CAV-2 Vector Development and Gene Transfer in the Central and Peripheral Nervous Systems

Combining Gene Transfer and Nonhuman Primates to Better Understand and Treat Parkinson’s Disease

(2019) Christelle Lasbleiz et al.   Frontiers in Molecular Neuroscience

Generation and characterization of a novel candidate gene therapy and vaccination vector based on human species D adenovirus type 56

(2018) Margaret R. Duffy et al.   JOURNAL OF GENERAL VIROLOGY

A Viral Receptor Complementation Strategy to Overcome CAV-2 Tropism for Efficient Retrograde Targeting of Neurons

(2018) Shu-Jing Li et al.   NEURON

Sensory overamplification in layer 5 auditory corticofugal projection neurons following cochlear nerve synaptic damage

(2018) Meenakshi M. Asokan et al.   Nature Communications

A Neural Circuit for Gut-Induced Reward

(2018) Wenfei Han et al.   CELL

A midline thalamic circuit determines reactions to visual threat

(2018) Lindsey D. Salay et al.   NATURE

Humoral immune response to adenovirus induce tolerogenic bystander dendritic cells that promote generation of regulatory T cells

(2018) Thi Thu Phuong Tran et al.   PLoS Pathogens

Dopamine enhances signal-to-noise ratio in cortical-brainstem encoding of aversive stimuli

(2018) Caitlin M. Vander Weele et al.   NATURE

A Brainstem-Spinal Circuit Controlling Nocifensive Behavior

(2018) Arnab Barik et al.   NEURON

Prefrontal projections to the thalamic nucleus reuniens mediate fear extinction

(2018) Karthik R. Ramanathan et al.   Nature Communications

Mesopontine cholinergic inputs to midbrain dopamine neurons drive stress-induced depressive-like behaviors

(2018) Sebastian P. Fernandez et al.   Nature Communications

Clinical Gene Therapy for Neurodegenerative Diseases: Past, Present, and Future

(2017) Françoise Piguet et al.   HUMAN GENE THERAPY

Alarmins and immunity

(2017) De Yang et al.   IMMUNOLOGICAL REVIEWS

Three novel, multiple recombinant types of species of human mastadenovirus D (HAdV-D 73, 74 & 75) isolated from diarrhoeal faeces of immunocompromised patients

(2017) Elias Hage et al.   JOURNAL OF GENERAL VIROLOGY

Prefrontal cortex output circuits guide reward seeking through divergent cue encoding

(2017) James M. Otis et al.   NATURE

Modular organization of the brainstem noradrenaline system coordinates opposing learning states

(2017) Akira Uematsu et al.   NATURE NEUROSCIENCE

Mapping the functional connectome in traumatic brain injury: What can graph metrics tell us?

(2017) Karen Caeyenberghs et al.   NEUROIMAGE

Getting genetic access to natural adenovirus genomes to explore vector diversity

(2017) Wenli Zhang et al.   VIRUS GENES

Aversive stimuli drive hypothalamus-to-habenula excitation to promote escape behavior

(2017) Salvatore Lecca et al.   eLife

Retrograde optogenetic characterization of the pontospinal module of the locus coeruleus with a canine adenoviral vector

(2016) Yong Li et al.   BRAIN RESEARCH

Redirecting adenovirus tropism by genetic, chemical, and mechanical modification of the adenovirus surface for cancer gene therapy

(2016) A-Rum Yoon et al.   Expert Opinion on Drug Delivery

Coxsackievirus Adenovirus Receptor Loss Impairs Adult Neurogenesis, Synapse Content, and Hippocampus Plasticity

(2016) C. Zussy et al.   JOURNAL OF NEUROSCIENCE

A cholinergic basal forebrain feeding circuit modulates appetite suppression

(2016) Alexander M. Herman et al.   NATURE

Locus coeruleus and dopaminergic consolidation of everyday memory

(2016) Tomonori Takeuchi et al.   NATURE

Divergent Routing of Positive and Negative Information from the Amygdala during Memory Retrieval

(2016) Anna Beyeler et al.   NEURON

Projection-Specific Dynamic Regulation of Inhibition in Amygdala Micro-Circuits

(2016) Elisabeth Vogel et al.   NEURON

A New Population of Parvocellular Oxytocin Neurons Controlling Magnocellular Neuron Activity and Inflammatory Pain Processing

(2016) Marina Eliava et al.   NEURON

Long-Distance Descending Spinal Neurons Ensure Quadrupedal Locomotor Stability

(2016) Ludwig Ruder et al.   NEURON

A Designer AAV Variant Permits Efficient Retrograde Access to Projection Neurons

(2016) D. Gowanlock R. Tervo et al.   NEURON

DREADDs for Neuroscientists

(2016) Bryan L. Roth   NEURON

Trained immunity: A program of innate immune memory in health and disease

(2016) M. G. Netea et al.   SCIENCE

Early Degeneration of Both Dopaminergic and Serotonergic Axons – A Common Mechanism in Parkinson’s Disease

(2016) Janina Grosch et al.   Frontiers in Cellular Neuroscience

E2F/Rb Family Proteins Mediate Interferon Induced Repression of Adenovirus Immediate Early Transcription to Promote Persistent Viral Infection

(2016) Yueting Zheng et al.   PLoS Pathogens

Immune-Complexed Adenovirus Induce AIM2-Mediated Pyroptosis in Human Dendritic Cells

(2016) Karsten Eichholz et al.   PLoS Pathogens

A simple and efficient seamless DNA cloning method using SLiCE from Escherichia coli laboratory strains and its application to SLiP site-directed mutagenesis

(2015) Ken Motohashi   BMC BIOTECHNOLOGY

Circuit Architecture of VTA Dopamine Neurons Revealed by Systematic Input-Output Mapping

(2015) Kevin T. Beier et al.   CELL

Intact-Brain Analyses Reveal Distinct Information Carried by SNc Dopamine Subcircuits

(2015) Talia N. Lerner et al.   CELL

Organization of the Locus Coeruleus-Norepinephrine System

(2015) Lindsay A. Schwarz et al.   CURRENT BIOLOGY

CAV-2—why a canine virus is a neurobiologist's best friend

(2015) Felix Junyent et al.   CURRENT OPINION IN PHARMACOLOGY

Ebola virus vaccine: benefit and risks of adenovirus-based vectors

(2015) Franck JD Mennechet et al.   Expert Review of Vaccines

Evaluation of helper-dependent canine adenovirus vectors in a 3D human CNS model

(2015) D Simão et al.   GENE THERAPY

Multiple Cross-Species Transmission Events of Human Adenoviruses (HAdV) during Hominine Evolution

(2015) Eileen Hoppe et al.   MOLECULAR BIOLOGY AND EVOLUTION

Viral-genetic tracing of the input–output organization of a central noradrenaline circuit

(2015) Lindsay A. Schwarz et al.   NATURE

A circuit mechanism for differentiating positive and negative associations

(2015) Praneeth Namburi et al.   NATURE

Optogenetics: 10 years after ChR2 in neurons—views from the community

(2015) Antoine Adamantidis et al.   NATURE NEUROSCIENCE

Transcriptional Response of Human Neurospheres to Helper-Dependent CAV-2 Vectors Involves the Modulation of DNA Damage Response, Microtubule and Centromere Gene Groups

(2015) Stefania Piersanti et al.   PLoS One

Modeling Human Neural FunctionalityIn Vitro: Three-Dimensional Culture for Dopaminergic Differentiation

(2015) Daniel Simão et al.   TISSUE ENGINEERING PART A

Regulation of Axonal Transport by Protein Kinases

(2015) Katherine L. Gibbs et al.   TRENDS IN BIOCHEMICAL SCIENCES

Canine helper-dependent vectors production: implications of Cre activity and co-infection on adenovirus propagation

(2015) Paulo Fernandes et al.   Scientific Reports

Ebola vaccines based on adenovirus vectors and risk of HIV

(2015) E. J. Kremer et al.   BMJ-British Medical Journal

Adenovirus Tales: From the Cell Surface to the Nuclear Pore Complex

(2015) Eric J. Kremer et al.   PLoS Pathogens

Ebola vaccines based on adenovirus vectors and risk of HIV

(2015) E. J. Kremer et al.   BMJ-British Medical Journal

Motor-Circuit Communication Matrix from Spinal Cord to Brainstem Neurons Revealed by Developmental Origin

(2014) Chiara Pivetta et al.   CELL

Adenovirus Infections in Immunocompetent and Immunocompromised Patients

(2014) T. Lion   CLINICAL MICROBIOLOGY REVIEWS

Impact of adenovirus life cycle progression on the generation of canine helper-dependent vectors

(2014) P Fernandes et al.   GENE THERAPY

Corrective GUSB transfer to the canine mucopolysaccharidosis VII cornea using a helper-dependent canine adenovirus vector

(2014) Nicolas Serratrice et al.   JOURNAL OF CONTROLLED RELEASE

Long-Range Connectivity Defines Behavioral Specificity of Amygdala Neurons

(2014) Verena Senn et al.   NEURON

Neural Circuit Reprogramming: A New Paradigm for Treating Neuropsychiatric Disease?

(2014) Kay M. Tye   NEURON

Combined Use of the Canine Adenovirus-2 and DREADD-Technology to Activate Specific Neural Pathways In Vivo

(2014) Arjen J. Boender et al.   PLoS One

Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

(2014) S. Saeed et al.   SCIENCE

Imaging of human differentiated 3D neural aggregates using light sheet fluorescence microscopy

(2014) Emilio J. Gualda et al.   Frontiers in Cellular Neuroscience

Optogenetic insights on the relationship between anxiety-related behaviors and social deficits

(2014) Stephen A. Allsop et al.   Frontiers in Behavioral Neuroscience

Central Nervous System Delivery of Helper-Dependent Canine Adenovirus Corrects Neuropathology and Behavior in Mucopolysaccharidosis Type VII Mice

(2013) Lorena Ariza et al.   HUMAN GENE THERAPY

Disruption of the Coxsackievirus and Adenovirus Receptor-Homodimeric Interaction Triggers Lipid Microdomain- and Dynamin-dependent Endocytosis and Lysosomal Targeting

(2013) Sara Salinas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Corrective GUSB Transfer to the Canine Mucopolysaccharidosis VII Brain

(2013) Aurelie Cubizolle et al.   MOLECULAR THERAPY

Genetic identification of a neural circuit that suppresses appetite

(2013) Matthew E. Carter et al.   NATURE

Axonal transport deficits and neurodegenerative diseases

(2013) Stéphanie Millecamps et al.   NATURE REVIEWS NEUROSCIENCE

Differentiated Neuroprogenitor Cells Incubated with Human or Canine Adenovirus, or Lentiviral Vectors Have Distinct Transcriptome Profiles

(2013) Stefania Piersanti et al.   PLoS One

Canine Adenovirus Type 2 Vector Generation via I-Sce1-Mediated Intracellular Genome Release

(2013) Sandy Ibanes et al.   PLoS One

Signalling endosomes in axonal transport: Travel updates on the molecular highway

(2013) Nathalie Schmieg et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Releasing the brake: restoring fast axonal transport in neurodegenerative disorders

(2013) Maria-Victoria Hinckelmann et al.   TRENDS IN CELL BIOLOGY

DREADDing the lateral habenula: A review of methodological approaches for studying lateral habenula function

(2012) Sunila G. Nair et al.   BRAIN RESEARCH

Generation and genetic modification of 3D cultures of human dopaminergic neurons derived from neural progenitor cells

(2012) Catarina Brito et al.   METHODS

SLiCE: a novel bacterial cell extract-based DNA cloning method

(2012) Yongwei Zhang et al.   NUCLEIC ACIDS RESEARCH

Coagulation Factor X Activates Innate Immunity to Human Species C Adenovirus

(2012) K. Doronin et al.   SCIENCE

Adenovirus receptors: implications for targeting of viral vectors

(2012) Niklas Arnberg   TRENDS IN PHARMACOLOGICAL SCIENCES

From Serendipity to Therapy

(2011) Elizabeth F. Neufeld   Annual Review of Biochemistry

An adenovirus traffic update: from receptor engagement to the nuclear pore

(2011) Daniel Henaff et al.   Future Microbiology

Helper-dependent canine adenovirus vector-mediated transgene expression in a neurodegenerative lysosomal storage disorder

(2011) Adeline A. Lau et al.   GENE

Self-inactivating helper virus for the production of high-capacity adenoviral vectors

(2011) M Gonzalez-Aparicio et al.   GENE THERAPY

Altering the Ad5 Packaging Domain Affects the Maturation of the Ad Particles

(2011) Raul Alba et al.   PLoS One

SGSH gene transfer in mucopolysaccharidosis type IIIA mice using canine adenovirus vectors

(2010) Adeline A. Lau et al.   MOLECULAR GENETICS AND METABOLISM

Modifications of Adenovirus Hexon Allow for Either Hepatocyte Detargeting or Targeting With Potential Evasion From Kupffer Cells

(2010) Jan-Michael Prill et al.   MOLECULAR THERAPY

Safe, Efficient, and Reproducible Gene Therapy of the Brain in the Dog Models of Sanfilippo and Hurler Syndromes

(2010) N Matthew Ellinwood et al.   MOLECULAR THERAPY

Parkinson's disease: a model dilemma

(2010) M. Flint Beal   NATURE

Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

(2010) Byoung Dae Lee et al.   NATURE MEDICINE

A hitchhiker's guide to the nervous system: the complex journey of viruses and toxins

(2010) Sara Salinas et al.   NATURE REVIEWS MICROBIOLOGY

The three-panel runway maze adapted to Microcebus murinus reveals age-related differences in memory and perseverance performances

(2010) Stéphanie G. Trouche et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

An Update on Canine Adenovirus Type 2 and Its Vectors

(2010) Thierry Bru et al.   Viruses-Basel

The locus coeruleus and noradrenergic modulation of cognition

(2009) Susan J. Sara   NATURE REVIEWS NEUROSCIENCE

Age-associated cerebral atrophy in mouse lemur primates

(2009) Audrey Kraska et al.   NEUROBIOLOGY OF AGING

CAR-Associated Vesicular Transport of an Adenovirus in Motor Neuron Axons

(2009) Sara Salinas et al.   PLoS Pathogens

Engineering and Selection of Shuffled AAV Genomes: A New Strategy for Producing Targeted Biological Nanoparticles

(2008) Wuping Li et al.   MOLECULAR THERAPY

Antibody response and plasma Aβ1-40 levels in young Microcebus murinus primates immunized with Aβ1-42 and its derivatives

(2008) Stéphanie G. Trouche et al.   VACCINE

Modification of Adenovirus Gene Transfer Vectors With Synthetic Polymers: A Scientific Review and Technical Guide

(2007) Florian Kreppel et al.   MOLECULAR THERAPY