The SF3B1 inhibitor spliceostatin A (SSA) elicits apoptosis in chronic lymphocytic leukaemia cells through downregulation of Mcl-1

The Anti-Apoptotic Bcl-2 Family Member Mcl-1 Promotes T Lymphocyte Survival at Multiple Stages

(2014) I. Dzhagalov et al.   JOURNAL OF IMMUNOLOGY

The impact of SF3B1 mutations in CLL on the DNA-damage response

(2014) G D te Raa et al.   LEUKEMIA

Multiple components of the spliceosome regulate Mcl1 activity in neuroblastoma

(2014) T W Laetsch et al.   Cell Death & Disease

Regulation of HPV16 E6 and MCL1 by SF3B1 inhibitor in head and neck cancer cells

(2014) Yang Gao et al.   Scientific Reports

Chemical Perturbation of Mcl-1 Pre-mRNA Splicing to Induce Apoptosis in Cancer Cells

(2013) Yang Gao et al.   ACS Chemical Biology

Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia

(2013) Dan A. Landau et al.   CELL

Transcriptome characterization by RNA sequencing identifies a major molecular and clinical subdivision in chronic lymphocytic leukemia

(2013) P. G. Ferreira et al.   GENOME RESEARCH

Reprogramming cell death: BCL2 family inhibition in hematological malignancies

(2013) Lydia Scarfò et al.   IMMUNOLOGY LETTERS

BH3 mimetic therapy: an emerging and promising approach to treating chronic lymphocytic leukemia

(2013) Mary Ann Anderson et al.   LEUKEMIA & LYMPHOMA

Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia

(2012) D. Rossi et al.   BLOOD

The clinical significance of NOTCH1 and SF3B1 mutations in the UK LRF CLL4 trial

(2012) D. G. Oscier et al.   BLOOD

Mcl-1 Phosphorylation Defines ABT-737 Resistance That Can Be Overcome by Increased NOXA Expression in Leukemic B cells

(2012) S. Mazumder et al.   CANCER RESEARCH

Comparison of Splicing Factor 3b Inhibitors in Human Cells

(2012) Yang Gao et al.   CHEMBIOCHEM

Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia

(2012) Wan Zhang et al.   NATURE CELL BIOLOGY

An antiapoptotic BCL-2 family expression index predicts the response of chronic lymphocytic leukemia to ABT-737

(2011) S. Al-harbi et al.   BLOOD

Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractoriness

(2011) D. Rossi et al.   BLOOD

Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia

(2011) D. Rossi et al.   BLOOD

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Tipping the Noxa/Mcl-1 Balance Overcomes ABT-737 Resistance in Chronic Lymphocytic Leukemia

(2011) J. M. Tromp et al.   CLINICAL CANCER RESEARCH

Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A

(2011) A. Corrionero et al.   GENES & DEVELOPMENT

Substantial Susceptibility of Chronic Lymphocytic Leukemia to BCL2 Inhibition: Results of a Phase I Study of Navitoclax in Patients With Relapsed or Refractory Disease

(2011) Andrew W. Roberts et al.   JOURNAL OF CLINICAL ONCOLOGY

Analysis of the chronic lymphocytic leukemia coding genome: role ofNOTCH1mutational activation

(2011) Giulia Fabbri et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Treatment of chronic lymphocytic leukemia requires targeting of the protective lymph node environment with novel therapeutic approaches

(2011) Rachel E. Hayden et al.   LEUKEMIA & LYMPHOMA

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

(2011) Xose S. Puente et al.   NATURE

Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia

(2011) Víctor Quesada et al.   NATURE GENETICS

The JAK3-selective inhibitor PF-956980 reverses the resistance to cytotoxic agents induced by interleukin-4 treatment of chronic lymphocytic leukemia cells: potential for reversal of cytoprotection by the microenvironment

(2010) A. J. Steele et al.   BLOOD

Homoharringtonine reduced Mcl-1 expression and induced apoptosis in chronic lymphocytic leukemia

(2010) R. Chen et al.   BLOOD

Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1

(2010) D. Yecies et al.   BLOOD

Spliceostatin A blocks angiogenesis by inhibiting global gene expression including VEGF

(2010) Ryohei Furumai et al.   CANCER SCIENCE

An Alternative Splicing Network Links Cell-Cycle Control to Apoptosis

(2010) Michael J. Moore et al.   CELL

Structural Requirements for the Antiproliferative Activity of Pre-mRNA Splicing Inhibitor FR901464

(2010) Sami Osman et al.   CHEMISTRY-A EUROPEAN JOURNAL

TP53Mutation and Survival in Chronic Lymphocytic Leukemia

(2010) Thorsten Zenz et al.   JOURNAL OF CLINICAL ONCOLOGY

Evaluation of FR901464 analogues in vitro and in vivo

(2010) Sami Osman et al.   MedChemComm

2-phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells

(2009) A. J. Steele et al.   BLOOD

R-DHAP is effective in fludarabine-refractory chronic lymphocytic leukemia

(2009) S H Tonino et al.   LEUKEMIA

Meayamycin inhibits pre-messenger RNA splicing and exhibits picomolar activity against multidrug-resistant cells

(2009) B. J. Albert et al.   MOLECULAR CANCER THERAPEUTICS

p53-mediated apoptosis of CLL cells: evidence for a transcription-independent mechanism

(2008) A. J. Steele et al.   BLOOD

Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers

(2008) C. Pepper et al.   BLOOD

Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia

(2008) M. Vogler et al.   BLOOD

CD38 expression in chronic lymphocytic leukemia is regulated by the tumor microenvironment

(2008) P. E. M. Patten et al.   BLOOD

Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia

(2008) S. M. O'Brien et al.   BLOOD

Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines

(2008) M. Hallek et al.   BLOOD