Cellular Proteostasis During Influenza A Virus Infection—Friend or Foe?

Predictors of Fatality in Influenza A Virus Subtypes Infection among inpatients in 2015-2016 season

(2019) S. Tekin et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Downregulation of MicroRNA hsa-miR-340-5p in Influenza A Virus Infected A549 Cells Suppresses Viral Replication by Targeting RIG-I and OAS2

(2019) Lianzhong Zhao et al.   Molecular Therapy-Nucleic Acids

Autophagy activation is required for influenza A virus-induced apoptosis and replication

(2018) B. Yeganeh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Molecular chaperones: from proteostasis to pathogenesis

(2018) Madhu Sudhan Ravindran   FEBS Journal

TRIM41-Mediated Ubiquitination of Nucleoprotein Limits Influenza A Virus Infection

(2018) Girish Patil et al.   JOURNAL OF VIROLOGY

Avian Influenza Virus PB1 Gene in H3N2 Viruses Evolved in Humans To Reduce Interferon Inhibition by Skewing Codon Usage toward Interferon-Altered tRNA Pools

(2018) Bartram L. Smith et al.   mBio

Autophagy diminishes the early interferon-β response to influenza A virus resulting in differential expression of interferon-stimulated genes

(2018) Brieuc P. Perot et al.   Cell Death & Disease

miRNA-based strategy for modulation of influenza A virus infection

(2018) Mohsen Keshavarz et al.   Epigenomics

Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition

(2018) Marios G. Koliopoulos et al.   Nature Communications

Endogenous Cellular MicroRNAs Mediate Antiviral Defense against Influenza A Virus

(2018) Shanxin Peng et al.   Molecular Therapy-Nucleic Acids

Host Shutoff in Influenza A Virus: Many Means to an End

(2018) Rachel Levene et al.   Viruses-Basel

HDAC6 restricts influenza A virus by deacetylation of the RNA polymerase PA subunit

(2018) Huan Chen et al.   JOURNAL OF VIROLOGY

Autophagy benefits the replication of influenza A virus in vitro

(2018) Ruifang Wang et al.   JOURNAL OF VIROLOGY

Evolution of Influenza A Virus by Mutation and Re-Assortment

(2017) Wenhan Shao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pathways of cellular proteostasis in aging and disease

(2017) Courtney L. Klaips et al.   JOURNAL OF CELL BIOLOGY

The highly pathogenic H5N1 influenza A virus down-regulated several cellular MicroRNAs which target viral genome

(2017) Rong Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Autophagy induction regulates influenza virus replication in a time-dependent manner

(2017) Neda Feizi et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Ubiquitination of the Cytoplasmic Domain of Influenza A Virus M2 Protein is Crucial for Production of Infectious Virus Particles

(2017) Wen-Chi Su et al.   JOURNAL OF VIROLOGY

Innate Sensing of Influenza A Virus Hemagglutinin Glycoproteins by the Host Endoplasmic Reticulum (ER) Stress Pathway Triggers a Potent Antiviral Response via ER-Associated Protein Degradation

(2017) Dylan A. Frabutt et al.   JOURNAL OF VIROLOGY

Influenza A Virus Virulence Depends on Two Amino Acids in the N-Terminal Domain of Its NS1 Protein To Facilitate Inhibition of the RNA-Dependent Protein Kinase PKR

(2017) Kristina L. Schierhorn et al.   JOURNAL OF VIROLOGY

Going against the Tide: Selective Cellular Protein Synthesis during Virally Induced Host Shutoff

(2017) Shuai Cao et al.   JOURNAL OF VIROLOGY

Exploring and Exploiting Proteome Organization during Viral Infection

(2017) Pierre M. Jean Beltran et al.   JOURNAL OF VIROLOGY

The UPR ER : Sensor and Coordinator of Organismal Homeostasis

(2017) Ashley E. Frakes et al.   MOLECULAR CELL

CNOT4-Mediated Ubiquitination of Influenza A Virus Nucleoprotein Promotes Viral RNA Replication

(2017) Yu-Chen Lin et al.   mBio

Influenza A virus-induced downregulation of miR-26a contributes to reduced IFNα/β production

(2017) Shijuan Gao et al.   VIROLOGICA SINICA

Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection

(2016) Nicholas S. Heaton et al.   IMMUNITY

Autophagy is involved in regulating influenza A virus RNA and protein synthesis associated with both modulation of Hsp90 induction and mTOR/p70S6K signaling pathway

(2016) Ge Liu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Subcellular Localizations of RIG-I, TRIM25, and MAVS Complexes

(2016) M. T. Sánchez-Aparicio et al.   JOURNAL OF VIROLOGY

Critical Role of the PA-X C-Terminal Domain of Influenza A Virus in Its Subcellular Localization and Shutoff Activity

(2016) Tsuyoshi Hayashi et al.   JOURNAL OF VIROLOGY

Phosphoproteomics to Characterize Host Response During Influenza A Virus Infection of Human Macrophages

(2016) Sandra Söderholm et al.   MOLECULAR & CELLULAR PROTEOMICS

Ubiquitin in Influenza Virus Entry and Innate Immunity

(2016) Alina Rudnicka et al.   Viruses-Basel

Shutoff of Host Gene Expression in Influenza A Virus and Herpesviruses: Similar Mechanisms and Common Themes

(2016) Hembly Rivas et al.   Viruses-Basel

Chemical Genomics Identifies the PERK-Mediated Unfolded Protein Stress Response as a Cellular Target for Influenza Virus Inhibition

(2016) Sara Landeras-Bueno et al.   mBio

Human Heat shock protein 40 (Hsp40/DnaJB1) promotes influenza A virus replication by assisting nuclear import of viral ribonucleoproteins

(2016) Jyoti Batra et al.   Scientific Reports

Interplay between the virus and the ubiquitin–proteasome system: molecular mechanism of viral pathogenesis

(2016) Honglin Luo   Current Opinion in Virology

Selective Degradation of Host RNA Polymerase II Transcripts by Influenza A Virus PA-X Host Shutoff Protein

(2016) Denys A. Khaperskyy et al.   PLoS Pathogens

Closing in on the causes of host shutoff

(2016) Ian Mohr   eLife

A systematic view on influenza induced host shutoff

(2016) Adi Bercovich-Kinori et al.   eLife

RNase L Activates the NLRP3 Inflammasome during Viral Infections

(2015) Arindam Chakrabarti et al.   Cell Host & Microbe

The Crystal Structure of the PB2 Cap-binding Domain of Influenza B Virus Reveals a Novel Cap Recognition Mechanism

(2015) Yong Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid Assemblies of Influenza A Virus PB1-F2 Protein Damage Membrane and Induce Cytotoxicity

(2015) Jasmina Vidic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hemagglutinin of Influenza A Virus Antagonizes Type I Interferon (IFN) Responses by Inducing Degradation of Type I IFN Receptor 1

(2015) Chuan Xia et al.   JOURNAL OF VIROLOGY

Timing Is Everything: Coordinated Control of Host Shutoff by Influenza A Virus NS1 and PA-X Proteins

(2015) Denys A. Khaperskyy et al.   JOURNAL OF VIROLOGY

Proteostasis and aging

(2015) Susmita Kaushik et al.   NATURE MEDICINE

Sequencing the cap-snatching repertoire of H1N1 influenza provides insight into the mechanism of viral transcription initiation

(2015) David Koppstein et al.   NUCLEIC ACIDS RESEARCH

The Ubiquitination of the Influenza A Virus PB1-F2 Protein Is Crucial for Its Biological Function

(2015) Ivan Košík et al.   PLoS One

Supersaturation is a major driving force for protein aggregation in neurodegenerative diseases

(2015) Prajwal Ciryam et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Acute Lung Injury Results from Innate Sensing of Viruses by an ER Stress Pathway

(2015) Eike R. Hrincius et al.   Cell Reports

TRIM32 Senses and Restricts Influenza A Virus by Ubiquitination of PB1 Polymerase

(2015) Bishi Fu et al.   PLoS Pathogens

Heat Shock Protein 70 Modulates Influenza A Virus Polymerase Activity

(2014) Rashid Manzoor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DnaJA1/Hsp40 Is Co-Opted by Influenza A Virus To Enhance Its Viral RNA Polymerase Activity

(2014) M. Cao et al.   JOURNAL OF VIROLOGY

Proteostasis and the Aging Proteome in Health and Disease

(2014) R. I. Morimoto et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Influenza A virus uses the aggresome processing machinery for host cell entry

(2014) Indranil Banerjee et al.   SCIENCE

Proteostasis impairment in protein-misfolding and -aggregation diseases

(2014) Mark S. Hipp et al.   TRENDS IN CELL BIOLOGY

Viral suppression of innate immunity via spatial isolation of TBK1/IKKε from mitochondrial antiviral platform

(2014) Yun-Jia Ning et al.   Journal of Molecular Cell Biology

Influenza A virus protein PB1-F2 translocates into mitochondria via Tom40 channels and impairs innate immunity

(2014) Takuma Yoshizumi et al.   Nature Communications

Influenza A Virus Host Shutoff Disables Antiviral Stress-Induced Translation Arrest

(2014) Denys A. Khaperskyy et al.   PLoS Pathogens

The expanding roles of endoplasmic reticulum stress in virus replication and pathogenesis

(2013) Shanshan Li et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Influenza A Infection of Primary Human Airway Epithelial Cells Up-Regulates Proteins Related to Purine Metabolism and Ubiquitin-Related Signaling

(2013) Andrea L. Kroeker et al.   JOURNAL OF PROTEOME RESEARCH

DNA Virus Replication Compartments

(2013) M. Schmid et al.   JOURNAL OF VIROLOGY

TRIM22 Inhibits Influenza A Virus Infection by Targeting the Viral Nucleoprotein for Degradation

(2013) A. Di Pietro et al.   JOURNAL OF VIROLOGY

Evasion of Antiviral Immunity through Sequestering of TBK1/IKK /IRF3 into Viral Inclusion Bodies

(2013) X. Wu et al.   JOURNAL OF VIROLOGY

Influenza A Virus Proteins NS1 and Hemagglutinin Along with M2 Are Involved in Stimulation of Autophagy in Infected Cells

(2013) O. P. Zhirnov et al.   JOURNAL OF VIROLOGY

Transient Aggregation of Ubiquitinated Proteins Is a Cytosolic Unfolded Protein Response to Inflammation and Endoplasmic Reticulum Stress

(2012) Xian-De Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Respiratory Syncytial Virus Nucleoprotein and Inclusion Bodies Antagonize the Innate Immune Response Mediated by MDA5 and MAVS

(2012) A. W. Lifland et al.   JOURNAL OF VIROLOGY

Influenza Virus Protein PB1-F2 Inhibits the Induction of Type I Interferon by Binding to MAVS and Decreasing Mitochondrial Membrane Potential

(2012) Zsuzsanna T. Varga et al.   JOURNAL OF VIROLOGY

Vaccinia and influenza A viruses select rather than adjust tRNAs to optimize translation

(2012) M. Pavon-Eternod et al.   NUCLEIC ACIDS RESEARCH

Virus-Induced Aggregates in Infected Cells

(2012) Adi Moshe et al.   Viruses-Basel

Species-Specific Inhibition of RIG-I Ubiquitination and IFN Induction by the Influenza A Virus NS1 Protein

(2012) Ricardo Rajsbaum et al.   PLoS Pathogens

Influenza Induces Endoplasmic Reticulum Stress, Caspase-12–Dependent Apoptosis, and c-Jun N-Terminal Kinase–Mediated Transforming Growth Factor–β Release in Lung Epithelial Cells

(2011) Elle C. Roberson et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Influenza A virus inhibits cytoplasmic stress granule formation

(2011) Denys A. Khaperskyy et al.   FASEB JOURNAL

The Cell Biology of the Unfolded Protein Response

(2011) J. Alan Diehl et al.   GASTROENTEROLOGY

Influenza A Viral Replication Is Blocked by Inhibition of the Inositol-requiring Enzyme 1 (IRE1) Stress Pathway

(2011) Ihab H. Hassan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Heat Shock Protein 70 Inhibits the Activity of Influenza A Virus Ribonucleoprotein and Blocks the Replication of Virus In Vitro and In Vivo

(2011) Gang Li et al.   PLoS One

Influenza A Virus Nucleoprotein Exploits Hsp40 to Inhibit PKR Activation

(2011) Kulbhushan Sharma et al.   PLoS One

The NS1 protein of influenza a virus interacts with heat shock protein Hsp90 in human alveolar basal epithelial cells: Implication for virus-induced apoptosis

(2011) Chuanfu Zhang et al.   Virology Journal

Cellular Strategies of Protein Quality Control

(2011) B. Chen et al.   Cold Spring Harbor Perspectives in Biology

Cell death regulation during influenza A virus infection by matrix (M1) protein: a model of viral control over the cellular survival pathway

(2011) U C Halder et al.   Cell Death & Disease

Virus factories, double membrane vesicles and viroplasm generated in animal cells

(2011) Christopher L Netherton et al.   Current Opinion in Virology

Quantitative Subcellular Proteome and Secretome Profiling of Influenza A Virus-Infected Human Primary Macrophages

(2011) Niina Lietzén et al.   PLoS Pathogens

Ubiquitination and deubiquitination of NP protein regulates influenza A virus RNA replication

(2010) Tsai-Ling Liao et al.   EMBO JOURNAL

Inhibition of the Ubiquitin-Proteasome System Affects Influenza A Virus Infection at a Postfusion Step

(2010) I. Widjaja et al.   JOURNAL OF VIROLOGY

Interaction of Hsp40 with influenza virus M2 protein: implications for PKR signaling pathway

(2010) Zhenhong Guan et al.   Protein & Cell

Autophagy is involved in influenza A virus replication

(2009) Zhi Zhou et al.   Autophagy

Matrix Protein 2 of Influenza A Virus Blocks Autophagosome Fusion with Lysosomes

(2009) Monique Gannagé et al.   Cell Host & Microbe

Influenza A Virus NS1 Targets the Ubiquitin Ligase TRIM25 to Evade Recognition by the Host Viral RNA Sensor RIG-I

(2009) Michaela Ulrike Gack et al.   Cell Host & Microbe

Quantitative analysis of cellular proteome alterations in human influenza A virus-infected mammalian cell lines

(2009) Diana Vester et al.   PROTEOMICS

The HIV-1 transcriptional activator Tat has potent nucleic acid chaperoning activities in vitro

(2008) Monika Kuciak et al.   NUCLEIC ACIDS RESEARCH

Hsp90 inhibitors reduce influenza virus replication in cell culture

(2008) Geoffrey Chase et al.   VIROLOGY

Maturation efficiency of viral glycoproteins in the ER impacts the production of influenza A virus

(2008) Mayo Ueda et al.   VIRUS RESEARCH