Cancer-associated mesenchymal stroma fosters the stemness of osteosarcoma cells in response to intratumoral acidosis via NF-κB activation

Tumor Stroma Manipulation By MSC

(2016) Giulia Grisendi et al.   CURRENT DRUG TARGETS

The immunomodulatory function of mesenchymal stem cells: mode of action and pathways

(2015) Antonio Uccelli et al.   Annals of the New York Academy of Sciences

CXCR1 knockdown improves the sensitivity of osteosarcoma to cisplatin

(2015) Xiu-guo Han et al.   CANCER LETTERS

High EMT Signature Score of Invasive Non-Small Cell Lung Cancer (NSCLC) Cells Correlates with NFκB Driven Colony-Stimulating Factor 2 (CSF2/GM-CSF) Secretion by Neighboring Stromal Fibroblasts

(2015) Albin Rudisch et al.   PLoS One

Chronic acidosis in the tumour microenvironment selects for overexpression of LAMP2 in the plasma membrane

(2015) Mehdi Damaghi et al.   Nature Communications

Microenvironmental Targets in Sarcoma

(2015) Monika Ehnman et al.   Frontiers in Oncology

Acidosis promotes invasiveness of breast cancer cells through ROS-AKT-NF-κB pathway

(2015) Subash C. Gupta et al.   Oncotarget

Role of mesenchymal stem cells in osteosarcoma and metabolic reprogramming of tumor cells

(2015) Gloria Bonuccelli et al.   Oncotarget

Canine Osteosarcoma: A Naturally Occurring Disease to Inform Pediatric Oncology

(2014) J. M. Fenger et al.   ILAR JOURNAL

The roles of mesenchymal stem cells in tumor inflammatory microenvironment

(2014) Zhao Sun et al.   Journal of Hematology & Oncology

Carbonic anhydrase IX, a hypoxia-induced catalytic component of the pH regulating machinery in tumors

(2014) Olga Sedlakova   Frontiers in Physiology

Cancer Associated Fibroblasts express pro-inflammatory factors in human breast and ovarian tumors

(2013) Neta Erez et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

V-ATPase is a candidate therapeutic target for Ewing sarcoma

(2013) Sofia Avnet et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

V-ATPase as an effective therapeutic target for sarcomas

(2013) Francesca Perut et al.   EXPERIMENTAL CELL RESEARCH

Effect of the cytokine levels in serum on osteosarcoma

(2013) Hong Xiao et al.   TUMOR BIOLOGY

Mesenchymal stem cells regulate epithelial-mesenchymal transition and tumor progression of pancreatic cancer cells

(2012) Ayano Kabashima-Niibe et al.   CANCER SCIENCE

Mesenchymal Stem Cells Provide an Advantageous Tumor Microenvironment for the Restoration of Cancer Stem Cells

(2012) Kanako Nishimura et al.   PATHOBIOLOGY

Bone Marrow-Derived Myofibroblasts Contribute to the Mesenchymal Stem Cell Niche and Promote Tumor Growth

(2011) Michael Quante et al.   CANCER CELL

Breast Cancer Stem Cells Are Regulated by Mesenchymal Stem Cells through Cytokine Networks

(2011) Suling Liu et al.   CANCER RESEARCH

Higher BMP receptor expression and BMP-2-induced osteogenic differentiation in tendon-derived stem cells compared with bone-marrow-derived mesenchymal stem cells

(2011) Yun Feng Rui et al.   INTERNATIONAL ORTHOPAEDICS

Human ovarian carcinoma–associated mesenchymal stem cells regulate cancer stem cells and tumorigenesis via altered BMP production

(2011) Karen McLean et al.   JOURNAL OF CLINICAL INVESTIGATION

Extracellular acidification stimulates IL-6 production and Ca2+ mobilization through proton-sensing OGR1 receptors in human airway smooth muscle cells

(2010) Isao Ichimonji et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Bone sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

(2010) P. C. W. Hogendoorn et al.   ANNALS OF ONCOLOGY

Human mesenchymal stem cells promote growth of osteosarcoma: Involvement of interleukin-6 in the interaction between human mesenchymal stem cells and Saos-2

(2010) Zhen-Yu Bian et al.   CANCER SCIENCE

The reverse Warburg Effect: Glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts

(2010) Gloria Bonuccelli et al.   CELL CYCLE

Mesenchymal stromal cells from primary osteosarcoma are non-malignant and strikingly similar to their bone marrow counterparts

(2010) Jan C. Brune et al.   INTERNATIONAL JOURNAL OF CANCER

Increased Number of Mesenchymal Stem Cell-like Cells in Peripheral Blood of Patients with Bone Sarcomas

(2009) Zhen-Yu Bian et al.   ARCHIVES OF MEDICAL RESEARCH

Human mesenchymal stem cells (hMSCs) target osteosarcoma and promote its growth and pulmonary metastasis

(2009) Wen-ting Xu et al.   CANCER LETTERS

Cancer cells, adipocytes and matrix metalloproteinase 11: a vicious tumor progression cycle

(2008) Elena Roza Motrescu et al.   BIOLOGICAL CHEMISTRY

Acidic pH stimulates the production of the angiogenic CXC chemokine, CXCL8 (interleukin‐8), in human adult mesenchymal stem cells via the extracellular signal‐regulated kinase, p38 mitogen‐activated protein kinase, and NF‐κB pathways

(2008) David S. Bischoff et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The tumor microenvironment and its role in promoting tumor growth

(2008) T L Whiteside   ONCOGENE

CANCER BIOLOGY: All in the Stroma: Cancer's Cosa Nostra

(2008) J. Marx   SCIENCE