The FGF21–adiponectin axis in controlling energy and vascular homeostasis

FGF21 attenuates pathological myocardial remodeling following myocardial infarction through the adiponectin-dependent mechanism

(2015) Yusuke Joki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pharmacokinetics and pharmacodynamics of PF-05231023, a novel long-acting FGF21 mimetic, in a first-in-human study

(2015) Jennifer Q. Dong et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Adiponectin Enhances Cold-Induced Browning of Subcutaneous Adipose Tissue via Promoting M2 Macrophage Proliferation

(2015) Xiaoyan Hui et al.   Cell Metabolism

Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice

(2015) Z. Lin et al.   CIRCULATION

Serum fibroblast growth factor 21 levels are increased in atrial fibrillation patients

(2015) Xinyuan Han et al.   CYTOKINE

Adipose tissue and its role in organ crosstalk

(2014) T. Romacho et al.   Acta Physiologica

Fibroblast growth factor 21 protects the heart from oxidative stress

(2014) Anna Planavila et al.   CARDIOVASCULAR RESEARCH

FGF21 Acts Centrally to Induce Sympathetic Nerve Activity, Energy Expenditure, and Weight Loss

(2014) Bryn M. Owen et al.   Cell Metabolism

FGF21 Maintains Glucose Homeostasis by Mediating the Cross Talk Between Liver and Brain During Prolonged Fasting

(2014) Q. Liang et al.   DIABETES

Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding

(2014) K. R. Markan et al.   DIABETES

FGF21 Increases Cholesterol Efflux by Upregulating ABCA1 Through the ERK1/2–PPARγ–LXRα Pathway in THP1 Macrophage-Derived Foam Cells

(2014) Xiao-Long Lin et al.   DNA AND CELL BIOLOGY

Possible role of fibroblast growth factor 21 on atherosclerosis via amelioration of endoplasmic reticulum stress-mediated apoptosis in apoE−/− mice

(2014) Xi Wu et al.   HEART AND VESSELS

Fibroblast growth factor 21 protects against acetaminophen-induced hepatotoxicity by potentiating peroxisome proliferator-activated receptor coactivator protein-1α-mediated antioxidant capacity in mice

(2014) Dewei Ye et al.   HEPATOLOGY

Novel Insights into the Cardio-Protective Effects of FGF21 in Lean and Obese Rat Hearts

(2014) Vanlata Patel et al.   PLoS One

Serum Fibroblast Growth Factor-21 Levels Are Associated With Carotid Atherosclerosis Independent of Established Cardiovascular Risk Factors

(2013) Wing Sun Chow et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Additive relationship between serum fibroblast growth factor 21 level and coronary artery disease

(2013) Yun Shen et al.   Cardiovascular Diabetology

Adiponectin Mediates the Metabolic Effects of FGF21 on Glucose Homeostasis and Insulin Sensitivity in Mice

(2013) Zhuofeng Lin et al.   Cell Metabolism

An FGF21-Adiponectin-Ceramide Axis Controls Energy Expenditure and Insulin Action in Mice

(2013) William L. Holland et al.   Cell Metabolism

The Effects of LY2405319, an FGF21 Analog, in Obese Human Subjects with Type 2 Diabetes

(2013) Gregory Gaich et al.   Cell Metabolism

FGF21 contributes to neuroendocrine control of female reproduction

(2013) Bryn M Owen et al.   NATURE MEDICINE

FGF21 regulates metabolism and circadian behavior by acting on the nervous system

(2013) Angie L Bookout et al.   NATURE MEDICINE

Fibroblast growth factor 21 protects against cardiac hypertrophy in mice

(2013) A. Planavila et al.   Nature Communications

Endocrine Protection of Ischemic Myocardium by FGF21 from the Liver and Adipose Tissue

(2013) Shu Q. Liu et al.   Scientific Reports

Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones

(2012) Paul A. Dutchak et al.   CELL

βKlotho Is Required for Fibroblast Growth Factor 21 Effects on Growth and Metabolism

(2012) Xunshan Ding et al.   Cell Metabolism

Fibroblast Growth Factor 21 as an emerging metabolic regulator: clinical perspectives

(2012) Y. C. Woo et al.   CLINICAL ENDOCRINOLOGY

Long-Acting FGF21 Has Enhanced Efficacy in Diet-Induced Obese Mice and in Obese Rhesus Monkeys

(2012) Murielle M. Véniant et al.   ENDOCRINOLOGY

TNF-α Represses β-Klotho Expression and Impairs FGF21 Action in Adipose Cells: Involvement of JNK1 in the FGF21 Pathway

(2012) Julieta Díaz-Delfín et al.   ENDOCRINOLOGY

Mitochondrial dysfunction leads to impairment of insulin sensitivity and adiponectin secretion in adipocytes

(2012) Chih-Hao Wang et al.   FEBS Journal

FGF21 regulates PGC-1  and browning of white adipose tissues in adaptive thermogenesis

(2012) f. M. Fisher et al.   GENES & DEVELOPMENT

Fibroblast Growth Factor-21 (FGF21) Regulates Low-density Lipoprotein Receptor (LDLR) Levels in Cells via the E3-ubiquitin Ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting Saposin-like Protein (Msap)

(2012) Hai Thi Do et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FGF21 Promotes Metabolic Homeostasis via White Adipose and Leptin in Mice

(2012) Murielle M. Véniant et al.   PLoS One

FGF21 Requires βklotho to Act In Vivo

(2012) Andrew C. Adams et al.   PLoS One

Treating Diabetes and Obesity with an FGF21-Mimetic Antibody Activating the  Klotho/FGFR1c Receptor Complex

(2012) I. N. Foltz et al.   Science Translational Medicine

The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue

(2012) Andrew C. Adams et al.   Molecular Metabolism

Muscle-to-organ cross talk mediated by myokines

(2012) Line Pedersen et al.   Adipocyte

Ethanol-Induced Oxidative Stress via the CYP2E1 Pathway Disrupts Adiponectin Secretion from Adipocytes

(2011) Hui Tang et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Adiponectin and cardiovascular health: an update

(2011) Xiaoyan Hui et al.   BRITISH JOURNAL OF PHARMACOLOGY

Adiponectin Inhibits Lipolysis in Mouse Adipocytes

(2011) L. Qiao et al.   DIABETES

Integrated Regulation of Hepatic Metabolism by Fibroblast Growth Factor 21 (FGF21)in Vivo

(2011) ffolliott M. Fisher et al.   ENDOCRINOLOGY

Fibroblast Growth Factor 21 Induces Glucose Transporter-1 Expression through Activation of the Serum Response Factor/Ets-Like Protein-1 in Adipocytes

(2011) Xuan Ge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Mechanism for Adiponectin-dependent M2 Macrophage Polarization

(2011) Palash Mandal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exercise Induces a Marked Increase in Plasma Follistatin: Evidence That Follistatin Is a Contraction-Induced Hepatokine

(2010) Jakob Hansen et al.   ENDOCRINOLOGY

Research Resource: Comprehensive Expression Atlas of the Fibroblast Growth Factor System in Adult Mouse

(2010) Klementina Fon Tacer et al.   MOLECULAR ENDOCRINOLOGY

Serum Levels of FGF-21 Are Increased in Coronary Heart Disease Patients and Are Independently Associated with Adverse Lipid Profile

(2010) Zhuofeng Lin et al.   PLoS One

Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models—association with liver and adipose tissue effects

(2009) Jing Xu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Transcriptional and post-translational regulation of adiponectin

(2009) Meilian Liu et al.   BIOCHEMICAL JOURNAL

Organ crosstalk: the role of the kidney

(2009) Xiang Li et al.   Current Opinion in Critical Care

Fibroblast Growth Factor 21 Regulates Lipolysis in White Adipose Tissue But Is Not Required for Ketogenesis and Triglyceride Clearance in Liver

(2009) Yuhei Hotta et al.   ENDOCRINOLOGY

Physiological and pathophysiological roles of adiponectin and adiponectin receptors in the integrated regulation of metabolic and cardiovascular diseases

(2009) T Yamauchi et al.   INTERNATIONAL JOURNAL OF OBESITY

FGF21 induces PGC-1  and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response

(2009) M. J. Potthoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Post-translational modifications of adiponectin: mechanisms and functional implications

(2008) Yu Wang et al.   BIOCHEMICAL JOURNAL

Serum FGF21 Levels Are Increased in Obesity and Are Independently Associated With the Metabolic Syndrome in Humans

(2008) X. Zhang et al.   DIABETES

Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice

(2008) J. Xu et al.   DIABETES

Plasma Adiponectin Complexes Have Distinct Biochemical Characteristics

(2008) Todd Schraw et al.   ENDOCRINOLOGY

FGF21 attenuates lipolysis in human adipocytes - A possible link to improved insulin sensitivity

(2008) Peter Arner et al.   FEBS LETTERS

βKlotho Is Required for Fibroblast Growth Factor (FGF) 21 Signaling through FGF Receptor (FGFR) 1c and FGFR3c

(2008) Masashi Suzuki et al.   MOLECULAR ENDOCRINOLOGY

A disulfide-bond A oxidoreductase-like protein (DsbA-L) regulates adiponectin multimerization

(2008) M. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FGF-21/FGF-21 receptor interaction and activation is determined by βKlotho

(2007) Alexei Kharitonenkov et al.   JOURNAL OF CELLULAR PHYSIOLOGY