Tracking cancer drugs in living cells by thermal profiling of the proteome

Ion Coalescence of Neutron Encoded TMT 10-Plex Reporter Ions

(2014) Thilo Werner et al.   ANALYTICAL CHEMISTRY

Overcoming the resistance to Crizotinib in patients with Non-Small Cell Lung Cancer harboring EML4/ALK translocation

(2014) Cesar A. Perez et al.   LUNG CANCER

Mass-spectrometry-based draft of the human proteome

(2014) Mathias Wilhelm et al.   NATURE

Minimal, encapsulated proteomic-sample processing applied to copy-number estimation in eukaryotic cells

(2014) Nils A Kulak et al.   NATURE METHODS

Vemurafenib: an unusual UVA-induced photosensitivity

(2013) Pauline Gelot et al.   EXPERIMENTAL DERMATOLOGY

Characterization of the Novel Broad-Spectrum Kinase Inhibitor CTx-0294885 As an Affinity Reagent for Mass Spectrometry-Based Kinome Profiling

(2013) Luxi Zhang et al.   JOURNAL OF PROTEOME RESEARCH

Measuring and Managing Ratio Compression for Accurate iTRAQ/TMT Quantification

(2013) Mikhail M. Savitski et al.   JOURNAL OF PROTEOME RESEARCH

Determining target engagement in living systems

(2013) Gabriel M Simon et al.   Nature Chemical Biology

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

(2013) D. M. Molina et al.   SCIENCE

Erythroid Heme Biosynthesis and Its Disorders

(2013) H. A. Dailey et al.   Cold Spring Harbor Perspectives in Medicine

Affinity Profiling of the Cellular Kinome for the Nucleotide Cofactors ATP, ADP, and GTP

(2012) Isabelle Becher et al.   ACS Chemical Biology

High-Resolution Enabled TMT 8-plexing

(2012) Thilo Werner et al.   ANALYTICAL CHEMISTRY

Mass Spectrometry–Based Proteomics and Network Biology

(2012) Ariel Bensimon et al.   Annual Review of Biochemistry

Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer

(2012) James S. Duncan et al.   CELL

Direct identification of ligand-receptor interactions on living cells and tissues

(2012) Andreas P Frei et al.   NATURE BIOTECHNOLOGY

Systems-pharmacology dissection of a drug synergy in imatinib-resistant CML

(2012) Georg E Winter et al.   Nature Chemical Biology

Structure and Allostery of the PKA RII  Tetrameric Holoenzyme

(2012) P. Zhang et al.   SCIENCE

Delayed Fragmentation and Optimized Isolation Width Settings for Improvement of Protein Identification and Accuracy of Isobaric Mass Tag Quantification on Orbitrap-Type Mass Spectrometers

(2011) Mikhail M. Savitski et al.   ANALYTICAL CHEMISTRY

Quantitative, High-Resolution Proteomics for Data-Driven Systems Biology

(2011) Jürgen Cox et al.   Annual Review of Biochemistry

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

(2011) Marcus Bantscheff et al.   NATURE BIOTECHNOLOGY

A Novel p53 Phosphorylation Site within the MDM2 Ubiquitination Signal

(2010) Jennifer A. Fraser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted data acquisition for improved reproducibility and robustness of proteomic mass spectrometry assays

(2010) Mikhail M. Savitski et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Chemoproteomics-based kinome profiling and target deconvolution of clinical multi-kinase inhibitors in primary chronic lymphocytic leukemia cells

(2010) U Kruse et al.   LEUKEMIA

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

(2010) Gideon Bollag et al.   NATURE

Protein folding stability and dynamics imaged in a living cell

(2010) Simon Ebbinghaus et al.   NATURE METHODS

GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists

(2009) Eran Eden et al.   BMC BIOINFORMATICS

Skin Ferrochelatase and Photosensitivity in Mice and Man

(2009) Staffan Wahlin et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Comparison of imatinib, dasatinib, nilotinib and INNO-406 in imatinib-resistant cell lines

(2008) Yasuyuki Deguchi et al.   LEUKEMIA RESEARCH

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY