Protective Effect of Klotho against Ischemic Brain Injury Is Associated with Inhibition of RIG-I/NF-κB Signaling

Neuroprotective effect of a novel gastrodin derivative against ischemic brain injury: involvement of peroxiredoxin and TLR4 signaling inhibition

(2017) Xiao-Na Mao et al.   Oncotarget

Interleukin-6 Receptor Polymorphisms Contribute to the Neurological Status of Korean Patients with Ischemic Stroke

(2016) Dong Hwan Kim et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Klotho Contributes to Pravastatin Effect on Suppressing IL-6 Production in Endothelial Cells

(2016) Weiwei Xia et al.   MEDIATORS OF INFLAMMATION

Executive Summary: Heart Disease and Stroke Statistics—2015 Update:

(2015) Dariush Mozaffarian et al.   CIRCULATION

Klotho Reduction in Alveolar Macrophages Contributes to Cigarette Smoke Extract-induced Inflammation in Chronic Obstructive Pulmonary Disease

(2015) Lingling Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ischemic tolerance is associated with VEGF-C and VEGFR-3 signaling in the mouse hippocampus

(2015) M.I.H. Bhuiyan et al.   NEUROSCIENCE

Ligustilide ameliorates neuroinflammation and brain injury in focal cerebral ischemia/reperfusion rats: involvement of inhibition of TLR4/peroxiredoxin 6 signaling

(2014) Xi Kuang et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Neuroprotective Effect of Klotho is Mediated via Regulation of Members of the Redox System

(2014) Ella Zeldich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Retinoic Acid-Inducible Gene-I Mediates Late Phase Induction of TNF-  by Lipopolysaccharide

(2014) J. Wang et al.   JOURNAL OF IMMUNOLOGY

Soluble serum Klotho levels in healthy subjects. Comparison of two different immunoassays

(2013) Lise Pedersen et al.   CLINICAL BIOCHEMISTRY

Klotho upregulation contributes to the neuroprotection of ligustilide in an Alzheimer's disease mouse model

(2013) Xi Kuang et al.   NEUROBIOLOGY OF AGING

Small-molecule Klotho enhancers as novel treatment of neurodegeneration

(2012) Carmela R Abraham et al.   Future Medicinal Chemistry

A Novel Hydrogen Sulfide-releasingN-Methyl-d-Aspartate Receptor Antagonist Prevents Ischemic Neuronal Death

(2012) Eizo Marutani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Promoter methylation and age-related downregulation of Klotho in rhesus monkey

(2011) Gwendalyn D. King et al.   AGE

Identification of novel small molecules that elevate Klotho expression

(2011) Gwendalyn D. King et al.   BIOCHEMICAL JOURNAL

Interrupted reperfusion reduces the activation of NADPH oxidase after cerebral I/R injury

(2011) Jia Shen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Klotho suppresses RIG-I-mediated senescence-associated inflammation

(2011) Feng Liu et al.   NATURE CELL BIOLOGY

Establishment of sandwich ELISA for soluble alpha-Klotho measurement: Age-dependent change of soluble alpha-Klotho levels in healthy subjects

(2010) Yuji Yamazaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Interleukin-6 receptor gene polymorphisms were associated with sporadic Alzheimer's disease in Chinese Han

(2010) Min Wang et al.   BRAIN RESEARCH

Klotho is a substrate for α-, β- and γ-secretase

(2009) Laura Bloch et al.   FEBS LETTERS

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production

(2009) Hendrik Poeck et al.   NATURE IMMUNOLOGY

Protective effect of Z-ligustilide against amyloid β-induced neurotoxicity is associated with decreased pro-inflammatory markers in rat brains

(2009) Xi Kuang et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Gene profile analysis implicates Klotho as an important contributor to aging changes in brain white matter of the rhesus monkey

(2007) James A. Duce et al.   GLIA

Early disruptions of the blood–brain barrier may contribute to exacerbated neuronal damage and prolonged functional recovery following stroke in aged rats

(2007) Vincent A. DiNapoli et al.   NEUROBIOLOGY OF AGING

Postischemic administration of Z-Ligustilide ameliorates cognitive dysfunction and brain damage induced by permanent forebrain ischemia in rats

(2007) X KUANG et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR