Validation and development of MTH1 inhibitors for treatment of cancer

Identification of potent and selective MTH1 inhibitors

(2016) Alessia Petrocchi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition

(2016) Lars Bräutigam et al.   CANCER RESEARCH

Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutations

(2016) Niels Frank Jensen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival

(2016) Jason G. Kettle et al.   JOURNAL OF MEDICINAL CHEMISTRY

Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival

(2016) Tatsuro Kawamura et al.   Scientific Reports

Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2

(2015) Megan Carter et al.   Nature Communications

Melanoma patient-derived xenografts accurately model the disease and develop fast enough to guide treatment decisions

(2015) Berglind O. Einarsdottir et al.   Oncotarget

Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy

(2014) Kilian V. M. Huber et al.   NATURE

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

(2014) Helge Gad et al.   NATURE

The cellular thermal shift assay for evaluating drug target interactions in cells

(2014) Rozbeh Jafari et al.   Nature Protocols

MutT Homolog 1 (MTH1) maintains multiple KRAS-driven pro-malignant pathways

(2014) A Patel et al.   ONCOGENE

Tracking cancer drugs in living cells by thermal profiling of the proteome

(2014) M. M. Savitski et al.   SCIENCE

Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors

(2012) J. Murai et al.   CANCER RESEARCH

Human MTH3 (NUDT18) Protein Hydrolyzes Oxidized Forms of Guanosine and Deoxyguanosine Diphosphates

(2012) Yasumitsu Takagi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE