PDE4 inhibition drives resolution of neutrophilic inflammation by inducing apoptosis in a PKA-PI3K/Akt-dependent and NF-κB-independent manner

Cyclic AMP enhances resolution of allergic pleurisy by promoting inflammatory cell apoptosis via inhibition of PI3K/Akt and NF-κB

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Regulation of neutrophil apoptosis by modulation of PKB/Akt activation

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Inhibition of cAMP Degradation Improves Regulatory T Cell-Mediated Suppression

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Cyclic AMP

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Caspase activation cascades in apoptosis

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Novel biphasic role for lymphocytes revealed during resolving inflammation

(2008) R. Rajakariar et al.   BLOOD

Resolution-phase macrophages possess a unique inflammatory phenotype that is controlled by cAMP

(2008) J. Bystrom et al.   BLOOD

Macrophage phagocytosis of apoptotic neutrophils is critically regulated by the opposing actions of pro-inflammatory and anti-inflammatory agents: key role for TNF-α

(2008) Sylwia Michlewska et al.   FASEB JOURNAL

A Novel Epac-Rap-PP2A Signaling Module Controls cAMP-dependent Akt Regulation

(2008) Kyoungja Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacological PKA Inhibition: All May Not Be What It Seems

(2008) A. J. Murray   Science Signaling

Novel pharmacological strategies for driving inflammatory cell apoptosis and enhancing the resolution of inflammation

(2008) John M. Hallett et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Phosphodiesterase 4 inhibitors delay human eosinophil and neutrophil apoptosis in the absence and presence of salbutamol

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