RAGE Signaling in Skeletal Biology

Targeting RAGE Signaling in Inflammatory Disease

(2018) Barry I. Hudson et al.   Annual Review of Medicine

Oxidized low-density lipoprotein promotes osteoclast differentiation from CD68 positive mononuclear cells by regulating HMGB1 release

(2018) Chunfeng Hou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

sRAGE prolonged stem cell survival and suppressed RAGE-related inflammatory cell and T lymphocyte accumulations in an Alzheimer's disease model

(2018) Seyeon Oh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

HMGB1-induced inflammatory response promotes bone healing in murine tooth extraction socket

(2018) Hiroaki Aoyagi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

RAGE-dependent mitochondria pathway: a novel target of silibinin against apoptosis of osteoblastic cells induced by advanced glycation end products

(2018) Y. X. Mao et al.   Cell Death & Disease

A prospective study of soluble receptor for advanced glycation end products and adipokines in association with pancreatic cancer in postmenopausal women

(2018) Donna L. White et al.   Cancer Medicine

Inhibition of RAGE axis signaling: a pharmacological challenge.

(2018) Armando Rojas et al.   CURRENT DRUG TARGETS

Advanced glycation end products and esRAGE are associated with bone turnover and incidence of hip fracture in older men

(2018) Lydia S Lamb et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Advanced glycation end products induced IL-6 and VEGF-A production and apoptosis in osteocyte-like MLO-Y4 cells by activating RAGE and ERK1/2, P38 and STAT3 signalling pathways

(2017) Helin Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Associations between Soluble Receptor for Advanced Glycation End Products (sRAGE) and S100A12 (EN-RAGE) with Mortality in Long-term Hemodialysis Patients

(2017) Eul Sik Jung et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Targeting the Receptor for Advanced Glycation Endproducts (RAGE): A Medicinal Chemistry Perspective

(2017) Salvatore Bongarzone et al.   JOURNAL OF MEDICINAL CHEMISTRY

Advanced glycation end-products produced systemically and by macrophages: A common contributor to inflammation and degenerative diseases

(2017) Kyunghee Byun et al.   PHARMACOLOGY & THERAPEUTICS

Prevalence and Risk Factors of Osteoporosis in Postmenopausal Women with Type 2 Diabetes Mellitus

(2017) Ivan Raška et al.   Central European Journal of Public Health

Evaluation of circulating sRAGE in osteoporosis according to BMI, adipokines and fracture risk: a pilot observational study

(2017) Emanuela Galliera et al.   Immunity & Ageing

Advanced glycation end products biphasically modulate bone resorption in osteoclast-like cells

(2016) Ziqing Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Emerging drugs to reduce abnormal β-amyloid protein in Alzheimer’s disease patients

(2016) Francesco Panza et al.   EXPERT OPINION ON EMERGING DRUGS

Regulation of Receptor for Advanced Glycation End Products (RAGE) Ectodomain Shedding and Its Role in Cell Function

(2016) Alex Braley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RAGE-mediated inflammation in patients with septic shock

(2016) Stefan Hofer et al.   JOURNAL OF SURGICAL RESEARCH

RAGE axis in neuroinflammation, neurodegeneration and its emerging role in the pathogenesis of amyotrophic lateral sclerosis

(2016) Rashmi Ray et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Advanced Glycation Endproducts and Bone Material Properties in Type 1 Diabetic Mice

(2016) Mishaela R. Rubin et al.   PLoS One

Receptor for Advanced Glycation End Products-Mediated Signaling Impairs the Maintenance of Bone Marrow Mesenchymal Stromal Cells in Diabetic Model Mice

(2016) Eriko Aikawa et al.   STEM CELLS AND DEVELOPMENT

Soluble RAGE Treatment Delays Progression of Amyotrophic Lateral Sclerosis in SOD1 Mice

(2016) Judyta K. Juranek et al.   Frontiers in Cellular Neuroscience

HMGB1 promotes the secretion of multiple cytokines and potentiates the osteogenic differentiation of mesenchymal stem cells through the Ras/MAPK signaling pathway

(2016) Lin Feng et al.   Experimental and Therapeutic Medicine

AGEs Induce Apoptosis in Rat Osteoblast Cells by Activating the Caspase-3 Signaling Pathway Under a High-Glucose Environment In Vitro

(2015) Jiaqiang Liu et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Effects of high glucose and advanced glycation end products on the expressions of sclerostin and RANKL as well as apoptosis in osteocyte-like MLO-Y4-A2 cells

(2015) Ken-ichiro Tanaka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Receptor for advanced glycation endproduct modulators: a new therapeutic target in Alzheimer’s disease

(2015) Douglas Walker et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The multiple faces of RAGE – opportunities for therapeutic intervention in aging and chronic disease

(2015) Ravichandran Ramasamy et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Advanced Glycation End Products Affect Osteoblast Proliferation and Function by Modulating Autophagy Via the Receptor of Advanced Glycation End Products/Raf Protein/Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Kinase/Extracellular Signal-regulated Kinase (RAGE/Raf/MEK/ERK) Pathway

(2015) Hong-Zheng Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A direct role of collagen glycation in bone fracture

(2015) Atharva A. Poundarik et al.   Journal of the Mechanical Behavior of Biomedical Materials

Effects of Curculigoside on Memory Impairment and Bone Loss via Anti-Oxidative Character in APP/PS1 Mutated Transgenic Mice

(2015) Lu Zhao et al.   PLoS One

Amyloid beta peptide is elevated in osteoporotic bone tissues and enhances osteoclast function

(2014) Shangfu Li et al.   BONE

Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease

(2014) Edgar Dawkins et al.   JOURNAL OF NEUROCHEMISTRY

Clinical trial of an inhibitor of RAGE-A  interactions in Alzheimer disease

(2014) D. Galasko et al.   NEUROLOGY

Collagen advanced glycation inhibits its Discoidin Domain Receptor 2 (DDR2)-mediated induction of lysyl oxidase in osteoblasts

(2013) Roozbeh Khosravi et al.   BONE

Swedish mutant APP suppresses osteoblast differentiation and causes osteoporotic deficit, which are ameliorated by N-acetyl-L-cysteine

(2013) Wen-Fang Xia et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Advanced glycation end products suppress lysyl oxidase and induce bone collagen degradation in a rat model of renal osteodystrophy

(2013) Chiharu Aoki et al.   LABORATORY INVESTIGATION

Alternative Splicing of the RAGE Cytoplasmic Domain Regulates Cell Signaling and Function

(2013) Joel Jules et al.   PLoS One

RAGE in tissue homeostasis, repair and regeneration

(2012) Guglielmo Sorci et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Intra-peritoneal sRAGE treatment induces alterations in cellular distribution of CD19+, CD3+ and Mac-1+ cells in lymphoid organs and peritoneal cavity

(2012) Mikael Brisslert et al.   CELL AND TISSUE RESEARCH

Is RAGE still a therapeutic target for Alzheimer’s disease?

(2012) Richard J Deane   Future Medicinal Chemistry

A multimodal RAGE-specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease

(2012) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

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(2012) Huan Yang et al.   MOLECULAR MEDICINE

S100B Engages RAGE or bFGF/FGFR1 in Myoblasts Depending on Its Own Concentration and Myoblast Density. Implications for Muscle Regeneration

(2012) Francesca Riuzzi et al.   PLoS One

In situ accumulation of advanced glycation endproducts (AGEs) in bone matrix and its correlation with osteoclastic bone resorption

(2011) X. Neil Dong et al.   BONE

Soluble Receptor for Advanced Glycation Endproducts Is Decreased in Patients with Juvenile Idiopathic Arthritis (ERA Category) and Inversely Correlates with Disease Activity and S100A12 Levels

(2011) A. MYLES et al.   JOURNAL OF RHEUMATOLOGY

APPswe/Aβ regulation of osteoclast activation and RAGE expression in an age-dependent manner

(2010) Shun Cui et al.   JOURNAL OF BONE AND MINERAL RESEARCH

RAGE supports parathyroid hormone-induced gains in femoral trabecular bone

(2009) Binu K. Philip et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Low Serum Level of the Endogenous Secretory Receptor for Advanced Glycation End Products (esRAGE) Is a Risk Factor for Prevalent Vertebral Fractures Independent of Bone Mineral Density in Patients With Type 2 Diabetes

(2009) M. Yamamoto et al.   DIABETES CARE

Alternative splicing of the murine receptor for advanced glycation end-products (RAGE) gene

(2009) Anastasia Z. Kalea et al.   FASEB JOURNAL

γ-Secretase-dependent cleavage of amyloid precursor protein regulates osteoblast behavior

(2009) Jane McLeod et al.   FASEB JOURNAL

Direct inhibitory and indirect stimulatory effects of RAGE ligand S100 on sRANKL-induced osteoclastogenesis

(2009) Tomohiko Yoshida et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

RAGE-mediated signaling contributes to intraneuronal transport of amyloid-  and neuronal dysfunction

(2009) K. Takuma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Soluble receptor for advanced glycation end products: a new biomarker in diagnosis and prognosis of chronic inflammatory diseases

(2009) H. Maillard-Lefebvre et al.   RHEUMATOLOGY

The decrease of soluble RAGE levels in rheumatoid arthritis patients following hormone replacement therapy is associated with increased bone mineral density and diminished bone/cartilage turnover: a randomized controlled trial

(2009) R. Pullerits et al.   RHEUMATOLOGY

Interaction of the RAGE Cytoplasmic Domain with Diaphanous-1 Is Required for Ligand-stimulated Cellular Migration through Activation of Rac1 and Cdc42

(2008) Barry I. Hudson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HMGB1 Regulates RANKL-Induced Osteoclastogenesis in a Manner Dependent on RAGE

(2008) Zheng Zhou et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Identification, classification, and expression of RAGE gene splice variants

(2007) Barry I. Hudson et al.   FASEB JOURNAL

Is HMGB1 an osteocyte alarmin?

(2007) Joseph P. Bidwell et al.   JOURNAL OF CELLULAR BIOCHEMISTRY