’s Disease

(2018) Amirah E.-E. Aly et al.   MOLECULAR NEUROBIOLOGY

Multifunctional nucleic acid nanostructures for gene therapies

(2018) Jianbing Liu et al.   Nano Research

Neuroprotective effect of gold nanoparticles composites in Parkinson's disease model

(2018) Kaikai Hu et al.   Nanomedicine-Nanotechnology Biology and Medicine

DNA methylation-based classification of central nervous system tumours

(2018) David Capper et al.   NATURE

Ultrasound-Triggered Effects of the Microbubbles Coupled to GDNF Plasmid-Loaded PEGylated Liposomes in a Rat Model of Parkinson's Disease

(2018) Peijian Yue et al.   Frontiers in Neuroscience

PEI-Coated Fe3O4 Nanoparticles Enable Efficient Delivery of Therapeutic siRNA Targeting REST into Glioblastoma Cells

(2018) Rui Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Non-viral vectors based on cationic niosomes as efficient gene delivery vehicles to central nervous system cells into the brain

(2018) Mohamed Mashal et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Systemic siRNA delivery to tumors by cell-penetrating α-helical polypeptide-based metastable nanoparticles

(2018) Yang Liu et al.   Nanoscale

Gene therapy for neurological disorders: progress and prospects

(2018) Benjamin E. Deverman et al.   NATURE REVIEWS DRUG DISCOVERY

An efficient bivalent cyclic RGD-PIK3CB siRNA conjugate for specific targeted therapy against glioblastoma in vitro and in vivo

(2018) Bohong Cen et al.   Molecular Therapy-Nucleic Acids

Immune Checkpoint Inhibitors for the Treatment of Central Nervous System (CNS) Metastatic Disease

(2018) Suneel D. Kamath et al.   Frontiers in Oncology

Interactions in DNA Condensation: An Important Factor for Improving the Efficacy of Gene Transfection

(2018) Xuan Nie et al.   BIOCONJUGATE CHEMISTRY

Developments in Blood-Brain Barrier Penetrance and Drug Repurposing for Improved Treatment of Glioblastoma

(2018) Bryan G. Harder et al.   Frontiers in Oncology

Intranasal delivery of hGDNF plasmid DNA nanoparticles results in long-term and widespread transfection of perivascular cells in rat brain

(2018) Amirah E-E. Aly et al.   Nanomedicine-Nanotechnology Biology and Medicine

Antitumor effect of a new nano-vector with miRNA-135a on malignant glioma

(2017) Chaofeng Liang et al.   International Journal of Nanomedicine

Hypoxia-responsive ionizable liposome delivery siRNA for glioma therapy

(2017) Hong-Mei Liu et al.   International Journal of Nanomedicine

Antitumoral Cascade-Targeting Ligand for IL-6 Receptor-Mediated Gene Delivery to Glioma

(2017) Shanshan Wang et al.   MOLECULAR THERAPY

An MSN-PEG-IP drug delivery system and IL13Rα2 as targeted therapy for glioma

(2017) Jinlong Shi et al.   Nanoscale

Will Nanotechnology Bring New Hope for Gene Delivery?

(2017) Joanna K.L. Wong et al.   TRENDS IN BIOTECHNOLOGY

Expression of ING4 is negatively correlated with cellular proliferation and microvessel density in human glioma

(2017) Bin Shao et al.   Oncology Letters

Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain

(2017) Y. Anraku et al.   Nature Communications

Glial Cell Line-Derived Neurotrophic Factor Gene Delivery in Parkinson's Disease: A Delicate Balance between Neuroprotection, Trophic Effects, and Unwanted Compensatory Mechanisms

(2017) Liliane Tenenbaum et al.   Frontiers in Neuroanatomy

Polyethylenimine Nanoparticle-Mediated siRNA Delivery to Reduce α-Synuclein Expression in a Model of Parkinson’s Disease

(2017) Christin Helmschrodt et al.   Molecular Therapy-Nucleic Acids

Viral vectors for gene therapy: Current state and clinical perspectives

(2016) A. N. Lukashev et al.   BIOCHEMISTRY-MOSCOW

A non-viral suicide gene delivery system traversing the blood brain barrier for non-invasive glioma targeting treatment

(2016) Shiqian Gao et al.   JOURNAL OF CONTROLLED RELEASE

MicroRNA-124 loaded nanoparticles enhance brain repair in Parkinson's disease

(2016) C. Saraiva et al.   JOURNAL OF CONTROLLED RELEASE

Non-invasive, neuron-specific gene therapy by focused ultrasound-induced blood-brain barrier opening in Parkinson's disease mouse model

(2016) Chung-Yin Lin et al.   JOURNAL OF CONTROLLED RELEASE

Co-encapsulation ofNigella sativaoil and plasmid DNA for enhanced gene therapy of Alzheimer’s disease

(2016) Abd Almonem Doolaanea et al.   JOURNAL OF MICROENCAPSULATION

microRNA-155 Regulates Alpha-Synuclein-Induced Inflammatory Responses in Models of Parkinson Disease

(2016) Aaron D. Thome et al.   JOURNAL OF NEUROSCIENCE

Development of Nonviral Vectors Targeting the Brain as a Therapeutic Approach For Parkinson's Disease and Other Brain Disorders

(2016) Hayate Javed et al.   MOLECULAR THERAPY

Combinatorial strategies based on CRAd-IL24 and CRAd-ING4 virotherapy with anti-angiogenesis treatment for ovarian cancer

(2016) Ahmad Mohammad Ashshi et al.   Journal of Ovarian Research

Dihydropyrimidine Dehydrogenase Is a Prognostic Marker for Mesenchymal Stem Cell-Mediated Cytosine Deaminase Gene and 5-Fluorocytosine Prodrug Therapy for the Treatment of Recurrent Gliomas

(2016) Taemoon Chung et al.   Theranostics

Neurotensin-Conjugated Reduced Graphene Oxide with Multi-Stage Near-Infrared-Triggered Synergic Targeted Neuron Gene Transfection In Vitro and In Vivo for Neurodegenerative Disease Therapy

(2016) Tsung-Ying Hsieh et al.   Advanced Healthcare Materials

Degradable polymer-coated gold nanoparticles for co-delivery of DNA and siRNA

(2015) Corey J. Bishop et al.   Acta Biomaterialia

Enhanced blood–brain barrier penetration and glioma therapy mediated by a new peptide modified gene delivery system

(2015) Hui Yao et al.   BIOMATERIALS

Enhanced gene expression in the brain following intravenous administration of lactoferrin-bearing polypropylenimine dendriplex

(2015) Sukrut Somani et al.   JOURNAL OF CONTROLLED RELEASE

Co-delivery of doxorubicin and siRNA for glioma therapy by a brain targeting system: angiopep-2-modified poly(lactic-co-glycolic acid) nanoparticles

(2015) Lei Wang et al.   JOURNAL OF DRUG TARGETING

Gold Nanoparticles Increase Endothelial Paracellular Permeability by Altering Components of Endothelial Tight Junctions, and Increase Blood-Brain Barrier Permeability in Mice

(2015) Ching-Hao Li et al.   TOXICOLOGICAL SCIENCES

Nanoparticle-Mediated Target Delivery of TRAIL as Gene Therapy for Glioblastoma

(2015) Kui Wang et al.   Advanced Healthcare Materials

Multifunctional, self-assembling anionic peptide-lipid nanocomplexes for targeted siRNA delivery

(2014) Aristides D. Tagalakis et al.   BIOMATERIALS

OX26/CTX-conjugated PEGylated liposome as a dual-targeting gene delivery system for brain glioma

(2014) Pei-jian Yue et al.   Molecular Cancer

Delivery of Hypoxia and Glioma Dual-Specific Suicide Gene Using Dexamethasone Conjugated Polyethylenimine for Glioblastoma-Specific Gene Therapy

(2014) Hyun Ah Kim et al.   MOLECULAR PHARMACEUTICS

Co-delivery of 5-fluorocytosine and cytosine deaminase into glioma cells mediated by an intracellular environment-responsive nanovesicle

(2014) Lu Wang et al.   Polymer Chemistry

Gene therapy and DNA delivery systems

(2013) D. Ibraheem et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Tumor suppressor ING4 overexpression contributes to proliferation and invasion inhibition in gastric carcinoma by suppressing the NF-κB signaling pathway

(2013) Shijie Li et al.   MOLECULAR BIOLOGY REPORTS

Angiopep-Conjugated Nanoparticles for Targeted Long-Term Gene Therapy of Parkinson’s Disease

(2013) Rongqin Huang et al.   PHARMACEUTICAL RESEARCH

Spherical Nucleic Acid Nanoparticle Conjugates as an RNAi-Based Therapy for Glioblastoma

(2013) S. A. Jensen et al.   Science Translational Medicine

Therapeutic effect of suicide gene-transferred mesenchymal stem cells in a rat model of glioma

(2012) H Kosaka et al.   CANCER GENE THERAPY

Co-delivery of TRAIL gene enhances the anti-glioblastoma effect of paclitaxel in vitro and in vivo

(2012) Changyou Zhan et al.   JOURNAL OF CONTROLLED RELEASE

Enhanced tumor suppression by an ING4/IL-24 bicistronic adenovirus-mediated gene cotransfer in human non-small cell lung cancer cells

(2011) Y Zhu et al.   CANCER GENE THERAPY

Synergistic antitumor effect of adenovirus-mediated hING4 gene therapy and 125I radiation therapy on pancreatic cancer

(2011) Yaodong Zhao et al.   CANCER LETTERS

MicroRNA profiling of Parkinson's disease brains identifies early downregulation of miR-34b/c which modulate mitochondrial function

(2011) Elena Miñones-Moyano et al.   HUMAN MOLECULAR GENETICS

Downregulation and translocation of nuclear ING4 is correlated with tumorigenesis and progression of head and neck squamous cell carcinoma

(2011) Xiao-han Li et al.   ORAL ONCOLOGY

MicroRNAs in neurodegenerative diseases and their therapeutic potential

(2011) Eunsung Junn et al.   PHARMACOLOGY & THERAPEUTICS

Enhanced antitumor activity by combining an adenovirus harboring ING4 with cisplatin for hepatocarcinoma cells

(2010) Y Xie et al.   CANCER GENE THERAPY

Poly(I:C)-Mediated Tumor Growth Suppression in EGF-Receptor Overexpressing Tumors Using EGF-Polyethylene Glycol-Linear Polyethylenimine as Carrier

(2010) David Schaffert et al.   PHARMACEUTICAL RESEARCH

Gene therapy using lactoferrin-modified nanoparticles in a rotenone-induced chronic Parkinson model

(2009) Rongqin Huang et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation

(2009) Myriam Aouadi et al.   NATURE

miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche

(2009) Li-Chun Cheng et al.   NATURE NEUROSCIENCE

Alterations of the microRNA network cause neurodegenerative disease

(2009) Sébastien S. Hébert et al.   TRENDS IN NEUROSCIENCES

The Inhibitor of Growth (ING) Gene Family: Potential Role in Cancer Therapy

(2008) Mehmet Gunduz et al.   CURRENT CANCER DRUG TARGETS

The ING gene family in the regulation of cell growth and tumorigenesis

(2008) Andrew H. Coles et al.   JOURNAL OF CELLULAR PHYSIOLOGY