Article
Agriculture, Dairy & Animal Science
Yeojin Hong, Anh Duc Truong, Thi Hao Vu, Sooyeon Lee, Jubi Heo, Suyeon Kang, Hyun S. Lillehoj, Yeong Ho Hong
Summary: In this study, the expression profiles of miRNAs in White Leghorn chickens infected with highly pathogenic avian influenza virus (HPAIV) H5N1 were investigated. Differentially expressed miRNAs were identified in the exosomes derived from infected chickens, and their target genes were predicted. The majority of the target genes were associated with the MAPK signaling pathway, and several immune-related genes were regulated by these differentially expressed miRNAs. The findings provide a theoretical basis for understanding the regulatory mechanisms of exosomal miRNAs in response to HPAIV H5N1 infection and identifying novel vaccine candidates.
Article
Immunology
Minjin Kim, Yucheol Cheong, Jinhee Lee, Jongkwan Lim, Sanguine Byun, Yo Han Jang, Baik Lin Seong
Summary: This study demonstrated that caspase-triggered live attenuated influenza vaccine induced broad reactive antibody response and provided heterosubtypic protection against diverse influenza viruses in mice model. The protection relied on non-neutralizing antibodies-mediated ADCC activities and robust mucosal secretion of sIgA, which highlight the potential of this vaccine as a promising option for developing a universal influenza vaccine.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Sreekumar Othumpangat, William G. Lindsley, Donald H. Beezhold, Michael L. Kashon, Carmen N. Burrell, Samira Mubareka, John D. Noti
Summary: miRNAs play key roles in cell survival and virus replication, while exosomes are important for intercellular communication. Studies show that miRNAs are involved in regulating influenza virus replication. Analysis of circulating serum miRNAs and cytokines in influenza patients revealed differences in expression patterns, suggesting potential biomarkers for early infection detection.
Review
Immunology
Claudia Maria Trombetta, Otfried Kistner, Emanuele Montomoli, Simonetta Viviani, Serena Marchi
Summary: Influenza is a vaccine preventable disease and vaccination is the most effective method of controlling the morbidity and mortality of seasonal influenza, especially among risk groups. The effectiveness of current influenza vaccines is suboptimal, but they are still effective against morbidity and mortality in all age and risk groups, particularly in young children and older adults.
Review
Chemistry, Analytical
Judit Bovari-Biri, Kitti Garai, Krisztina Banfai, Veronika Csongei, Judit E. Pongracz
Summary: The human body has multiple barriers to protect it from harm and maintain its integrity. These barriers include the skin, intestinal and respiratory epithelia, blood-brain barrier, and immune system. This review focuses on the physical barriers formed by cell layers and emphasizes the role of microRNA in maintaining the integrity of these barriers. Detecting changes in microRNA patterns has become important in diagnostics, prognosis, and therapy-response markers. The review also highlights the challenges in using liquid biopsies for assessing barrier integrity and differential microRNA detection.
Article
Microbiology
Weigang Ren, Shuli Pei, Wenming Jiang, Meixia Zhao, Le Jiang, Honggang Liu, Yongxiang Yi, Mizhou Hui, Junwei Li
Summary: A replication-deficient recombinant influenza virus was developed in this study, which stimulated robust immune response and conferred complete protection against H5N1 or H9N2 influenza virus infections in mice.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Immunology
Rina Fajri Nuwarda, Abdulsalam Abdullah Alharbi, Veysel Kayser
Summary: Influenza is a major public health concern, and vaccines are an effective method for prevention and control. New vaccine platforms and advancements in vaccine manufacturing processes are being explored to improve effectiveness and stability.
Review
Virology
Jiali Li, Yifan Zhang, Xinglong Zhang, Longding Liu
Summary: China has a high number of influenza cases and deaths, and the effectiveness of the flu vaccine is reduced due to viral antigenic drift. Therefore, the development of a universal influenza vaccine is necessary.
Article
Biochemistry & Molecular Biology
Zhenchu Tang, Shenglan Hu, Ziwei Wu, Miao He
Summary: This study evaluated the value of exosome-based microRNA therapy in SCA3 and demonstrated the therapeutic effects of intravenously administrated ATXN3 targeting microRNAs in transgenic SCA3 mouse models. The targeted delivery of miR-25 and miR-181a by modified exosomes successfully reduced mutant ATXN3 expression and improved motor abilities in SCA3 mice without increasing neuroinflammatory response.
MOLECULAR MEDICINE
(2023)
Article
Immunology
Danuta M. Skowronski, Siobhan Leir, Suzana Sabaiduc, Catharine Chambers, Macy Zou, Caren Rose, Romy Olsha, James A. Dickinson, Anne-Luise Winter, Agatha Jassem, Jonathan B. Gubbay, Steven J. Drews, Hugues Charest, Tracy Chan, Rebecca Hickman, Nathalie Bastien, Yan Li, Mel Krajden, Gaston De Serres
Summary: This study investigates the genetic diversity of influenza A(H3N2) viruses and the impact of vaccination history on vaccine effectiveness. The findings show heterogeneity in vaccine effectiveness and suggest that pivotal mutations and repeat vaccination using unchanged antigen may reduce vaccine effectiveness.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Vasilis C. Pliasas, Zach Menne, Virginia Aida, Ji-Hang Yin, Maria C. Naskou, Peter J. Neasham, J. Fletcher North, Dylan Wilson, Katharine A. Horzmann, Joshy Jacob, Ioanna Skountzou, Constantinos S. Kyriakis
Summary: This study evaluated the immunogenicity and efficacy of a novel vaccine against influenza virus infection in a pig model. The results showed that the vaccine induced high levels of anti-NA antibodies and provided protection comparable to a commercial vaccine.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hae-Ji Kang, Ki-Back Chu, Keon-Woong Yoon, Gi-Deok Eom, Jie Mao, Fu-Shi Quan
Summary: This study demonstrates that influenza B virus-like particle vaccines expressing hemagglutinin, neuraminidase, or both antigens can provide cross-protections against mismatched Victoria lineage virus infections, by inducing antibody and T cell responses to reduce lung viral loads and minimize infection outcomes.
Article
Chemistry, Multidisciplinary
Jingdi Pan, Qihui Wang, Mi Qi, Jianjun Chen, Xuefan Wu, Xiaowei Zhang, Wei Li, Xian-En Zhang, Zongqiang Cui
Summary: Researchers have developed an intranasal multivalent epitope-based nanoparticle vaccine that provides broad protection against diverse influenza A and B viruses. The vaccine induces potent immune responses, including cross-reactive antibodies and T cell-mediated responses, and confers full protection against lethal challenge with different influenza viruses. The HMNF nanoparticle demonstrates long-lasting immunity and shows promise as a universal influenza vaccine candidate.
Article
Immunology
Hiroaki Kato, Takao Hozawa, Wakaba Fukushima, Eri Nobusawa, Yoshio Hirota
Summary: The Ministry of Health, Labour and Welfare in Japan designates specific virus strains for the seasonal influenza vaccine and domestic manufacturers produce vaccines with the same formulation. The focus has been on the antigenic match between the vaccine strains and epidemic viruses. However, in 2017, the selection system had issues with vaccine productivity, leading to reforms in 2018. A symposium was held to discuss vaccine virus selection, evaluation, and new formulation efforts in Japan.
Article
Multidisciplinary Sciences
Katherine Kaugars, Joseph Dardick, Anna Paula de Oliveira, Kayla A. Weiss, Regy Lukose, John Kim, Lawrence Leung, Saranathan Rajagopalan, Sydney Wolin, Leor Akabas, David M. Knipe, Goran Bajic, William R. Jacobs Jr
Summary: Despite annual vaccination efforts, influenza continues to cause significant morbidity and mortality worldwide. To improve vaccine efficacy, researchers are exploring the use of antibodies that can activate immune cell effector functions, such as ADCC. Evidence suggests that ADCC is crucial for protection against influenza and other infectious diseases, leading to the development of innovative vaccine strategies such as using Delta gD-2 as a vector for a broadly protective influenza vaccine.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Mehdi Shahgolzari, Hassan Dianat-Moghadam, Steven Fiering
Summary: Plant virus nanoparticles (PVNPs) have been investigated as immune adjuvants to stimulate anti-tumor immune response. Their immune stimulatory ability, nanoparticle structure, and ability to deliver other therapeutic molecules provide a flexible platform for cancer immunotherapy. Researching multifunctional PVNPs and their modification will generate novel reagents for cancer immunotherapy.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mehdi Mahmudpour, Katayoun Vahdat, Mohsen Keshavarz, Iraj Nabipour
Summary: This study suggests that insulin resistance, rather than direct damage to beta-cells, is the main cause of rapid metabolic deterioration in diabetes patients with COVID-19. A proposed molecular tetrahedron highlights the complex interactions between COVID-19 and diabetes, involving the entry of SARS-CoV-2, viral replication, inflammatory responses, and resulting insulin resistance.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Developmental Biology
Amin Alizadegan, Hassan Dianat-Moghadam, Nasrin Shadman, Mohammad Nouri, Kobra Hamdi, Alieh Ghasemzadeh, Maryam Akbarzadeh, Parisa Sarvarian, Amir Mehdizadeh, Sanam Dolati, Mehdi Yousefi
Summary: Various biopsy and sampling methods are used for preimplantation genetic diagnosis of embryos. These invasive procedures have adverse effects on embryo development and are expensive. Therefore, non-invasive methods, such as cell free DNA (cfDNA) evaluation, have been proposed. cfDNA can be found in body fluids, such as blood, follicular fluid, amniotic fluid, spent embryo culture medium, and blastocoel fluid. This review highlights the potential of cfDNA as a supplemental tool for improving IVF and pregnancy outcomes, as well as female infertility management. However, successful application of cfDNA requires understanding of its biological properties, collection time, detection methods with high sensitivity and specificity, as well as limitations and challenges in clinical settings.
Article
Oncology
Hassan Dianat-Moghadam, Mohammadreza Sharifi, Rasoul Salehi, Mohsen Keshavarz, Mehdi Shahgolzari, Zohreh Amoozgar
Summary: Intra-tumoral immune cells promote the stemness of cancer stem cells (CSCs) in the tumor microenvironment, which can play a role in tumor progression, relapse, and resistance to immunotherapy. Stem-like T cells and stem cell-derived NK cells show promising potential in improving the therapeutic efficacy of immunotherapy.
Review
Oncology
Amirhossein Davoodvandi, Sahand Sadeghi, Seyed Mohammad Amin Alavi, Seyedeh Shaghayegh Alavi, Ameneh Jafari, Haroon Khan, Michael Aschner, Hamed Mirzaei, Mehran Sharifi, Zatollah Asemi
Summary: Cancer is a serious health issue and drug therapy is commonly used for treatment. There is increasing interest in using natural compounds to overcome drug resistance and adverse reactions in cancer treatment. One such compound is berberine, which has a wide range of pharmacological activities and has shown anticancer effects on various gastrointestinal cancers. In this article, the therapeutic effects of berberine and its mechanisms on esophageal, gastric, colorectal, hepatocarcinoma, and pancreatic cancers are summarized.
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Virology
Saied Ghorbani, Vahid Tambrchi, Rana Farzi, Alireza Khatami, Rahil Nahid Samiei, Hassan Saadati, Maryam Noori, Arash Letafati, Atefeh Bahavar, Noorin Hezarpishe, Mehrshid Musavioun, Bahareh Mirzaei, Mohadeseh Sadat Meftagh, Najme Khodaei Doust, Fatemeh Hejami, Seyed Jalal Kiani
Summary: Brain cancer, although rare, can potentially be influenced by viral infections, particularly Epstein-Barr virus (EBV). This study conducted a systematic review and meta-analysis to assess the relationship between EBV infection and brain cancer. The results showed that EBV infection was prevalent (9%) among brain cancer patients and was associated with an increased risk of developing brain cancer.
Article
Virology
Mohsen Keshavarz, Somayeh Ghasemi, Yaser Arjeini, Haideh Namdari, Hassan Maleki, Neda Mousavi, Talat Mokhtari-Azad, Farhad Rezaei
Summary: Skin rash is a common complication in childhood, often caused by viral infections. This study aimed to investigate the prevalence and genetic variability of Human Herpesvirus 6 and 7 in children with skin rash. The results showed that a significant number of cases had HHV-6 and HHV-7 infections, with certain genetic variations found in HHV-6 strains. These findings highlight the importance of evaluating the frequency and distribution of HHV6/7 in children with skin rash and the potential impact on vaccine research and antiviral drug development.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Chemistry, Medicinal
Mohammad Jaber MasodKhooy, Massoumeh Farasat, Mohamadreza Salehi Salmi, Hamed Mirzaei
Summary: This study evaluated the antitumor effect of a combination of Silybum marianum essential oils and 5-fluorouracil (5-FU) on hepatocellular carcinoma. The combination treatment significantly reduced migration, invasion, and angiogenesis, while also modulating apoptosis, autophagy, and NF-kappa B and Wnt pathway-related proteins. In vivo experiments showed that the combined treatment prolonged survival in a mouse model of hepatocellular carcinoma compared to either treatment alone.
PHYTOTHERAPY RESEARCH
(2023)
Article
Nanoscience & Nanotechnology
Hamed Mirzaei, Jack McClelland, Devansh Sharma, Mohammad Arjmand, Mohammad H. H. Zarifi
Summary: This study focuses on investigating the real-time resonant microwave behavior of two polydimethylsiloxane (PDMS) structures in interaction with tetrahydrofuran (THF) and acetone, which are primary swelling agents. The interaction of the PDMS structures with target gases alters their structure, resulting in changes in the dielectric properties of the PDMS/gas system. Microwave resonators show substantial potential as versatile tools for investigating the physical changes in polymers during their interaction with gases.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Cell Biology
Sepideh Karkon-Shayan, Hasan Aliashrafzadeh, Hassan Dianat-Moghadam, Nima Rastegar-Pouyani, Mohammadreza Majidi, Mahdi Zarei, Sadegh Moradi-Vastegani, Yaser Bahramvand, Sepideh Babaniamansour, Emad Jafarzadeh
Summary: Glioblastoma multiforme (GBM) is a highly aggressive brain and spinal cord tumor, and current anticancer drugs are ineffective due to the development of resistance in GBM cells. Multiple signaling pathways and biological processes are involved in GBM progression and malignancy. Resveratrol (RESV), a non-flavonoid polyphenol, has shown potential in regulating signaling pathways and inhibiting GBM progression through apoptotic cell death, radiotherapy sensitization, and chemotherapy sensitization.
Review
Cell & Tissue Engineering
Hadi Sadeghzadeh, Hassan Dianat-Moghadam, Azizeh Rahmani Del Bakhshayesh, Daryush Mohammadnejad, Ahmad Mehdipour
Summary: The multidisciplinary research field of regenerative medicine and tissue engineering has effectively resolved numerous issues related to bone tissue disorders caused by aging, diseases, and injuries. Nanotechnology, combined with tissue engineering, has made significant contributions to tissue repair and regeneration. Studies have demonstrated that the incorporation of magnetic nanoparticles (MNPs) into composite scaffolds enhances their healing capabilities for bone defects. Furthermore, the induction of osteogenic differentiation in mesenchymal stem cells (MSCs) has been investigated and verified in the presence of these nanoparticles. This article reviews the different types and unique properties of MNPs, as well as their application in healing damaged bone tissue. It also discusses the molecular effects of MNPs on cell behavior, particularly in osteogenesis. Lastly, the potential applications of MNP-containing nanocomposite scaffolds in the treatment of bone lesions and injuries are outlined. Overall, this review article emphasizes the role of nanocomposite scaffolds containing MNPs as a solution for treating bone defects in tissue engineering and regenerative medicine.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Immunology
Hassan Dianat-Moghadam, Reza Nedaeinia, Mohsen Keshavarz, Mehdi Azizi, Mohammad Kazemi, Rasoul Salehi
Summary: Angiogenesis is a characteristic of cancer biology, and current therapies targeting tumor vasculature have limitations. By combining immunotherapy and nanocarriers, the efficacy of antiangiogenic agents could be improved while reducing the dosage of chemotherapy drugs. Furthermore, the combination of immunotherapies and nano-based delivery systems can extend the window of vascular normalization and overcome the challenges of antiangiogenic agents in treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Hassan Dianat-Moghadam, Soheil Abbasspour-Ravasjani, Hamed Hamishehkar, Reza Rahbarghazi, Mahammad Nouri
Summary: Reprogrammed metabolism and active stemness are important for the survival and tumor formation of cancer stem cells (CSCs). The LXR signaling pathway regulates metabolism in different types of cancers. An inhibitor called SR9243 (SR) can specifically target and eliminate non-CSC tumor cells. CD133 is a marker for CSCs in solid tumors and is associated with active lipogenesis. The use of anti-CD133 monoclonal antibodies can enhance drug delivery systems and improve the effectiveness of drugs with poor water solubility, such as SR. In this study, targeted immunoliposomes (ILipo) were developed to deliver SR specifically to CD133 + CSCs and induce their functional effects. The results showed that ILipo, with an average size of 64.79 nm, can encapsulate SR effectively and bind to CSCs. Flow cytometry analysis demonstrated that ILipo was taken up more efficiently by CD133 + CSCs compared to non-targeted liposomes. ILipo-SR was significantly more toxic to CD133 + CSCs compared to free SR and non-targeted liposomes. ILipo-SR also reduced clonogenicity, stemness, and lipogenesis in CD133 + CSCs, increased ROS generation, and induced apoptosis more effectively than Lipo-SR. This study suggests that targeting CD133 and LXR simultaneously could be a promising strategy for targeting CD133 + CSCs with dynamic metabolism and self-renewal potentials.
Review
Environmental Sciences
Mahmood Fadaie, Hassan Dianat-Moghadam, Elham Ghafouri, Shamsi Naderi, Mohammad Hossein Darvishali, Mahsa Ghovvati, Hossein Khanahmad, Maryam Boshtam, Pooyan Makvandi
Summary: M13 phages have shown potential in antibody-based therapy, anticancer vaccine design, biosensor development, and targeting antimicrobial genes. Further research is needed to fully understand the biological and genetic behaviors of M13 phages and overcome current challenges in their development and marketing.
ENVIRONMENTAL RESEARCH
(2023)
