Novel Therapeutic Effects of Leonurine On Ischemic Stroke: New Mechanisms of BBB Integrity

Clematichinenoside protects blood brain barrier against ischemic stroke superimposed on systemic inflammatory challenges through up-regulating A20

(2016) Dan Han et al.   BRAIN BEHAVIOR AND IMMUNITY

HDAC9 exacerbates endothelial injury in cerebral ischaemia/reperfusion injury

(2016) Weichen Shi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Cellular response of the blood-brain barrier to injury: Potential biomarkers and therapeutic targets for brain regeneration

(2016) M.M. Tenreiro et al.   NEUROBIOLOGY OF DISEASE

Gp130-mediated STAT3 activation by S-propargyl-cysteine, an endogenous hydrogen sulfide initiator, prevents doxorubicin-induced cardiotoxicity

(2016) J Wu et al.   Cell Death & Disease

Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury

(2016) Yejie Shi et al.   Nature Communications

Role of NADPH oxidase in the regulation of autophagy in cardiomyocytes

(2015) Sebastiano Sciarretta et al.   CLINICAL SCIENCE

Excess salt exacerbates blood-brain barrier disruption via a p38/MAPK/SGK1-dependent pathway in permanent cerebral ischemia

(2015) Tongshuai Zhang et al.   Scientific Reports

Rational modulation of the innate immune system for neuroprotection in ischemic stroke

(2015) Diana Amantea et al.   Frontiers in Neuroscience

Compromised blood-brain barrier competence in remote brain areas in ischemic stroke rats at the chronic stage

(2014) Svitlana Garbuzova-Davis et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Calycosin-7-O-β-d-glucoside regulates nitric oxide /caveolin-1/matrix metalloproteinases pathway and protects blood–brain barrier integrity in experimental cerebral ischemia–reperfusion injury

(2014) Shuping Fu et al.   JOURNAL OF ETHNOPHARMACOLOGY

The pathobiology of diabetic vascular complications—cardiovascular and kidney disease

(2014) Stephen P. Gray et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Hydrogen sulfide protects blood-brain barrier integrity following cerebral ischemia

(2014) Yali Wang et al.   JOURNAL OF NEUROCHEMISTRY

Stepwise Recruitment of Transcellular and Paracellular Pathways Underlies Blood-Brain Barrier Breakdown in Stroke

(2014) Daniel Knowland et al.   NEURON

Tramiprosate protects neurons against ischemic stroke by disrupting the interaction between PSD95 and nNOS

(2014) Shuangchan Wu et al.   NEUROPHARMACOLOGY

Non-pharmaceutical therapies for stroke: Mechanisms and clinical implications

(2014) Fan Chen et al.   PROGRESS IN NEUROBIOLOGY

Astragaloside IV reduces cerebral edema post-ischemia/reperfusion correlating the suppression of MMP-9 and AQP4

(2013) Min Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inhibition of NADPH oxidase 4-related signaling by sodium hydrosulfide attenuates myocardial fibrotic response

(2013) Li-Long Pan et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The tension mounts: Stress fibers as force-generating mechanotransducers

(2013) Keith Burridge et al.   JOURNAL OF CELL BIOLOGY

HDAC4/5-HMGB1 signalling mediated by NADPH oxidase activity contributes to cerebral ischaemia/reperfusion injury

(2013) Min He et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Hemorrhagic Transformation after Ischemic Stroke in Animals and Humans

(2013) Glen C Jickling et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Moderate Hypoxia Followed by Reoxygenation Results in Blood-Brain Barrier Breakdown via Oxidative Stress-Dependent Tight-Junction Protein Disruption

(2013) Christoph M. Zehendner et al.   PLoS One

Matrix Metalloproteinases and Blood-Brain Barrier Disruption in Acute Ischemic Stroke

(2013) Shaheen E. Lakhan et al.   Frontiers in Neurology

Neuroprotection After Stroke by Targeting NOX4 As a Source of Oxidative Stress

(2012) Kim A. Radermacher et al.   ANTIOXIDANTS & REDOX SIGNALING

Biochemistry, Physiology, and Pathophysiology of NADPH Oxidases in the Cardiovascular System

(2012) Bernard Lassègue et al.   CIRCULATION RESEARCH

Cerebralcare Granule® attenuates blood–brain barrier disruption after middle cerebral artery occlusion in rats

(2012) Ping Huang et al.   EXPERIMENTAL NEUROLOGY

Leonurine (SCM-198) attenuates myocardial fibrotic response via inhibition of NADPH oxidase 4

(2012) Xin-Hua Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Glibenclamide Enhances Neurogenesis and Improves Long-Term Functional Recovery after Transient Focal Cerebral Ischemia

(2012) Francisco J Ortega et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The inhibitory effect of S-nitrosoglutathione on blood-brain barrier disruption and peroxynitrite formation in a rat model of experimental stroke

(2012) Mushfiquddin Khan et al.   JOURNAL OF NEUROCHEMISTRY

Matrix Metalloproteinase-2-Mediated Occludin Degradation and Caveolin-1-Mediated Claudin-5 Redistribution Contribute to Blood-Brain Barrier Damage in Early Ischemic Stroke Stage

(2012) J. Liu et al.   JOURNAL OF NEUROSCIENCE

Pharmacological inhibition of TLR4-NOX4 signal protects against neuronal death in transient focal ischemia

(2012) Yukiya Suzuki et al.   Scientific Reports

Leonurine protects against tumor necrosis factor-α-mediated inflammation in human umbilical vein endothelial cells

(2011) Xinhua Liu et al.   ATHEROSCLEROSIS

Matrix metalloproteinases as drug targets in ischemia/reperfusion injury

(2011) Eline Dejonckheere et al.   DRUG DISCOVERY TODAY

Nrf2 regulates hyperoxia-induced Nox4 expression in human lung endothelium: Identification of functional antioxidant response elements on the Nox4 promoter

(2011) Srikanth Pendyala et al.   FREE RADICAL BIOLOGY AND MEDICINE

Histone deacetylase inhibition activates transcription factor Nrf2 and protects against cerebral ischemic damage

(2011) Bing Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of myocardial growth and death by NADPH oxidase

(2011) Yasuhiro Maejima et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Engaging neuroscience to advance translational research in brain barrier biology

(2011) Edward A. Neuwelt et al.   NATURE REVIEWS NEUROSCIENCE

Transcriptional regulation of NADPH oxidase isoforms, Nox1 and Nox4, by nuclear factor-κB in human aortic smooth muscle cells

(2010) Adrian Manea et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Crucial Role of Nrf3 in Smooth Muscle Cell Differentiation From Stem Cells

(2010) Anna Elena Pepe et al.   CIRCULATION RESEARCH

The NADPH Oxidase Subunit NOX4 Is a New Target Gene of the Hypoxia-inducible Factor-1

(2010) Isabel Diebold et al.   MOLECULAR BIOLOGY OF THE CELL

Leonurine Protects Middle Cerebral Artery Occluded Rats Through Antioxidant Effect and Regulation of Mitochondrial Function

(2010) Kok Poh Loh et al.   STROKE

Targeting the correct HDAC(s) to treat cognitive disorders

(2010) André Fischer et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Post-Stroke Inhibition of Induced NADPH Oxidase Type 4 Prevents Oxidative Stress and Neurodegeneration

(2010) Christoph Kleinschnitz et al.   PLOS BIOLOGY

JAK/STAT Signaling Pathway Regulates Nox1 and Nox4-Based NADPH Oxidase in Human Aortic Smooth Muscle Cells

(2009) Adrian Manea et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cerebral protection of purified Herba Leonuri extract on middle cerebral artery occluded rats

(2009) Kok Poh Loh et al.   JOURNAL OF ETHNOPHARMACOLOGY

HDAC4 Regulates Neuronal Survival in Normal and Diseased Retinas

(2009) B. Chen et al.   SCIENCE

Regulation of Endothelial Junctional Permeability

(2008) Emily Vandenbroucke et al.   Annals of the New York Academy of Sciences

Positive regulation of the NADPH oxidase NOX4 promoter in vascular smooth muscle cells by E2F

(2008) Li Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE