Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2

InheritedNUDT15Variant Is a Genetic Determinant of Mercaptopurine Intolerance in Children With Acute Lymphoblastic Leukemia

(2015) Jun J. Yang et al.   JOURNAL OF CLINICAL ONCOLOGY

Preventive DNA repair by sanitizing the cellular (deoxy)nucleoside triphosphate pool

(2014) Gergely N. Nagy et al.   FEBS Journal

Cellular Levels of 8-Oxoguanine in either DNA or the Nucleotide Pool Play Pivotal Roles in Carcinogenesis and Survival of Cancer Cells

(2014) Yusaku Nakabeppu   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy

(2014) Kilian V. M. Huber et al.   NATURE

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

(2014) Helge Gad et al.   NATURE

A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia

(2014) Suk-Kyun Yang et al.   NATURE GENETICS

DNA-Damaging Agents in Cancer Chemotherapy: Serendipity and Chemical Biology

(2013) Kahlin Cheung-Ong et al.   CHEMISTRY & BIOLOGY

Human MTH3 (NUDT18) Protein Hydrolyzes Oxidized Forms of Guanosine and Deoxyguanosine Diphosphates

(2012) Yasumitsu Takagi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Redox Control of the Survival of Healthy and Diseased Cells

(2011) Yuxing Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Crystal structure of human MTH1 and the 8-oxo-dGMP product complex

(2011) Linda M. Svensson et al.   FEBS LETTERS

Diverse substrate recognition and hydrolysis mechanisms of human NUDT5

(2011) Takao Arimori et al.   NUCLEIC ACIDS RESEARCH

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Suppression of mutagenesis by 8-hydroxy-2′-deoxyguanosine 5′-triphosphate (7,8-dihydro-8-oxo-2′-deoxyguanosine 5′-triphosphate) by human MTH1, MTH2, and NUDT5

(2010) Mika Hori et al.   FREE RADICAL BIOLOGY AND MEDICINE

Enhanced elimination of oxidized guanine nucleotides inhibits oncogenic RAS-induced DNA damage and premature senescence

(2010) P Rai et al.   ONCOGENE

Molecular replacement withMOLREP

(2009) Alexei Vagin et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

DAMMIF, a program for rapidab-initioshape determination in small-angle scattering

(2009) Daniel Franke et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY