FGF21 Protects Against Hypoxia Injury Through Inducing HSP72 in Cerebral Microvascular Endothelial Cells

Design and Evaluation of Lyophilized Fibroblast Growth Factor 21 and Its Protection against Ischemia Cerebral Injury

(2018) Xuanxin Yang et al.   BIOCONJUGATE CHEMISTRY

FGF21 Prevents Angiotensin II-Induced Hypertension and Vascular Dysfunction by Activation of ACE2/Angiotensin-(1–7) Axis in Mice

(2018) Xuebo Pan et al.   Cell Metabolism

FGF21 Protects the Blood–Brain Barrier by Upregulating PPARγ via FGFR1/β-klotho after Traumatic Brain Injury

(2018) Jun Chen et al.   JOURNAL OF NEUROTRAUMA

Nicotinic acetylcholine receptor α7 subunit improves energy homeostasis and inhibits inflammation in nonalcoholic fatty liver disease

(2018) Dong-Jie Li et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Recombinant FGF21 Protects Against Blood-Brain Barrier Leakage Through Nrf2 Upregulation in Type 2 Diabetes Mice

(2018) Zhanyang Yu et al.   MOLECULAR NEUROBIOLOGY

Protective Effect of Klotho against Ischemic Brain Injury Is Associated with Inhibition of RIG-I/NF-κB Signaling

(2018) Hong-Jing Zhou et al.   Frontiers in Pharmacology

Asiaticoside Attenuates Cell Growth Inhibition and Apoptosis Induced by Aβ1-42 via Inhibiting the TLR4/NF-κB Signaling Pathway in Human Brain Microvascular Endothelial Cells

(2018) Daqiang Song et al.   Frontiers in Pharmacology

Cholinergic anti-inflammatory pathway inhibits neointimal hyperplasia by suppressing inflammation and oxidative stress

(2018) Dong-Jie Li et al.   Redox Biology

Fibroblast growth factor 21 attenuates hypoxia-induced pulmonary hypertension by upregulating PPARγ expression and suppressing inflammatory cytokine levels

(2018) Jingjing Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nicotinic ACh receptor α7 inhibits PDGF-induced migration of vascular smooth muscle cells by activating mitochondrial deacetylase sirtuin 3

(2018) Dong-Jie Li et al.   BRITISH JOURNAL OF PHARMACOLOGY

Fibroblast Growth Factor 21—Metabolic Role in Mice and Men

(2017) Harald Staiger et al.   ENDOCRINE REVIEWS

Peripherally derived FGF21 promotes remyelination in the central nervous system

(2017) Mariko Kuroda et al.   JOURNAL OF CLINICAL INVESTIGATION

The novel exercise-induced hormone irisin protects against neuronal injury via activation of the Akt and ERK1/2 signaling pathways and contributes to the neuroprotection of physical exercise in cerebral ischemia

(2017) Dong-Jie Li et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Dickkopf-3 Upregulates VEGF in Cultured Human Endothelial Cells by Activating Activin Receptor-Like Kinase 1 (ALK1) Pathway

(2017) Carla L. Busceti et al.   Frontiers in Pharmacology

Ginsenoside F1 Ameliorates Endothelial Cell Inflammatory Injury and Prevents Atherosclerosis in Mice through A20-Mediated Suppression of NF-kB Signaling

(2017) Meng Qin et al.   Frontiers in Pharmacology

Feedback Activation of Basic Fibroblast Growth Factor Signaling via the Wnt/β-Catenin Pathway in Skin Fibroblasts

(2017) Xu Wang et al.   Frontiers in Pharmacology

Hydrogen Sulfide Inhibits Cigarette Smoke-Induced Endoplasmic Reticulum Stress and Apoptosis in Bronchial Epithelial Cells

(2017) Fan Lin et al.   Frontiers in Pharmacology

Attenuation of TNF-α-Induced Inflammatory Injury in Endothelial Cells by Ginsenoside Rb1 via Inhibiting NF-κB, JNK and p38 Signaling Pathways

(2017) Ping Zhou et al.   Frontiers in Pharmacology

Understanding the Physiology of FGF21

(2016) Ffolliott Martin Fisher et al.   Annual Review of Physiology

Blood biomarkers indicate mild neuroaxonal injury and increased amyloidβproduction after transient hypoxia during breath-hold diving

(2016) Magnus Gren et al.   BRAIN INJURY

FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues

(2016) Christian Schlein et al.   Cell Metabolism

The FGF21–adiponectin axis in controlling energy and vascular homeostasis

(2016) Xiaoyan Hui et al.   Journal of Molecular Cell Biology

Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice

(2015) Z. Lin et al.   CIRCULATION

Heat acclimation attenuates physiological strain and the HSP72, but not HSP90α, mRNA response to acute normobaric hypoxia

(2015) Oliver R. Gibson et al.   JOURNAL OF APPLIED PHYSIOLOGY

How Hsp70 Molecular Machines Interact with Their Substrates to Mediate Diverse Physiological Functions

(2015) Eugenia M. Clerico et al.   JOURNAL OF MOLECULAR BIOLOGY

Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes

(2015) Ruidan Xue et al.   NATURE MEDICINE

The Role of HSP70 Heat Shock Proteins in the Pathogenesis and Treatment of Inflammatory Bowel Diseases

(2015) Paweł Samborski et al.   Advances in Clinical and Experimental Medicine

Human Monocyte Heat Shock Protein 72 Responses to Acute Hypoxic Exercise after 3 Days of Exercise Heat Acclimation

(2015) Ben J. Lee et al.   Biomed Research International

Fibroblast growth factor 21 protects the heart from oxidative stress

(2014) Anna Planavila et al.   CARDIOVASCULAR RESEARCH

Chronic Arsenic Exposure and Angiogenesis in Human Bronchial Epithelial Cells via the ROS/miR-199a-5p/HIF-1α/COX-2 Pathway

(2014) Jun He et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Heat shock protein 72 suppresses apoptosis by increasing the stability of X-linked inhibitor of apoptosis protein in renal ischemia/reperfusion injury

(2014) BAIYU ZHANG et al.   Molecular Medicine Reports

An FGF21-Adiponectin-Ceramide Axis Controls Energy Expenditure and Insulin Action in Mice

(2013) William L. Holland et al.   Cell Metabolism

The Effects of LY2405319, an FGF21 Analog, in Obese Human Subjects with Type 2 Diabetes

(2013) Gregory Gaich et al.   Cell Metabolism

HSP72 Is a Mitochondrial Stress Sensor Critical for Parkin Action, Oxidative Metabolism, and Insulin Sensitivity in Skeletal Muscle

(2013) Brian G. Drew et al.   DIABETES

Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones

(2012) Paul A. Dutchak et al.   CELL

Heat shock protein 72 inhibits c-Jun N-terminal kinase 3 signaling pathway via Akt1 during cerebral ischemia

(2012) Dashi Qi et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Treating Diabetes and Obesity with an FGF21-Mimetic Antibody Activating the  Klotho/FGFR1c Receptor Complex

(2012) I. N. Foltz et al.   Science Translational Medicine

Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1-dependent adenosine monophosphate-activated kinase pathway

(2011) Pei Wang et al.   ANNALS OF NEUROLOGY

Up-regulation of PPARγ, heat shock protein-27 and -72 by naringin attenuates insulin resistance, β-cell dysfunction, hepatic steatosis and kidney damage in a rat model of type 2 diabetes

(2011) Ashok Kumar Sharma et al.   BRITISH JOURNAL OF NUTRITION

Hydrogen Sulfide Protects against Chemical Hypoxia-Induced Cytotoxicity and Inflammation in HaCaT Cells through Inhibition of ROS/NF-κB/COX-2 Pathway

(2011) Chuntao Yang et al.   PLoS One

Cyclooxygenase-2 inhibition provides lasting protection against neonatal hypoxic-ischemic brain injury*

(2010) Nancy Fathali et al.   CRITICAL CARE MEDICINE

The effect of acute hypoxia on heat shock protein 72 expression and oxidative stress in vivo

(2010) Lee Taylor et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Astrocyte targeted overexpression of Hsp72 or SOD2 reduces neuronal vulnerability to forebrain ischemia

(2010) Lijun Xu et al.   GLIA

Heat shock protein 72 (Hsp72) improves long term recovery after focal cerebral ischemia in mice

(2010) Lijun Xu et al.   NEUROSCIENCE LETTERS

Emerging concepts in acute mountain sickness and high-altitude cerebral edema: from the molecular to the morphological

(2009) Damian Miles Bailey et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Perivascular adipose tissue-derived visfatin is a vascular smooth muscle cell growth factor: role of nicotinamide mononucleotide

(2008) Pei Wang et al.   CARDIOVASCULAR RESEARCH

The Circulating Metabolic Regulator FGF21 Is Induced by Prolonged Fasting and PPARα Activation in Man

(2008) Cecilia Gälman et al.   Cell Metabolism

Serum Levels of the Adipokine FGF21 Depend on Renal Function

(2008) S. Stein et al.   DIABETES CARE

Heat Shock Protein Hsp72 Controls Oncogene-Induced Senescence Pathways in Cancer Cells

(2008) V. L. Gabai et al.   MOLECULAR AND CELLULAR BIOLOGY

Reactive oxygen species produced by NADPH oxidase, xanthine oxidase, and mitochondrial electron transport system mediate heat shock-induced MMP-1 and MMP-9 expression

(2007) Mi Hee Shin et al.   FREE RADICAL BIOLOGY AND MEDICINE