Proteasome dysfunction induces excessive proteome instability and loss of mitostasis that can be mitigated by enhancing mitochondrial fusion or autophagy

Vps13D Encodes a Ubiquitin-Binding Protein that Is Required for the Regulation of Mitochondrial Size and Clearance

(2018) Allyson L. Anding et al.   CURRENT BIOLOGY

Basal mitophagy is widespread inDrosophilabut minimally affected by loss of Pink1 or parkin

(2018) Juliette J. Lee et al.   JOURNAL OF CELL BIOLOGY

Pathways of cellular proteostasis in aging and disease

(2017) Courtney L. Klaips et al.   JOURNAL OF CELL BIOLOGY

Milder degenerative effects of Carfilzomib vs. Bortezomib in the Drosophila model: a link to clinical adverse events

(2017) Eleni N. Tsakiri et al.   Scientific Reports

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Neuroendocrine Coordination of Mitochondrial Stress Signaling and Proteostasis

(2016) Kristen M. Berendzen et al.   CELL

Facilitation of axon regeneration by enhancing mitochondrial transport and rescuing energy deficits

(2016) Bing Zhou et al.   JOURNAL OF CELL BIOLOGY

Carfilzomib and dexamethasone versus bortezomib and dexamethasone for patients with relapsed or refractory multiple myeloma (ENDEAVOR): a randomised, phase 3, open-label, multicentre study

(2016) Meletios A Dimopoulos et al.   LANCET ONCOLOGY

Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice

(2016) W. P. Vermeij et al.   NATURE

Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease

(2016) Sentiljana Gumeni et al.   Oxidative Medicine and Cellular Longevity

p62- and ubiquitin-dependent stress-induced autophagy of the mammalian 26S proteasome

(2016) Victoria Cohen-Kaplan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gates, Channels, and Switches: Elements of the Proteasome Machine

(2016) Daniel Finley et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

Promoting Health and Longevity through Diet: From Model Organisms to Humans

(2015) Luigi Fontana et al.   CELL

Opa1 Overexpression Ameliorates the Phenotype of Two Mitochondrial Disease Mouse Models

(2015) Gabriele Civiletto et al.   Cell Metabolism

Titration of mitochondrial fusion rescuesMff-deficient cardiomyopathy

(2015) Hsiuchen Chen et al.   JOURNAL OF CELL BIOLOGY

The renoprotective role of autophagy activation in proximal tubular epithelial cells in diabetic nephropathy

(2015) Ying Xu et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Autophagic Degradation of the 26S Proteasome Is Mediated by the Dual ATG8/Ubiquitin Receptor RPN10 in Arabidopsis

(2015) Richard S. Marshall et al.   MOLECULAR CELL

Autophagy mediates degradation of nuclear lamina

(2015) Zhixun Dou et al.   NATURE

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

(2015) Konstantinos Palikaras et al.   NATURE

Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus

(2015) Keisuke Mochida et al.   NATURE

Proteostasis and aging

(2015) Susmita Kaushik et al.   NATURE MEDICINE

Atg17/FIP200 localizes to perilysosomal Ref(2)P aggregates and promotes autophagy by activation of Atg1 inDrosophila

(2014) Péter Nagy et al.   Autophagy

Functional Characterization of drim2, theDrosophila melanogasterHomolog of the Yeast Mitochondrial Deoxynucleotide Transporter

(2014) Caterina Da-Rè et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduction of endoplasmic reticulum stress attenuates the defects caused byDrosophilamitofusin depletion

(2014) Valentina Debattisti et al.   JOURNAL OF CELL BIOLOGY

Proteasome dysfunction inDrosophilasignals to an Nrf2-dependent regulatory circuit aiming to restore proteostasis and prevent premature aging

(2013) Eleni N. Tsakiri et al.   AGING CELL

After the banquet

(2013) Jianhui Zhu et al.   Autophagy

Improvement of ER stress-induced diabetes by stimulating autophagy

(2013) Etty Bachar-Wikstrom et al.   Autophagy

Impaired proteasomal degradation enhances autophagy via hypoxia signaling in Drosophila

(2013) Péter Lőw et al.   BMC CELL BIOLOGY

Mitochondrial fusion and fission proteins: novel therapeutic targets for combating cardiovascular disease

(2013) A R Hall et al.   BRITISH JOURNAL OF PHARMACOLOGY

XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity

(2013) Rebecca C. Taylor et al.   CELL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency

(2013) Sara Cogliati et al.   CELL

The Scaffold Protein Atg11 Recruits Fission Machinery to Drive Selective Mitochondria Degradation by Autophagy

(2013) Kai Mao et al.   DEVELOPMENTAL CELL

Differential regulation of proteasome functionality in reproductive vs. somatic tissues of Drosophila during aging or oxidative stress

(2013) Eleni N. Tsakiri et al.   FASEB JOURNAL

Diet-derived advanced glycation end products or lipofuscin disrupts proteostasis and reduces life span in Drosophila melanogaster

(2013) Eleni N. Tsakiri et al.   FREE RADICAL BIOLOGY AND MEDICINE

Non-enzymatic post-translational protein modifications and proteostasis network deregulation in carcinogenesis

(2013) Ioannis P. Trougakos et al.   Journal of Proteomics

The Ubiquitin-Proteasome System Regulates Mitochondrial Intermembrane Space Proteins

(2013) P. Bragoszewski et al.   MOLECULAR AND CELLULAR BIOLOGY

Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration

(2013) K. M. Holmstrom et al.   Biology Open

Mitochondrial quality control by the ubiquitin–proteasome system: Figure 1

(2012) Eric B. Taylor et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Yeast Ribosomal Protein L40 Assembles Late into Precursor 60 S Ribosomes and Is Required for Their Cytoplasmic Maturation

(2012) Antonio Fernández-Pevida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The E3-Ubiquitin Ligase TRIM50 Interacts with HDAC6 and p62, and Promotes the Sequestration and Clearance of Ubiquitinated Proteins into the Aggresome

(2012) Carmela Fusco et al.   PLoS One

Mitochondria removal by autophagy

(2011) Ke Wang et al.   Autophagy

RNAi screen of the druggable genome identifies modulators of proteasome inhibitor sensitivity in myeloma including CDK5

(2011) Y. X. Zhu et al.   BLOOD

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

(2011) Jenni Durieux et al.   CELL

Serine 403 Phosphorylation of p62/SQSTM1 Regulates Selective Autophagic Clearance of Ubiquitinated Proteins

(2011) Gen Matsumoto et al.   MOLECULAR CELL

Mitochondrial protein quality control during biogenesis and aging

(2011) Brooke M. Baker et al.   TRENDS IN BIOCHEMICAL SCIENCES

Quality Control of Mitochondrial Proteostasis

(2011) M. J. Baker et al.   Cold Spring Harbor Perspectives in Biology

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

(2010) Derek Narendra et al.   Autophagy

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

(2010) Atsushi Tanaka et al.   JOURNAL OF CELL BIOLOGY

Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin

(2010) E. Ziviani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease

(2010) G. P. Sykiotis et al.   Science Signaling

Integration of Clearance Mechanisms: The Proteasome and Autophagy

(2010) E. Wong et al.   Cold Spring Harbor Perspectives in Biology

Regulation of OPA1 processing and mitochondrial fusion bym-AAA protease isoenzymes and OMA1

(2009) Sarah Ehses et al.   JOURNAL OF CELL BIOLOGY

Heterozygous Mutation of Opa1 in Drosophila Shortens Lifespan Mediated through Increased Reactive Oxygen Species Production

(2009) Sha Tang et al.   PLoS One

Deletion of Drosophila insulin-like peptides causes growth defects and metabolic abnormalities

(2009) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila

(2008) Gerasimos P. Sykiotis et al.   DEVELOPMENTAL CELL

PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria

(2008) Shih-Ching Lo et al.   EXPERIMENTAL CELL RESEARCH

Genetic Evidence Linking Age-Dependent Attenuation of the 26S Proteasome with the Aging Process

(2008) A. Tonoki et al.   MOLECULAR AND CELLULAR BIOLOGY

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Regulation of the Cellular Heat Shock Response in Caenorhabditis elegans by Thermosensory Neurons

(2008) V. Prahlad et al.   SCIENCE