Delineating the Role of Helical Intermediates in Natively Unfolded Polypeptide Amyloid Assembly and Cytotoxicity

Islet Amyloid-Induced Cell Death and Bilayer Integrity Loss Share a Molecular Origin Targetable with Oligopyridylamide-Based α-Helical Mimetics

(2015) Sunil Kumar et al.   CHEMISTRY & BIOLOGY

Secondary conformational conversion is involved in glycosaminoglycans-mediated cellular uptake of the cationic cell-penetrating peptide PACAP

(2014) Armelle Tchoumi Neree et al.   FEBS LETTERS

New insights into the roles of sulfated glycosaminoglycans in islet amyloid polypeptide amyloidogenesis and cytotoxicity

(2013) Carole Anne De Carufel et al.   BIOPOLYMERS

Islet amyloid: From fundamental biophysics to mechanisms of cytotoxicity

(2013) Ping Cao et al.   FEBS LETTERS

Mechanism of IAPP amyloid fibril formation involves an intermediate with a transient  -sheet

(2013) L. E. Buchanan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Islet amyloid polypeptide toxicity and membrane interactions

(2013) P. Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane Disruption and Early Events in the Aggregation of the Diabetes Related Peptide IAPP from a Molecular Perspective

(2011) Jeffrey R. Brender et al.   ACCOUNTS OF CHEMICAL RESEARCH

A Membrane-Bound Antiparallel Dimer of Rat Islet Amyloid Polypeptide

(2011) Abhinav Nath et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mechanisms of transthyretin cardiomyocyte toxicity inhibition by resveratrol analogs

(2011) Steve Bourgault et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structure and membrane orientation of IAPP in its natively amidated form at physiological pH in a membrane environment

(2011) Ravi Prakash Reddy Nanga et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Biphasic Effects of Insulin on Islet Amyloid Polypeptide Membrane Disruption

(2011) Jeffrey R. Brender et al.   BIOPHYSICAL JOURNAL

Concentration-dependent transitions govern the subcellular localization of islet amyloid polypeptide

(2011) Mazin Magzoub et al.   FASEB JOURNAL

The Amyloid Formation Mechanism in Human IAPP: Dimers Have β-Strand Monomer−Monomer Interfaces

(2011) Nicholas F. Dupuis et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus

(2011) Per Westermark et al.   PHYSIOLOGICAL REVIEWS

Islet amyloid polypeptide demonstrates a persistent capacity to disrupt membrane integrity

(2011) N. B. Last et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic α-Helix Mimetics as Agonists and Antagonists of Islet Amyloid Polypeptide Aggregation

(2009) Ishu Saraogi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Peptidomimetic Approach to Targeting Pre-amyloidogenic States in Type II Diabetes

(2009) James A. Hebda et al.   CHEMISTRY & BIOLOGY

Dynamic α-Helix Structure of Micelle-bound Human Amylin

(2009) Sharadrao M. Patil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Helix Stabilization Precedes Aqueous and Bilayer-Catalyzed Fiber Formation in Islet Amyloid Polypeptide

(2009) Jessica A. Williamson et al.   JOURNAL OF MOLECULAR BIOLOGY

Three-Dimensional Structure and Orientation of Rat Islet Amyloid Polypeptide Protein in a Membrane Environment by Solution NMR Spectroscopy

(2009) Ravi Prakash Reddy Nanga et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Association of Highly Compact Type II Diabetes Related Islet Amyloid Polypeptide Intermediate Species at Physiological Temperature Revealed by Diffusion NMR Spectroscopy

(2009) Ronald Soong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Human Islet Amyloid Polypeptide Monomers Form Ordered β-hairpins: A Possible Direct Amyloidogenic Precursor

(2009) Nicholas F. Dupuis et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A critical assessment of the role of helical intermediates in amyloid formation by natively unfolded proteins and polypeptides

(2009) A. Abedini et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Structure of α-Helical Membrane-bound Human Islet Amyloid Polypeptide and Its Implications for Membrane-mediated Misfolding

(2008) Melania Apostolidou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY