Article
Multidisciplinary Sciences
Zengpeng Han, Nengsong Luo, Wenyu Ma, Xiaodong Liu, Yuxiang Cai, Jiaxin Kou, Jie Wang, Lei Li, Siqi Peng, Zihong Xu, Wen Zhang, Yuxiang Qiu, Yang Wu, Chaohui Ye, Kunzhang Lin, Fuqiang Xu
Summary: Viral tracers are important for studying neural circuits and brain diseases. AAV11 is a powerful retrograde viral tracer that allows for analyzing circuit connectivity and shows superior astrocytic tropism compared to commonly used AAV vectors. AAV11 can be used for monitoring neuronal activities and studying neuron-astrocyte connections.
NATURE COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Wenda Wu, Xuezhen Xue, Yan Chen, Ning Zheng, Jichuang Wang
Summary: The article summarizes the functions and mechanisms of the prolyl isomerase Pin1 in the therapeutic resistance of various cancers, discussing its relationship with tumor resistance and the important role and mechanism in cancer therapy.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Wan-Ling Wu, Chen-Yi Chiang, Szu-Chia Lai, Chia-Yi Yu, Yu-Ling Huang, Hung-Chun Liao, Ching-Len Liao, Hsin-Wei Chen, Shih-Jen Liu
Summary: Most therapeutic monoclonal antibodies (mAbs) target the receptor-binding domain (RBD) of SARS-CoV-2 spike protein, which is prone to mutations in variants. However, we identified mAbs that recognize the non-mutated S2 region of the spike protein and can neutralize SARS-CoV-2 infection and protect animals. Humanization of variable region sequences led to the selection of a high-affinity humanized mAb, hMab5.17, which effectively neutralized both SARS-CoV-2 and its variants. This suggests that an mAb targeting the S2 region could serve as a potential universal therapeutic for COVID-19.
Article
Biochemistry & Molecular Biology
Elaine Lai-Han Leung, Jumin Huang, Junmin Zhang, Juanhong Zhang, Meifang Wang, Yingjie Zhu, Zhiqiang Meng, Haijie Yu, Erwin Neher, Lijuan Ma, Xiaojun Yao
Summary: This article summarizes the potential role of microbial neurotransmitters in cancer therapy and highlights their importance in enhancing immunity and limiting tumor growth.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Review
Microbiology
Yishan Liu, Tao Zhou, Jiajia Hu, Shouheng Jin, Jianfeng Wu, Xiangdong Guan, Yaoxing Wu, Jun Cui
Summary: Selective autophagy plays a crucial role in host defense against viral infection, but viruses can also exploit this process to facilitate their replication. Understanding the intricate relationship between selective autophagy and viral infection is essential for developing novel antiviral therapeutic strategies.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Alexander G. J. Skorput, Reshma Gore, Rachel Schorn, Maureen S. Riedl, Ezequiel Marron Fernandez de Velasco, Bailey Hadlich, Kelley F. Kitto, Carolyn A. Fairbanks, Lucy Vulchanova
Summary: This study compared the transduction patterns of neurons using AAV9 and AAV2retro vectors. The results revealed notable differences in the access of the two AAV serotypes to primary afferent neurons in the colon and spinal projection neurons in the parabrachial complex. Additionally, the study emphasized the superior sensitivity of neuronal transduction detection based on reporter gene expression compared to viral protein expression.
Article
Cell Biology
Huning Jiang, Jiahua Cui, Hao Chu, Tingting Xu, Mengyan Xie, Xinming Jing, Jiali Xu, Jianwei Zhou, Yongqian Shu
Summary: This study evaluated the therapeutic potential of targeting interleukin-8 (IL8) to overcome chemotherapy resistance in advanced gastric cancer. It was found that IL8 could reverse chemotherapy resistance with limited toxicity in vivo and vitro experiments. Sequential treatment with first-line, second-line chemotherapy and reparixin also inhibited gastric cancer growth, reduced toxicity, and prolonged survival.
CELL DEATH DISCOVERY
(2022)
Review
Pharmacology & Pharmacy
Manfei Pi, Huixian Kuang, Chunyan Yue, Qixuan Yang, Anqin Wu, Yuhua Li, Yehuda G. Assaraf, Dong-Hua Yang, Shaojie Wu
Summary: Cancer cell metabolism plays a crucial role in cancer progression and drug resistance. Various signal transduction pathways regulate tumor metabolism, and targeting these pathways could be a promising therapeutic strategy for cancer treatment.
DRUG RESISTANCE UPDATES
(2022)
Article
Multidisciplinary Sciences
Yasuhiko Matsumoto, Tae Nagamachi, Asami Yoshikawa, Hideki Yamazaki, Yusuke Yamasaki, Tsuyoshi Yamada, Takashi Sugita
Summary: Trichosporon asahii is a pathogenic fungus causing severe infections, and establishing an efficient gene-targeting system in a highly pathogenic strain can aid in elucidating its infection mechanisms. Using a gene transfer system, a ku70 gene-deficient mutant with higher efficiency was obtained to construct a mutant lacking the cnb1 gene, which showed reduced pathogenicity. This suggests that studying a highly pathogenic strain using a gene-targeting system can help understand the molecular mechanisms of infection by T. asahii.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Medicinal
Anamika Singh, Isaiah T. Arkin
Summary: This study demonstrates the potential of targeting viral ion channels as a treatment strategy to enhance and complement our antiviral arsenal against COVID-19. In cell-based experiments, several ion channel blockers exhibited antiviral activity, and there was synergism between certain blockers. These findings are significant for further pandemic control and development of treatment options.
Article
Multidisciplinary Sciences
Jaspreet Kaur, Rune W. Berg
Summary: Targeting specific subtypes of interneurons in the spinal cord is often limited to a small group of genetic model animals. However, using adeno-associated virus (AAV) to deliver endogenous enhancers and promoters has shown promise in expressing specific subtypes of neurons in the forebrain of wild-type animals. This study tested the specificity and efficiency of the mDlx enhancer in targeting inhibitory interneurons in the lumbar spinal cord of wild-type rats using AAV serotype 2 (AAV2), as well as the expression and specificity of the CamKIIa and hSynapsin promoters using AAV serotype 9 (AAV9).
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Hong-Yan Geng, Gordon Arbuthnott, Wing-Ho Yung, Ya Ke
Summary: This study mapped all long-range monosynaptic inputs to M1 deep output neurons in layer 5 (L5) and revealed that most upstream areas innervate both dendritic compartments concurrently. The dichotomous inputs arise mostly from spatially segregated neuronal subpopulations within an upstream nucleus, indicating a previously unknown and highly intricate synaptic input pattern of M1L5 neurons.
Review
Virology
Varada Anirudhan, Hyun Lee, Han Cheng, Laura Cooper, Lijun Rong
Summary: The review provides information on potential treatment strategies for COVID-19 that target the essential proteins of the virus, specifically 3CL(pro) and PLpro, which are key in inhibiting viral replication and may offer insights from previous experience with SARS-CoV.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Gastroenterology & Hepatology
Mirco Glitscher, David Heiler Martin, Kathrin Woytinek, Benjamin Schmidt, Denna Tabari, Catharina Scholl, Julia C. Stingl, Evelyn Seelow, Mira Choi, Eberhard Hildt
Summary: The study found that HEV infection leads to decreased cellular cholesterol levels and affects lipid concentrations in patients. Modulating intracellular cholesterol content through drug treatment can impact HEV release, with cholesterol playing a crucial role in this process. This highlights the potential of targeting cholesterol metabolism as an antiviral strategy against HEV.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Zheng Liang, Huifen Xu, Yong Zhang, Guozhen Liu, Shenglong Chu, Yuli Tao, Xiaoxiao Xu, Shendong Xu, Liying Zhang, Xiaojing Chen, Baomin Xu, Zhengguo Xiao, Xu Pan, Jiajiu Ye
Summary: This study investigated mixed lead-tin perovskite solar cells as a candidate for achieving higher power conversion efficiency. A selective targeting anchor passivation strategy was established to enhance the open-circuit voltage and conversion efficiency.
ADVANCED MATERIALS
(2022)
Review
Neurosciences
Gord Fishell, Adam Kepecs
ANNUAL REVIEW OF NEUROSCIENCE, VOL 43
(2020)
Letter
Neurosciences
Michael Browning, Cameron S. Carter, Christopher Chatham, Hanneke Den Ouden, Claire M. Gillan, Justin T. Baker, Adam M. Chekroud, Roshan Cools, Peter Dayan, James Gold, Rita Z. Goldstein, Catherine A. Hartley, Adam Kepecs, Rebecca P. Lawson, Janaina Mourao-Mir, Mary L. Phillips, Diego A. Pizzagalli, Albert Powers, David Rindskopf, Jonathan P. Roiser, Katharina Schmack, Daniela Schiller, Miriam Sebold, Klaas Enno Stephan, Michael J. Frank, Quentin Huys, Martin Paulus
BIOLOGICAL PSYCHIATRY
(2020)
Article
Multidisciplinary Sciences
Ebru Demir, Kenneth Li, Natasha Bobrowski-Khoury, Joshua I. Sanders, Robert J. Beynon, Jane L. Hurst, Adam Kepecs, Richard Axel
Article
Neurosciences
Armin Lak, Michael Okun, Morgane M. Moss, Harsha Gurnani, Karolina Farrell, Miles J. Wells, Charu Bai Reddy, Adam Kepecs, Kenneth D. Harris, Matteo Carandini
Article
Engineering, Biomedical
Aseema Mohanty, Qian Li, Mohammad Amin Tadayon, Samantha P. Roberts, Gaurang R. Bhatt, Euijae Shim, Xingchen Ji, Jaime Cardenas, Steven A. Miller, Adam Kepecs, Michal Lipson
NATURE BIOMEDICAL ENGINEERING
(2020)
Editorial Material
Biochemistry & Molecular Biology
Michelle Monje, Jeremy C. Borniger, Nisha J. D'Silva, Benjamin Deneen, Peter B. Dirks, Faranak Fattahi, Paul S. Frenette, Livia Garzia, David H. Gutmann, Douglas Hanahan, Shawn L. Hervey-Jumper, Hubert Hondermarck, Jonathan B. Hurov, Adam Kepecs, Sarah M. Knox, Alison C. Lloyd, Claire Magnon, Jami L. Saloman, Rosalind A. Segal, Erica K. Sloan, Xin Sun, Michael D. Taylor, Kevin J. Tracey, Lloyd C. Trotman, David A. Tuveson, Timothy C. Wang, Ruth A. White, Frank Winkler
Article
Cell Biology
Huateng Cao, Min-Yin Li, Guangying Li, Shu-Jing Li, Bincheng Wen, Yuan Lu, Xiang Yu
Article
Biology
Armin Lak, Emily Hueske, Junya Hirokawa, Paul Masset, Torben Ott, Anne E. Urai, Tobias H. Donner, Matteo Carandini, Susumu Tonegawa, Naoshige Uchida, Adam Kepecs
Article
Biochemistry & Molecular Biology
Paul Masset, Torben Ott, Armin Lak, Junya Hirokawa, Adam Kepecs
Article
Neurosciences
Tamas Laszlovszky, Daniel Schlingloff, Panna Hegedus, Tamas F. Freund, Attila Gulyas, Adam Kepecs, Balazs Hangya
NATURE NEUROSCIENCE
(2020)
Correction
Neurosciences
Tamas Laszlovszky, Daniel Schlingloff, Panna Hegedus, Tamas F. Freund, Attila Gulyas, Adam Kepecs, Balazs Hangya
NATURE NEUROSCIENCE
(2020)
Article
Multidisciplinary Sciences
K. Schmack, M. Bosc, T. Ott, J. F. Sturgill, A. Kepecs
Summary: Hallucination-like perception in mice was found to be correlated with elevated dopamine levels and could be induced by optogenetic stimulation, providing insights into the neural circuit mechanisms underlying hallucinations. These findings suggest potential for developing circuit-based treatments for psychotic disorders.
Article
Neurosciences
Jing Zhang, Shu-Jing Li, Wanying Miao, Xiaodi Zhang, Jing-Jing Zheng, Chen Wang, Xiang Yu
Summary: The study shows that oxytocin can affect the frequency of synaptic transmission in neurons, with effects varying by age and reaching a critical period around P18. Both sensory experience and oxytocin peak in their effects on pyramidal neurons around P14 and stabilize by P18. Oxtr expression shifts from glutamatergic neurons to GABAergic neurons as mice age.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Torben Ott, Paul Masset, Thiago S. Gouvea, Adam Kepecs
Summary: Rational decision makers aim to maximize gains, but biases and distortions often affect humans and animals in their decision-making. A recent study found that humans, mice, and rats fall victim to the sunk cost fallacy in economic decisions. By using a computational model, researchers were able to illustrate how a rational decision maker's behavior can be replicated and proposed a new task design to differentiate sunk costs from decision valuation fluctuations.
Article
Neurosciences
Amelia J. Christensen, Torben Ott, Adam Kepecs
Summary: The frontal cortex, responsible for advanced cognitive abilities, shows diverse neural activity. Two approaches, one focusing on dynamic trajectories and the other on cell-type diversity, have been successful in addressing this challenge. This study proposes a combination of population and cell-type-specific approaches, suggesting cell-type constraints inherited through evolution create the foundation for frontal population dynamics.
CURRENT OPINION IN NEUROBIOLOGY
(2022)