Intranasal Delivery of pGDNF DNA Nanoparticles Provides Neuroprotection in the Rat 6-Hydroxydopamine Model of Parkinson’s Disease

DNA Nanoparticles: Detection of Long-Term Transgene Activity in Brain using Bioluminescence Imaging

(2018) David M. Yurek et al.   Molecular Imaging

Intracerebral injections of DNA nanoparticles encoding for a therapeutic gene provide partial neuroprotection in an animal model of neurodegeneration

(2017) David Yurek et al.   Nanomedicine-Nanotechnology Biology and Medicine

Paravascular channels, cisterns, and the subarachnoid space in the rat brain: A single compartment with preferential pathways

(2016) Beatrice Bedussi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Intranasal gene delivery for treating Parkinson’s disease: overcoming the blood–brain barrier

(2015) Amirah E-E Aly et al.   Expert Opinion on Drug Delivery

Rapid Transport within Cerebral Perivascular Spaces Underlies Widespread Tracer Distribution in the Brain after Intranasal Administration

(2015) Jeffrey J Lochhead et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Trophic factors for Parkinson's disease: To live or let die

(2015) C. Warren Olanow et al.   MOVEMENT DISORDERS

Intranasal administration of glial-derived neurotrophic factor (GDNF) rapidly and significantly increases whole-brain GDNF level in rats

(2015) T.S. Bender et al.   NEUROSCIENCE

Intranasal administration of plasmid DNA nanoparticles yields successful transfection and expression of a reporter protein in rat brain

(2014) B T Harmon et al.   GENE THERAPY

Neurotrophic and neuroprotective efficacy of intranasal GDNF in a rat model of Parkinson’s disease

(2014) M.M. Migliore et al.   NEUROSCIENCE

Comparison of Fetal Mesencephalic Grafts, AAV-delivered GDNF, and Both Combined in an MPTP-induced Nonhuman Primate Parkinson’s Model

(2013) D Eugene Redmond et al.   MOLECULAR THERAPY

Safety/feasibility of targeting the substantia nigra with AAV2-neurturin in Parkinson patients

(2013) R. T. Bartus et al.   NEUROLOGY

Intranasal Delivery of HMGB1 siRNA Confers Target Gene Knockdown and Robust Neuroprotection in the Postischemic Brain

(2012) Il-Doo Kim et al.   MOLECULAR THERAPY

Intranasal delivery of biologics to the central nervous system

(2011) Jeffrey J. Lochhead et al.   ADVANCED DRUG DELIVERY REVIEWS

Intranasal delivery of therapeutic proteins for neurological diseases

(2011) Francesca Malerba et al.   Expert Opinion on Drug Delivery

Transgene expression in the striatum following intracerebral injections of DNA nanoparticles encoding for human glial cell line-derived neurotrophic factor

(2011) A.M. Fletcher et al.   NEUROSCIENCE

A new approach with less damage: intranasal delivery of tetracycline-inducible replication-defective herpes simplex virus type-1 vector to brain

(2011) Y. Jiang et al.   NEUROSCIENCE

Gene delivery to mitotic and postmitotic photoreceptors via compacted DNA nanoparticles results in improved phenotype in a mouse model of retinitis pigmentosa

(2009) Xue Cai et al.   FASEB JOURNAL

Brain delivery of proteins by the intranasal route of administration: A comparison of cationic liposomes versus aqueous solution formulations

(2009) Mattia M. Migliore et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Intranasal delivery to the central nervous system: Mechanisms and experimental considerations

(2009) Shyeilla V. Dhuria et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Long-term Transgene Expression in the Central Nervous System Using DNA Nanoparticles

(2009) David M Yurek et al.   MOLECULAR THERAPY

Nigrostriatal rAAV-mediated GDNF Overexpression Induces Robust Weight Loss in a Rat Model of Age-related Obesity

(2009) Fredric P Manfredsson et al.   MOLECULAR THERAPY

GDNF isoform affects intracellular trafficking and secretion of GDNF in neuronal cells

(2008) Yue Wang et al.   BRAIN RESEARCH

Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2–neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial

(2008) William J Marks et al.   LANCET NEUROLOGY

Delivery of interferon-β to the monkey nervous system following intranasal administration

(2008) R.G. Thorne et al.   NEUROSCIENCE