Boolean network modeling of β-cell apoptosis and insulin resistance in type 2 diabetes mellitus

Inhibition of FOXO1 transcription factor in primary human adipocytes mimics the insulin-resistant state of type 2 diabetes

(2018) Meenu R. Rajan et al.   BIOCHEMICAL JOURNAL

Modeling signaling‐dependent pluripotency with Boolean logic to predict cell fate transitions

(2018) Ayako Yachie‐Kinoshita et al.   Molecular Systems Biology

A long-term mechanistic computational model of physiological factors driving the onset of type 2 diabetes in an individual

(2018) Joydeep Sarkar et al.   PLoS One

Tumor Necrosis Factor-Alpha: Role in Development of Insulin Resistance and Pathogenesis of Type 2 Diabetes Mellitus

(2017) Muhammad Sajid Hamid Akash et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

(2014) Rachel J. Perry et al.   NATURE

Targeting inflammation in the treatment of type 2 diabetes: time to start

(2014) Marc Y. Donath   NATURE REVIEWS DRUG DISCOVERY

GLUT4 Defects in Adipose Tissue Are Early Signs of Metabolic Alterations in Alms1GT/GT, a Mouse Model for Obesity and Insulin Resistance

(2014) Francesca Favaretto et al.   PLoS One

Boolean modeling: a logic-based dynamic approach for understanding signaling and regulatory networks and for making useful predictions

(2014) Réka Albert et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

A mathematical model of the unfolded protein stress response reveals the decision mechanism for recovery, adaptation and apoptosis

(2013) Kamil Erguler et al.   BMC Systems Biology

ER stress potentiates insulin resistance through PERK-mediated FOXO phosphorylation

(2013) W. Zhang et al.   GENES & DEVELOPMENT

Insulin Signaling in Type 2 Diabetes

(2013) Cecilia Brännmark et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tribbles 3 mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle

(2013) Ho-Jin Koh et al.   Nature Communications

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

(2012) Paul D. Ray et al.   CELLULAR SIGNALLING

FoxO1, the transcriptional chief of staff of energy metabolism

(2011) Stavroula Kousteni   BONE

Regulation of glucose homeostasis through a XBP-1–FoxO1 interaction

(2011) Yingjiang Zhou et al.   NATURE MEDICINE

Targeting Forkhead Box O1 from the Concept to Metabolic Diseases: Lessons from Mouse Models

(2010) Zhiyong Cheng et al.   ANTIOXIDANTS & REDOX SIGNALING

Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic beta cell dysfunction and apoptosis

(2010) F. Allagnat et al.   DIABETOLOGIA