Inhibition of the sphingosine‐1‐phosphate pathway promotes the resolution of neutrophilic inflammation

De novo synthesis of sphingolipids is essential for decidualization in mice

(2018) Nai-Zheng Ding et al.   THERIOGENOLOGY

Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer’s Disease

(2018) Ju Youn Lee et al.   Nature Communications

Sphingosine-1 phosphate promotes intestinal epithelial cell proliferation via S1PR2

(2017) Huiping Zhou   Frontiers in Bioscience-Landmark

Population pharmacokinetics of moxifloxacin, cycloserine, p -aminosalicylic acid and kanamycin for the treatment of multi-drug-resistant tuberculosis

(2017) Min Jung Chang et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Neutrophil Elastase Regulates Emergency Myelopoiesis Preceding Systemic Inflammation in Diet-induced Obesity

(2017) Jun-Yuan Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discordant American College of Physicians and international rheumatology guidelines for gout management: consensus statement of the Gout, Hyperuricemia and Crystal-Associated Disease Network (G-CAN)

(2017) Nicola Dalbeth et al.   Nature Reviews Rheumatology

Vitamin D attenuates sphingosine-1-phosphate (S1P)-mediated inhibition of extravillous trophoblast migration

(2017) Melissa Westwood et al.   PLACENTA

β-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares

(2017) Emily L. Goldberg et al.   Cell Reports

Reprogramming mitochondrial metabolism in macrophages as an anti-inflammatory signal

(2016) Evanna L. Mills et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Novel Resolvin D2 Receptor Axis in Infectious Inflammation

(2016) Nan Chiang et al.   JOURNAL OF IMMUNOLOGY

Proresolving Actions of Synthetic and Natural Protease Inhibitors Are Mediated by Annexin A1

(2016) Juliana P. Vago et al.   JOURNAL OF IMMUNOLOGY

Sphingosine-1-phosphate receptor-1 (S1P1) is expressed by lymphocytes, dendritic cells and endothelium and modulated during inflammatory bowel disease

(2016) T Karuppuchamy et al.   Mucosal Immunology

Resolution of inflammation: a new therapeutic frontier

(2016) James N. Fullerton et al.   NATURE REVIEWS DRUG DISCOVERY

Nitric oxide-mediated apoptosis of neutrophils through caspase-8 and caspase-3-dependent mechanism

(2016) Megha Dubey et al.   Cell Death & Disease

Neutrophil Extracellular Traps Form a Barrier between Necrotic and Viable Areas in Acute Abdominal Inflammation

(2016) Rostyslav Bilyy et al.   Frontiers in Immunology

Antinociceptive effects of FTY720 during trauma-induced neuropathic pain are mediated by spinal S1P receptors

(2015) Dong Dong Zhang et al.   BIOLOGICAL CHEMISTRY

Implementing guidelines on reporting research using animals (ARRIVE etc.): new requirements for publication in BJP

(2015) John C McGrath et al.   BRITISH JOURNAL OF PHARMACOLOGY

Increased sphingosine 1-phosphate mediates inflammation and fibrosis in tubular injury in diabetic nephropathy

(2015) Dania Yaghobian et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Damage-associated molecular pattern-activated neutrophil extracellular trap exacerbates sterile inflammatory liver injury

(2015) Hai Huang et al.   HEPATOLOGY

The sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 axis regulates early airway T-cell infiltration in murine mast cell–dependent acute allergic responses

(2015) Carole A. Oskeritzian et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Role and Effects of Glucocorticoid-Induced Leucine Zipper in the Context of Inflammation Resolution

(2015) Juliana P. Vago et al.   JOURNAL OF IMMUNOLOGY

Rapid externalization of 27-kDa heat shock protein (HSP27) and atypical cell death in neutrophils treated with the sphingolipid analog drug FTY720

(2015) J. Skrzeczynska-Moncznik et al.   JOURNAL OF LEUKOCYTE BIOLOGY

SphK1 mediates hepatic inflammation in a mouse model of NASH induced by high saturated fat feeding and initiates proinflammatory signaling in hepatocytes

(2015) Tuoyu Geng et al.   JOURNAL OF LIPID RESEARCH

Macrophage SR-BI mediates efferocytosis via Src/PI3K/Rac1 signaling and reduces atherosclerotic lesion necrosis

(2015) Huan Tao et al.   JOURNAL OF LIPID RESEARCH

Cardio-protective effects of pentraxin 3 produced from bone marrow-derived cells against ischemia/reperfusion injury

(2015) Takeshi Shimizu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

FTY720 induces autophagy-related apoptosis and necroptosis in human glioblastoma cells

(2015) Li Zhang et al.   TOXICOLOGY LETTERS

Induction of eosinophil apoptosis by hydrogen peroxide promotes the resolution of allergic inflammation

(2015) A C Reis et al.   Cell Death & Disease

Discovering Molecules That Regulate Efferocytosis Using Primary Human Macrophages and High Content Imaging

(2015) Sandra Santulli-Marotto et al.   PLoS One

Resolution of acute inflammation bridges the gap between innate and adaptive immunity

(2014) J. Newson et al.   BLOOD

Fingolimod (FTY720) therapy in Japanese patients with relapsing multiple sclerosis over 12 months: results of a phase 2 observational extension

(2014) Jun-ichi Kira et al.   BMC Neurology

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

(2014) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Neutrophils Exhibit Differential Requirements for Homing Molecules in Their Lymphatic and Blood Trafficking into Draining Lymph Nodes

(2014) Carolina V. Gorlino et al.   JOURNAL OF IMMUNOLOGY

Tumor necrosis factor-related apoptosis-inducing ligand mediates the resolution of allergic airway inflammation induced by chronic allergen inhalation

(2014) L Faustino et al.   Mucosal Immunology

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

Eosinophils in the Lung – Modulating Apoptosis and Efferocytosis in Airway Inflammation

(2014) Jennifer M. Felton et al.   Frontiers in Immunology

Critical role of sphingosine-1-phosphate receptor 2 (S1PR2) in acute vascular inflammation

(2013) G. Zhang et al.   BLOOD

Rapid αβ T-cell responses orchestrate innate immunity in response to Staphylococcal enterotoxin A

(2013) S Kumar et al.   Mucosal Immunology

Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators

(2012) J. Dalli et al.   BLOOD

Identification of novel functional and spatial associations between sphingosine kinase 1, sphingosine 1-phosphate receptors and other signaling proteins that affect prognostic outcome in estrogen receptor-positive breast cancer

(2012) Jan Ohotski et al.   INTERNATIONAL JOURNAL OF CANCER

Annexin A1 modulates natural and glucocorticoid-induced resolution of inflammation by enhancing neutrophil apoptosis

(2012) Juliana P. Vago et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Structure of the First Sphingosine 1-Phosphate Receptor

(2012) A. L. Parrill et al.   Science Signaling

New Lives Given by Cell Death: Macrophage Differentiation Following Their Encounter with Apoptotic Leukocytes during the Resolution of Inflammation

(2012) Amiram Ariel et al.   Frontiers in Immunology

Sphingosine-1-phosphate facilitates trafficking of hematopoietic stem cells and their mobilization by CXCR4 antagonists in mice

(2011) J. G. Juarez et al.   BLOOD

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

(2011) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Regulation of Mammalian Physiology, Development, and Disease by the Sphingosine 1-Phosphate and Lysophosphatidic Acid Receptors

(2011) Victoria A. Blaho et al.   CHEMICAL REVIEWS

Signaling via Macrophage G2A Enhances Efferocytosis of Dying Neutrophils by Augmentation of Rac Activity

(2011) S. Courtney Frasch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine-1-Phosphate Modulates Vascular Permeability and Cell Recruitment in Acute Inflammation In Vivo

(2011) F. Roviezzo et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Sphingosine 1-phosphate in coagulation and inflammation

(2011) Hideru Obinata et al.   Seminars in Immunopathology

Sphingosine-1-phosphate is increased in patients with idiopathic pulmonary fibrosis and mediates epithelial to mesenchymal transition

(2011) Javier Milara et al.   THORAX

Mechanism of Action of Oral Fingolimod (FTY720) in Multiple Sclerosis

(2010) Jerold Chun et al.   CLINICAL NEUROPHARMACOLOGY

Targeting granulocyte apoptosis: mechanisms, models, and therapies

(2010) Rodger Duffin et al.   IMMUNOLOGICAL REVIEWS

PDE4 inhibition drives resolution of neutrophilic inflammation by inducing apoptosis in a PKA-PI3K/Akt-dependent and NF-κB-independent manner

(2010) Lirlândia P. Sousa et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Improving bioscience research reporting: ARRIVE-ing at a solution

(2010) C Kilkenny et al.   LABORATORY ANIMALS

A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis

(2010) Ludwig Kappos et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis

(2010) Jeffrey A. Cohen et al.   NEW ENGLAND JOURNAL OF MEDICINE

FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation

(2010) J. W. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Effects of Sphingosine 1–Phosphate Receptors on Airway and Vascular Barrier Function in the Murine Lung

(2009) Saad Sammani et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Sphingosine-1-phosphate increases human alveolar epithelial IL-8 secretion, proliferation and neutrophil chemotaxis

(2009) Javier Milara et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Distinct Roles of Sphingosine Kinase 1 and 2 in Murine Collagen-Induced Arthritis

(2009) W.-Q. Lai et al.   JOURNAL OF IMMUNOLOGY

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY